Lactoferrin as a natural immune modulator.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Current pharmaceutical design

• Publication date

  2009-05-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/138161209788453202PMID 19519436PMCID PMC2915836
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunomodulatory effects of lactoferrin on antigen presenting cells.

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• Influence of bovine lactoferrin on expression of presentation molecules on BCG-infected bone marrow derived macrophages.

  2009influential reference
• Antimicrobial properties of lactoferrin.

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• Mitochondrial mechanisms of sepsis-induced organ failure.

  2008cited by this paper
• Immunological decision‐making: how does the immune system decide to mount a helper T‐cell response?

  2008cited by this paper
• Lactoferrin receptor mediates apo- but not holo-lactoferrin internalization via clathrin-mediated endocytosis in trophoblasts.

  2008cited by this paper
• Human antimicrobial peptides’ antifungal activity against Aspergillus fumigatus

  2008cited by this paper
• Lactoferrin structure and functions.

  2008cited by this paper
• Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells

  2008cited by this paper
• Bovine lactoferrin supplementation supports immune and antioxidant status in healthy human males.

  2008cited by this paper
• Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response

  2008cited by this paper
• Lactoferrin-monophosphoryl lipid A complex enhances immunity of mice to Plesiomonas shigelloides CNCTC 138/92.

  2008cited by this paper
• Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice.

  2008cited by this paper
• Lactoferrin modulation of antigen-presenting-cell response to BCG infection.

  2007influential reference
• Bovine lactoferrin prevents the entry and intercellular spread of herpes simplex virus type 1 in Green Monkey Kidney cells.

  2007cited by this paper
• Induction of a Th1 Response from Th2-Polarized T Cells by Activated Dendritic Cells: Dependence on TCR:Peptide-MHC Interaction, ICAM-1, IL-12, and IFN-γ1

  2007cited by this paper
• Differential suppression of dendritic cell cytokine production by anti‐inflammatory drugs

  2007cited by this paper
• Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain.

  2007cited by this paper
• Antibacterial Activity of Bovine Lactoferrin Hydrolysate against Mastitis Pathogens and Its Effect on Superoxide Production of Bovine Neutrophils

  2007cited by this paper
• Antibiotic properties and applications of lactoferrin.

  2007cited by this paper
• Early experience with novel immunomodulators for cancer treatment

  2007cited by this paper
• Lactoferrin in health and disease.

  2007cited by this paper
• Lactoferrin enhanced efficacy of the BCG vaccine to generate host protective responses against challenge with virulent Mycobacterium tuberculosis.

  2007cited by this paper
• Inflammatory caspases and inflammasomes: master switches of inflammation

  2007cited by this paper
• Toxoplasma gondii: inhibition of the intracellular growth by human lactoferrin.

  2007cited by this paper
• Role of endogenous interferon and LPS in the immunomodulatory effects of bovine lactoferrin in murine peritoneal macrophages

  2007cited by this paper
• Lactoferrin modulation of IL-12 and IL-10 response from activated murine leukocytes

  2007influential reference
• Iron-mediated dismutation of superoxide anion augments antigen-induced allergic inflammation: effect of lactoferrin.

  2007cited by this paper
• A role for milk proteins and their peptides in cancer prevention.

  2007cited by this paper
• Differential Modulation of Human Lactoferrin Activity against Both R5 and X4-HIV-1 Adsorption on Epithelial Cells and Dendritic Cells by Natural Antibodies1

  2006cited by this paper
• Breast Milk Lactoferrin Regulates Gene Expression by Binding Bacterial DNA CpG Motifs But Not Genomic DNA Promoters in Model Intestinal Cells

  2006cited by this paper
• Regulation of physiological and pathological Th1 and Th2 responses by lactoferrin.

  2006cited by this paper
• Lactoferrin decreases pollen antigen‐induced allergic airway inflammation in a murine model of asthma

  2006cited by this paper
• Dietary immunostimulants influence specific immune response and resistance of healthy and immunocompromised Asian catfish Clarias batrachus to Aeromonas hydrophila infection.

  2006cited by this paper
• A complex of lactoferrin with monophosphoryl lipid A is an efficient adjuvant of the humoral and cellular immune response in mice

  2006cited by this paper
• Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies.

  2006cited by this paper
• Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways.

  2006influential reference
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  2006cited by this paper
• Adjuvant effect of mushroom glucan and bovine lactoferrin upon Aeromonas hydrophila vaccination in catla, Catla catla (Hamilton).

  2006cited by this paper
• B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties.

  2006cited by this paper
• Interactions of lactoferrin with cells involved in immune function.

  2006cited by this paper
• Epigenetic regulation of Th1 and Th2 cell development.

  2006cited by this paper
• Modulation of Immunity-Related Gene Expression in Small Intestines of Mice by Oral Administration of Lactoferrin

  2006influential reference
• Influences of orally administered lactoferrin on IFN-gamma and IL-10 production by intestinal intraepithelial lymphocytes and mesenteric lymph-node cells.

  2006cited by this paper
• Release of surface‐expressed lactoferrin from polymorphonuclear neutrophils after contact with CD4+T cells and its modulation on Th1/Th2 cytokine production

  2006cited by this paper
• Lactoferrin Prevents Dendritic Cell-Mediated Human Immunodeficiency Virus Type 1 Transmission by Blocking the DC-SIGN—gp120 Interaction

  2005cited by this paper
• Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection: Proof of Principle Using Mouse Intraperitoneal Infection

  2005cited by this paper
• Staphylococcal superantigens: do they play a role in sepsis?

