Gene therapy in orthopaedic surgery.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Instructional Course Lectures

• Publication date

  2002-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2106/00004623-200206000-00023PMID 12690900
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• EGF and IL-1 alpha modulate the release of collagenase, gelatinase and TIMP-1 as well as the release of calcium by rabbit calvarial bone explants.

  2010cited by this paper
• Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2.

  2002cited by this paper
• IGF‐1 receptor as an alternative receptor for metabolic signaling in insulin receptor‐deficient muscle cells

  2001cited by this paper
• Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer.

  2001cited by this paper
• Systemic IFN-β gene therapy results in long-term survival in mice with established colorectal liver metastases

  2001cited by this paper
• Lentivirus administration to rat muscle provides efficient sustained expression of erythropoietin.

  2001cited by this paper
• The promise and potential hazards of adenovirus gene therapy

  2001cited by this paper
• Exogenously regulated stem cell-mediated gene therapy for bone regeneration.

  2001cited by this paper
• Growth factor supplemented matrigel improves ectopic skeletal muscle formation—a cell therapy approach

  2001cited by this paper
• Dystrophin Expression in Muscle Following Gene Transfer with a Fully Deleted ("Gutted") Adenovirus Is Markedly Improved by Trans-Acting Adenoviral Gene Products

  2001cited by this paper
• High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects.

  2001cited by this paper
• Lentivirus vectors: difficulties and hopes before clinical trials.

  2001cited by this paper
• Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies

  2001cited by this paper
• Muscle-derived stem cells: characterization and potential for cell-mediated therapy.

  2001cited by this paper
• Herpesvirus-mediated systemic delivery of nerve growth factor.

  2001cited by this paper
• Enhanced matrix synthesis and in vitro formation of cartilage‐like tissue by genetically modified chondrocytes expressing BMP‐7

  2001cited by this paper
• The Use of an Antifibrosis Agent to Improve Muscle Recovery after Laceration *

  2001cited by this paper
• Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle.

  2001cited by this paper
• Adenoviral Delivery of LIM Mineralization Protein-1 Induces New-Bone Formation in Vitro and in Vivo

  2001cited by this paper
• Muscle-Specific Overexpression of the Adenovirus Primary Receptor CAR Overcomes Low Efficiency of Gene Transfer to Mature Skeletal Muscle

  2001cited by this paper
• Effect of Bone Morphogenetic Protein-2-Expressing Muscle-Derived Cells on Healing of Critical-Sized Bone Defects in Mice

  2001cited by this paper
• Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

  2001cited by this paper
• Muscular dystrophy in adult and aged anti‐NGF transgenic mice resembles an inclusion body myopathy

  2000cited by this paper
• Human Bone Morphogenetic Protein Allografting for Reconstruction of Femoral Nonunion

  2000cited by this paper
• Osteoinduction by bone morphogenetic protein-2 via adenoviral vector under transient immunosuppression.

  2000cited by this paper
• Use of Growth Factors to Improve Muscle Healing After Strain Injury

  2000cited by this paper
• Synthetic DNA delivery systems

  2000cited by this paper
• Endothelin-1 responsiveness of a 1.4 kb phospholamban promoter fragment in rat cardiomyocytes transfected by the gene gun.

  2000cited by this paper
• Ex vivo gene delivery using an adenovirus vector in treatment for cartilage defects.

  2000cited by this paper
• Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist.

  2000cited by this paper
• Clonal Isolation of Muscle-Derived Cells Capable of Enhancing Muscle Regeneration and Bone Healing

  2000cited by this paper
• Gene Therapy-Directed Osteogenesis: BMP-7-Transduced Human Fibroblasts Form Bone in Vivo

  2000cited by this paper
• Biology of Lumbar Spine Fusion and Use of Bone Graft Substitutes: Present, Future, and Next Generation

  2000cited by this paper
• Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1.

  2000cited by this paper
• Growth factors improve muscle healing in vivo

  2000cited by this paper
• The Marshall R. Urist Young Investigator Award. Orthopaedic applications of gene therapy. From concept to clinic.

  2000cited by this paper
• Lentiviral vectors: turning a deadly foe into a therapeutic agent

  2000cited by this paper
• Targeted delivery of plasmid DNA to myogenic cells via transferrin-conjugated peptide nucleic acid.

  2000cited by this paper
• Efficient lipid-mediated gene transfer to articular chondrocytes

  2000cited by this paper
• Tissue engineering via local gene delivery: update and future prospects for enhancing the technology.

