Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B" and their cognate RNAs

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Nature

• Publication date

  1990-06-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/345502A0PMID 2140872
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA

  1992cited by this paper
• The biochemistry of 3'-end cleavage and polyadenylation of messenger RNA precursors.

  1992cited by this paper
• Proximal sequence element factor binding and species specificity in vertebrate U6 snRNA promoters.

  1992cited by this paper
• RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.

  1991cited by this paper
• Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA‐binding domain between humans and yeast.

  1991cited by this paper
• Analysis of in vitro binding of U1-A protein mutants to U1 snRNA.

  1991cited by this paper
• Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions

  1991cited by this paper
• Biochemical mechanisms of constitutive and regulated pre-mRNA splicing.

  1991cited by this paper
• A weak interaction between the U2A' protein and U2 snRNA helps to stabilize their complex with the U2B" protein.

  1991cited by this paper
• Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding.

  1991cited by this paper
• Messenger RNA splicing in yeast: clues to why the spliceosome is a ribonucleoprotein.

  1991cited by this paper
• Structure of spliceosomal snRNPs and their role in pre-mRNA splicing.

  1990cited by this paper
• The U2B″ RNP motif as a site of protein‐protein interaction.

  1990cited by this paper
• Structural and functional analysis of the human thymidylate synthase gene.

  1990cited by this paper
• Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing.

  1990cited by this paper
• Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.

  1990cited by this paper
• Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

  1990cited by this paper
• Do the poly(A) tail and 3' untranslated region control mRNA translation?

  1990cited by this paper
• The helix-turn-helix DNA binding motif.

  1989cited by this paper
• Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA.

  1989cited by this paper
• Sex in flies: the splice of life

  1989cited by this paper
• Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

  1989cited by this paper
• Drosophila sex determination: a cascade of regulated splicing.

  1989cited by this paper
• Determinants of target gene specificity for steroid/thyroid hormone receptors.

  1989cited by this paper
• Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor.

  1989cited by this paper
• A binding consensus: RNA-protein interactions in splicing, snRNPs, and sex.

  1989cited by this paper
• Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.

  1989cited by this paper
• A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.

  1989cited by this paper
• DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9.

  1989cited by this paper
• How do proteins recognize specific RNA sites? New clues from autogenously regulated ribosomal proteins.

  1989cited by this paper
• The U1 RNA-Binding Site of the U1 Small Nuclear Ribonucleoprotein (snRNP)-Associated A Protein Suggests a Similarity with U2 snRNPs

  1989cited by this paper
• The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice

  1989cited by this paper
• Functional analysis of mutant Xenopus U2 snRNAs.

  1989cited by this paper
• Regulated splicing in early development and stage-specific U snRNPs.

  1989cited by this paper
• Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein.

  1989cited by this paper
• RNA-binding proteins as developmental regulators.

  1989cited by this paper
• Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

  1989cited by this paper
• 5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

  1988cited by this paper
• Posttranscriptional regulatory mechanisms in Escherichia coli.

  1988cited by this paper
• Spliceosomal snRNAs.

  1988cited by this paper
• Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.

  1988cited by this paper
• Functions of the Abundant U-snRNPs

  1988cited by this paper
• Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides.

  1988cited by this paper
• Internal sequences that distinguish yeast from metazoan U2 snRNA are unnecessary for pre-mRNA splicing

  1988cited by this paper
• A versatile in vivo and in vitro eukaryotic expression vector for protein engineering

  1988cited by this paper
• A U1 snRNA:pre‐mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

  1988cited by this paper
• Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen.

  1987cited by this paper
• cDNA cloning of the human U1 snRNA‐associated A protein: extensive homology between U1 and U2 snRNP‐specific proteins.

  1987cited by this paper
• Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA.

  1987cited by this paper
• A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen.

  1987cited by this paper
• The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.

  1987cited by this paper
• In vitro assembly of U1 snRNPs.

  1987cited by this paper
• mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence

  1986cited by this paper
• The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases.

  1986cited by this paper
• Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs.

  1986cited by this paper
• Cloning of the human cDNA for the U1 RNA‐associated 70K protein.

