Dif, a dorsal-related gene that mediates an immune response in Drosophila.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Cell

• Publication date

  1993-11-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(93)90495-CPMID 8242747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila.

  1993cited by this paper
• Insect immunity. Two 17 bp repeats nesting a kappa B‐related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria‐challenged Drosophila.

  1993cited by this paper
• Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen.

  1993cited by this paper
• pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo.

  1993cited by this paper
• Immune reactions in Drosophila and other insects: a model for innate immunity.

  1993cited by this paper
• kappa B-like motifs regulate the induction of immune genes in Drosophila.

  1993cited by this paper
• Purification and characterization of a 59-kilodalton protein that specifically binds to NF-kappa B-binding motifs of the defense protein genes of Sarcophaga peregrina (the flesh fly)

  1993cited by this paper
• CecC, a cecropin gene expressed during metamorphosis in Drosophila pupae.

  1992cited by this paper
• Cecropia immunoresponsive factor, an insect immunoresponsive factor with DNA-binding properties similar to nuclear-factor kappa B.

  1992cited by this paper
• Regulation of translation and proteolysis during the development of embryonic dorso-ventral polarity in Drosophila. Homology of easter proteinase with Limulus proclotting enzyme and translational activation of Toll receptor synthesis.

  1992cited by this paper
• The weak, fine-tuned binding of ubiquitous transcription factors to the Il-2 enhancer contributes to its T cell-restricted activity.

  1992cited by this paper
• Insect immune systems

  1992cited by this paper
• dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

  1992cited by this paper
• Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter.

  1992cited by this paper
• Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancer.

  1992cited by this paper
• cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the I kappa B gene family of vertebrates.

  1992cited by this paper
• Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity.

  1992cited by this paper
• IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

  1992cited by this paper
• Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements.

  1992cited by this paper
• Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins.

  1992cited by this paper
• The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

  1992cited by this paper
• I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family.

  1992cited by this paper
• A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements.

  1992cited by this paper
• Cellular distribution of nuclear factor kappa B binding activity in rat liver.

  1992cited by this paper
• In vitro induction of cecropin genes--an immune response in a Drosophila blood cell line.

  1992cited by this paper
• A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man.

  1992cited by this paper
• cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

  1992cited by this paper
• Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

  1991cited by this paper
• The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila.

  1991cited by this paper
• Drosophila Toll and IL-1 receptor

  1991cited by this paper
• Constitutive and NF-kappa B-like proteins in the regulation of the serum amyloid A gene by interleukin 1.

  1991cited by this paper
• Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

  1991cited by this paper
• Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation.

  1991cited by this paper
• The inducible transcription activator NF-kappa B: regulation by distinct protein subunits.

  1991cited by this paper
• Rel-associated pp40: an inhibitor of the rel family of transcription factors.

  1991cited by this paper
• A quantitative model for translational control of the GCN4 gene of Saccharomyces cerevisiae.

  1991cited by this paper
• DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide.

  1991cited by this paper
• Structure and expression of the attacin genes in Hyalophora cecropia.

  1991cited by this paper
• Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting.

  1991cited by this paper
• The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal.

  1991cited by this paper
• Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.

  1991cited by this paper
• Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.

  1991cited by this paper
• Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.

  1991cited by this paper
• Cell-free immunity in Cecropia. A model system for antibacterial proteins.

  1991cited by this paper
• DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

  1991cited by this paper
• Cell-free immunity in Cecropia

  1991cited by this paper
• The inducible transcription activator NF-κB: regulation by distinct protein subunits

  1991cited by this paper
• The physiology of the NF-κB transcription factor

  1991cited by this paper
• The immune response in Drosophila: pattern of cecropin expression and biological activity.

  1990cited by this paper
• The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.

  1990cited by this paper
• Interleukin-1-mediated enhancement of mouse factor B gene expression via NF kappa B-like hepatoma nuclear factor

  1990cited by this paper
• The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

  1990cited by this paper
• Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

  1990cited by this paper
• A family of constitutive C/EBP‐like DNA binding proteins attenuate the IL‐1 alpha induced, NF kappa B mediated trans‐activation of the angiotensinogen gene acute‐phase response element.

