Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Nature

• Publication date

  2011-09-22

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/nature10370PMID 21874019PMCID PMC3324908
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dual-mode phospholipid regulation of human inward rectifying potassium channels.

  2011cited by this paper
• Inositol phosphate synthesis and the nuclear processes they affect.

  2010cited by this paper
• Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.

  2010cited by this paper
• Features and development of Coot

  2010cited by this paper
• SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

  2010cited by this paper
• Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

  2009cited by this paper
• Direct Regulation of BK Channels by Phosphatidylinositol 4,5-Bisphosphate as a Novel Signaling Pathway

  2008cited by this paper
• Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands.

  2007cited by this paper
• Regulation of ion transport proteins by membrane phosphoinositides

  2007cited by this paper
• Phosphoinositide-mediated gating of inwardly rectifying K+ channels

  2007cited by this paper
• PI(3,4,5)P3 and PI(4,5)P2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane

  2006cited by this paper
• Regulation of the desensitization and ion selectivity of ATP‐gated P2X2 channels by phosphoinositides

  2006cited by this paper
• Direct Modulation of Kir Channel Gating by Membrane Phosphatidylinositol 4,5-Bisphosphate*♦

  2005cited by this paper
• Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification

  2005cited by this paper
• Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.

  2005cited by this paper
• Membrane-protein interactions in cell signaling and membrane trafficking.

  2005cited by this paper
• Towards complete validated models in the next generation of ARP/wARP.

  2004cited by this paper
• research papers Acta Crystallographica Section D Biological

  2003cited by this paper
• Specificity of activation by phosphoinositides determines lipid regulation of Kir channels

  2003cited by this paper
• Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies.

  2002cited by this paper
• Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0.

  2002cited by this paper
• The Complex and Intriguing Lives of PIP2 with Ion Channels and Transporters

  2001cited by this paper
• PI(4,5)P(2) regulation of surface membrane traffic.

  2001cited by this paper
• An approach to multi-copy search in molecular replacement.

  2000cited by this paper
• Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions

  1999cited by this paper
• Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

  1998cited by this paper
• Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton

  1996cited by this paper
• Regulation of Cardiac Na+,Ca2+ Exchange and KATP Potassium Channels by PIP2

  1996cited by this paper
• Inositol Trisphosphate and Calcium Signaling

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• [Cellular electrophysiological basis of proarrhythmic and antiarrhythmic effects of ischemia-related lipid metabolites].

  1993cited by this paper
• Inositol trisphosphate and calcium signalling

  1993cited by this paper
• Electronic Reprint Biological Crystallography Phenix : a Comprehensive Python-based System for Macromolecular Structure Solution

  year unknowncited by this paper

• Mutagenesis-Centered Integrative Approaches for Identifying Binding Sites in Ion Channels and Uncovering Modulatory Mechanisms.

  2026cites this paper
• Bioactive lipid-mediated structural and functional regulation of the essential human potassium channel Kir7.1.

  2026cites this paper
• Ligand-like lipid interactions with membrane proteins: Simulations and machine learning.

  2026cites this paper
• Understanding Ion Channel Gating Mechanisms by Molecular Dynamics Simulations.

  2026cites this paper
• Lipid Modulation of Ion Channel Function

  2026cites this paper
• Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights.

  2026cites this paper
• Opening closed inward rectifier potassium channel doors.

  2026cites this paper
• Anionic Lipid Trafficking and Cell Mechanics Regulate Membrane Electrical Potential in Non-Excitable Tissue Cells

  2025cites this paper
• The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel

  2025cites this paper
• Investigating the Dynamics of the KCNN4 Channel: From the Determination of the Complete K+ Permeation Pathway Across the Channel to Its Opening by PIP2

  2025cites this paper
• The Influence of Phosphoinositide Lipids in the Molecular Biology of Membrane Proteins: Recent Insights from Simulations

  2025cites this paper
• Elucidating the structure and assembly mechanism of actinoporin pores in complex membrane environments

  2025cites this paper
• Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera

  2025influential citation
• Membrane‐forming phospholipids allosterically modulate native‐state prolyl isomerization in a CNG channel

  2025cites this paper
• Mechanisms of General Anesthesia.

