Tolerance of class I histocompatibility antigens expressed extrathymically

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Nature

• Publication date

  1989-06-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/339622A0PMID 2786608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunological tolerance: new approaches using transgenic mice.

  1989cited by this paper
• Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

  1989cited by this paper
• Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.

  1988cited by this paper
• Positive and negative selection of an antigen receptor on T cells in transgenic mice

  1988cited by this paper
• Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

  1988cited by this paper
• Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

  1988cited by this paper
• Antigen presenting function of class II MHC expressing pancreatic beta cells

  1988cited by this paper
• Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells.

  1988cited by this paper
• Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

  1988cited by this paper
• T cell tolerance by clonal elimination in the thymus.

  1987cited by this paper
• Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

  1987cited by this paper
• Recognition Requirements for the Activation, Differentiation and Function of T‐Helper Cells Specific for Class I MHC Alloantigens

  1987cited by this paper
• Function and specificity of T cell subsets in the mouse.

  1987cited by this paper

• A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia.

  2023cites this paper
• Pillars article: Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell. 1993. 72: 551-560.

  2013cites this paper
• Antigen Immunotherapy of Tumors Expressing the T Cells or CTL + High-Affinity CD8 Peripheral Tissue Does Not Preclude Recovery of Expression of a Tolerizing Tumor Antigen in

  2011cites this paper
• The use of mouse models to better understand mechanisms of autoimmunity and tolerance.

  2010cites this paper
• Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.

  2008cites this paper
• Generation and characterization of transgenic mice expressing a T‐cell receptor specific for the tumour‐associated antigen MDM2

  2008cites this paper
• Low TCR avidity and lack of tumor cell recognition in CD8+ T cells primed with the CEA-analogue CAP1-6D peptide

  2007cites this paper
• Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis.

  2007cites this paper
• A Study of T Cell Tolerance to the Tumor-Associated Antigen MDM2: Cytokines Can Restore Antigen Responsiveness, but Not High Avidity T Cell Function

  2007cites this paper
• Oxidatively modified autoantigens in autoimmune diseases.

  2006cites this paper
• Characterization of dendritic cells transduced with Venezuelan equine encephalitis virus replicon particles as therapeutic cancer vaccines

  2006cites this paper
• Adoptive T-cell therapy of cancer.

  2006cites this paper
• Broadly expressed tumour?associated proteins as targets for cytotoxic T lymphocyte-based cancer immunotherapy

  2005cites this paper
• Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: how can we tilt the balance towards immune-mediated cancer control?

  2005cites this paper
• Regulatory T cells in the establishment and maintenance of self-tolerance: role of the thymic epithelium.

  2005cites this paper
• Induction of Oral Tolerance in Experimental Sjögren's Syndrome Autoimmunity

  2005cites this paper
• New Books

  2005cites this paper
• Tissue-specific expression of theHLA-DRA gene in transgenic mice

  2005cites this paper
• Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading.

  2005cites this paper
• T-cell receptor-transgenic NOD mice: a reductionist approach to understand autoimmune diabetes.

  2004cites this paper
• T cells causing immunological disease

  2004cites this paper
• Tissue-specific expression of the HLA-DRA gene in transgenic mice

  2004cites this paper
• Endothelial cells present antigens in vivo

  2004cites this paper
• Dissecting the Mechanism of T Cell Tolerance for More Effective Breast Cancer Vaccine Development

  2004cites this paper
• Induction of Unresponsiveness Limits Tumor Protection by Adoptively Transferred MDM2-Specific Cytotoxic T Lymphocytes

  2004cites this paper
• Peripheral tolerance in transgenic mice expressing class I MHC L(d) only on cardiac cells.

  2004cites this paper
• Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells

  2003cites this paper
• Allogeneic Parenchymal and Hematopoietic Tissues Differ in Their Ability to Induce Deletion of Donor‐Reactive T Cells

  2003cites this paper
• HER-2 / neu-Transgenic Mice Mammary Tumors from Class I Epitope Presented by Spontaneous Immunodominant Rat HER-2 / neu MHC Identification and Characterization of

  2003cites this paper
• Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-Transgenic Mice1

  2003cites this paper
• CD8+ T Cell Tolerance and Cancer Immunotherapy

  2003influential citation
• Can the Low-Avidity Self-Specific T Cell Repertoire Be Exploited for Tumor Rejection?1

  2002cites this paper
• CD8+ T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function

  2002cites this paper
• I: Influence of APC Type and IL-2 Native and Fragmented DNA Topoisomerase Distinct Autoreactive T Cell Responses to

  2001cites this paper
• A soluble survival signal from CD14+ cells and its possible role in the pathogenesis of rheumatoid arthritis

  2001cites this paper
• Immunogenicity of L(d+) transgenic mouse hearts.

  2001cites this paper
• [Dendritic cells and interaction with other cell types. Immune tolerance].

  2001cites this paper
• Cellules dendritiques et interaction avec d'autres types cellulaires. La tolérance immunitaire

  2001cites this paper
• Regulation of Activator Protein-1 and NF-κB in CD8+ T Cells Exposed To Peripheral Self-Antigens1

  2001cites this paper
• the Antigen CTL Immunotherapy of Tumors Expressing T Cells or + Recovery of High-Affinity CD8 Peripheral Tissue Does Not Preclude Expression of a Tolerizing Tumor Antigen in

  2001cites this paper
• Expression of a Tolerizing Tumor Antigen in Peripheral Tissue Does Not Preclude Recovery of High-Affinity CD8+ T Cells or CTL Immunotherapy of Tumors Expressing the Antigen1

  2001cites this paper
• Rejection?Repertoire Be Exploited for Tumor Can the Low-Avidity Self-Specific T Cell

  2001cites this paper
• Distinct Autoreactive T Cell Responses to Native and Fragmented DNA Topoisomerase I: Influence of APC Type and IL-21

  2001cites this paper
• Regulation of activator protein-1 and NF-kappa B in CD8+ T cells exposed to peripheral self-antigens.

