Pre‐operative oral nutritional supplementation with dietary advice versus dietary advice alone in weight‐losing patients with colorectal cancer: single‐blind randomized controlled trial

Pre‐operative weight loss has been consistently associated with increased post‐operative morbidity. The study aims to determine if pre‐operative oral nutritional supplements (ONSs) with dietary advice reduce post‐operative complications.

• Publication year

  2017

• Venue

  Journal of Cachexia, Sarcopenia and Muscle

• Publication date

  2017-01-03

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jcsm.12170PMID 28052576PMCID 5476846
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• The intervention was tested to see whether it could reduce post-operative complications.

  Confidence 0.90

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review
• The trial focused on weight-losing patients with colorectal cancer.

  Confidence 0.97

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review
• Pre-operative oral nutritional supplementation with dietary advice was evaluated against dietary advice alone in a single-blind randomized controlled trial.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review

• dietary advice

  interventions

  Nutritional counseling or diet guidance provided to participants as part of the treatment strategy in this trial.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review
• dietary advice alone

  comparators

  The comparator condition in which participants received dietary advice without added oral nutritional supplements.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review
• post-operative complications

  outcomes

  Complications occurring after surgery that were the clinical outcome of interest in the trial.

  Aliases: post-operative morbidity

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review
• pre-operative oral nutritional supplementation

  interventions

  Oral nutritional supplements given before surgery as part of the nutritional intervention studied here.

  Aliases: pre-operative ONSs, ONSs

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review
• single-blind randomized controlled trial

  study designs

  A randomized trial design in which participants were assigned to study groups under single-blind conditions.

  Aliases: single-blind RCT, RCT

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review
• weight-losing colorectal cancer patients

  populations

  Patients with colorectal cancer who had experienced weight loss and formed the study population.

  Aliases: weight-losing patients with colorectal cancer

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewGahyoun (29ua5897xm) reviewmexicorea (qjvnbu8xg3) review

• Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2019

  2019cited by this paper
• Pre‐operative oral nutritional supplementation with dietary advice versus dietary advice alone in weight‐losing patients with colorectal cancer: single‐blind randomized controlled trial

  2017cited by this paper
• Ethical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017

  2017cited by this paper
• An exploration of food and the lived experience of individuals after treatment for colorectal cancer using a phenomenological approach.

  2016cited by this paper
• Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection

  2016cited by this paper
• Patient experiences of perioperative nutrition within an Enhanced Recovery After Surgery programme for colorectal surgery: a qualitative study

  2016cited by this paper
• Functional compromise reflected by sarcopenia, frailty, and nutritional depletion predicts adverse postoperative outcome after colorectal cancer surgery.

  2015cited by this paper
• The relationship between immediate preoperative serum 25-hydroxy-vitamin D₃ levels and cardiac function, dysglycemia, length of stay, and 30-d readmissions in cardiac surgery patients.

  2015cited by this paper
• Sarcopenia, as defined by low muscle mass, strength and physical performance, predicts complications after surgery for colorectal cancer

  2015cited by this paper
• Micronutrient intakes and potential inadequacies of community-dwelling older adults: a systematic review

  2015cited by this paper
• Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

  2015cited by this paper
• The role of computed tomography in evaluating body composition and the influence of reduced muscle mass on clinical outcome in abdominal malignancy: a systematic review

  2015cited by this paper
• Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2015

  2015cited by this paper
• Prehabilitation to enhance perioperative care.

  2015cited by this paper
• Immediate preoperative nutritional status of patients with colorectal cancer: a warning.

  2014cited by this paper
• The influence of preoperative nutritional status on the outcomes of an enhanced recovery after surgery (ERAS) programme for colorectal cancer surgery

  2014cited by this paper
• Clinical outcomes related to muscle mass in humans with cancer and catabolic illnesses.

  2013cited by this paper
• The Comprehensive Complication Index: A Novel Continuous Scale to Measure Surgical Morbidity

  2013cited by this paper
• Pre-operative nutrition support in patients undergoing gastrointestinal surgery.

  2012cited by this paper
• An unblinded randomised controlled trial of preoperative oral supplements in colorectal cancer patients.

  2011cited by this paper
• A systematic review of enhanced recovery protocols in colorectal surgery.

  2011cited by this paper
• Nutritional status of preoperative colorectal cancer patients.

  2010cited by this paper
• Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics".

  2010cited by this paper
• Nutritional status, nutrition practices and post-operative complications in patients with gastrointestinal cancer.

  2010cited by this paper
• Preoperative Nutrition in Patients Undergoing Gastrointestinal Surgery.

