Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Nature

• Publication date

  2003-03-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nature01456PMID 12646924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of a Multifunctional Binding Site on Ubc9p Required for Smt3p Conjugation*

  2002cited by this paper
• Cytoskeletal Regulation by the Nedd8 Ubiquitin-Like Protein Modification Pathway

  2002cited by this paper
• Mechanisms underlying ubiquitination.

  2001cited by this paper
• Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB–MoaD complex

  2001cited by this paper
• Distinct Functional Surface Regions on Ubiquitin*

  2001cited by this paper
• All in the Ubiquitin Family

  2000cited by this paper
• Ubiquitin and its kin: how close are the family ties?

  2000cited by this paper
• Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

  1999cited by this paper
• Automated MAD and MIR structure solution

  1999cited by this paper
• A new NEDD8-ligating system for cullin-4A.

  1998cited by this paper
• Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex.

  1998cited by this paper
• A novel protein modification pathway related to the ubiquitin system

  1998cited by this paper
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  1998cited by this paper
• The ubiquitin-related protein RUB1 and auxin response in Arabidopsis.

  1998cited by this paper
• Crystal Structure of the Human Ubiquitin-like Protein NEDD8 and Interactions with Ubiquitin Pathway Enzymes*

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• [27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

  1997cited by this paper
• The ubiquitin‐like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.

  1996cited by this paper
• Site-directed mutagenesis of ubiquitin. Differential roles for arginine in the interaction with ubiquitin-activating enzyme.

  1994cited by this paper
• Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1).

  1994cited by this paper
• The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53.

  1993cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Cloning of ubiquitin activating enzyme from wheat and expression of a functional protein in Escherichia coli.

  1990cited by this paper
• Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation.

  1988cited by this paper
• Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.

  1984cited by this paper
• Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

  1983cited by this paper
• The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis.

  1982cited by this paper
• Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.

  1982cited by this paper

• Decoding neddylation in malignancies: molecular mechanisms, biological functions, therapeutic resistance, and clinical potential

  2026cites this paper
• SUMOylation and anticancer drug resistance.

  2026cites this paper
• Cryo-EM structures of UBA6 reveal mechanisms of E1-E2 specificity and dual FAT10/ubiquitin thioester transfer.

  2026cites this paper
• E2 conjugating enzymes: A silent but crucial player in Ubiquitin Biology.

  2025cites this paper
• UBA protein family: An emerging set of E1 ubiquitin ligases in cancer-A review.

  2025cites this paper
• Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer

  2025cites this paper
• VOPP1, a Determinant of the Sensitivity of Non-Small Cell Lung Cancer Cells to NAE Inhibitors.

  2025cites this paper
• UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6.

  2025cites this paper
• Mechanism of degrader-targeted protein ubiquitinability

  2024cites this paper
• E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration

  2024cites this paper
• Biochemical and Structural Consequences of NEDD8 Acetylation

  2024cites this paper
• The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and Therapy

  2024cites this paper
• A Novel Confocal Scanning Protein–Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin

  2024cites this paper
• Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer

  2023cites this paper
• Targeting cullin neddylation for cancer and fibrotic diseases

  2023cites this paper
• Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation.

  2023cites this paper
• Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions

  2023influential citation
• A guide to UFMylation, an emerging posttranslational modification

  2023cites this paper
• Atg7 senses ATP levels and regulates AKT1-PDCD4 phosphorylation-ubiquitination axis to promote survival during metabolic stress

  2023cites this paper
• The Ubiquitin-like Proteins of Saccharomyces cerevisiae

  2023cites this paper
• SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy

  2022cites this paper
• Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway

  2022cites this paper
• NAE modulators: A potential therapy for gastric carcinoma.

  2022cites this paper
• Differential dynamics of cullin deneddylation via COP9 signalosome subunit 5 interaction.

  2022cites this paper
• Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles

  2022influential citation
• The Role of RAD6B and PEDF in Retinal Degeneration.

  2021cites this paper
• How Is the Fidelity of Proteins Ensured in Terms of Both Quality and Quantity at the Endoplasmic Reticulum? Mechanistic Insights into E3 Ubiquitin Ligases

  2021cites this paper
• SUMO conjugating enzyme: a vital player of SUMO pathway in plants

  2021cites this paper
• E1 Enzymes as Therapeutic Targets in Cancer

  2021cites this paper
• Targeting neddylation E2s: a novel therapeutic strategy in cancer

  2021cites this paper
• Direct Conjugation of NEDD8 to the N-Terminus of a Model Protein Can Induce Degradation

  2021cites this paper
• Assembly and Regulation of CRL Ubiquitin Ligases.

  2020cites this paper
• The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress

  2020cites this paper
• Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier

  2020cites this paper
• Structural and Functional Characterisation of the Domains of Ubiquitin-Activating Enzyme (E1) of Saccharomyces cerevisiae

  2020cites this paper
• Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Nav1.5.

  2020cites this paper
• Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control

  2020cites this paper
• Neddylation of M1 negatively regulates the replication of influenza A virus.

  2020cites this paper
• Structural basis for adenylation and thioester bond formation in the ubiquitin E1

  2019cites this paper
• ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

  2019cites this paper
• UFM1-Activating Enzyme 5 (Uba5) Requires an Extension to Get the Job Done Right.

