Advances in MicroRNAs: Implications for Gene Therapists

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Human Gene Therapy

• Publication date

  2008-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/hum.2007.147PMID 18092919PMCID PMC2760384
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus

  2007cited by this paper
• Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

  2007cited by this paper
• Specificity, duplex degradation and subcellular localization of antagomirs

  2007cited by this paper
• Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

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• A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice.

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• The let-7 microRNA represses cell proliferation pathways in human cells.

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• Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNA.

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• MicroRNA signatures in human ovarian cancer.

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• microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder

  2007cited by this paper
• Target mimicry provides a new mechanism for regulation of microRNA activity

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• miR-21-mediated tumor growth

  2007cited by this paper
• MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

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• Marek's Disease Virus Type 2 (MDV-2)-Encoded MicroRNAs Show No Sequence Conservation with Those Encoded by MDV-1

  2007cited by this paper
• MicroRNAs in Viral Replication and Pathogenesis

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• DNA Methyltransferase Inhibitors for Cancer Therapy

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• Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

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• Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.

  2007cited by this paper
• A protocol for designing siRNAs with high functionality and specificity

  2007cited by this paper
• Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirus.

  2007cited by this paper
• MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

  2007cited by this paper
• MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)*

  2007cited by this paper
• Argonaute proteins: mediators of RNA silencing.

  2007cited by this paper
• AAV Vector Integration Sites in Mouse Hepatocellular Carcinoma

  2007cited by this paper
• MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.

  2007cited by this paper
• Expression and function of microRNAs in viruses great and small.

  2006cited by this paper
• LNA-modified oligonucleotides mediate specific inhibition of microRNA function.

  2006cited by this paper
• MicroRNA signatures in human cancers

  2006cited by this paper
• A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

  2006cited by this paper
• Oncomirs — microRNAs with a role in cancer

  2006cited by this paper
• Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

  2006cited by this paper
• Marek's Disease Virus Encodes MicroRNAs That Map to meq and the Latency-Associated Transcript

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• Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

  2006cited by this paper
• Epstein–Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed

  2006cited by this paper
• miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

  2006cited by this paper
• Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues

  2006cited by this paper
• 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

  2006cited by this paper
• Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

  2006cited by this paper
• MicroRNAs: a new class of regulatory genes affecting metabolism.

  2006cited by this paper
• Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis.

  2006cited by this paper
• Prediction and Identification of Herpes Simplex Virus 1-Encoded MicroRNAs

  2006cited by this paper
• Expression profiling identifies microRNA signature in pancreatic cancer

  2006cited by this paper
• Improved targeting of miRNA with antisense oligonucleotides

  2006influential reference
• Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice.

  2006cited by this paper
• A brain-specific microRNA regulates dendritic spine development

  2006cited by this paper
• Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines.

  2006cited by this paper
• The diverse functions of microRNAs in animal development and disease.

  2006cited by this paper
• Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript

  2006cited by this paper
• RAS is regulated by the let-7 microRNA family.

  2005cited by this paper
• Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome

  2005cited by this paper
• MicroRNA expression profiles classify human cancers

  2005cited by this paper
• Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs.

  2005cited by this paper
• Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

  2005cited by this paper
• An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi

  2005cited by this paper
• Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

  2005cited by this paper
• MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.

  2005cited by this paper
• miR-15 and miR-16 induce apoptosis by targeting BCL2.

  2005cited by this paper
• A Cellular MicroRNA Mediates Antiviral Defense in Human Cells

  2005cited by this paper
• Real-time quantification of microRNAs by stem–loop RT–PCR

  2005cited by this paper
• siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

  2005cited by this paper
• Accumulation of miR-155 and BIC RNA in human B cell lymphomas.

  2005cited by this paper
• MicroRNAs in vertebrate development.

  2005cited by this paper
• Real-time expression profiling of microRNA precursors in human cancer cell lines

  2005cited by this paper
• BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

  2005cited by this paper
• A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.

  2005cited by this paper
• Identification of microRNAs of the herpesvirus family

  2005cited by this paper
• Gene transfer for hemophilia: can therapeutic efficacy in large animals be safely translated to patients?

  2005cited by this paper
• Suppression of RNA Interference by Adenovirus Virus-Associated RNA

  2005cited by this paper
• Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes.

  2005cited by this paper
• Regulation of human immunodeficiency virus 1 transcription by nef microRNA.

  2005cited by this paper
• Selective sentinel lymphadenectomy for human solid cancer

  2005cited by this paper
• MicroRNAs and viral infection.

  2005cited by this paper
• Antisense-Mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development

  2005cited by this paper
• A microRNA polycistron as a potential human oncogene

  2005cited by this paper
• Cloning and Identification of a MicroRNA Cluster within the Latency-Associated Region of Kaposi's Sarcoma-Associated Herpesvirus

  2005cited by this paper
• The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

  2005cited by this paper
• Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

  2005cited by this paper
• MicroRNA gene expression deregulation in human breast cancer.

  2005cited by this paper
• SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells

  2005influential reference
• Silencing of CXCR4 blocks breast cancer metastasis.

  2005cited by this paper
• Silencing of microRNAs in vivo with ‘antagomirs’

  2005cited by this paper
• Depletion of Human Micro-RNA miR-125b Reveals That It Is Critical for the Proliferation of Differentiated Cells but Not for the Down-regulation of Putative Targets during Differentiation*

  2005cited by this paper
• Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells.