  2010cited by this paper
• An Enhanced-Recovery Protocol Improves Outcome After Colorectal Resection Already During the First Year: A Single-Center Experience in 168 Consecutive Patients

  2009cited by this paper
• Nutritional risk is a clinical predictor of postoperative mortality and morbidity in surgery for colorectal cancer

  2009cited by this paper
• Frailty is associated with postoperative complications in older adults with medical problems.

  2009cited by this paper
• CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.

  2008cited by this paper
• Transitions between states of disability and independence among older persons.

  2005cited by this paper
• Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial.

  2005cited by this paper
• Classification of Surgical Complications: A New Proposal With Evaluation in a Cohort of 6336 Patients and Results of a Survey

  2004cited by this paper
• Randomized clinical trial of the effects of preoperative and postoperative oral nutritional supplements on clinical course and cost of care

  2004cited by this paper
• Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y

  2002cited by this paper
• Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer

  2002cited by this paper
• A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer.

  2002cited by this paper
• Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice.

  1999cited by this paper
• Comparison of dietary assessment methods in nutritional epidemiology: weighed records v. 24 h recalls, food-frequency questionnaires and estimated-diet records

  1994cited by this paper
• Height-normalized indices of the body's fat-free mass and fat mass: potentially useful indicators of nutritional status.

  1990cited by this paper
• Laparoscopic surgery versus open surgery for colon cancer : short-term outcomes of a randomised trial

  year unknowncited by this paper

• Promoting postoperative recovery in older adult surgical patients: a randomized controlled trial of MDT-based perioperative comprehensive nutritional management model

  2026cites this paper
• The role of nutritional supplementation in preventing postoperative complications: a systematic review and meta-analysis.

  2026cites this paper
• ESPEN guideline on clinical nutrition in surgery - Update 2025.

  2025cites this paper
• Preliminary Outcomes of a Digital Remote Care Solution for Colorectal Cancer Patients

  2025cites this paper
• How Robust is the Evidence for Prehabilitation in Cancer Surgery?: A Systematic Review and Fragility Index Analysis

  2025cites this paper
• Association between sarcopenia and postoperative delirium in elderly surgical patients: a systematic review and meta-analysis

  2025cites this paper
• Impact of Prehabilitation in Major Gastrointestinal Oncological Surgery: a Systematic Review

  2025cites this paper
• Validation of nutritional screening tools in patients undergoing cancer surgery in low- and middle-income countries

  2025cites this paper
• Participation and Adherence to Prehabilitation Programs for Colorectal Cancer

  2025cites this paper
• Perioperative nutrition therapy for patients with head and neck or gastrointestinal cancer: a systematic review and meta-analysis.

  2025cites this paper
• The Molecular Mechanisms and Treatment of Cancer-Related Cachexia.

  2025cites this paper
• Oral nutritional supplementation in cancer patients: A systematic review and dose-response meta-analysis.

  2025cites this paper
• Preoperative Weight Loss in Patients With Excess Weight and Colorectal Cancer

  2025cites this paper
• Are cancer prognostic factors useful in predicting surgical site infections after spinal instrumentation surgery?

  2025cites this paper
• The power of prehabilitation, the reporting of power calculations in randomised clinical trials evaluating prehabilitation in cancer surgery; a systematic review and meta-research study.

  2025cites this paper
• Nutritional Prehabilitation: Trends in Supplementation Based on Sustainable Dairy Protein Sources

  2025cites this paper
• Pathways of development in minimally invasive surgery for colorectal cancer (literature review)

  2025cites this paper
• Outcome Heterogeneity in Prehabilitation Trials-Are We Comparing Apples and Oranges?

  2024cites this paper
• Factors related to surgical site infection in spinal instrumentation surgery: a retrospective study in Japan

  2024cites this paper
• A rapid review of nutrition and exercise approaches to managing unintentional weight loss, muscle loss, and malnutrition in cancer

  2024cites this paper
• The Impact of Preoperative and Postoperative Nutritional Interventions on Treatment Outcomes and Quality of Life in Colorectal Cancer Patients—A Comprehensive Review

  2024cites this paper
• Effect of preoperative oral nutritional supplements on clinical outcomes in patients undergoing surgery for gastrointestinal cancer: A systematic review and meta-analysis

  2024cites this paper
• Overall mortality for community‐dwelling adults over 50 years at risk of malnutrition

  2024cites this paper
• Exploring the Acceptability of and Adherence to Prehabilitation and Rehabilitation in Patients Undergoing Major Abdominal Surgery: A Systematic Review and Meta-analysis.

