Decreased platelet miR-223 expression is associated with high on-clopidogrel platelet reactivity.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Thrombosis Research

• Publication date

  2013-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.thromres.2013.02.015PMID 23498169
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Forc

  2012cited by this paper
• High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study.

  2012cited by this paper
• Prospective study on circulating MicroRNAs and risk of myocardial infarction.

  2012cited by this paper
• 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Forc

  2012cited by this paper
• Effect of CYP2C19*2 and *3 Loss-of-Function Alleles on Platelet Reactivity and Adverse Clinical Events in East Asian Acute Myocardial Infarction Survivors Treated With Clopidogrel and Aspirin

  2011cited by this paper
• Clopidogrel and proton pump inhibitors: influence of pharmacological interactions on clinical outcomes and mechanistic explanations.

  2011cited by this paper
• Kardiologische Aspekte der präoperativen Risikostratifizierung

  2011cited by this paper
• High on-treatment platelet reactivity to both aspirin and clopidogrel is associated with the highest risk of adverse events following percutaneous coronary intervention

  2011cited by this paper
• Randomized double‐blind placebo‐controlled crossover study to determine the effects of esomeprazole on inhibition of platelet function by clopidogrel

  2011cited by this paper
• Association of cytochrome P450 2C19*2 polymorphism with clopidogrel response variability and cardiovascular events in Koreans treated with drug-eluting stents

  2011cited by this paper
• MicroRNA function in myeloid biology.

  2011cited by this paper
• Regulation of mRNA translation and stability by microRNAs.

  2010cited by this paper
• Mammalian microRNAs predominantly act to decrease target mRNA levels

  2010cited by this paper
• Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity.

  2010cited by this paper
• De novo protein synthesis in mature platelets: a consideration for transfusion medicine

  2010cited by this paper
• VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA

  2010cited by this paper
• Prognostic significance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: systematic review and meta-analysis.

  2010cited by this paper
• Letter by Aboyans et al regarding article, "Smoking, clopidogrel, and mortality in patients with established cardiovascular disease".

  2010cited by this paper
• Existence of a microRNA pathway in anucleate platelets

  2009cited by this paper
• Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

  2009cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome. Shifting from antiplatelet resistance to bleeding risk assessment?

  2009cited by this paper
• Assessment of P2Y(12) inhibition with the point-of-care device VerifyNow P2Y12 in patients treated with prasugrel or clopidogrel coadministered with aspirin.

  2009cited by this paper
• Cytochrome p-450 polymorphisms and response to clopidogrel.

  2009cited by this paper
• Logistic Regression

  2008cited by this paper
• Calcium channel blockers reduce the antiplatelet effect of clopidogrel

  2008cited by this paper
• Reproducibility and standardized reporting of the vasodilator-stimulated phosphoprotein phosphorylation assay

  2008cited by this paper
• Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel.

  2008cited by this paper
• Vasodilator‐stimulated phosphoprotein phosphorylation analysis prior to percutaneous coronary intervention for exclusion of postprocedural major adverse cardiovascular events

  2007cited by this paper
• Different methodologies for evaluating the effect of clopidogrel on platelet function in high‐risk coronary artery disease patients

  2007cited by this paper
• The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis

  2007cited by this paper
• High post‐treatment platelet reactivity identified low‐responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome

  2006cited by this paper
• Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases

  2005cited by this paper
• The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease.

  2005cited by this paper
• Protein structure and function

  2004cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• SNARE protein structure and function.

  2003cited by this paper

• The Platelet-Specific Gene Signature in the Immunoglobulin G4-Related Disease Transcriptome

  2025cites this paper
• Circulating miR-223-3p as an Independent Biomarker of Recurrent Thrombotic Risk After Ischemic Stroke

  2025cites this paper
• MicroRNA dynamics and their link to platelet function following acute ST-segment elevation myocardial infarction.

  2025cites this paper
• MicroRNA-223-3p is a determinant of platelet procoagulant activity

  2025cites this paper
• Mechanisms and recent advances in non-coding RNAs and RNA modifications in antiplatelet drug resistance

  2025cites this paper
• Utilization of TEP miRNAs in tumor proliferation, diagnostic evaluation, therapeutic intervention, and prognostic assessment

  2025cites this paper
• Roles of miR-223 in Platelet Function and High On-Treatment Platelet Reactivity: A Brief Report and Review

  2025cites this paper
• Intraplatelet miRNA-126 regulates thrombosis and its reduction contributes to platelet inhibition.

  2024cites this paper
• Ticagrelor downregulates the expression of proatherogenic and proinflammatory miR125-b compared to clopidogrel: A randomized, controlled trial.

  2024cites this paper
• Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease

  2023cites this paper
• Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis

  2023cites this paper
• Lower Plasma miR-223 Level Is Associated with Clopidogrel Resistance in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis

  2023cites this paper
• Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish Thrombopoiesis

  2023cites this paper
• An Insight into Platelets at Older Age: Cellular and Clinical Perspectives.

