New regulators of melanin biosynthesis and the autodestruction of melanoma cells

No abstract is available for this paper.

• Publication year

  1980

• Venue

  Nature

• Publication date

  1980-08-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/286617A0PMID 6772968
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An experimental approach to the chemotherapy of melanoma.

  1980cited by this paper
• The Coat Colors of Mice

  1979cited by this paper
• The coat colours of mice. A model for mammalian gene action and interaction.

  1979cited by this paper
• Pelage color cycles and hair follicle tyrosinase activity in the Siberian hamster.

  1978cited by this paper
• 5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity

  1978cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Factors regulating growth and pigmentation of melanoma cells.

  1976cited by this paper
• Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone.

  1975cited by this paper
• Immunoglobulin origin of amyloid.

  1972cited by this paper
• On the etiology of vitiligo and gray hair.

  1971cited by this paper
• Structure and Control of the Melanocyte

  1966cited by this paper
• Investigation on the Structure of Melanin in Malignant Melanoma with 3H- and 14C-Dopa Labelled at Different Positions

  1966cited by this paper
• O-Methylation in the conversion of tyrosine to melanin.

  1963cited by this paper
• Comparative biochemistry of the phenolase complex.

  1955cited by this paper
• The chemistry of melanin; mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase.

  1948cited by this paper
• Origin of melanophores and their role in development of color patterns in vertebrates.

  1948cited by this paper

• Black-spot linked gut microbiota shifts in Oujiang color carp: insights from TYR knockout and metabolomic integration

  2025cites this paper
• Laccase-Treated Polystyrene Surfaces with Caffeic Acid, Dopamine, and L-3,4-Dihydroxyphenylalanine Substrates Facilitate the Proliferation of Melanocytes and Embryonal Carcinoma Cells NTERA-2

  2024cites this paper
• Recent Advances in Characterization of Melanin Pigments in Biological Samples

  2023cites this paper
• Eumelanin Detection in Melanized Focal Changes but Not in Red Focal Changes on Atlantic Salmon (Salmo salar) Fillets

  2023cites this paper
• Protein Biochemistry and Molecular Modeling of the Intra-Melanosomal Domain of Human Recombinant Tyrp2 Protein and OCA8-Related Mutant Variants

  2022cites this paper
• The Immunogenetics of Vitiligo: An Approach Toward Revealing the Secret of Depigmentation.

  2022cites this paper
• Melanins in Vertebrates

  2021cites this paper
• Conceptual Study On Samprapti (Pathogenies) Of Śvitra w.s.r To Vitiligo

  2021cites this paper
• Chemical and biochemical control of skin pigmentation with special emphasis on mixed melanogenesis

  2021cites this paper
• Serum Interleukin-15 in Egyptian Vitiligo Patients

  2021cites this paper
• Nonenzymatic Spontaneous Oxidative Transformation of 5,6-Dihydroxyindole

  2020cites this paper
• Use of tyrosine hydroxylase RNAi to study Megoura viciae (Hemiptera: Aphididae) sequestration of its host's l-DOPA for body melanism.

  2019cites this paper
• Insect cuticular melanins are distinctly different from those of mammalian epidermal melanins

  2018cites this paper
• Kinetics of Melanin Polymerization during Enzymatic and Nonenzymatic Oxidation.

  2018cites this paper
• Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy.

  2018cites this paper
• Parkinson’s Disease and Melanoma: Co-Occurrence and Mechanisms

  2018cites this paper
• G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma.

  2017cites this paper
• Enzyme-Mediated and Mechanistic Investigations of Tetrahydroisoquinoline Synthesis through the Pictet-Spengler Reaction

  2016cites this paper
• Promoter-Associated RNAs Regulate HSPC152 Gene Expression in Malignant Melanoma

  2016cites this paper
• Critical Analysis of the Melanogenic Pathway in Insects and Higher Animals

  2016cites this paper
• Melanogenesis-Promoting Effects of Sophora japonica Methanol Extract in Mean-a Cells

  2015cites this paper
• Blood Supply--Susceptible Formation of Melanin Pigment in Hair Bulb Melanocytes of Mice

  2015cites this paper
• Synthesis and analysis of activity of a potential anti-melanoma prodrug with a hydrazine linker.

