NF-κB inducing kinase: a key regulator in the immune system and in cancer.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cytokine & growth factor reviews

• Publication date

  2010-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cytogfr.2010.06.002PMID 20685151PMCID PMC2939163
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Classical and/or alternative NF-kappaB pathway activation in multiple myeloma.

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• Activation of Noncanonical NF-κB Signaling by the Oncoprotein Tio*

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• Overexpression of NF-κB inducing kinase underlies constitutive NF-κB activation in lung cancer cells.

  2010cited by this paper
• Constitutive activation of nuclear factor‐κB is preferentially involved in the proliferation of basal‐like subtype breast cancer cell lines

  2009cited by this paper
• B-cell CLL/Lymphoma 10 (BCL10) Is Required for NF-κB Production by Both Canonical and Noncanonical Pathways and for NF-κB-inducing Kinase (NIK) Phosphorylation*

  2009cited by this paper
• NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells.

  2009influential reference
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• Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer.

  2009cited by this paper
• NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis.

  2009cited by this paper
• Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.

  2009cited by this paper
• Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.

  2008influential reference
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  2008influential reference
• The Lymphotoxin-β Receptor Is an Upstream Activator of NF-κB-mediated Transcription in Melanoma Cells*

  2008cited by this paper
• NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

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  2008influential reference
• TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.

  2008cited by this paper
• Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.

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• Respiratory Syncytial Virus Induces RelA Release from Cytoplasmic 100-kDa NF-κB2 Complexes via a Novel Retinoic Acid-inducible Gene-I·NF-κB-inducing Kinase Signaling Pathway*

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• Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

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• Dendritic Cells Require the NF-κB2 Pathway for Cross-Presentation of Soluble Antigens1

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• IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

  2007influential reference
• Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-κB Activation and p52-Dependent Chemokine Expression in Monocytes1

  2007cited by this paper
• A Fourth IkB Protein within the NF-kB Signaling Module

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• NF-κB-Inducing Kinase Regulates Cyclooxygenase 2 Gene Expression in Macrophages by Phosphorylation of PU.11

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• Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1

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• Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.

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• Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.

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• Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation.

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• Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.

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• A fourth IkappaB protein within the NF-kappaB signaling module.

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• LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.

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• ATP Binding by Monarch-1/NLRP12 Is Critical for Its Inhibitory Function

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• Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

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• NF-κB-Inducing Kinase Is Involved in the Activation of the CD28 Responsive Element through Phosphorylation of c-Rel and Regulation of Its Transactivating Activity1

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• NIK Is Involved in Nucleosomal Regulation by Enhancing Histone H3 Phosphorylation by IKKα*

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• Activation of NF-κB by the intracellular expression of NF-κB-inducing kinase acts as a powerful vaccine adjuvant

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  2005cited by this paper
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  2005cited by this paper
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• NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.

  2005cited by this paper
• Essential Role of IκB Kinase α in the Constitutive Processing of NF-κB2 p100*

  2005cited by this paper
• Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100.

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• NIBP, a Novel NIK and IKKβ-binding Protein That Enhances NF-κB Activation*

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• An Atypical Tumor Necrosis Factor (TNF) Receptor-associated Factor-binding Motif of B Cell-activating Factor Belonging to the TNF Family (BAFF) Receptor Mediates Induction of the Noncanonical NF-κB Signaling Pathway*

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• NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis.

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• Control of lymphocyte development by nuclear factor-κB

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• Interferon Induces NF-κB-inducing Kinase/Tumor Necrosis Factor Receptor-associated Factor-dependent NF-κB Activation to Promote Cell Survival*

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• NF-κB–inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

  2005cited by this paper
• Differential Regulation of CD40-Mediated TNF Receptor-Associated Factor Degradation in B Lymphocytes1

  2005cited by this paper
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• Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation.

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• NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

  2004cited by this paper
• Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation*

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• Nuclear Factor-inducing Kinase Plays a Crucial Role in Osteopontin-induced MAPK/IκBα Kinase-dependent Nuclear Factor κB-mediated Promatrix Metalloproteinase-9 Activation*

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• TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells.

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• Induction of p100 Processing by NF-κB-inducing Kinase Involves Docking IκB Kinase α (IKKα) to p100 and IKKα-mediated Phosphorylation*

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• Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-κB inducing kinase NIK

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• TNAP, a Novel Repressor of NF-κB-inducing Kinase, Suppresses NF-κB Activation*

  2004cited by this paper
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• NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner1

  2004cited by this paper
• Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.

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• Receptor-Specific Signaling for Both the Alternative and the Canonical NF-κB Activation Pathways by NF-κB-Inducing Kinase

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• Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade

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• The IκB Function of NF-κB2 p100 Controls Stimulated Osteoclastogenesis

  2003cited by this paper
• NIK-dependent RelB Activation Defines a Unique Signaling Pathway for the Development of Vα14i NKT Cells

  2003cited by this paper
• Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways.

  2003cited by this paper
• NIK is a component of the EGF/heregulin receptor signaling complexes

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• Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade.

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• Epstein–Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation

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• Lymphotoxin β Receptor Induces Sequential Activation of Distinct NF-κB Factors via Separate Signaling Pathways*

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• BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

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• A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells.

  2002cited by this paper
• The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.

  2002cited by this paper
• BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

  2002cited by this paper

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