Structure and function of human perforin

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Nature

• Publication date

  1988-09-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/335448A0PMID 3419519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The structure of human complement component C7 and the C5b-7 complex.

  1988cited by this paper
• Structure, Function and Expression of Murine and Human Perforin 1 (P1)

  1988cited by this paper
• Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells.

  1988cited by this paper
• Induction of expression of cell-surface homologous restriction factor upon anti-CD3 stimulation of human peripheral lymphocytes.

  1988cited by this paper
• Primary sequence homology between the effector molecules that mediate complement and T-lymphocyte cytotoxicity.

  1987cited by this paper
• Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

  1987cited by this paper
• Cytotoxic T lymphocyte mediated lysis without release of serine esterase

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

  1987cited by this paper
• High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells.

  1987cited by this paper
• Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9.

  1987cited by this paper
• Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.

  1987cited by this paper
• Induction of synthesis of the cytolytic C9 (ninth component of complement)-related protein in human peripheral mononuclear cells by monoclonal antibody OKT3 or interleukin 2: correlation with cytotoxicity and lymphocyte phenotype.

  1987cited by this paper
• Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes.

  1987cited by this paper
• Mechanism of cytotoxicity of human large granular lymphocytes: relationship of the cytotoxic lymphocyte protein to the ninth component (C9) of human complement.

  1986cited by this paper
• Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

  1986cited by this paper
• Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

  1985cited by this paper
• Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

  1984cited by this paper
• Molecular composition of the tubular structure of the membrane attack complex of complement.

  1984cited by this paper
• Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization

  1984cited by this paper
• Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

  1984cited by this paper
• Patterns of amino acids near signal-sequence cleavage sites.

  1983cited by this paper
• Immunology: Are complement lysis and lymphocytotoxicity analogous?

  1983cited by this paper
• A simple and very efficient method for generating cDNA libraries.

  1983cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

  1983cited by this paper
• Homologous species restriction in lysis of erythrocytes by terminal complement proteins.

  1981cited by this paper

• Updates in the pathogenesis of SJS/TEN

  2025cites this paper
• The important role of Perforin in protecting against Mycobacterium avium infection in mice

  2025cites this paper
• [Cu(NN1)2]ClO4, a Copper (I) Complex as an Antimicrobial Agent for the Treatment of Piscirickettsiosis in Atlantic Salmon

  2024cites this paper
• Oral administration of a new copper (I) complex with coumarin as ligand: modulation of the immune response and the composition of the intestinal microbiota in Onchorhynchus mykiss

  2024cites this paper
• Laboratory Features and Pathology of Cytokine Storm Syndromes.

  2024cites this paper
• Genetics of Primary Hemophagocytic Lymphohistiocytosis.

  2024cites this paper
• Unveiling the nanoscale architectures and dynamics of protein assembly with in situ atomic force microscopy

  2024cites this paper
• Transcription factor networks drive perforin activity in the anti-bacterial immune response of tilapia.

  2024cites this paper
• A natural killer cell mimic against intracellular pathogen infections

  2024cites this paper
• Hemophagocytic Lymphohistiocytosis (HLH) – The Great Mimicker: Case Report

  2023cites this paper
• Regulation and distribution of European sea bass perforins point to their role in the adaptive cytotoxic response against NNV.

  2023cites this paper
• It Takes a Village: The Multifaceted Immune Response to Mycobacterium tuberculosis Infection and Vaccine-Induced Immunity

  2022cites this paper
• Pore-forming proteins and their role in cancer and inflammation: Mechanistic insights and plausible druggable targets.

  2022cites this paper
• Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease

  2022cites this paper
• Perforin: An intriguing protein in allograft rejection immunology (Review).

  2022cites this paper
• Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity

  2022cites this paper
• Genetic Analysis for Type 1 Diabetes Genes in Juvenile Dermatomyositis Unveils Genetic Disease Overlap.

  2022cites this paper
• Oxidative and Non-Oxidative Antimicrobial Activities of the Granzymes

  2021cites this paper
• Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis).