  2001cites this paper
• Effect of localized cytokine dysregulation: Accelerated rejection of IL‐2‐expressing skin grafts

  2001cites this paper
• Identification of the Autoimmune Regulator Gene, its mutation pattern in APECED patients and Localisation of the Gene Expression

  2001cites this paper
• Antitumor Immunity as Therapy for Human Cancer

  2000cites this paper
• Graft-versus-host disease prevention by rapamycin: cellular mechanisms.

  2000cites this paper
• Persistence of Physiological Self Antigen Is Required for the Regulation of Self Tolerance1

  2000cites this paper
• of Danger Vigorous Allograft Rejection in the Absence

  2000cites this paper
• The physiological role of regulatory T cells in the prevention of autoimmunity: generation, specificity and mode of action.

  2000cites this paper
• A study of graft versus host disease using bile duct implants under the kidney capsule.

  2000cites this paper
• Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells.

  2000cites this paper
• Vigorous Allograft Rejection in the Absence of Danger1

  2000cites this paper
• Mechanisms of induction of tolerance to organ allografts.

  2000cites this paper
• Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

  1999cites this paper
• Regulatory T Cells in the Control of Autoimmunity: the Essential Role of  Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes

  1999cites this paper
• Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4 CD45RC Cells and CD4 CD8 (cid:50) Thymocytes

  1999cites this paper
• Immunoregulation in Experimental Autoimmune Endocrine Disease

  1999cites this paper
• Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4 CD45RC Cells and CD4 CD8 (cid:50) Thymocytes

  1999cites this paper
• Immune Response to Self Nuclear Autoantigen Determines the Fate of Altered Expression Level of a Systemic

  1999cites this paper
• Immunological Tolerance, Autoimmunity and Host Defense

  1999cites this paper
• Antigen presentation by parenchymal cells: a route to peripheral tolerance?

  1999cites this paper
• Permanent survival of organ transplants without immunosuppression: Experimental approaches and possibilities for tolerance induction in clinical transplantation

  1999cites this paper
• Altered expression level of a systemic nuclear autoantigen determines the fate of immune response to self.

  1999cites this paper
• The Avidity Spectrum of  T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model

  1999cites this paper
• Cloning of two members of the SIRPα family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells

  1998cites this paper
• All or none peripheral tolerance induction in H-Y antigen-specific TCR transgenic mice.

  1998cites this paper
• Induction of Tolerance via the Respiratory Mucosa

  1998cites this paper
• Immunotolerance against a foreign antigen transgenically expressed in the lens.

  1998cites this paper
• Contributions of Transgenic and Knockout Mice to Immunological Knowledge

  1998cites this paper
• Amnion Epithelial Cells, in Contrast to Trophoblast Cells, Express All Classical HLA Class I Molecules Together With HLA‐G

  1997cites this paper
• The immune system: A functional perspective

  1997cites this paper
• 6 – Immunoregulation: The Search for the Holy Grail

  1997cites this paper
• Peripheral Selection of  T Cell Repertoires: The Role of Continuous Thymus Output

  1997cites this paper
• Premature ovarian failure and ovarian autoimmunity.

  1997cites this paper
• A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

  1997cites this paper
• Split tolerance to the MHC class I molecule H-2Dd in animals transgenic for its soluble analog.

  1997cites this paper
• T Cells are Unresponsive to Transgenic MHC Class II Molecules Expressed on Pancreatic β Cells

  1997cites this paper
• T cell tolerance and autoimmunity.

  1997cites this paper
• Breakdown of T cell tolerance to IgG2ab in Igha mice by de novo emerging anti-IgG2ab T cells and not anergy reversion.

  1997cites this paper
• Increased expression of B7-1 costimulatory molecule on cerebrospinal fluid cells of patients with multiple sclerosis and infectious central nervous system disease.

  1997cites this paper
• The role of the thymus in the control of autoimmunity.

  1996cites this paper
• The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients

  1996cites this paper
• Syngeneic bone marrow expressing a single donor class I MHC molecule permits acceptance of a fully allogeneic cardiac allograft.

  1996cites this paper
• Peripheral tolerance in T cell receptor‐transgenic mice: Evidence for T cell anergy

  1996cites this paper
• Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro autoantigen results in anti-Ro ribonucleoprotein autoimmunity.

  1996cites this paper
• Spontaneous breakdown of T cell tolerance in the mouse IgG2ab-suppression model despite long-term tolerogenesis since the perinatal period.

  1996cites this paper
• Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

  1996cites this paper
• The immune response: the afferent arm.

  1996cites this paper
• Multiple levels of regulation for self-tolerance in beef insulin transgenic mice.

  1996cites this paper
• The avian model in the study of tolerance to self.

  1996cites this paper
• Tolerance and cancer: a critical issue in tumor immunology.

  1996cites this paper
• Peptide‐mediated regulation of the allergic immune response

  1996cites this paper
• From epitopes to peptides to immunotherapy.

  1996cites this paper
• Regulatory T cells in maintenance and reversal of peripheral tolerance in vivo.

  1996cites this paper
• Pancreatic Islet Allograft Immunity and Tolerance: the Two‐Signal Hypothesis Revisited

  1996cites this paper
• T lymphocyte indifference to extrathymic islet allografts.

  1996cites this paper
• Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity.

  1995cites this paper
• New concepts in immunobiology

  1995cites this paper