  1990cited by this paper
• Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal.

  1990cited by this paper
• Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response.

  1990cited by this paper
• Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.

  1989cited by this paper
• Stimulation of Hepatic Acute Phase Response by Cytokines and Glucocorticoids a

  1989cited by this paper
• A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.

  1989cited by this paper
• Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function.

  1989cited by this paper
• A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo.

  1989cited by this paper
• The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo.

  1989cited by this paper
• Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein

  1989cited by this paper
• The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila.

  1989cited by this paper
• Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation.

  1988cited by this paper
• Functional cDNA libraries from Drosophila embryos.

  1988cited by this paper
• Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel.

  1987cited by this paper
• Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility.

  1987cited by this paper
• Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.

  1987cited by this paper
• The Acute-phase response to injury and infection : the roles of interleukin 1 and other mediators

  1985cited by this paper
• A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

  1984cited by this paper
• Immunological method for mapping genes on Drosophila polytene chromosomes.

  1982cited by this paper
• Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.

  1980cited by this paper
• Inducible Antibacterial Defence System in Drosophila

  1972cited by this paper

• Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

  2026cites this paper
• Identification of alternative splicing transcripts of dorsal from Procambarus clarkii and their roles in innate immunity

  2025cites this paper
• Mask protein keeps NF-κB precursor inactive by inducing a closed conformation and isolating it in biomolecular condensates.

  2025cites this paper
• Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

  2025cites this paper
• The Conserved Network of NF-κB Transcriptional Partners from Drosophila to Mammals.

  2025cites this paper
• Manipulation of host-plant preference by virus-induced changes to its insect vector's olfactory system.

  2025cites this paper
• Developmental transcriptomics reveals stage-specific immune gene expression profiles in Spodoptera frugiperda

  2025cites this paper
• Layers of immunity: Deconstructing the Drosophila effector response

  2025cites this paper
• The Enhanced activation of innate immunity in Drosophila S2 cells by Micrococcus luteus VKM Ac-2230 is mediated by Relish.

  2025cites this paper
• A U3 snoRNA is required for the regulation of chromatin dynamics and antiviral response in Drosophila melanogaster

  2025cites this paper
• Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain

  2025cites this paper
• From periphery to center stage: 50 years of advancements in innate immunity

  2024cites this paper
• Drosophila Sleep Homeostasis in Sickness and in Health.

  2024cites this paper
• Fungi activate Toll-1 dependent immune evasion to induce cell loss in the host brain

  2024cites this paper
• Pattern recognition receptors in Crustacea: immunological roles under environmental stress

  2024cites this paper
• Loss of function in Drosophila transcription factor Dif delays brain development in larvae resulting in aging adult brain.

  2024cites this paper
• Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches

  2024cites this paper
• Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model

  2023cites this paper
• A comprehensive review on the dynamic role of toll-like receptors (TLRs) in frontier aquaculture research and as a promising avenue for fish disease management.

  2023cites this paper
• The multimodal action of G alpha q in coordinating growth and homeostasis in the Drosophila wing imaginal disc

  2023cites this paper
• Of Flies and Men—The Discovery of TLRs

  2022cites this paper
• Pelle and Tube contribute to the Toll pathway-dependent antimicrobial peptide production in the red flour beetle, Tribolium castaneum (Coleoptera: Tenebrionidae)

  2022cites this paper
• Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

  2022cites this paper
• Advances in the Immune Regulatory Role of Non-Coding RNAs (miRNAs and lncRNAs) in Insect-Pathogen Interactions

  2022cites this paper
• A Non-Nuclear NF-κB Modulates Alcohol Sensitivity But Not Immunity

  2022cites this paper
• Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem Cell Loss

  2022cites this paper
• Drosophila as a Model for Human Viral Neuroinfections

  2022cites this paper
• PvML1 suppresses bacterial infection by recognizing LPS and regulating AMP expression in shrimp

  2022cites this paper
• The role of micro RNAs (miRNAs) in the regulation of Drosophila melanogaster’s innate immunity

  2022influential citation
• Dorsal regulates the expression of two phage lysozymes acquired via horizontal gene transfer in triangle sail mussel Hyriopsis cumingii.