  2005influential reference
• Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.

  2005cited by this paper
• Adenovirus VA1 Noncoding RNA Can Inhibit Small Interfering RNA and MicroRNA Biogenesis

  2004cited by this paper
• MicroRNA-143 Regulates Adipocyte Differentiation*

  2004cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.

  2004cited by this paper
• Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

  2004cited by this paper
• Identification of Virus-Encoded MicroRNAs

  2004cited by this paper
• A pancreatic islet-specific microRNA regulates insulin secretion

  2004cited by this paper
• Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.

  2004cited by this paper
• Sequence-Specific Inhibition of Small RNA Function

  2004cited by this paper
• MicroRNAs Modulate Hematopoietic Lineage Differentiation

  2004cited by this paper
• An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues.

  2004cited by this paper
• Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

  2004cited by this paper
• Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4

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• High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma

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• Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins.

  2004influential reference
• Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells.

  2003cited by this paper
• Expression profiling reveals off-target gene regulation by RNAi

  2003cited by this paper

• Synergistic effects of miR‐143 with miR‐99a inhibited cell proliferation and induced apoptosis in breast cancer

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• miRNA contributes to neuropathic pains.

  2023cites this paper
• Intersection of stem cell biology and engineering towards next generation in vitro models of human fibrosis

  2022cites this paper
• An Improved Method for Identification of Pre-miRNA in Drosophila

  2020cites this paper
• HPV16+‐miRNAs in cervical cancer and the anti‐tumor role played by miR‐5701

  2019cites this paper
• The roles of circular RNAs in human development and diseases.

  2019cites this paper
• Role of MicroRNA in Breast Cancer

  2018cites this paper
• 4.33 Engineering Viruses For Gene Therapy

  2017cites this paper
• Investigative and extrapolative role of microRNAs’ genetic expression in breast carcinoma

  2016cites this paper
• Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation

  2016cites this paper
• FGF Receptors: Cancer Biology and Therapeutics

  2014cites this paper
• Differentially expressed microRNA in multiple sclerosis: A window into pathogenesis?

  2014cites this paper
• Estudo funcional de microRNAs na infecção pelo HTLV-1

  2013cites this paper
• MicroRNAs as Molecular Targets for Cancer Therapy: On the Modulation of MicroRNA Expression

  2013cites this paper
• miRNA-Based Therapeutic Strategies

  2013cites this paper
• Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.

  2013cites this paper
• Pharmacogenomics for Individualized Therapy

  2013cites this paper
• A Modified Algorithm for Quantifying of Pre-mature MiRNAs using Some Fractal Parameters

  2012cites this paper
• A new algorithm for quantitative deciphering of pre-mature MiRNAs using some statistical parameters

  2012cites this paper
• [Targeted epigenetic therapy of cancer. Achievements and perspectives].

  2012cites this paper
• Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon.

  2012cites this paper
• Ribonomic Approaches to Identify Protein–mRNA and microRNA–mRNA Interactions: Implications for Drug Design

  2012cites this paper
• Leucine-rich repeat kinase 2 (Lrrk2): Functional characterization and interactome analysis of a protein kinase associated with Parkinson’s disease

  2012cites this paper
• Retinal Degenerations: Genetics, Mechanisms, and Therapies

  2011cites this paper
• Approaches for Manipulation of Gene Expression

  2011cites this paper
• Terapia génica: los ácidos nucleicos como fármacos. Mecanismos de acción y vías de entrega a la célula Gene therapy: nucleic acids as drugs. Action mechanisms and delivery into the cell

  2011cites this paper
• Creating a flexible multiple microRNA expression vector by linking precursor microRNAs.

  2011cites this paper
• [Progress in gene therapy].

  2011cites this paper
• 2.202 – Engineering Viruses For Gene Therapy

  2011cites this paper
• Variables and Strategies in Development of Therapeutic Post-Transcriptional Gene Silencing Agents

  2011cites this paper
• Therapeutic Oligonucleotides

  2011cites this paper
• Physiological and tissue-specific vectors for treatment of inherited diseases

  2011cites this paper
• The Therapeutic Potential of Lentivector-delivered RNAi

  2010cites this paper
• Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver

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• Incorporating miRNA target sites in protein-coding RNA

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• A miR-21 hairpin structure-based gene knockdown vector.

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• Molecular Biosafety

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• Novel approaches on epigenetics.

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• Design and validation of siRNAs and shRNAs.

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• Toll gates to periodontal host modulation and vaccine therapy.

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• [Molecular pathology as an necessity: its role in diagnostic and predictive pathology].

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• MicroRNA-21 Mediated Post-Transcriptional Gene Regulation in Ovarian Function

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• Gene-Silencing von Adhäsionsmolekülrezeptorproteinen an Herzmuskelzellen zur transienten Myokardprotektion während extrakorporaler Zirkulation

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  2009cites this paper
• Molekularpathologie als Notwendigkeit

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• MicroRNA dysregulation during chemical carcinogenesis.

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• MicroRNAs and lung cancer: new oncogenes and tumor suppressors, new prognostic factors and potential therapeutic targets.

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• Forward and robust selection of the most potent and noncellular toxic siRNAs from RNAi libraries

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• miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy.

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• Formulation of New Algorithmics for miRNAs

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• On the relationship between GC content and the number of predicted microRNA binding sites by MicroInspector

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• Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).

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  year unknowncites this paper