  2025cites this paper
• Seasonal regulation and PIP2 dependence of inwardly rectifying potassium channels (Kir) in retinal horizontal cells of goldfish (Carassius auratus).

  2025cites this paper
• Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles

  2025cites this paper
• CCD2MD: A Suite of Packages for Preparing Co-Folded Outputs for Molecular Dynamics Simulations

  2025cites this paper
• Force Field Sensitivity of Ion Occupancy in Potassium Channels.

  2025cites this paper
• Brain Capillary Ion Channels: Physiology and Channelopathies.

  2025cites this paper
• GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons

  2025cites this paper
• The machinery of healthy vasodilatation: an overview

  2025cites this paper
• Linking Circadian Rhythms to Gut‐Brain Axis Lipid Metabolism Associated With Endoplasmic Reticulum Stress in Alzheimer's Disease

  2025cites this paper
• Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue.

  2025cites this paper
• Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases

  2025cites this paper
• PIP2 Regulation of TRPV4 Channels: Binding Sites and Dynamic Coupling.

  2025cites this paper
• Inwardly rectifying potassium channels (KIR) in GtoPdb v.2025.4

  2025cites this paper
• PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating.

  2025cites this paper
• Lipid-dependent uncoupling of agonist binding and channel gating in the nicotinic acetylcholine receptor

  2025cites this paper
• Direct crosstalk between GPCRs and ion channels via G proteins

  2025cites this paper
• Flow Sensitive Ion Channels in Vascular Endothelial Cells: Mechanisms of Activation and Roles in Mechanotransduction.

  2025cites this paper
• Lipid probes to study ion channels.

  2025cites this paper
• Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP2 regeneration and activation of Kir2.1 channels

  2025cites this paper
• Inwardly rectifying potassium channels (KIR) in GtoPdb v.2025.3

  2025cites this paper
• Structure-based identification of GIRK2-PIP2 modulators among known drugs and metabolites using docking, MM-GBSA, ADMET, and molecular dynamics

  2025cites this paper
• Coordination of bilayer properties by an inward-rectifier K+ channel is a cooperative process driven by protein-lipid interaction

  2024cites this paper
• The action mechanism of actinoporins revealed through the structure of pore-forming intermediates

  2024cites this paper
• Molecular dynamics simulations of lipid-protein interactions in SLC4 proteins.

  2024cites this paper
• Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

  2024cites this paper
• Cryo-EM structure of human HCN3 channel and its regulation by cAMP

  2024cites this paper
• Structure-function and pharmacologic aspects of ion channels relevant to neurologic channelopathies.

  2024cites this paper
• Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome

  2024influential citation
• Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation

  2024cites this paper
• Biochemical, biophysical, and structural investigations of two mutants (C154Y and R312H) of the human Kir2.1 channel involved in the Andersen-Tawil syndrome

  2024cites this paper
• Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels

  2024cites this paper
• Bidirectional Allosteric Coupling between PIP2 Binding and the Pore of the Oncochannel TRPV6

  2024cites this paper
• Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

  2024influential citation
• Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses

  2024cites this paper
• The Kir2.1-NaV1.5 Channelosome and its role in Arrhythmias in Inheritable Cardiac Diseases.

  2024cites this paper
• Cholesterol regulation of mechanosensitive ion channels

  2024cites this paper
• A phenylalanine at the extracellular side of Kir1.1 facilitates potassium permeation

  2024cites this paper
• Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants

  2024cites this paper
• Dynamic duo: Kir6 and SUR in KATP channel structure and function

  2024cites this paper
• Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

  2024cites this paper
• The Role of the Swollen State in Cell Proliferation

  2024cites this paper
• Getting attached to membranes - How plant signalling networks employ PtdIns(4,5)P2.

  2024cites this paper
• GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons

  2024cites this paper
• Dual pattern of cholesterol-induced decoupling of residue-residue interactions of Kir2.2.

