An achaete-scute homologue essential for neuroendocrine differentiation in the lung

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Nature

• Publication date

  1997-04-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/386852A0PMID 9126746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.

  1997cited by this paper
• A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA.

  1996cited by this paper
• Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes.

  1996cited by this paper
• Spectrum of neuroendocrine differentiation in lung cancer cell lines featured by cytomorphology, markers, and their corresponding tumors

  1996cited by this paper
• Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

  1995cited by this paper
• Signalling downstream of activated mammalian Notch

  1995cited by this paper
• The cellular function of MASH1 in autonomic neurogenesis.

  1995cited by this paper
• Genetic control of cell fate specification in Drosophila peripheral nervous system.

  1994cited by this paper
• Impact of Neuroendocrine Differentiation in Non-small Cell Lung Cancer

  1994cited by this paper
• Impact of neuroendocrine differentiation in non-small cell lung cancer. The LCSG experience.

  1994cited by this paper
• Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.

  1993cited by this paper
• Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.

  1993cited by this paper
• Expression of c-myc in progenitor cells of the bronchopulmonary epithelium and in a large number of non-small cell lung cancers.

  1993cited by this paper
• Transitions between lung cancer phenotypes--implications for tumor progression.

  1991cited by this paper
• Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.

  1991cited by this paper
• Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors

  1990cited by this paper
• v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line.

  1990cited by this paper
• Transcription factor levels in medullary thyroid carcinoma cells differentiated by Harvey ras oncogene: c-jun is increased.

  1990cited by this paper
• Expression of neuroendocrine cell markers L-dopa decarboxylase, chromogranin A, and dense core granules in human tumors of endocrine and nonendocrine origin.

  1988cited by this paper
• Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas.

  1988cited by this paper
• Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium.

  1986cited by this paper
• Establishment and identification of small cell lung cancer cell lines having classic and variant features.

  1985cited by this paper
• Molecular genetics of the achaete-scute gene complex of D. melanogaster.

  1985cited by this paper
• Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.

  1985cited by this paper
• Establishment and characterization of a continuous lung squamous cell carcinoma cell line (U-1752).

  1981cited by this paper
• Isolation and growth characteristics of continuous cell lines from small‐cell carcinoma of the lung

  1980cited by this paper
• Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties.

  1980cited by this paper

• Stem cell control and cancer initiation by an autocrine, injury-activated Igf complex

  2026cites this paper
• Single-cell profiling of tumor lineage plasticity and the immune microenvironment in transformed small cell lung cancer.

  2026cites this paper
• A robust human airway organoid platform enables scalable expansion and trajectory mapping of pulmonary neuroendocrine cells

  2026cites this paper
• Immunohistochemical profiling of small cell lung cancer reveals subtype heterogeneity and a tuft cell-like subtype characterized by LRMP and TRPM5.

  2026cites this paper
• The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ

  2026cites this paper
• Purinergic Signaling in Swallowing Reflex Initiation: Mechanisms and Therapeutic Implications for Oropharyngeal Dysphagia—A Narrative Review

  2025cites this paper
• Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome

  2025cites this paper
• Chromatin remodeling complexes: architects influencing breast cancer progression

  2025cites this paper
• Challenges of small cell lung cancer heterogeneity and phenotypic plasticity

  2025cites this paper
• ASCL1 protein domains with distinct functions in neuronal differentiation and subtype specification.

  2025cites this paper
• Neuroendocrine tumours of the urinary bladder: recent advances

  2025cites this paper
• Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification

  2025cites this paper
• Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma

  2025cites this paper
• FOXA2 promotes metastatic competence in small cell lung cancer

  2025cites this paper
• Lineage Tracing of Distal Lung Epithelial Progenitors in Injury‐Induced Regeneration

  2025cites this paper
• Paraneurons.

  2025cites this paper
• Expression of Survivin, CK7, ASH1, HMGB3, L587S, and CLCA2 in Peripheral Blood of Lung Cancer Patients by Real-Time Polymerase Chain Reaction

  2024cites this paper
• Differential NEUROD1, ASCL1, and POU2F3 Expression Defines Molecular Subsets of Bladder Small Cell/Neuroendocrine Carcinoma with Prognostic Implications.

  2024cites this paper
• Molecular subtypes and prognostic factors of lung large cell neuroendocrine carcinoma

  2024cites this paper
• Distinct Regulation of ASCL1 by the Cell Cycle and Chemotherapy in Small Cell Lung Cancer

  2024cites this paper
• Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.

  2024cites this paper
• Jumonji histone demethylases are therapeutic targets in small cell lung cancer

  2024cites this paper
• Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

  2024cites this paper
• Applied models and molecular characteristics of small cell lung cancer

  2024cites this paper
• Exploring Emerging Therapeutic Targets and Opportunities in Neuroendocrine Tumors: Updates on Receptor Tyrosine Kinases

  2024cites this paper
• Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

  2024cites this paper
• A vagal reflex evoked by airway closure

  2024cites this paper
• Lung NETs and GEPNETs: One Cancer with Different Origins or Two Distinct Cancers?

  2024cites this paper
• Updates on Urinary Bladder Tumors With Neuroendocrine Features

  2024cites this paper
• PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity

  2024cites this paper
• Fibrinogen induces inflammatory responses via the immune activating receptor LILRA2

  2024cites this paper
• Characterization of cell cycle, inflammation, and oxidative stress signaling role in non-communicable diseases: Insights into genetic variants, microRNAs and pathways

  2024cites this paper
• An Overview of Altered Pathways Associated with Sensitivity to Platinum-Based Chemotherapy in Neuroendocrine Tumors: Strengths and Prospects

  2024cites this paper
• Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models

  2024cites this paper
• Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1.