  2014cites this paper
• Análise de polimorfismos dos genes KIR e HLA em pacientes com vitiligo

  2014influential citation
• The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.

  2014cites this paper
• Vitiligo: a review of the pathogenesis

  2014cites this paper
• Vitiligo: Hipótesis autoinmune

  2014cites this paper
• Melanins and melanogenesis: methods, standards, protocols

  2013cites this paper
• Effects of melamine on growth performance and skin color of darkbarbel catfish (Pelteobagrus vachelli)

  2011cites this paper
• Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation

  2011influential citation
• Structure of Melanins

  2011cites this paper
• The association between Parkinson's disease and melanoma

  2011cites this paper
• p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis

  2010cites this paper
• Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function

  2009cites this paper
• Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells

  2009cites this paper
• Factores psicobiológicos en vitiligo infantil: Posible rol en su génesis e impacto en la calidad de vida

  2009cites this paper
• Tyrosinase activated melanoma prodrugs.

  2009cites this paper
• [Possible role of psychological and environmental factors in the genesis of childhood vitiligo].

  2009cites this paper
• Effect of pyrroloquinoline quinone (PQQ) on melanogenic protein expression in murine B16 melanoma.

  2009cites this paper
• Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?

  2008cites this paper
• The effcect of Gorynju and a Soju extract Psoraleae fructus on Melanin synthesis of B16 melanoma cells

  2008cites this paper
• The role of peroxidase in melanogenesis revisited.

  2008cites this paper
• Membrane glycoproteins common to vesicles and melanosomes in mouse melanoma cells.

  2008cites this paper
• The nature of tyrosinase isozymes.

  2008cites this paper
• Chemistry of Mixed Melanogenesis—Pivotal Roles of Dopaquinone †

  2008cites this paper
• Melanogenesis in Cryptococcus neo formans

  2008cites this paper
• Depigmenting Mechanisms of All-Trans Retinoic Acid and Retinol on B16 Melanoma Cells

  2008cites this paper
• Autoantibody responses to melanocytes in the depigmenting skin disease vitiligo.

  2007cites this paper
• Melanin, melanogenesis, and vitiligo.

  2007cites this paper
• Autoimmunity as an aetiological factor in vitiligo

  2007cites this paper
• Incorporation of [ 125 l ]-5-lodo-2-thiouracil in Cultured Hamster , Rabbit , and Human Melanoma Cells 1

  2006cites this paper
• DNA Damage and Selective Toxicity of Dopa and Ascorbate : Copper in Human Melanoma Cells 1

  2006cites this paper
• into Athymic Mice Receptor , and Tyrosinase in Hamster Melanoma Transplanted Effects of Estradiol on Estrogen Receptor , Progesterone Updated

  2006cites this paper
• Effects of Estradici on Estrogen Receptor, Progesterone Receptor, and Tyrosinase in Hamster Melanoma Transplanted into Athymic Mice1

  2006cites this paper
• The effects of Hominis Placenta extract on Melanin synthesis of B16 melanoma cells

  2006cites this paper
• Function-blocking autoantibodies to the melanin-concentrating hormone receptor in vitiligo patients

  2006cites this paper
• Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin.

  2006cites this paper
• 5,6-Dihydroxyindoles and Indole-5,6-diones

  2005cites this paper
• Eumelanin and pheomelanin contents in hair and 5-S-cysteinyldopa and 5-hydroxy-6-methoxyindole-2-carboxylic acid levels in urine in Japanese oculocutaneous albinism

  2005cites this paper
• New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT).