  2024cites this paper
• Development of new Kir2.1 channel openers from propafenone analogues

  2024cites this paper
• TREK2 Lipid Binding Preferences Revealed by Native Mass Spectrometry

  2024cites this paper
• Computational investigation of missense somatic mutations in cancer and potential links to pH-dependence and proteostasis

  2024cites this paper
• Heterozygous Variants in KCNJ10 Cause Paroxysmal Kinesigenic Dyskinesia Via Haploinsufficiency

  2024cites this paper
• In Silico Methods for the Discovery of Kv7.2/7.3 Channels Modulators: A Comprehensive Review

  2024influential citation
• PI4KIIIβ-Mediated Phosphoinositides Metabolism Regulates Function of the VTA Dopaminergic Neurons and Depression-Like Behavior

  2024cites this paper
• Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance

  2024influential citation
• Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens

  2024cites this paper
• Cooperative Gating of a K+ Channel by Unmodified Biological Anionic Lipids Viewed by Solid-State NMR Spectroscopy

  2024cites this paper
• Subunit gating resulting from individual protonation events in Kir2 channels

  2023influential citation
• CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications

  2023cites this paper
• From Crosstalk to Synergism: The Combined Effect of Cholesterol and PI(4,5)P2 on Inwardly Rectifying Potassium Channels.

  2023cites this paper
• Specificities of Protein Homology Modeling for Allosteric Drug Design.

  2023cites this paper
• Inwardly rectifying potassium channels (KIR) in GtoPdb v.2023.1

  2023cites this paper
• Role of Lysosomal Cholesterol in Regulating PI(4,5)P2-Dependent Ion Channel Function.

  2023cites this paper
• Regulation of PIEZO1 channels by lipids and the structural components of extracellular matrix/cell cytoskeleton

  2023cites this paper
• PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease

  2023cites this paper
• Lipidomic investigation of the protective effects of Polygonum perfoliatum against chemical liver injury in mice.

  2023cites this paper
• PI(4,5)P2 regulates the gating of NaV1.4 channels

  2023cites this paper
• Cholesterol Regulation of Membrane Proteins Revealed by Two-Color Super-Resolution Imaging

  2023cites this paper
• Freestanding lipid bilayer tensiometer for the study of mechanosensitive ion channels

  2023cites this paper
• Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1

  2023cites this paper
• PI(4,5)P2 and Cholesterol: Synthesis, Regulation, and Functions.

  2023cites this paper
• Interaction of ROMK2 channel with lipid kinases DGKE and AGK: Potential channel activation by localized anionic lipid synthesis.

  2023cites this paper
• Appreciating the potential for GPCR crosstalk with ion channels.

  2023cites this paper
• Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na+ Channel (ENaC)

  2023cites this paper
• Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2

  2023cites this paper
• The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: A novel player in energy homeostasis control.

  2023cites this paper
• Roles of Cholesterol and PtdIns(4,5)P2 in the Regulation of STIM1-Orai1 Channel Function.

  2023cites this paper
• The interplay of nuclear pores and lipids.

  2023cites this paper
• PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease

  2023cites this paper
• Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1

  2023cites this paper
• Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters

  2023cites this paper
• Super-resolution imaging of potassium channels with genetically encoded EGFP

  2023cites this paper
• Genome mining yields putative disease-associated ROMK variants with distinct defects

  2023cites this paper
• Epidermal Growth Factor Receptors in Vascular Endothelial Cells Contribute to Functional Hyperemia in the Brain

  2023cites this paper
• Subunit gating resulting from individual protonation events in Kir2 channels

  2023cites this paper
• Epidermal growth factor receptors in vascular endothelial cells contribute to functional hyperemia in the brain

  2023cites this paper
• Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

  2023cites this paper
• Nutrigenomics of inward rectifier potassium channels.

  2023cites this paper
• Combining native mass spectrometry and lipidomics to uncover specific membrane protein–lipid interactions from natural lipid sources

  2023cites this paper
• Molecular Biophysics of Class A G Protein Coupled Receptors–Lipids Interactome at a Glance—Highlights from the A2A Adenosine Receptor

  2023cites this paper