  1986cited by this paper
• Changing the binding specificity of a represser by redesigning an α-helix

  1985cited by this paper
• Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins.

  1985cited by this paper
• Changing the binding specificity of a repressor by redesigning an alpha-helix.

  1985cited by this paper
• Intron splicing: a conserved internal signal in introns of Drosophila pre-mRNAs

  1985cited by this paper
• Generation of AKR mink cell focus-forming viruses: a conserved single-copy xenotrope-like provirus provides recombinant long terminal repeat sequences

  1984cited by this paper
• Xenopus laevis U1 snRNA genes: characterisation of transcriptionally active genes reveals major and minor repeated gene families.

  1984cited by this paper
• Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region.

  1984cited by this paper
• Xenopus laevis U2 snRNA genes: tandemly repeated transcription units sharing 5′ and 3′ flanking homology with other RNA polymerase II transcribed genes.

  1983cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

  1983cited by this paper
• Expression of the herpes thymidine kinase gene in Xenopus laevis oocytes: an assay for the study of deletion mutants constructed in vitro.

  1980cited by this paper
• THE WEAK INTERACTION

  1977cited by this paper

• Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family

  2022cites this paper
• RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma

  2022cites this paper
• RBM10 Interacts with CTBNNBIP1 and Represses Lung Adenocarcinoma Progression Through the Wnt/β- catenin Pathway

  2021cites this paper
• The Chloroplast Ribonucleoprotein CP33B Quantitatively Binds the psbA mRNA

  2020cites this paper
• Structural and functional modularity of the U2 snRNP in pre-mRNA splicing

  2019cites this paper
• Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

  2018cites this paper
• RBM10: Harmful or helpful‐many factors to consider

  2018cites this paper
• Small Nuclear Ribonucleoprotein Polypeptide A–Mediated Alternative Polyadenylation of STAT5B during Th1 Cell Differentiation

  2017cites this paper
• Association of U2AF35, U2AF65 and U2 snRNP with constitutively and alternatively spliced pre-mRNA

  2016cites this paper
• Co-evolution of SNF spliceosomal proteins with their RNA targets in trans-splicing nematodes

  2016cites this paper
• Climbing the vertebrate branch of U 1 A / U 2 B ′ ′ protein evolution

  2015cites this paper
• Structure and Organization of the Engraulidae Family U2 snRNA: An Evolutionary Model Gene?

  2015cites this paper
• Climbing the vertebrate branch of U1A/U2B″ protein evolution

  2014cites this paper
• A compare-and-contrast NMR dynamics study of two related RRMs: U1A and SNF.

  2014cites this paper
• The regulation of U12-dependent splicing and its significance to mRNA stability

  2014cites this paper
• Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes

  2014cites this paper
• Sex determination in the Caenorhabditis elegans germline.

  2013cites this paper
• Resurrection of an Urbilaterian U1A/U2B″/SNF protein.

  2013cites this paper
• can block splicing. nuclear RNA: strengthening conserved stem I Multiple functional domains of human U2 small

  2013cites this paper
• Macromolecular Interactions in West Nile Virus RNA-TIAR Protein Complexes and of Membrane Associated Kv Channel Peptides

  2013cites this paper
• Resurrection of an Urbilaterian U 1 A / U 2 B ′′ / SNF Protein iams

  2013influential citation
• Architecture of the spliceosome.

  2012cites this paper
• Structure and assembly of the SF3a splicing factor complex of U2 snRNP

  2012cites this paper
• Cross-linking, ligation, and sequencing of hybrids reveals RNA–RNA interactions in yeast

  2011cites this paper
• Human U2B″ protein binding to snRNA stemloops.

  2011cites this paper
• Multistep kinetics of the U1A-SL2 RNA complex dissociation.

  2011cites this paper
• U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations.

  2011cites this paper
• Role of the C. elegans U2 snRNP protein MOG-2 in sex determination, meiosis, and splice site selection.

