Neuromechanical principles underlying movement modularity and their implications for rehabilitation.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Neuron

• Publication date

  2015-04-08

• Fields of study

  Medicine, Engineering, Psychology

• Identifiers
  DOI 10.1016/j.neuron.2015.02.042PMID 25856485PMCID PMC4392340
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Are Movement Disorders and Sensorimotor Injuries Pathologic Synergies? When Normal Multi-Joint Movement Synergies Become Pathologic

  2015cited by this paper
• Motor neuronal activity varies least among individuals when it matters most for behavior.

  2015cited by this paper
• Can modular strategies simplify neural control of multidirectional human locomotion?

  2014influential reference
• Temporal structure of motor variability is dynamically regulated and predicts motor learning ability

  2014cited by this paper
• A framework for using signal, noise, and variation to determine whether the brain controls movement synergies or single muscles.

  2014cited by this paper
• Modular organization across changing task demands in healthy and poststroke gait

  2014cited by this paper
• Motor variability is not noise, but grist for the learning mill

  2014cited by this paper
• Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury.

  2014cited by this paper
• Task constraints and minimization of muscle effort result in a small number of muscle synergies during gait

  2014cited by this paper
• The singer and the song: the neuromechanics of avian sound production.

  2014cited by this paper
• Targeting paretic propulsion to improve poststroke walking function: a preliminary study.

  2014cited by this paper
• Do Improvements in Balance Relate to Improvements in Long-Distance Walking Function after Stroke?

  2014cited by this paper
• Neuromuscular constraints on muscle coordination during overground walking in persons with chronic incomplete spinal cord injury.

  2014influential reference
• Freezing of gait subtypes have different cognitive correlates in Parkinson's disease.

  2014cited by this paper
• Cortical Activation Associated with Muscle Synergies of the Human Male Pelvic Floor

  2014cited by this paper
• Neuromuscular Complexity During Gait is not Responsive to Medication in Persons with Parkinson’s Disease

  2014cited by this paper
• Muscle synergies may improve optimization prediction of knee contact forces during walking.

  2014cited by this paper
• Useful properties of spinal circuits for learning and performing planar reaches

  2014cited by this paper
• Modular control of varied locomotor tasks in children with incomplete spinal cord injuries.

  2013cited by this paper
• Sensorimotor feedback based on task-relevant error robustly predicts temporal recruitment and multidirectional tuning of muscle synergies.

  2013cited by this paper
• Common muscle synergies for balance and walking

  2013influential reference
• Persons with Parkinson's disease exhibit decreased neuromuscular complexity during gait.

  2013cited by this paper
• Spinal vascular endothelial growth factor (VEGF) and erythropoietin (EPO) induced phrenic motor facilitation after repetitive acute intermittent hypoxia.

  2013cited by this paper
• Flexibility of movement organization in piano performance

  2013cited by this paper
• Practical limits on muscle synergy identification by non-negative matrix factorization in systems with mechanical constraints

  2013cited by this paper
• The neural origin of muscle synergies

  2013cited by this paper
• The influence of locomotor rehabilitation on module quality and post-stroke hemiparetic walking performance.

  2013cited by this paper
• Changes in the activation and function of the ankle plantar flexor muscles due to gait retraining in chronic stroke survivors

  2013cited by this paper
• Executive dysfunction in Parkinson's disease: a review.

  2013cited by this paper
• Differences in Adaptation Rates after Virtual Surgeries Provide Direct Evidence for Modularity

  2013cited by this paper
• Daily intermittent hypoxia enhances walking after chronic spinal cord injury

  2013influential reference
• The Effects of Adapted Tango on Spatial Cognition and Disease Severity in Parkinson's Disease

  2013cited by this paper
• Neurophysiology of gait: From the spinal cord to the frontal lobe

  2013influential reference
• The influence of merged muscle excitation modules on post-stroke hemiparetic walking performance.

  2013influential reference
• Motor primitives and synergies in the spinal cord and after injury—the current state of play

  2013cited by this paper
• A two‐year randomized controlled trial of progressive resistance exercise for Parkinson's disease

  2013cited by this paper
• Synergistic effects of BDNF and rehabilitative training on recovery after cervical spinal cord injury.

  2013cited by this paper
• Time Course of Functional and Biomechanical Improvements During a Gait Training Intervention in Persons With Chronic Stroke

  2013influential reference
• The number and choice of muscles impact the results of muscle synergy analyses

  2013influential reference
• Modularizing speech

  2013cited by this paper
• Absence of postural muscle synergies for balance after spinal cord transection.