  2021cites this paper
• Characterization and functional analysis of a Relish gene from the Asian corn borer, Ostrinia furnacalis (Guenée).

  2021cites this paper
• SUMOylation of Dorsal attenuates Toll/NF-κB signaling

  2021cites this paper
• Nematode infection and antinematode immunity in Drosophila.

  2021cites this paper
• Injury-induced inflammatory signaling and hematopoiesis in Drosophila

  2021cites this paper
• lncRNA-CR46018 positively regulates the Drosophila Toll immune response by interacting with Dif/Dorsal.

  2021cites this paper
• Damaging effects of TiO2 nanoparticles on the ovarian cells of Bombyx mori

  2021cites this paper
• cGMP signaling pathway that modulates NF-κB activation in innate immune responses

  2021cites this paper
• The antiviral immunity of ticks against transmitted viral pathogens.

  2021cites this paper
• Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila

  2021cites this paper
• Signaling cross-talk during development: Context-specific networking of Notch, NF-κB and JNK signaling pathways in Drosophila.

  2021cites this paper
• The Toll gene in Drosophila pattern formation.

  2021cites this paper
• The Drosophila miR-959–962 Cluster Members Repress Toll Signaling to Regulate Antibacterial Defense during Bacterial Infection

  2021cites this paper
• Eight‐carbon volatiles are more toxic to wild‐type Drosophila melanogaster than to flies with blocked immune system mutations

  2021cites this paper
• Insights from model systems

  2021cites this paper
• The potential of antimicrobial peptides isolated from freshwater crayfish species in new drug development: A review.

  2021cites this paper
• Formation, interpretation, and regulation of the Drosophila Dorsal/NF-κB gradient.

  2020cites this paper
• Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila

  2020cites this paper
• Osa-Containing Brahma Complex Regulates Innate Immunity and the Expression of Metabolic Genes in Drosophila

  2020cites this paper
• Correction: Osa-Containing Brahma Complex Regulates Innate Immunity and the Expression of Metabolic Genes in Drosophila

  2020cites this paper
• The crab Relish plays an important role in white spot syndrome virus and Vibrio alginolyticus infection

  2019cites this paper
• Expression of foreign proteins by antimicrobial peptide gene promoters in mosquitoes

  2019cites this paper
• Oxidative stress and the presence of bacteria increase gene expression of the antimicrobial peptide aclasin, a fungal CSαβ defensin in Aspergillus clavatus

  2019cites this paper
• Regulation of immune and tissue homeostasis by Drosophila POU factors.

  2019cites this paper
• The miR‐317 functions as a negative regulator of Toll immune response and influences Drosophila survival

  2019cites this paper
• Defensins: Transcriptional regulation and function beyond antimicrobial activity.

  2019cites this paper
• An in vitro study of NF‐&kgr;B factors cooperatively in regulation of Drosophila melanogaster antimicrobial peptide genes

  2019cites this paper
• Pathogen Sensing: Toll-Like Receptors and NODs (Innate Immunity)

  2019cites this paper
• Cloning and analysis of peptidoglycan recognition protein-LC and immune deficiency from the diamondback moth, Plutella xylostella.

  2018cites this paper
• The Role of NFκB Factor Relish in Developmentally Programmed Cell Death

  2018influential citation
• Genomic analysis of NF‐&kgr;B signaling pathway reveals its complexity in Crassostrea gigas

  2018cites this paper
• Identification and functional analysis of immune deficiency (IMD) from Scylla paramamosain: The first evidence of IMD signaling pathway involved in immune defense against bacterial infection in crab species

  2018cites this paper
• Dietary yeast hydrolysate and brewer's yeast supplementation could enhance growth performance, innate immunity capacity and ammonia nitrogen stress resistance ability of Pacific white shrimp (Litopenaeus vannamei)

  2018cites this paper
• Drosophila DNA/RNA methyltransferase contributes to robust host defense in aging animals by regulating sphingolipid metabolism

  2018cites this paper
• Molecular cloning and analysis of PGRP-L1 and IMD from silkworm Bombyx mori.

