The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  DNA Repair

• Publication date

  2002-06-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1568-7864(02)00031-9PMID 12509233
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro.

  2001cited by this paper
• A multistep damage recognition mechanism for global genomic nucleotide excision repair.

  2001cited by this paper
• Centrosome Protein Centrin 2/Caltractin 1 Is Part of the Xeroderma Pigmentosum Group C Complex That Initiates Global Genome Nucleotide Excision Repair*

  2001cited by this paper
• Strong Functional Interactions of TFIIH with XPC and XPG in Human DNA Nucleotide Excision Repair, without a Preassembled Repairosome

  2001cited by this paper
• Reconstitution of damage DNA excision reaction from SV40 minichromosomes with purified nucleotide excision repair proteins.

  2000cited by this paper
• The xeroderma pigmentosum group C gene leads to selective repair of cyclobutane pyrimidine dimers rather than 6-4 photoproducts.

  2000cited by this paper
• Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.

  2000cited by this paper
• The Xeroderma Pigmentosum Group C Protein Complex XPC-HR23B Plays an Important Role in the Recruitment of Transcription Factor IIH to Damaged DNA*

  2000cited by this paper
• Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.

  2000cited by this paper
• The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

  1999cited by this paper
• Stopping DNA Replication in Its Tracks

  1999cited by this paper
• hRAD30 mutations in the variant form of xeroderma pigmentosum.

  1999cited by this paper
• Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia.

  1998cited by this paper
• Assembly, subunit composition, and footprint of human DNA repair excision nuclease.

  1998cited by this paper
• Interactions of the transcription/DNA repair factor TFIIH and XP repair proteins with DNA lesions in a cell-free repair assay.

  1998cited by this paper
• Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.

  1998cited by this paper
• DNA Damage Recognition by XPA Protein Promotes Efficient Recruitment of Transcription Factor II H*

  1997cited by this paper
• Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein

  1997cited by this paper
• The Non-catalytic Function of XPG Protein during Dual Incision in Human Nucleotide Excision Repair*

  1997cited by this paper
• Nucleotide Excision Repair in Mammalian Cells*

  1997cited by this paper
• Characterization of Reaction Intermediates of Human Excision Repair Nuclease*

  1997cited by this paper
• Mechanism of open complex and dual incision formation by human nucleotide excision repair factors

  1997cited by this paper
• XPC interacts with both HHR23B and HHR23A in vivo.

  1997cited by this paper
• Identification and characterization of XPC-binding domain of hHR23B

  1997cited by this paper
• An Affinity of Human Replication Protein A for Ultraviolet-damaged DNA

  1996cited by this paper
• Overproduction, Purification, and Characterization of the XPC Subunit of the Human DNA Repair Excision Nuclease*

  1996cited by this paper
• HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro

  1996cited by this paper
• DNA Repair Protein XPA Binds Replication Protein A (RPA) (*)

  1995cited by this paper
• RPA involvement in the damage-recognition and incision steps of nucleotide excision repair

  1995cited by this paper
• Reconstitution of Human DNA Repair Excision Nuclease in a Highly Defined System (*)

  1995cited by this paper
• Mammalian DNA nucleotide excision repair reconstituted with purified protein components.

  1995cited by this paper
• Nucleotide excision repair and the link with transcription.

  1995cited by this paper
• Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

  1994cited by this paper
• DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells.

  1994cited by this paper
• Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II

  1994cited by this paper
• The XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA damage.

  1994cited by this paper
• Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts. I. Development of a cell-free system detecting excision repair of UV-irradiated SV40 chromosomes.

  1993cited by this paper
• Characterization of molecular defects in xeroderma pigmentosum group C

  1993cited by this paper
• Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C

  1992cited by this paper
• Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C

  1992cited by this paper
• Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes

  1991cited by this paper
• The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA.

  1990cited by this paper
• Cloning and nucleotide sequence analysis of the Saccharomyces cerevisiae RAD4 gene required for excision repair of UV-damaged DNA.

  1988cited by this paper
• Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts.

  1988cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1987cited by this paper
• A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.

  1987cited by this paper
• Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene.

  1987cited by this paper
• DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall.

  1985cited by this paper
• Rapid and efficient site-specific mutagenesis without phenotypic selection.

  1985cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Protein-protein interactions in the core nucleotide excision repair pathway.

  2024cites this paper
• A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases

  2023cites this paper
• The role of Transcription Factor IIH complex in nucleotide excision repair

  2023cites this paper
• Structural modeling and analyses of genetic variations in the human XPC nucleotide excision repair protein

  2023cites this paper
• ASH1L-MRG15 methyltransferase deposits H3K4me3 and FACT for damage verification in nucleotide excision repair

  2023cites this paper
• Mechanism of action of nucleotide excision repair machinery.