  2024cites this paper
• Effectiveness of Prehabilitation Modalities on Postoperative Outcomes Following Colorectal Cancer Surgery: A Systematic Review of Randomised Controlled Trials

  2024cites this paper
• Compliance analysis of oral nutritional supplements in hospitalized postsurgical patients with colorectal cancer: A prospective study.

  2024cites this paper
• Access, acceptance and adherence to cancer prehabilitation: a mixed-methods systematic review

  2024cites this paper
• Preoperative nutrition therapy in people undergoing gastrointestinal surgery.

  2024cites this paper
• Effect of Preoperative Lifestyle Management and Prehabilitation on Postoperative Capability of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

  2024cites this paper
• Assessing Impact of Nutrition Care by Registered Dietitian Nutritionists on Patient Medical and Treatment Outcomes in Outpatient Cancer Clinics: A Cohort Feasibility Study

  2023cites this paper
• The effects of oral nutritional supplements interventions on nutritional status in patients undergoing colorectal cancer surgery: A systematic review.

  2023cites this paper
• Mismatch of populations between randomised controlled trials of perioperative interventions in major abdominal surgery and current clinical practice

  2023cites this paper
• Adherence to Oral Nutrition Supplementation in Gastrointestinal Cancer Patients: A Systematic Review of the Literature

  2023cites this paper
• Kolorektal Kanser Cerrahisinde Perioperatif Beslenme Yönetimi

  2023cites this paper
• Malnutrition risk in elective surgery patients and effectiveness of preoperative nutritional interventions at a pre-anaesthetic clinic: a 4-year apart, single-centre, observational study

  2023cites this paper
• A global analysis of nutrition support practices in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancy.

  2023cites this paper
• The effect of preoperative oral nutritional supplementation on surgical site infections among adult patients undergoing elective surgery: A systematic review and meta-analysis.

  2023cites this paper
• Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial.

  2023cites this paper
• A systematic review and meta-analysis of the effects of community use of oral nutritional supplements on clinical outcomes

  2023cites this paper
• Nutrition as prevention for improved cancer health outcomes: a systematic literature review

  2023cites this paper
• Nutritional screening in a cancer prehabilitation programme: A cohort study.

  2022cites this paper
• Total Parenteral Nutrition Treatment Improves the Nutrition Status of Gynecological Cancer Patients by Improving Serum Albumin Level

  2022cites this paper
• Exercise-Based Interventions to Counteract Skeletal Muscle Mass Loss in People with Cancer: Can We Overcome the Odds?

  2022cites this paper
• The Prognostic Significance of the Geriatric Nutritional Risk Index in Colorectal Cancer Patients

  2022cites this paper
• Malnutrition, Cachexia, and Sarcopenia in Older Adults with Cancer and Frailty

  2022cites this paper
• A Qualitative Exploration of Nutrition Screening, Assessment and Oral Support Used in Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries

  2022cites this paper
• Preoperative Nutritional Optimization of the Oncology Patient: A Scoping Review.

  2022cites this paper
• The Value of Artificial Intelligence-Assisted Imaging in Identifying Diagnostic Markers of Sarcopenia in Patients with Cancer

  2022cites this paper
• Surgical Planning in Penetrating Abdominal Crohn's Disease

  2022cites this paper
• Nutritional Treatment of Patients with Colorectal Cancer

  2022cites this paper
• Dietary modulation of gut microbiota in patients with colorectal cancer undergoing surgery: A review.

  2022cites this paper
• Nutritional Interventions to Improve Cachexia Outcomes in Cancer—A Systematic Review

  2022influential citation
• Postoperative Diet with an Oligomeric Hyperproteic Normocaloric Supplement versus a Supplement with Immunonutrients in Colorectal Cancer Surgery: Results of a Multicenter, Double-Blind, Randomized Clinical Trial

  2022cites this paper
• Malnutrition and nutritional screening in patients undergoing surgery in low and middle income countries: A systematic review

  2022cites this paper
• Acute Sarcopenia after Elective and Emergency Surgery

  2022cites this paper
• The influence of serum cholinesterase levels and sarcopenia on postoperative infectious complications in colorectal cancer surgery

  2022cites this paper
• Beneficial Effects of Oral Nutritional Supplements on Body Composition and Biochemical Parameters in Women with Breast Cancer Undergoing Postoperative Chemotherapy: A Propensity Score Matching Analysis

  2021cites this paper
• Parietal and Visceral Peritonectomy

  2021cites this paper
• Impact of a Geriatric Intervention to Improve Screening and Management of Undernutrition in Older Patients Undergoing Surgery for Colorectal Cancer: Results of the ANC Stepped-Wedge Trial

  2021cites this paper
• The Effect of Nutrition Intervention With Oral Nutritional Supplements on Ovarian Cancer Patients Undergoing Chemotherapy

  2021cites this paper
• Relationship Between Early Postoperative Change in Total Psoas Muscle Area and Long-term Prognosis in Esophagectomy for Patients with Esophageal Cancer

  2021cites this paper
• A multi-national survey of experience and attitudes towards commencing home parenteral nutrition for patients with advanced cancer.