  2018cites this paper
• The Toll Pathway in the Central Nervous System of Flies and Mammals

  2018cites this paper
• Isoform-specific regulation of Drosophila gut immunity and regeneration by the POU/Oct transcription factor Nub/Pdm1

  2018influential citation
• The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer

  2018cites this paper
• Spatially restricted regulation of cell competition by the cytokine Spaetzle

  2018influential citation
• Oxidative stress and the presence of bacteria increase gene expression of the antimicrobial peptide [i]aclasin[i], a fungal CSαβ defensin in [i]Aspergillus clavatus[i]

  2018cites this paper
• Nubbin isoform antagonism governs Drosophila intestinal immune homeostasis

  2018cites this paper
• A role of tumor susceptibility gene 101 (TSG101) in innate immune response of crayfish Procambarus clarkii

  2017cites this paper
• Insect Antimicrobial Defences: A Brief History, Recent Findings, Biases, and a Way Forward in Evolutionary Studies

  2017cites this paper
• Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors

  2017cites this paper
• Drosophila as a Model for Human Diseases-Focus on Innate Immunity in Barrier Epithelia.

  2017cites this paper
• Knockdown of genes in the Toll pathway reveals new lethal RNA interference targets for insect pest control

  2017cites this paper
• Identification and functional analysis of pointed homologs in Bombyx mori.

  2017cites this paper
• Activation of Toll Pathway Is Different between Kuruma Shrimp and Drosophila

  2017cites this paper
• How Toll Met Hippo.

  2016cites this paper
• Molecular characterization of the Drosophila responses towards nematodes

  2016cites this paper
• Co-expression of Dorsal and Rel2 Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta

  2016cites this paper
• Genome Wide Association Studies of Phagocytosis and the Cellular Immune Response in Drosophila melanogaster.

  2016cites this paper
• Cytokines in Drosophila immunity.

  2016cites this paper
• Towards a paradigm shift in innate immunity—seminal work by Hans G. Boman and co-workers

  2016cites this paper
• Charon Mediates Immune Deficiency–Driven PARP-1–Dependent Immune Responses in Drosophila

  2016cites this paper
• The Drosophila Toll Pathway: A Model of Innate Immune Signalling Activated by Endogenous Ligands

  2016cites this paper
• Regulation o f N F - k B by the HTLV-1 Tax Protein

  2016cites this paper
• The Friend of GATA Transcriptional Co-Regulator, U-Shaped, Is a Downstream Antagonist of Dorsal-Driven Prohemocyte Differentiation in Drosophila

  2016cites this paper
• Annotation of the Asian Citrus Psyllid Genome Reveals a Reduced Innate Immune System

  2016cites this paper
• Erythropoietin-mediated neuroprotection in insects

  2016cites this paper
• Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation.

  2016cites this paper
• Bombyx mori E26 transformation‐specific 2 (BmEts2), an Ets family protein, represses Bombyx mori Rels (BmRels)‐mediated promoter activation of antimicrobial peptide genes in the silkworm Bombyx mori

  2016cites this paper
• Transcriptomic insight into the immune defenses in the ghost moth, Hepialus xiaojinensis, during an Ophiocordyceps sinensis fungal infection.

  2015cites this paper
• Genetic manipulation of Anopheles stephensi immunity to increase plasmodium falciparum salivary gland sporozoite infection levels

  2015cites this paper
• The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling*

  2015cites this paper
• Peptidoglycan Recognition Protein S2 From Silkworm Integument: Characterization, Microbe-Induced Expression, and Involvement in the Immune-Deficiency Pathway

  2015cites this paper
• Régulations immunitaires et cellulaires impliquées dans le maintien et le contrôle des bactéries endosymbiotiques du charançon des céréales du genre Sitophilus spp.

  2015cites this paper
• Expression of dengue virus NS3 protein in Drosophila alters its susceptibility to infection

  2015cites this paper
• Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults

  2015cites this paper
• Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract.

  2015cites this paper
• Alternative NF-κB Isoforms in the Drosophila Neuromuscular Junction and Brain

  2015cites this paper