SCIENCE@home

A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth

A. Gholipour,C. Rollins,C. Velasco-Annis,Abdelhakim Ouaalam,A. Akhondi-Asl,O. Afacan,C. Ortinau,Sean Clancy,C. Limperopoulos,E. Yang,J. Estroff,S. Warfield

Published 2017 in Scientific Reports

ABSTRACT

Longitudinal characterization of early brain growth in-utero has been limited by a number of challenges in fetal imaging, the rapid change in size, shape and volume of the developing brain, and the consequent lack of suitable algorithms for fetal brain image analysis. There is a need for an improved digital brain atlas of the spatiotemporal maturation of the fetal brain extending over the key developmental periods. We have developed an algorithm for construction of an unbiased four-dimensional atlas of the developing fetal brain by integrating symmetric diffeomorphic deformable registration in space with kernel regression in age. We applied this new algorithm to construct a spatiotemporal atlas from MRI of 81 normal fetuses scanned between 19 and 39 weeks of gestation and labeled the structures of the developing brain. We evaluated the use of this atlas and additional individual fetal brain MRI atlases for completely automatic multi-atlas segmentation of fetal brain MRI. The atlas is available online as a reference for anatomy and for registration and segmentation, to aid in connectivity analysis, and for groupwise and longitudinal analysis of early brain growth.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-85 of 85 references · Page 1 of 1

CITED BY

Showing 1-100 of 322 citing papers · Page 1 of 4

1234
Next