  2011influential citation
• Apobec-1 Complementation Factor (ACF) Binds and Regulates Multiple RNAs

  2011cites this paper
• Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts

  2010cites this paper
• Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

  2009cites this paper
• Special Sm Core Complex Functions in Assembly of the U2 Small Nuclear Ribonucleoprotein of Trypanosoma brucei

  2009influential citation
• The Arabidopsis CBP20 targets the cap-binding complex to the nucleus, and is stabilized by CBP80.

  2009cites this paper
• Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion.

  2009influential citation
• U2 snRNA variants are differentially incorporated into spliceosomes

  2009cites this paper
• Cloning and characterization of the gene encoding the bovine BOULE protein

  2008cites this paper
• Structural analyses of spliceosomal proteins: the Prp19-complex and the U11/U12 65K protein.

  2008cites this paper
• A birth‐to‐death view of mRNA from the RNA recognition motif perspective

  2008cites this paper
• Changing U1A levels regulate expression of immunoglobulin M and the transcriptional repressor ZHXL during B cell differentiation

  2008cites this paper
• The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization

  2008cites this paper
• Cleavage of RNA by an amphiphilic compound lacking traditional catalytic groups.

  2008cites this paper
• Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation.

  2008cites this paper
• Conformationally restricted nucleotides as a probe of structure-function relationships in RNA.

  2008cites this paper
• Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts.

  2007cites this paper
• protein complex required in prespliceosome assembly . Interactions between PRP 9 and SPP 91 splicing factors identify a

  2007cites this paper
• A generic method for the production of recombinant proteins in Escherichia coli using a dual hexahistidine-maltose-binding protein affinity tag.

  2007cites this paper
• Crystallization of RNA-protein complexes.

  2007cites this paper
• Distance-Dependent Processing of Adeno-Associated Virus Type 5 RNA Is Controlled by 5′ Exon Definition

  2007cites this paper
• Recognition of essential purines by the U1A protein

  2007cites this paper
• A study of collective atomic fluctuations and cooperativity in the U1A-RNA complex based on molecular dynamics simulations.

  2007influential citation
• snRNP A protein : implications for snRNP protein function in An enhancer screen identifies a gene that encodes the yeast U 1

  2007cites this paper
• Functional redundancy of worm spliceosomal proteins U1A and U2B″

  2007cites this paper
• The role of RNA structure in the interaction of U1A protein with U1 hairpin II RNA.

  2006cites this paper
• Intron Removal Requires Proofreading of U2AF/3' Splice Site Recognition by DEK

  2006cites this paper
• Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP.

  2006cites this paper
• p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation.

  2006cites this paper
• RNA binding motif (RBM) proteins: A novel family of apoptosis modulators?

  2005cites this paper
• NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: contribution of a beta hairpin to RNA binding.

  2005cites this paper
• The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure

  2005cites this paper
• 13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein.

  2005cites this paper
• DISSECTION DU MÉCANISME DE TERMINAISON/ANTITERMINAISON AU NIVEAU DU TERMINATEUR TRI DU PHAGE LAMBDA : APPLICATION A L'ÉTUDE DES COMPLEXES ARN-PROTÉINE IN VIVO

  2004cites this paper
• The structure and biochemical properties of the human spliceosomal protein U1C.

  2004cites this paper
• Probing specificity of RNA : ribonucleoprotein interactions through in vitro selection

  2004cites this paper
• Identifizierung und Charakterisierung des Poly(A)-Bindungsproteins aus Rattus Norvegicus (Berkenhout, 1769) als trans-agierender Faktor der dendritisch lokalisierten Vasopressin mRNA

  2004cites this paper
• Biochemical and structural studies of the celullar mRNA export factor TAP, and its interaction with the viral CTE-RNA

  2004cites this paper
• Contributions of the RNA-binding and linker domains and RNA structure to the specificity and affinity of the nucleolin RBD12/NRE interaction.

  2004cites this paper
• The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo.