  2022cites this paper
• “Flexible hinge” dynamics in mismatched DNA revealed by fluorescence correlation spectroscopy

  2022cites this paper
• Structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in Nucleotide Excision Repair

  2021cites this paper
• Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair

  2021cites this paper
• Tethering-facilitated DNA ‘opening’ and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

  2020cites this paper
• Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex

  2019cites this paper
• TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.

  2019cites this paper
• Mechanism and regulation of DNA damage recognition in mammalian nucleotide excision repair.

  2019cites this paper
• Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair.

  2018cites this paper
• Structural dynamics and interactions of Xeroderma pigmentosum complementation group A (XPA98–210) with damaged DNA

  2018cites this paper
• Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates

  2017cites this paper
• Lesion Recognition by XPC (Rad4) Protein

  2017cites this paper
• The role of RAD4/XPC and RAD7 homologues in Arabidopsis UV tolerance

  2017cites this paper
• RAD4 and RAD23/HMR Contribute to Arabidopsis UV Tolerance

  2017cites this paper
• Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide excision repair complex

  2017cites this paper
• SINGLE-MOLECULE STUDIES OF RAD4-RAD23 REVEAL A DYNAMIC DNA DAMAGE RECOGNITION PROCESS

  2017cites this paper
• Chromatin remodeler CHD1 promotes XPC‐to‐TFIIH handover of nucleosomal UV lesions in nucleotide excision repair

  2017cites this paper
• Global-genome Nucleotide Excision Repair Controlled by Ubiquitin/Sumo Modifiers

  2016cites this paper
• Diagnosis of Xeroderma Pigmentosum Groups A and C by Detection of Two Prevalent Mutations in West Algerian Population: A Rapid Genotyping Tool for the Frequent XPC Mutation c.1643_1644delTG

  2016cites this paper
• DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repair

  2016cites this paper
• XPA: A key scaffold for human nucleotide excision repair.

  2016cites this paper
• The Relationship of XPC Poly AT Sequence with Breast Cancer

  2016cites this paper
• بررسی پیوستگی پیاپی بودن پلی AT ژن XPC در بیماران دچار بدخیمی پستان

  2016cites this paper
• Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells

  2015cites this paper
• Xeroderma pigmentosum group C sensor: unprecedented recognition strategy and tight spatiotemporal regulation

  2015cites this paper
• Architecture of the human XPC DNA repair and stem cell coactivator complex

  2015cites this paper
• The C‐terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 in mouse embryonic stem cells

  2014cites this paper
• Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin

  2014cites this paper
• Cockayne Syndrome: Varied Requirement of Transcription-Coupled Nucleotide Excision Repair for the Removal of Three Structurally Different Adducts from Transcribed DNA

  2014cites this paper
• JCB_201403096 1..10

  2014cites this paper
• Etude du complexe de réparation par excision de nucléotides

  2014cites this paper
• Co-expression of antioxidant enzymes with expression of p53, DNA repair, and heat shock protein genes in the gamma ray-irradiated hermaphroditic fish Kryptolebias marmoratus larvae.

  2013cites this paper
• University of Groningen Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex Bergink,

  2013cites this paper
• Single molecule studies of damaged recognition by the human UV-damaged DNA-binding protein (UV-DDB)

  2013cites this paper
• Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER

  2013influential citation
• Molecular and Cellular Pathobiology Nucleotide Excision Repair Factor XPC Enhances DNA Damage – Induced Apoptosis by Downregulating the Antiapoptotic Short Isoform of Caspase-2

  2012cites this paper
• Recognition of DNA damage by XPC coincides with disruption of the XPC–RAD23 complex

  2012cites this paper
• V A novel, functionally distinct, bipartite Rad4-Rad23 interaction in Nucleotide Excision Repair

  2012cites this paper
• IV Phenotypic analysis of a rad4 mutant carrying a homologous change that in XPC leads to the XP disorder

  2012cites this paper
• Regulation of Nucleotide Excision Repair by UV-DDB: Prioritization of Damage Recognition to Internucleosomal DNA

  2011cites this paper
• The Role of Chosen Polymorphisms in Genes Coding Xenobiotic Metabolizing Enzymes and DNA Repair Proteins in Laryngeal Cancers Znaczenie wybranych polimorfizmów w genach kodujących enzymy metabolizujące ksenobiotyki i białka naprawy DNA w raku krtani

  2011cites this paper
• Dissection of the Xeroderma Pigmentosum Group C Protein Function by Site-Directed Mutagenesis

  2011cites this paper
• Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells.

  2011cites this paper
• A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.

  2011influential citation
• Nucleotide Excision repair pathway modulating both cancer risk and therapy

  2010cites this paper
• Dynamic two-stage mechanism of versatile DNA damage recognition by xeroderma pigmentosum group C protein.

  2010cites this paper
• Recognition and Removal of Bulky DNA Lesions by the Nucleotide Excision Repair System

  2010cites this paper
• Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes.