  2000cited by this paper
• Adeno-Associated Virus Production of Soluble Tumor Necrosis Factor Receptor Neutralizes Tumor Necrosis Factor α and Reduces Arthritis

  2000cited by this paper
• Repair of Articular Cartilage Defects One Year After Treatment with Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)*

  2000cited by this paper
• BIOLOGICAL INTERVENTION BASED ON CELL AND GENE THERAPY TO IMPROVE MUSCLE HEALING AFTER LACERATION

  2000cited by this paper
• Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.

  2000cited by this paper
• Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene.

  2000cited by this paper
• Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints.

  2000cited by this paper
• The quantitative characteristics of efficiency of ballistic transfection of chimeric antibody genes.

  2000cited by this paper
• Gene therapy for bone formation: In vitro and in vivo osteogenic activity of an adenovirus expressing BMP7

  2000cited by this paper
• The Use of Adeno-Associated Virus to Circumvent the Maturation-Dependent Viral Transduction of Muscle Fibers

  2000cited by this paper
• Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts

  2000cited by this paper
• Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4

  2000cited by this paper
• Increased matrix synthesis following adenoviral transfer of a transforming growth factor β1 gene into articular chondrocytes

  2000cited by this paper
• Adeno-associated virus-mediated delivery of IL-4 prevents collagen-induced arthritis

  2000cited by this paper
• The Efficiency of Muscle-Derived Cell-Mediated Bone Formation

  2000cited by this paper
• Modification of vascular tone using iNOS under the control of a radiation-inducible promoter

  2000cited by this paper
• Adeno-associated virus vector carrying human minidystrophin genes effectively ameliorates muscular dystrophy in mdx mouse model.

  2000cited by this paper
• Osteoprogenitor cells within skeletal muscle

  2000cited by this paper
• Gene delivery to human chondrocytes by an adeno associated virus vector.

  2000cited by this paper
• The Use of rhBMP-2 in Interbody Fusion Cages: Definitive Evidence of Osteoinduction in Humans: A Preliminary Report

  2000cited by this paper
• Nerve growth factor (NGF) influences differentiation and proliferation of myogenic cells in vitro via TrKA

  2000cited by this paper
• Ex Vivo Gene Therapy to Produce Bone Using Different Cell Types

  2000cited by this paper
• Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene

  2000cited by this paper
• Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone.

  1999cited by this paper
• A gene therapy approach to accelerating bone healing Evaluation of gene expression in a New Zealand white rabbit model

  1999cited by this paper
• Herpes simplex virus vector‐mediated dystrophin gene transfer and expression in MDX mouse skeletal muscle

  1999cited by this paper
• Efficient infection of mature skeletal muscle with herpes simplex virus vectors by using dextran sulfate as a co-receptor

  1999cited by this paper
• VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

  1999cited by this paper
• Effect of interleukin-6 secreted by engineered human stromal cells on osteoclasts in human bone.

  1999cited by this paper
• Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: The use of different viral vectors and the effects of injury

  1999cited by this paper
• Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment.

  1999cited by this paper
• Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis

  1999cited by this paper
• The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats.

  1999cited by this paper
• The use of lateral patellar autologous grafts for the repair of large osteochondral defects in the knee.

  1999cited by this paper
• Direct-, Fibroblast- and Myoblast-Mediated Gene Transfer to the Anterior Cruciate Ligament

  1999cited by this paper
• In Vivo Endochondral Bone Formation Using a Bone Morphogenetic Protein 2 Adenoviral Vector

  1999cited by this paper
• Transfer of lacZ marker gene to the meniscus.

  1999cited by this paper
• Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell‐mediated gene therapy

  1999cited by this paper
• rAAV vector-mediated sarcogylcan gene transfer in a hamster model for limb girdle muscular dystrophy

  1999cited by this paper
• Design and applications of parathyroid hormone analogues.

  1999cited by this paper
• Enhanced repair of extensive articular defects by insulin‐like growth factor‐I‐laden fibrin composites

  1999cited by this paper
• Convergence of the BMP and EGF signaling pathways on Smad1 in the regulation of chondrogenesis.

  1999cited by this paper
• Gene therapy expression vectors based on the clotting Factor IX promoter

  1999cited by this paper
• Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration

  1999cited by this paper
• Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene.

  1999cited by this paper
• Direct in vivo gene transfer to healing rat patellar ligament by intra‐arterial delivery of haemagglutinating virus of Japan liposomes

  1999cited by this paper
• Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function.