  2024cites this paper
• Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

  2024cites this paper
• Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity.

  2024cites this paper
• Role of Notch1 Signaling Pathway in Small Cell Lung Carcinoma

  2024cites this paper
• Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors

  2024cites this paper
• Molecular pathology of small cell lung cancer: Overview from studies on neuroendocrine differentiation regulated by ASCL1 and Notch signaling

  2024influential citation
• Neuroendocrine cells initiate protective upper airway reflexes

  2024cites this paper
• A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung

  2023cites this paper
• YAP1 expression is associated with survival and immunosuppression in small cell lung cancer

  2023cites this paper
• Molecular classification of small cell lung cancer subtypes: Characteristics, prognostic factors, and clinical translation

  2023cites this paper
• Phox2B is a sensitive and reliable marker of paraganglioma—Phox2B immunohistochemistry in diagnosis of neuroendocrine neoplasms

  2023cites this paper
• Distinct microRNA signature and suppression of ZFP36L1 define ASCL1-positive lung adenocarcinoma.

  2023cites this paper
• The bHLH Transcription Factor ASCL1 Promotes Differentiation of Endocrine Cells in the Stomach and is Regulated by Notch Signaling.

  2023cites this paper
• Targeting the Notch signaling pathway and the Notch ligand, DLL3, in small cell lung cancer.

  2023cites this paper
• Stem/Progenitor Cells and Related Therapy in Bronchopulmonary Dysplasia

  2023cites this paper
• Cellular and molecular mechanisms of the organogenesis and development, and function of the mammalian parathyroid gland

  2023cites this paper
• Bioinformatics-based screening of key genes for transformation of tyrosine kinase inhibitor-resistant lung adenocarcinoma to small cell lung cancer

  2023cites this paper
• Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation.

  2023cites this paper
• 小细胞肺癌的分子分型及其治疗策略的研究进展

  2023cites this paper
• Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus

  2023cites this paper
• An abundance of brain-expressed genes show ectopic activation in lung adenocarcinoma

  2023cites this paper
• Clinical and morphological features of large-cell neuroendocrine carcinomas and small-cell lung carcinomas expressing the DLL3 and ASCL1 oncoproteins

  2023cites this paper
• Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

  2023cites this paper
• Genetic variants of NEUROD1 target genes are associated with clinical outcomes of small‐cell lung cancer patients

  2023cites this paper
• Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy

  2023cites this paper
• Progress in the knowledge on the transformation of lung adenocarcinoma to small-cell lung cancer

  2023cites this paper
• ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers

  2023cites this paper
• Killing SCLC: insights into how to target a shapeshifting tumor

  2022influential citation
• Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation

  2022cites this paper
• Multivalent state transitions shape the intratumoral composition of small cell lung carcinoma

  2022cites this paper
• Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells

  2022cites this paper
• KSR2 promotes self-renewal and clonogenicity of small-cell lung carcinoma

  2022cites this paper
• Emerging Biomarkers and the Changing Landscape of Small Cell Lung Cancer

  2022cites this paper
• Developmental origins of cell heterogeneity in the human lung

  2022cites this paper
• Involvement of Epithelial–Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity

  2022cites this paper
• A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

  2022cites this paper
• Pulmonary Neuroendocrine Cells and Small Cell Lung Carcinoma: Immunohistochemical Study Focusing on Mechanisms of Neuroendocrine Differentiation

  2022cites this paper
• Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells

  2022cites this paper
• Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer

  2022cites this paper
• A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

  2022cites this paper
• Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer.

  2022cites this paper
• Development of the Lung

  2021cites this paper
• Diagnosis and Molecular Profiles of Large Cell Neuroendocrine Carcinoma With Potential Targets for Therapy

  2021cites this paper
• Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

  2021cites this paper
• Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer

  2021cites this paper
• Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.

  2021cites this paper
• Epithelial Barrier Dysfunction in Chronic Respiratory Diseases

  2021cites this paper
• Pathways in small cell lung cancer and its therapeutic perspectives.

  2021cites this paper
• Studying the Pulmonary NEB ME: A Multidisciplinary Approach.

  2021cites this paper
• Small-Cell Carcinoma of the Lung: What We Learned about It?

  2021cites this paper
• Airway basal stem cells generate distinct subpopulations of PNECs

  2021cites this paper
• Neuroendocrine cells in lung development and disease

  2021cites this paper
• Functional Exploration of the Pulmonary NEB ME.

  2021cites this paper
• Normal Lung

  2021cites this paper
• Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas

  2021cites this paper
• Small Cell Lung Cancer: Biology Advances

  2021cites this paper
• MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

  2021cites this paper
• Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and Treatments

  2021cites this paper
• Pulmonary Sensory Receptors.

  2021cites this paper
• NOTCH alteration in EGFR-mutated lung adenocarcinoma leads to histological small-cell carcinoma transformation under EGFR-TKI treatment

  2021cites this paper
• SCLC-J1, a novel small cell lung cancer cell line

  2021cites this paper
• Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

  2021cites this paper
• ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer

  2021influential citation
• Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibition as Maintenance Treatment for SCLC: The Search Must Continue.

  2021cites this paper
• Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla

  2021cites this paper
• Potential interactions between the TBX4-FGF10 and SHH-FOXF1 signaling during human lung development revealed using ChIP-seq

  2021cites this paper