  2023cites this paper
• Circulating microRNAs as biomarkers and mediators of platelet activation

  2022cites this paper
• Expression of microRNA Predicts Cardiovascular Events in Patients with Stable Coronary Artery Disease

  2022cites this paper
• microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician’s Perspective

  2022cites this paper
• Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease

  2022cites this paper
• Aus der Medizinischen Universitätsklinik und Poliklinik Tübingen Abteilung Innere Medizin III (Schwerpunkt: Kardiologie und Angiologie) Platelet miRNAs 103 and 155 are differentially expressed in patients with symptomatic coronary artery disease Inaugural-Dissertation zur Erlangung des Doktorgrade

  2022cites this paper
• Influence of Genetic and Epigenetic Factors of P2Y12 Receptor on the Safety and Efficacy of Antiplatelet Drugs

  2022cites this paper
• Mechanism and Potential Target of Blood-Activating Chinese Botanical Drugs Combined With Anti-Platelet Drugs: Prevention and Treatment of Atherosclerotic Cardiovascular Diseases

  2022cites this paper
• Alteration of circulating platelet-related and diabetes-related microRNAs in individuals with type 2 diabetes mellitus: a stepwise hypoglycaemic clamp study

  2022cites this paper
• Dysregulation in the Expression of Platelet Surface Receptors in Acute Coronary Syndrome Patients—Emphasis on P2Y12

  2022cites this paper
• Circulating and Platelet MicroRNAs in Cardiovascular Risk Assessment and Antiplatelet Therapy Monitoring

  2022cites this paper
• Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches

  2022cites this paper
• The role of miRNAs in regulation of platelet activity and related diseases - a bioinformatic analysis

  2022cites this paper
• AMD Genomics: Non-Coding RNAs as Biomarkers and Therapeutic Targets

  2022cites this paper
• Dissecting miRNA–Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine

  2022cites this paper
• Epigenetics in precision medicine of cardiovascular disease

  2022cites this paper
• Screening Analysis of Platelet miRNA Profile Revealed miR-142-3p as a Potential Biomarker in Modeling the Risk of Acute Coronary Syndrome

  2021cites this paper
• Peripheral blood microRNAs and the COVID-19 patient: methodological considerations, technical challenges and practice points

  2021cites this paper
• Influence of GAS5/MicroRNA‐223‐3p/P2Y12 Axis on Clopidogrel Response in Coronary Artery Disease

  2021cites this paper
• The Function and Regulation of Platelet P2Y12 Receptor

  2021cites this paper
• Do miRNAs Have a Role in Platelet Function Regulation?

  2021cites this paper
• MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty

  2021cites this paper
• MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction

  2021cites this paper
• MicroRNA as Biomarkers for Platelet Function and Maturity in Patients with Cardiovascular Disease

  2021cites this paper
• Platelet Microparticles Enriched in miR-223 Reduce ICAM-1-Dependent Vascular Inflammation in Septic Conditions

  2021cites this paper
• New Insights Into Platelet-enriched miRNAs: Production, Functions, Roles in Tumors, and Potential Targets for Tumor Diagnosis and Treatment

  2021cites this paper
• MicroRNAs in Acute ST Elevation Myocardial Infarction—A New Tool for Diagnosis and Prognosis: Therapeutic Implications

  2021cites this paper
• MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review

  2021cites this paper
• The expression profile of platelet‐derived miRNA in coronary artery disease patients with clopidogrel resistance

  2021cites this paper
• MiR-223-3p in Cardiovascular Diseases: A Biomarker and Potential Therapeutic Target

  2021cites this paper
• Whole Blood miR-210, miR-122, miR-223 Expression Levels and Their Relationship With Iron Status Parameters and Hypercoagulability Indices in Children With Iron Deficiency Anemia

  2021cites this paper
• Platelet microRNA-15b protects against high platelet reactivity in patients undergoing percutaneous coronary intervention through Bcl-2-mediated platelet apoptosis

  2020influential citation
• Platelet microRNA expression and association with platelet maturity and function in patients with essential thrombocythemia

  2020cites this paper
• Modulation of microRNAs by aspirin in cardiovascular disease.

  2020cites this paper
• Coding SNPs in hsa-miR-1343-3p and hsa-miR-6783-3p target sites of CYP2C19 modulates clopidogrel response in individuals with cardiovascular diseases.

  2020cites this paper
• Circulating MicroRNA Profiling in Non-ST Elevated Coronary Artery Syndrome Highlights Genomic Associations with Serial Platelet Reactivity Measurements

  2020cites this paper
• Circulating MicroRNA Levels Indicate Platelet and Leukocyte Activation in Endotoxemia Despite Platelet P2Y12 Inhibition

  2020cites this paper
• microRNAs as Promising Biomarkers of Platelet Activity in Antiplatelet Therapy Monitoring

  2020influential citation
• The Landscape of Coding and Noncoding RNAs in Platelets

  2020cites this paper
• Screening on platelet LncRNA expression profile discloses novel residual platelet reactivity biomarker

  2020cites this paper
• Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis

  2020cites this paper
• MicroRNA and hyperaggregability of platelets in women with sticky platelet syndrome and pregnancy complications.