  1998cited by this paper
• Respiratory muscles as a target for adenovirus-mediated gene therapy.

  1998cited by this paper
• A comparison of in vivo gene delivery methods for antisense therapy in ligament healing

  1998cited by this paper
• Articular cartilage repair and transplantation.

  1998cited by this paper
• The Effect of Implants Loaded with Autologous Mesenchymal Stem Cells on the Healing of Canine Segmental Bone Defects*

  1998cited by this paper
• Early biological effect of in vivo gene transfer of platelet-derived growth factor (PDGF)-B into healing patellar ligament

  1998cited by this paper
• Molecular Lysis of Synovial Lining Cells by In Vivo Herpes Simplex Virus-Thymidine Kinase Gene Transfer

  1998cited by this paper
• Development of approaches to improve the healing following muscle contusion.

  1998cited by this paper
• Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects.

  1998cited by this paper
• Adenovirus mediated gene delivery to the joints of guinea pigs.

  1998cited by this paper
• 1998 Volvo Award Winner in Basic Science Studies: Lumbar Spine Fusion by Local Gene Therapy With a cDNA Encoding a Novel Osteoinductive Protein (LMP‐1)

  1998cited by this paper
• Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.

  1998cited by this paper
• Overexpression of IGF-1 Exclusively in Skeletal Muscle Prevents Age-related Decline in the Number of Dihydropyridine Receptors*

  1998cited by this paper
• Semiquantitative reverse transcription‐polymerase chain reaction analysis of mRNA for growth factors and growth factor receptors from normal and healing rabbit medial collateral ligament tissue

  1998cited by this paper
• Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro.

  1998cited by this paper

• Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction

  2024cites this paper
• Tissue engineering in oral and maxillofacial surgery

  2020cites this paper
• Lentiviral Gene Therapy for Bone Repair Using Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells

  2019cites this paper
• Designing Bioactive Scaffolds for Dental Tissue Engineering

  2017cites this paper
• Controlled Gene Delivery Systems for Articular Cartilage Repair

  2017cites this paper
• Sicherheitsnachweis zum Ausschluss einer systemischen Genexpression nach lokaler Applikation wachstumsfaktor- spezifischer Plasmide am Kaninchenmodell

  2016cites this paper
• Lentiviral-mediated multiple gene transfer to chondrocytes promotes chondrocyte differentiation and bone formation in rabbit bone marrow-derived mesenchymal stem cells.

  2015cites this paper
• Tissue engineering in oral and maxillofacial reconstruction

  2015cites this paper
• Pharmacological interventions for the treatment of Achilles tendinopathy: a systematic review of randomized controlled trials.

  2015cites this paper
• Current and future options of regeneration methods and reconstructive surgery of the facial skeleton.

  2015cites this paper
• New therapeutic modalities to modulate orthodontic tooth movement

  2014cites this paper
• Tissue Engineering in Oral and Maxillofacial Surgery

  2014cites this paper
• Two Stage Repair of Composite Craniofacial Defects with Antibiotic Releasing Porous Poly(methyl methacrylate) Space Maintainers and Bone Regeneration

  2013cites this paper
• Modulation of Polyplex Release from Biodegradable Microparticles through Poly(ethylenimine) Modification and Varying Loading Concentration

  2013cites this paper
• Chapter 31 – Achilles Tendon Repair and Rehabilitation

  2013cites this paper
• Effects of allogenous periosteal-derived cells transfected with adenovirus-mediated BMP-2 on repairing defects of the mandible in rabbits.

  2013cites this paper
• Regenerative Endodontics In The Light Of Recent Research

  2013cites this paper
• Overview of Tissue Engineering Concepts and Applications

  2013cites this paper
• Clinical Relevance of Gene Therapy and Growth Factors in Sports Injuries

  2012cites this paper
• Gene Therapy in the Treatment of Knee Disorders

  2012cites this paper
• Potential treatment of hypoparathyroidism with recombinant plasmids encoding preproparathyroid hormone

  2012cites this paper
• Control and Augmentation of Long-Term Plasmid Transgene Expression In Vivo in Murine Muscle Tissue and Ex Vivo in Patient Mesenchymal Tissue

  2012cites this paper
• Gene Therapy for Cartilage Repair

  2011cites this paper
• In vitro evaluation of a double-stranded self-complementary adeno-associated virus type2 vector in bone marrow stromal cells for bone healing

  2011cites this paper
• Comparison between the effects of platelet-rich plasma and bone marrow concentrate on defect consolidation in the rabbit tibia

  2011cites this paper
• The Future of Cartilage Restoration

  2010cites this paper
• Biodegradable branched polycationic polymers as non-viral gene delivery vectors for bone tissue engineering

  2010cites this paper
• Gene Therapy for Fracture Healing

  2010cites this paper
• MANIPULAÇÃO DE GENES E DESEMPENHO ESPORTIVO: TENDÊNCIA OU REALIDADE?