  2005cites this paper
• Neural differentiation in the OTT-6050 mouse teratoma

  2005cites this paper
• Aluminum Facilitation of the Iron-Mediated Oxidation of DOPA to Melanin

  2004cites this paper
• Enzyme-Catalyzed Activation of Anticancer Prodrugs

  2004cites this paper
• Autoantibodies as diagnostic and predictive markers of vitiligo.

  2004cites this paper
• Melanocytes and Pigmentation Are Affected in Dopachrome Tautomerase Knockout Mice

  2004cites this paper
• Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells.

  2004cites this paper
• Melanin pigmentation in mammalian skin and its hormonal regulation.

  2004cites this paper
• Chemical and biological aspects of melanin.

  2003cites this paper
• The IFPCS presidential lecture: a chemist's view of melanogenesis.

  2003cites this paper
• A Chemist's View of Melanogenesis

  2003cites this paper
• Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?

  2003cites this paper
• Chapter 12 – Pigmentary Abnormalities

  2003cites this paper
• Biosynthesis of Neuromelanin and Melanin: The Potential Involvement of Macrophage Inhibitory Factor and Dopachrome Tautomerase as Rescue Enzymes

  2002cites this paper
• Comparative biochemistry of eumelanogenesis and the protective roles of phenoloxidase and melanin in insects.

  2002cites this paper
• mosaic eyes: a zebrafish gene required in pigmented epithelium for apical localization of retinal cell division and lamination.

  2001cites this paper
• Interaction of melanin with proteins--the importance of an acidic intramelanosomal pH.

  2001cites this paper
• Immunological pathomechanisms in vitiligo

  2001cites this paper
• Vitiligo‐like leucoderma during photochemotherapy for mycosis fungoides

  2001cites this paper
• Autoimmune Aspects of Vitiligo

  2001cites this paper
• Metabolism of Aromatic Compounds and Nucleic Acid Bases

  2001cites this paper
• Alternative splicing of the tyrosinase gene transcript in normal human melanocytes and lymphocytes.

  2001cites this paper
• Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress.

  2000cites this paper
• Melanocytes are not absent in lesional skin of long duration vitiligo.

  2000cites this paper
• Enzyme Activity of Macrophage Migration Inhibitory Factor toward Oxidized Catecholamines*

  1999cites this paper
• Formation of a new quinone methide intermediate during the oxidative transformation of 3,4-dihydroxyphenylacetic acids: implication for eumelanin biosynthesis.

  1999cites this paper
• Insect melanogenesis. II. Inability of Manduca phenoloxidase to act on 5,6-dihydroxyindole-2-carboxylic acid.

  1999cites this paper
• Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues.

  1999cites this paper
• Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma.

  1999cites this paper
• α‐melanocyte stimulating hormone inhibits tumour necrosis factor‐α stimulated intercellular adhesion molecule‐1 expression in normal cutaneous human melanocytes and in melanoma cell lines

  1998cites this paper
• Unified Mechanism for Sclerotization of Insect Cuticle

  1998cites this paper
• Reducing compounds initiate the TRP2-catalyzed conversion of L-dopachrome to DHICA.

  1998cites this paper
• Variations in melanin formation by cultured melanocytes from different skin types

  1998cites this paper
• Cellular and developmental aspects of androgenetic alopecia

  1998cites this paper
• Interactions of alpha-melanotropin and agouti on B16 melanoma cells: evidence for inverse agonism of agouti.

  1997cites this paper
• Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation.

  1997cites this paper
• Relationship between 4-hydroxyanisole toxicity and dopa oxidase activity for three melanoma cell lines

  1997cites this paper
• Immune mechanisms in vitiligo.

  1997cites this paper
• Immune response in insects: the role of phenoloxidase in defense reactions in relation to melanization and sclerotization.

  1996cites this paper
• Tyrosinase and related proteins in mammalian pigmentation

  1996cites this paper
• Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein.

  1996cites this paper