  2021cites this paper
• Summary and comparison of the perforin in teleosts and mammals: A review

  2021cites this paper
• Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes

  2021cites this paper
• The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities

  2021cites this paper
• Genetic diseases predisposing to HLH

  2020cites this paper
• Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model

  2020cites this paper
• Associations between PRF1 Ala91Val polymorphism and risk of hemophagocytic lymphohistiocytosis: a meta-analysis based on 1366 subjects

  2020cites this paper
• PRF1 Deficiency

  2019cites this paper
• Laboratory Features and Pathology of the Cytokine Storm Syndromes

  2019cites this paper
• Genetics of Primary Hemophagocytic Lymphohistiocytosis

  2019cites this paper
• Validation of immunogenic PASD1 peptides against HLA-A*24:02 colorectal cancer.

  2019cites this paper
• Perforin-2 Permeabilizes the Envelope of Phagocytosed Bacteria

  2018cites this paper
• Macrophage Activation Syndrome

  2018cites this paper
• Perforin-2 Breaches the Envelope of Phagocytosed Bacteria Allowing Antimicrobial Effectors Access to Intracellular Targets

  2018cites this paper
• Bridging the Gaps in the Vaccine Development: Avant-Garde Vaccine Approach with Secreted Heat Shock Protein gp96-Ig

  2018cites this paper
• Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection

  2018cites this paper
• Chapter 2 Distribution of MACPF / CDC Proteins

  2018cites this paper
• Genetics and Pathogenesis of Hemophagocytic Lymphohistiocytosis

  2018cites this paper
• Molecular characterization of three novel perforins in common carp (Cyprinus carpio L.) and their expression patterns during larvae ontogeny and in response to immune challenges

  2018cites this paper
• Network Analysis-Based Approach for Exploring the Potential Diagnostic Biomarkers of Acute Myocardial Infarction

  2016cites this paper
• Control of IFN-γ response via autocrine activation of the C5a complement receptors and the NLRP3 inflammasome within human T lymphocytes

  2016cites this paper
• 噬血细胞性淋巴组织细胞增生症患儿及其家系穿孔素和颗粒酶B的表达

  2016cites this paper
• Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs.

  2016cites this paper
• Giant MACPF/CDC pore forming toxins: A class of their own.

  2016cites this paper
• L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors.

  2016cites this paper
• Killing of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer Proteins

  2016cites this paper
• Macrophage Activation Syndrome.

  2015cites this paper
• Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

  2015cites this paper
• Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

  2015influential citation
• Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding*

  2015cites this paper
• Immunotherapy of Leukemic Stem Cells using Natural Killer Cell Lines

  2015cites this paper
• Investigations into the fate and functionality of apoptotic vesicles

  2014cites this paper
• Variations of the perforin gene in patients with chronic inflammatory demyelinating polyradiculoneuropathy

  2014cites this paper
• Antibacterial activity and immune responses of a molluscan macrophage expressed gene-1 from disk abalone, Haliotis discus discus.

  2014cites this paper
• Hemophagocytic lymphohistiocytosis associated with viral infections: Diagnostic challenge and therapeutic dilemma

  2014cites this paper
• New regulatory CD19(+)CD25(+) B-cell subset in clinically isolated syndrome and multiple sclerosis relapse. Changes after glucocorticoids.

  2014cites this paper
• Structural biology of the membrane attack complex.

  2014cites this paper
• Perforin: a key pore-forming protein for immune control of viruses and cancer.

  2014cites this paper
• MACPF/CDC Proteins - Agents of Defence, Attack and Invasion

  2014cites this paper
• Journal of Biotechnology Research Center (Special edition) Vol. 8 No. 1

  2014cites this paper
• Perforin and human diseases.

  2014cites this paper
• Distribution of MACPF/CDC proteins.