  2021cites this paper
• Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults.

  2021cites this paper
• Adherence to Oral Nutritional Supplements in Patients With Gastrointestinal Cancer

  2021cites this paper
• Pre-admission interventions (prehabilitation) to improve outcome after major elective surgery: a systematic review and meta-analysis

  2021cites this paper
• Post-discharge oral nutritional supplements with dietary advice in patients at nutritional risk after surgery for gastric cancer: A randomized clinical trial.

  2020cites this paper
• Impact of oral nutritional supplements in post-discharge patients at nutritional risk following colorectal cancer surgery: A randomised clinical trial.

  2020cites this paper
• Perioperative Optimization of Patient Nutritional Status

  2020cites this paper
• Protein nutritional support: the classical and potential new mechanisms in the prevention and therapy of sarcopenia.

  2020cites this paper
• [Valoración y tratamiento nutricional en el paciente oncogeriátrico. Aspectos diferenciales].

  2020cites this paper
• Impact of Dietitian Delivered Intensive Nutrition Intervention on Dietary Intake and Weight Outcome Among Gynecology Cancer Outpatient Prior to Surgery

  2020cites this paper
• Predictive value of CRP/albumin ratio in major abdominal surgery

  2020cites this paper
• The Prognostic Impact of Nutritional Status upon Postoperative Outcomes in Glioblastoma.

  2020cites this paper
• Diet and weight management by people with nonmetastatic colorectal cancer during chemotherapy: mixed methods research

  2020cites this paper
• Effect of Oral Nutritional Supplementation on the Prognostic Nutritional Index in Gastric Cancer Patients

  2020cites this paper
• Prehabilitation in elective abdominal cancer surgery in older patients: systematic review and meta‐analysis

  2020cites this paper
• Oral nutrition interventions in patients undergoing gastrointestinal surgery for cancer: A systematic literature review

  2020cites this paper
• Nutritional status and interventions for patients with cancer - A systematic review.

  2020cites this paper
• Safety of dietary supplements use among patients with cancer: A systematic review.

  2020cites this paper
• Critical appraisal on the impact of preoperative rehabilitation and outcomes after major abdominal and cardiothoracic surgery: A systematic review and meta-analysis.

  2020cites this paper
• Measurement of Muscle Mass and Sarcopenia Using Anthropometry, Bioelectrical Impedance, and Computed Tomography in Surgical Patients with Colorectal Malignancy: Comparison of Agreement Between Methods

  2020cites this paper
• Effect of Perioperative Nutritional Supplementation on Postoperative Complications—Systematic Review and Meta-Analysis

  2019cites this paper
• Clinical Value of Muscle Mass Assessment in Clinical Conditions Associated with Malnutrition

  2019cites this paper
• Priority setting for adult malnutrition and nutritional screening in healthcare: a James Lind Alliance.

  2019cites this paper
• Healthy eating interventions in adults living with and beyond colorectal cancer: a systematic review.

  2019cites this paper
• Perioperative nutrition and enhanced recovery after surgery in gastrointestinal cancer patients. A position paper by the ESSO task force in collaboration with the ERAS society (ERAS coalition).

  2018cites this paper
• Muscle wasting and sarcopenia in heart failure: a brief overview of the current literature

  2018cites this paper
• Mangelernährung in der Onkologie. Ursachen, Folgen und Bedeutung der Ernährungstherapie

  2018cites this paper
• Verfahren der parietalen und viszeralen Peritonektomie interenterisch

  2018cites this paper
• Cachexia as a common characteristic in multiple chronic disease

  2018cites this paper
• Pre‐operative oral nutritional supplementation with dietary advice versus dietary advice alone in weight‐losing patients with colorectal cancer: single‐blind randomized controlled trial

  2017cites this paper
• Nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies

  2017cites this paper
• Perioperative nutrition for the treatment of bladder cancer by radical cystectomy.

  2012cites this paper