  2003cites this paper
• Cloning and Identification of a Novel Human RNPC3 Gene That Encodes a Protein with Two RRM Domains and Is Expressed in the Cell Nucleus

  2003cites this paper
• Sequences Adjacent to the 5′ Splice Site Control U1A Binding Upstream of the IgM Heavy Chain Secretory Poly(A) Site*

  2003cites this paper
• Cloning and characterization of two subunits of Arabidopsis thaliana nuclear cap-binding complex.

  2002influential citation
• The splicing regulator TIA‐1 interacts with U1‐C to promote U1 snRNP recruitment to 5′ splice sites

  2002cites this paper
• Selective Translation of Eukaryotic mRNAs: Functional Molecular Analysis of GRSF-1, a Positive Regulator of Influenza Virus Protein Synthesis

  2002influential citation
• Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1.

  2002cites this paper
• U 1 A N-terminal RNA binding domain Contribution of the tyrosines to the structure and function of the

  2002cites this paper
• Protein Synthesis Positive Regulator of Influenza Virus Functional Molecular Analysis of GRSF-1 , a Selective Translation of Eukaryotic mRNAs :

  2002cites this paper
• Mutational Definition of RNA-binding and Protein-Protein Interaction Domains of Heterogeneous Nuclear RNP C1*

  2001cites this paper
• The Drosophila U2 snRNP protein U2A' has an essential function that is SNF/U2B" independent.

  2001cites this paper
• The Drosophila U 2 snRNP protein U 2 A ′ has an essential function that is SNF / U 2 B ′′ independent

  2001cites this paper
• Covariance analysis of RNA recognition motifs identifies functionally linked amino acids.

  2001cites this paper
• An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles.

  2001cites this paper
• Structure and assembly of the spliceosomal snRNPs. Novartis Medal Lecture.

  2001cites this paper
• T7 phage display: A novel genetic selection system for cloning RNA-binding proteins from cDNA libraries

  2001cites this paper
• Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding

  2001cites this paper
• Two Functionally Distinct Steps Mediate High Affinity Binding of U1A Protein to U1 Hairpin II RNA*

  2001cites this paper
• Molecular dynamics simulation of the human U2B" protein complex with U2 snRNA hairpin IV in aqueous solution.

  2001cites this paper
• Differential expression of potato U1A spliceosomal protein genes: a rapid method for expression profiling of multigene families

  2001cites this paper
• Active disruption of an RNA-protein interaction by a DExH/D RNA helicase.

  2001cites this paper
• Stem-loop 1 of the U1 snRNP plays a critical role in the suppression of HIV-1 polyadenylation.

  2000cites this paper
• Molecular mechanisms of fragile X syndrome.

  2000cites this paper
• Function of RRM domains of Drosophila melanogaster ELAV: Rnp1 mutations and rrm domain replacements with ELAV family proteins and SXL.

  2000influential citation
• A General Approach for Identification of RNA-Protein Cross-linking Sites within Native Human Spliceosomal Small Nuclear Ribonucleoproteins (snRNPs)

  2000cites this paper
• The structure of the mRNA export factor TAP reveals a cis arrangement of a non‐canonical RNP domain and an LRR domain

  2000cites this paper
• Fourteen Residues of the U1 snRNP-Specific U1A Protein Are Required for Homodimerization, Cooperative RNA Binding, and Inhibition of Polyadenylation

  2000cites this paper
• Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles.

  1999cites this paper
• The Sm core domain mediates targeting of U1 snRNP to subnuclear compartments involved in transcription and splicing.

  1999cites this paper
• Chemical shift perturbation studies of the interactions of the second RNA-binding domain of the Drosophila sex-lethal protein with the transformer pre-mRNA polyuridine tract and 3' splice-site sequences.

  1999cites this paper
• Combined Biochemical and Electron Microscopic Analyses Reveal the Architecture of the Mammalian U2 snRNP

  1999influential citation
• RNA recognition by the human U1A protein is mediated by a network of local cooperative interactions that create the optimal binding surface.

  1999cites this paper
• RNA Structure and RNA-Protein Recognition During Regulation of Eukaryotic Gene Expression

  1999cites this paper
• The RNA-binding protein gene, hermes, is expressed at high levels in the developing heart.

  1999cites this paper