  2009cites this paper
• The Osteochondral Junction and Its Repair via Bi-Phasic Tissue Engineering Scaffolds

  2009cites this paper
• Bone regeneration after topical BMP-2-gene delivery in circumferential peri-implant bone defects.

  2008cites this paper
• Efficient and stable gene transfer of growth factors into chondrogenic cells and primary articular chondrocytes using a VSV.G pseudotyped retroviral vector.

  2008cites this paper
• Tissue engineering approaches for the construction of a completely autologous tendon substitute

  2008cites this paper
• Musculoskeletal Fundamentals: Form, Function, and a Survey of Healing Strategies

  2008cites this paper
• Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model.

  2008cites this paper
• Biology of Bone Allograft and Clinical Application

  2008cites this paper
• Pathophysiologie der chronischen Wunde

  2008cites this paper
• Gentherapie zur Behandlung der akuten inflammatorischen Immunantwort

  2007cites this paper
• Muscle Cell Transplants

  2007cites this paper
• In vivo analysis of retroviral gene transfer to chondrocytes within collagen scaffolds for the treatment of osteochondral defects.

  2007cites this paper
• In vitro and in vivo induction of bone formation based on adeno-associated virus-mediated BMP-7 gene therapy using human adipose-derived mesenchymal stem cells

  2007cites this paper
• Oral and maxillofacial surgery

  2007cites this paper
• Localized viral vector delivery to enhance in situ regenerative gene therapy

  2007cites this paper
• Gene therapy in orthopaedics.

  2006cites this paper
• Runx2 Overexpression Enhances Osteoblastic Differentiation and Mineralization in Adipose - Derived Stem Cells in vitro and in vivo

  2006cites this paper
• Tendon tissue engineering and gene transfer: the future of surgical treatment.

  2006cites this paper
• The role of gene therapy for craniofacial and dental tissue engineering.

  2006cites this paper
• Stellenwert der Gentherapie in Unfallchirurgie und Orthopädie

  2006cites this paper
• Biomechanical basis for tendinopathy.

  2006cites this paper
• Rééducation des lésions tendineuses traumatiques de la main

  2006cites this paper
• Laboratory Investigations Runx2 Overexpression Enhances Osteoblastic Differentiation and Mineralization in Adipose - Derived Stem Cells in vitro and in vivo

  2006cites this paper
• Rehabilitación de las lesiones tendinosas traumáticas de la mano

  2006cites this paper
• Adeno-associated virus-mediated bone morphogenetic protein-7 gene transfer induces C2C12 cell differentiation into osteoblast lineage cells

  2005cites this paper
• Biologic approaches to articular cartilage surgery: future trends.

  2005cites this paper
• In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7.

  2005cites this paper
• Tendon injury and tendinopathy: healing and repair.

  2005cites this paper
• Musculoskeletal gene therapy and its potential use in the treatment of complicated musculoskeletal infection.

  2005cites this paper
• Bone Regeneration in Cranial Defects Previously Treated with Radiation

  2005cites this paper
• Osteoinductivity of commercially available demineralized bone matrix. Preparations in a spine fusion model.

  2004cites this paper
• Combination of porous hydroxyapatite and cationic liposomes as a vector for BMP-2 gene therapy.

  2004cites this paper
• Retargeting recombinant adenoviral vectors expressing bone morphogenic protein 2 ( BMP 2 ) to improve the efficacy of bone formation in mice with applications in spinal fusion

  2004cites this paper
• Tissue engineering: the current status of this futuristic modality in head neck reconstruction

  2004cites this paper
• Genetic Modification of Stem Cells to Enhance Bone Repair

  2004cites this paper
• Current concepts in meniscus surgery: resection to replacement.

  2003cites this paper
• IN-SITU TISSUE ENGINEERING OF THE INTERVERTEBRAL DISC

  2003cites this paper
• The biological treatment of focal articular cartilage lesions in the knee: future trends?

  2003cites this paper
• Current concepts review: Achilles tendinopathy

  2002cites this paper