Control of Virus-Specific CD8+ T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Virology

• Publication date

  2008-01-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.01350-07PMID 18199651PMCID PMC2268476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcriptional regulation of T cell tolerance.

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• Immunity by ubiquitylation: a reversible process of modification

  2005cited by this paper
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  2005cited by this paper
• T cell response in hepatitis C virus infection.

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  2004cited by this paper
• Memory CD8 T-Cell Differentiation during Viral Infection

  2004cited by this paper
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• Differential Tissue-Specific Regulation of Antiviral CD8+ T-Cell Immune Responses during Chronic Viral Infection

  2004influential reference
• The Evolution of Antigen-Specific CD8+ T Cell Responses after Natural Primary Infection of Humans with Epstein-Barr Virus

  2003cited by this paper
• GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.

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  2003cited by this paper
• Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control.

  2002cited by this paper
• Viral immune evasion: a masterpiece of evolution

  2002cited by this paper
• Neutralizing antibodies

  2002cited by this paper
• Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection

  2002cited by this paper
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• Escaping High Viral Load Exhaustion: CD8 Cells with Altered Tetramer Binding in Chronic Hepatitis B Virus Infection

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  2001cited by this paper
• NFATc1 and NFATc2 together control both T and B cell activation and differentiation.

  2001cited by this paper
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  2001cited by this paper
• Viral mechanisms of immune evasion

  2000cited by this paper
• Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

  2000cited by this paper
• Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

  2000cited by this paper
• Host factors influencing viral persistence.

  2000cited by this paper
• HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Viral subversion of the immune system.

  2000cited by this paper
• Viral mechanisms of immune evasion

  2000cited by this paper
• Cytotoxic T‐lymphocyte escape viral variants: how important are they in viral evasion of immune clearance in vivo?

  1998cited by this paper
• CD4+ T-cell induction and effector functions: a comparison of immunity against soluble antigens and viral infections.

  1998cited by this paper
• Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

  1997cited by this paper
• Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus.

  1995cited by this paper
• Anergic T cells as suppressor cells in vitro.

  1994cited by this paper
• Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

  1994cited by this paper
• CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

  1994cited by this paper
• Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

  1993cited by this paper
• Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

  1993cited by this paper
• Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates.

  1991cited by this paper
• Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

  1990cited by this paper
• Virus-induced delayed-type hypersensitivity reaction is sequentially mediated by CD8+ and CD4+ T lymphocytes.

  1989cited by this paper
• Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

  1989cited by this paper
• Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

  1989cited by this paper
• Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

  1987cited by this paper
• Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections

  1982cited by this paper

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