  2005cited by this paper
• Reduction of concanavalin A-induced expression of interferon-gamma by bovine lactoferrin in feline peripheral blood mononuclear cells.

  2005cited by this paper
• Immune evasion by staphylococci

  2005cited by this paper
• Molecular structure, binding properties and dynamics of lactoferrin.

  2005cited by this paper
• Lactoferrin Accelerates Reconstitution of the Humoral and Cellular Immune Response During Chemotherapy-induced Immunosuppression and Bone Marrow Transplant in Mice

  2005cited by this paper
• Gateways to clinical trials.

  2005cited by this paper
• Lactoferrin

  2005cited by this paper
• Lactoferrin

  2005cited by this paper
• Lactoferrin augments BCG vaccine efficacy to generate T helper response and subsequent protection against challenge with virulent Mycobacterium tuberculosis.

  2005cited by this paper
• Lactoferrin

  2005cited by this paper
• Lactoferricin

  2005cited by this paper
• Sialic acid-containing milk proteins show differential immunomodulatory activities independent of sialic acid.

  2005cited by this paper
• Anti herpes simplex virus activity of lactoferrin/lactoferricin – an example of antiviral activity of antimicrobial protein/peptide

  2005cited by this paper
• Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant

  2004cited by this paper
• Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans.

  2004cited by this paper
• Lactoferrin inhibits human papillomavirus binding and uptake in vitro.

  2004cited by this paper
• Lactoferrin blocks the initial host cell attachment mechanism of Enteropathogenic E. coli (EPEC).

  2004cited by this paper
• Lactoferricin influences early events of Listeria monocytogenes infection in THP-1 human macrophages.

  2004cited by this paper
• Gateways to clinical trials.

  2004cited by this paper
• The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells.

  2004cited by this paper
• Characteristics of Vibrio cholerae proteinases: potential, candidate vaccine antigens.

  2004cited by this paper
• Detection of bovine lactoferrin binding protein on Jurkat human lymphoblastic T cell line.

  2004cited by this paper
• B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.

  2004cited by this paper
• Oral Lactoferrin Prevents Body Weight Loss and Increases Cytokine Responses during Herpes Simplex Virus Type 1 Infection of Mice

  2004cited by this paper
• The antimicrobial activity of lactoferrin: Current status and perspectives

  2004cited by this paper
• Regulation of Fungal Infection by a Combination of Amphotericin B and Peptide 2, a Lactoferrin Peptide That Activates Neutrophils

  2004cited by this paper
• Modulation of In Vitro Fungicidal Activity of Human Lactoferrin against Candida albicans by Extracellular Cation Concentration and Target Cell Metabolic Activity

  2004cited by this paper
• Identification of anti‐inflammatory drugs according to their capacity to suppress type‐1 and type‐2 T cell profiles

  2004cited by this paper
• Protection against infections by oral lactoferrin: Evaluation in animal models

  2004cited by this paper
• Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis.

  2004cited by this paper
• Interleukin-18: recent advances

  2004cited by this paper
• Lactoferrin works as a new LPS-binding protein in inflammatory activation of macrophages.

  2004cited by this paper
• Effect of lactoferrin on the methotrexate-induced suppression of the cellular and humoral immune response in mice.

  2004cited by this paper
• Antiviral activity of lactoferrin towards naked viruses

  2004cited by this paper
• The mode of oral bovine lactoferrin administration influences mucosal and systemic immune responses in mice.

  2004cited by this paper
• Bovine lactoferrin decreases histopathological changes in the liver and regulates cytokine production by splenocytes of obstructive jaundiced rats

  2003cited by this paper
• Reconstitution of the cellular immune response by lactoferrin in cyclophosphamide-treated mice is correlated with renewal of T cell compartment.

  2003cited by this paper
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  2003cited by this paper
• Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.

  2003cited by this paper
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  2003influential reference
• Orally administered lactoferrin restores humoral immune response in immunocompromised mice.

  2003cited by this paper
• Lactoferrin Feeding Augments Peritoneal Macrophage Activities in Mice Intraperitoneally Injected with Inactivated Candida albicans

  2003cited by this paper
• Lactoferrin--a multifunctional protein with antimicrobial properties.

  2003cited by this paper
• Biodefense properties of milk: the role of antimicrobial proteins and peptides.

  2003cited by this paper
• Interleukin-12 and the regulation of innate resistance and adaptive immunity

  2003cited by this paper
• IL-1beta-induced Langerhans' cell migration and TNF-alpha production in human skin: regulation by lactoferrin.

  2003influential reference
• IL‐1β‐induced Langerhans’ cell migration and TNF‐α production in human skin: regulation by lactoferrin

  2003cited by this paper
• Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro.

  2002cited by this paper
• Lactoferrin: influences on Langerhans cells, epidermal cytokines, and cutaneous inflammation.

  2002cited by this paper
• The adjuvant activity of lactoferrin in the generation of DTH to ovalbumin can be inhibited by bovine serum albumin bearing alpha-D-mannopyranosyl residues.

  2002cited by this paper
• Enhanced Th1 Response to Staphylococcus aureus Infection in Human Lactoferrin-Transgenic Mice1

  2002influential reference
• Immunoregulatory activities of lactoferrin in the delayed type hypersensitivity in mice are mediated by a receptor with affinity to mannose.

  2002cited by this paper
• Oxidative stress in allergic respiratory diseases.

  2002cited by this paper

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