  2009cites this paper
• Molecular Analysis of the Function of Xeroderma Pigmentosum Group A Protein by Site-directed Mutagenesis

  2009cites this paper
• The sequence dependence of human nucleotide excision repair efficiencies of benzo[a]pyrene-derived DNA lesions: insights into the structural factors that favor dual incisions.

  2009cites this paper
• The Role of p53 and Hypoxia in Nucleotide Excision Repair

  2009cites this paper
• Gene Expression Patterns in Colon Crypts and those that Define Colon Cell Maturation

  2009cites this paper
• Cells from long-lived mutant mice exhibit enhanced repair of UV lesions

  2009cites this paper
• Two‐stage dynamic DNA quality check by xeroderma pigmentosum group C protein

  2009cites this paper
• Versatile protection from mutagenic DNA lesions conferred by bipartite recognition in nucleotide excision repair.

  2008cites this paper
• Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology

  2008cites this paper
• Dissection of the Molecular Defects Caused by Pathogenic Mutations in the DNA Repair Factor XPC

  2008cites this paper
• The nucleotide excision repair of DNA in human cells and its association with xeroderma pigmentosum.

  2008cites this paper
• XPC: its product and biological roles.

  2008cites this paper
• The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4.

  2008cites this paper
• The carboxy-terminal domain of xeroderma pigmentosum complementation group C protein, involved in TFIIH and centrin binding, is highly disordered.

  2008cites this paper
• The NER protein Rad 33 shows functional homology to human Centrin 2 and is involved in modification of Rad 4

  2008cites this paper
• Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.

  2008cites this paper
• New factors in nucleotide excision repair : a study in saccharomyces cerevisiae

  2008influential citation
• Chapter 4 The Rad 4 homologue YDR 314 C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae

  2008cites this paper
• Chapter 4 . 1 Supplement : Further analysis of the two Rad 4 homologues in Saccharomyces cerevisiae 91

  2008influential citation
• Biochemical and Structural Domain-Analysis of XPC †

  2008influential citation
• Coin and Jean Marc Egly Factor Xpc by Pathogenic Mutations in the Dna Repair Dissection of the Molecular Defects Caused Supplemental Material

  2008cites this paper
• Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase

  2007cites this paper
• Single Nucleotide Polymorphism Analysis of the Nucleotide Excision Repair Genes XPC, XPA, and XPG in the Indian Population

  2007cites this paper
• In Vivo Destabilization and Functional Defects of the Xeroderma Pigmentosum C Protein Caused by a Pathogenic Missense Mutation

  2007cites this paper
• Nucleotide Excision Repair in Yeast

  2007cites this paper
• An Aromatic Sensor with Aversion to Damaged Strands Confers Versatility to DNA Repair

  2007influential citation
• Structural, thermodynamic, and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein.

  2007cites this paper
• Xeroderma pigmentosum C is involved in Epstein Barr virus DNA replication.

  2007cites this paper
• Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin‐induced chromosomal aberrations

  2007cites this paper
• Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair

  2007cites this paper
• The Regulation of Cellular Stress Resistance and DNA Repair in a Long-Lived Mutant Mouse.

  2007cites this paper
• Structure of the Mouse Peptide N-Glycanase-HR23 Complex Suggests Co-evolution of the Endoplasmic Reticulum-associated Degradation and DNA Repair Pathways*

  2006cites this paper
• The Involvement of Ataxia-telangiectasia Mutated Protein Activation in Nucleotide Excision Repair-facilitated Cell Survival with Cisplatin Treatment*

  2006cites this paper
• Molecular mechanisms of mammalian global genome nucleotide excision repair.

  2006cites this paper
• Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.

  2006cites this paper
• Genome wide analysis of dna repair by expression profiling

  2006cites this paper
• Interplay of the Ubiquitin Proteasome System with Nucleotide Excision Repair

  2006cites this paper
• Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein.

  2006cites this paper
• The protein shuffle

  2006cites this paper
• CENTRIN2 Interacts with the Arabidopsis Homolog of the Human XPC Protein (AtRAD4) and Contributes to Efficient Synthesis-dependent Repair of Bulky DNA Lesions

  2006cites this paper
• Analysis of germline mutation rates in DNA-repair deficient mice.

  2005cites this paper
• The involvement of XPC protein in the cisplatin DNA damaging treatment-mediated cellular responses

  2005cites this paper
• Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells

  2005cites this paper
• The Rad4 homologue YDR314C is essential for strand‐specific repair of RNA polymerase I‐transcribed rDNA in Saccharomyces cerevisiae

  2005cites this paper
• Centrin 2 Stimulates Nucleotide Excision Repair by Interacting with Xeroderma Pigmentosum Group C Protein

  2005cites this paper
• Nucleotide excision repair.

  2005cites this paper
• Mechanisms of DNA damage recognition and strand discrimination in human nucleotide excision repair.

  2004cites this paper
• CPD-photolyase adenovirus-mediated gene transfer in normal and DNA-repair-deficient human cells

  2004cites this paper