  2020cites this paper
• Methods to Investigate miRNA Function: Focus on Platelet Reactivity

  2020cites this paper
• The Role of Epigenetics in the Regulation of Hemostatic Balance

  2020cites this paper
• Клинико-фармакологические технологии персонализации фармакотерапии сердечно-сосудистых заболеваний: фокус на прямые оральные антикоагулянты Clinical Pharmacology Technologies for Personalization of Cardiovascular Diseases Drug Treatment: Focus on Direct Oral Anticoagulants

  2019cites this paper
• Cardiovascular Disease and Diabetes: A Journey from Bench to Bedside

  2019cites this paper
• Platelet MicroRNAs

  2019cites this paper
• The role of acetylsalicylic acid and circulating microRNAs in primary prevention of cardiovascular events in patients with Diabetes Mellitus Type 2 - A Review.

  2019cites this paper
• Vestnik 5-2019 COLOR.indd

  2019cites this paper
• MicroRNAs as potential regulators of platelet function and bleeding diatheses

  2019cites this paper
• Platelet MicroRNA 365-3p Expression Correlates with High On-treatment Platelet Reactivity in Coronary Artery Disease Patients

  2019cites this paper
• Exploring indirect effects of microRNA-21 in cardiac fibrosis : a proteomics approach in platelets

  2019cites this paper
• miRNAs in drug response variability: potential utility as biomarkers for personalized medicine.

  2019cites this paper
• Chapter 6 Platelets : Functional Biomarkers of Epigenetic Drift

  2019cites this paper
• MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

  2019cites this paper
• Horizontal RNA transfer goes deep: platelet consumption and microRNA utilization by vascular smooth muscle cells

  2019cites this paper
• [Micro-RNA as a new biomarker of activity of the cytochrome system P-450: significance for predicting the antiplatelet action of P2Y12 receptor inhibitors].

  2019cites this paper
• The effect of Xuefu Zhuyu decoction on clopidogrel resistance and its association with the P2Y12 Gene polymorphisms and promoter DNA methylation.

  2019cites this paper
• Course of platelet miRNAs after cessation of P2Y12 antagonists

  2019cites this paper
• Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links

  2018cites this paper
• microRNAs in the haemostatic system: More than witnesses of thromboembolic diseases?

  2018cites this paper
• The Potential Role of Platelet-Related microRNAs in the Development of Cardiovascular Events in High-Risk Populations, Including Diabetic Patients: A Review

  2018cites this paper
• MicroRNAs in acute myocardial infarction: Evident value as novel biomarkers?

  2018cites this paper
• Mechanism of Immune Response Through mRNA/miRNA Effect in Vascular Dysfunctions

  2018cites this paper
• Platelets: Functional Biomarkers of Epigenetic Drift

  2018cites this paper
• Novel Antiplatelet Agents

  2018cites this paper
• Discordance Between VASP Phosphorylation and Platelet Aggregation in Defining High On-Clopidogrel Platelet Reactivity After ST-Segment Elevation Myocardial Infarction

  2018cites this paper
• Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine?

  2018cites this paper
• Pharmacogenomics of Antiplatelet Drugs

  2017cites this paper
• Noncoding RNAs in Platelet Biology

  2017cites this paper
• Interaction between platelet-derived microRNAs and CYP2C19*2 genotype on clopidogrel antiplatelet responsiveness in patients with ACS.

  2017cites this paper
• MicroRNAs in control of gene regulatory programs in diabetic vasculopathy.

  2017cites this paper
• The Platelet Transcriptome: Coding RNAs

  2017cites this paper
• Platelet microRNA for predicting acute myocardial infarction

  2017cites this paper
• MicroRNAs and Cardiovascular Disease in Diabetes Mellitus

  2017cites this paper
• Platelet-Enriched MicroRNAs and Cardiovascular Homeostasis

  2017cites this paper
• Hematopoietic Deficiency of miR-223 Attenuates Thrombosis in Response to Photochemical Injury in Mice

  2017cites this paper
• MicroRNA Biomarkers and Platelet Reactivity: The Clot Thickens

  2017cites this paper
• An exploration of the relationship between cardiovascular health, lifestyle factors and platelet function.

  2017cites this paper
• Platelet extracellular vesicles and the transfer of microRNA in atherosclerosis

  2016cites this paper
• Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity.

  2016cites this paper
• Genetics in Anti-Platelet Treatment.

  2016cites this paper
• MicroRNAs in Platelet Physiology and Function

  2016cites this paper
• Association of MicroRNAs and YRNAs With Platelet Function.

  2016cites this paper
• Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis.

  2015cites this paper
• Sweet dicer: impairment of micro-RNA processing by diabetes.

  2015cites this paper
• Dissociation of SERPINE1 mRNA from the translational repressor proteins Ago2 and TIA-1 upon platelet activation

  2015cites this paper