  2019cites this paper
• The function and regulation of OTU deubiquitinases

  2019cites this paper
• Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme.

  2019cites this paper
• Structural insights into SUMO E1-E2 interactions in Arabidopsis uncovers a distinctive platform for securing SUMO conjugation specificity across evolution.

  2019cites this paper
• Anticancer drug discovery by targeting cullin neddylation

  2019cites this paper
• New Insights into the Mechanisms Underlying NEDD8 Structural and Functional Specificities

  2019cites this paper
• RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration

  2019cites this paper
• Molecular mechanisms in SUMO conjugation.

  2019cites this paper
• Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

  2019cites this paper
• Control of SUMO and Ubiquitin by ROS: Signaling and disease implications.

  2018cites this paper
• Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments.

  2018cites this paper
• Genome-wide analysis of genes encoding core components of the ubiquitin system in soybean (Glycine max) reveals a potential role for ubiquitination in host immunity against soybean cyst nematode

  2018influential citation
• Crystal structure of SUMO E1 in complex with an allosteric inhibitor

  2018cites this paper
• Resistance Mechanisms to Novel Therapies in Myeloma

  2018cites this paper
• Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways

  2018cites this paper
• Neddylation, a novel paradigm in liver cancer.

  2018cites this paper
• Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

  2018cites this paper
• Explorer Post-translational modification by SUMO

  2018cites this paper
• Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism

  2017cites this paper
• Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions

  2017cites this paper
• Investigating Protein Complex Dynamics: Analysis of Cullin-Ring Ligase Machinery through Development of Quantitative Cross-linking Mass Spectrometry Strategies

  2017cites this paper
• Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1.

  2017cites this paper
• Targeting Protein Synthesis, Folding, and Degradation Pathways in Cancer

  2017cites this paper
• DENEDDYLASE1 Protein Counters Automodification of Neddylating Enzymes to Maintain NEDD8 Protein Homeostasis in Arabidopsis*

  2017influential citation
• Domain alternation and active site remodeling are conserved structural features of ubiquitin E1

  2017cites this paper
• Characterization of the mammalian family of DCN-type NEDD8 E3 ligases

  2016cites this paper
• Specificity and disease in the ubiquitin system

  2016cites this paper
• Role of ubiquitin-modifying enzymes in regulating the endothelial response to VEGF-A

  2016cites this paper
• Targeted inhibition of the COP9 signalosome for treatment of cancer

  2016cites this paper
• Chapter Eight - Ubiquitin-Mediated Regulation of Cellular Responses to Vascular Endothelial Growth Factors.

  2016cites this paper
• Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis.

  2016cites this paper
• A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades.

  2015cites this paper
• Differential domain architecture directs Nedd4 family E3 ligase function.

  2015cites this paper
• Caracterización molecular y funcional de Small-Ubiquitin-related MOdifier en Arabidopsis thaliana

  2015cites this paper
• Regulation of cancer-related pathways by protein NEDDylation and strategies for the use of NEDD8 inhibitors in the clinic.

  2015cites this paper
• Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems*

  2015cites this paper
• Protein neddylation: beyond cullin–RING ligases

  2014cites this paper
• Cycle on Wheels: Is APP Key to the AppBp1 Pathway?

  2014cites this paper
• Conjugation Pathway Mechanistic Study of Uba 5 Enzyme and the Enzymology :

  2014cites this paper
• Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway

  2014cites this paper
• Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast.

  2014cites this paper
• Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying β-catenin degradation.

  2014cites this paper
• Construction of a mouse Aos1-Uba2 chimeric SUMO-E1 enzyme, mAU, and its expression in baculovirus-insect cells

  2014cites this paper
• Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation

  2014cites this paper
• Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.

  2014cites this paper
• Expression, purification, and crystal structure of N-terminal domains of human ubiquitin-activating enzyme (E1)

  2014influential citation
• Mutations in UBA 3 Confer Resistance to the NEDD 8-Activating Enzyme Inhibitor MLN 4924 in Human Leukemic Cells

  2014cites this paper
• Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.

  2014cites this paper
• - Catenin Degradation β of Hepatocellular Carcinoma by Modifying Ubiquitin-like Protein FAT 10 Promotes the Invasion and Metastasis

  2014cites this paper
• Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells

  2013cites this paper
• Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.

  2013cites this paper
• Macromolecular juggling by ubiquitylation enzymes

  2013cites this paper
• Profiling the Cross Reactivity of Ubiquitin with the Nedd8 Activating Enzyme by Phage Display

  2013cites this paper
• Native protein complexes in the cytoplasm of red blood cells.

  2013cites this paper
• Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes.

  2013cites this paper
• Mechanism of ubiquitin transfer by RING E3 ligases

  2013cites this paper
• Insights into NEDD8 function and the regulation of its conjugation system

  2013cites this paper
• Université de Montréal-Thèse numérique

  2013cites this paper
• The roles and regulation of ubiquitin/ubiquitin-like protein conjugation pathways in responses to oxidative stress in Schizosaccharomyces pombe

  2013cites this paper
• Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells

  2012cites this paper