  2014cites this paper
• Perforin: an important player in immune response

  2014cites this paper
• The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

  2014cites this paper
• The Role of Tim-3 Receptor in CD8+ T cells Cytotoxicity in Chronic HIV Infection

  2013cites this paper
• Ekspresija čimbenika stanične smrti u neuroblastomu

  2013cites this paper
• Perforin-2 Restricts Growth of Chlamydia trachomatis in Macrophages

  2013cites this paper
• Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

  2013cites this paper
• Enhanced Gene Expression Following Vaccination in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

  2013cites this paper
• HIV mother-to-child transmission: a complex genetic puzzle tackled by Brazil and Argentina research teams.

  2013cites this paper
• Killing machines: three pore-forming proteins of the immune system

  2013cites this paper
• Characterization of Perforin-2, a novel anti-bacterial, poreforming protein of the innate immune system

  2013cites this paper
• Hemophagocytic Lymphohistiocytosis An Update on Diagnosis and Pathogenesis

  2013cites this paper
• perforin gene A proportion of patients with lymphoma may harbor mutations of the

  2013cites this paper
• Performance of Polymerase Chain Reaction Techniques Detecting Granzyme B in the Diagnosis of Acute Renal Rejection: A Meta-Analysis

  2013cites this paper
• Hemophagocytic lymphohistiocytosis: an update on diagnosis and pathogenesis.

  2013cites this paper
• Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

  2013cites this paper
• An atomic-force basis for the bacteriolytic effects of granulysin.

  2012cites this paper
• Ectopically Expressed Perforin-1 Is Proapoptotic in Tumor Cell Lines by Increasing Caspase-3 Activity and the Nuclear Translocation of Cytochrome c

  2012cites this paper
• Intercellular communication via the endo-lysosomal system: translocation of granzymes through membrane barriers.

  2012cites this paper
• Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)*♦

  2012cites this paper
• Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones.

  2012cites this paper
• Performance of Polymerase Chain Reaction Techniques Detecting Perforin in the Diagnosis of Acute Renal Rejection: A Meta-Analysis

  2012cites this paper
• Inhibition of Intracellular Bacterial Replication in Fibroblasts Is Dependent on the Perforin-Like Protein (Perforin-2) Encoded by Macrophage-Expressed Gene 1

  2012cites this paper
• Genetic, cellular and clinical studies of hemophagocytic lymphohistiocytosis

  2012cites this paper
• Cellular and molecular characterisation of familial haemophagocytic lymphohistiocytosis type 1

  2011cites this paper
• Involvement of pore-forming molecules in immune defense and development of the Mediterranean mussel (Mytilus galloprovincialis).

  2011cites this paper
• Gene Expression Changes Are Associated With Loss of Kidney Graft Function and Interstitial Fibrosis and Tubular Atrophy: Diagnosis Versus Prediction

  2011cites this paper
• Low frequency of HIV-1 tropism evolution in patients successfully treated for at least 2 years

  2011cites this paper
• Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles.

  2011cites this paper
• A promoter DNA demethylation landscape of human hematopoietic differentiation

  2011cites this paper
• The structure and function of mammalian membrane-attack complex/perforin-like proteins.

  2010cites this paper
• allograftsin acutely rejecting renal Heightened intragraft CTL gene

  2010cites this paper
• The structural basis for membrane binding and pore formation by lymphocyte perforin

  2010cites this paper
• Insights into the Cytotoxic Potential of Human CD8+ T Cells: Implications for Virologic Control of HIV

  2010cites this paper
• Phenotype of NK Cells and Cytotoxic/Apoptotic Mediators Expression in Ectopic Pregnancy

  2010cites this paper
• Perforin deficiency and susceptibility to cancer

  2010cites this paper
• Multiple Sclerosis Polymorphisms in the Susceptibility to Gender-Associated Differences of Perforin

  2010cites this paper
• Perforin: structure, function, and role in human immunopathology

  2010cites this paper
• Gender-Associated Differences of Perforin Polymorphisms in the Susceptibility to Multiple Sclerosis

  2010cites this paper
• Natural killer cytolytic activity

  2010cites this paper
• Inherited defects in lymphocyte cytotoxic activity

  2010cites this paper