  2013influential reference
• Review and perspective: neuromechanical considerations for predicting muscle activation patterns for movement

  2012cited by this paper
• Challenges and New Approaches to Proving the Existence of Muscle Synergies of Neural Origin

  2012influential reference
• Getting Neurorehabilitation Right

  2012cited by this paper
• The bliss (not the problem) of motor abundance (not redundancy)

  2012cited by this paper
• Optimization of Muscle Activity for Task-Level Goals Predicts Complex Changes in Limb Forces across Biomechanical Contexts

  2012influential reference
• Optimal isn’t good enough

  2012cited by this paper
• Normal and pathological gait: what we learn from Parkinson's disease

  2012cited by this paper
• Modular organization of balance control following perturbations during walking.

  2012cited by this paper
• Task-level feedback can explain temporal recruitment of spatially fixed muscle synergies throughout postural perturbations.

  2012cited by this paper
• The evolutionary origins of modularity

  2012cited by this paper
• Repetitive Intermittent Hypoxia Induces Respiratory and Somatic Motor Recovery after Chronic Cervical Spinal Injury

  2012cited by this paper
• Voluntary and Reactive Recruitment of Locomotor Muscle Synergies during Perturbed Walking

  2012cited by this paper
• Muscle Coordination Is Habitual Rather than Optimal

  2012cited by this paper
• Microstimulation activates a handful of muscle synergies.

  2012cited by this paper
• Muscle synergy patterns as physiological markers of motor cortical damage

  2012cited by this paper
• Randomized Controlled Trial of Community-Based Dancing to Modify Disease Progression in Parkinson Disease

  2012cited by this paper
• Three-dimensional modular control of human walking.

  2012cited by this paper
• Tai chi and postural stability in patients with Parkinson's disease.

  2012cited by this paper
• Shaping reversibility? Long-term deep brain stimulation in dystonia: the relationship between effects on electrophysiology and clinical symptoms.

  2011cited by this paper
• Common muscle synergies for control of center of mass and force in nonstepping and stepping postural behaviors.

  2011influential reference
• It Is Not About the Bike, It Is About the Pedaling: Forced Exercise and Parkinson's Disease

  2011cited by this paper
• Influence of a Locomotor Training Approach on Walking Speed and Distance in People With Chronic Spinal Cord Injury: A Randomized Clinical Trial

  2011cited by this paper
• Spikes alone do not behavior make: why neuroscience needs biomechanics.

  2011cited by this paper
• Exposure to Acute Intermittent Hypoxia Augments Somatic Motor Function in Humans With Incomplete Spinal Cord Injury

  2011cited by this paper
• Superposition and modulation of muscle synergies for reaching in response to a change in target location.

  2011cited by this paper
• White matter lesions in Parkinson disease

  2011cited by this paper
• Locomotor Primitives in Newborn Babies and Their Development

  2011cited by this paper
• Combined effects of fast treadmill walking and functional electrical stimulation on post-stroke gait.

  2011cited by this paper
• Sensitivity to Change and Responsiveness of Four Balance Measures for Community-Dwelling Older Adults

  2011cited by this paper
• Coping with variability in small neuronal networks.

  2011cited by this paper
• Modules in the brain stem and spinal cord underlying motor behaviors.

  2011influential reference
• Muscle Synergies: Implications for Clinical Evaluation and Rehabilitation of Movement.

  2011influential reference
• Stability in a frontal plane model of balance requires coupled changes to postural configuration and neural feedback control.

  2011cited by this paper
• Distinct fast and slow processes contribute to the selection of preferred step frequency during human walking.

  2011cited by this paper
• Rehabilitation of gait after stroke: a review towards a top-down approach

  2011cited by this paper
• A simple experimentally based model using proprioceptive regulation of motor primitives captures adjusted trajectory formation in spinal frogs.

  2010cited by this paper
• Relationship between mild cognitive impairment and falls in older people with and without Parkinson's disease: 1-Year Prospective Cohort Study.

  2010cited by this paper
• Convergence of Pyramidal and Medial Brain Stem Descending Pathways Onto Macaque Cervical Spinal Interneurons

  2010cited by this paper
• The relevance of clinical balance assessment tools to differentiate balance deficits.

  2010influential reference
• Unilateral pedunculopontine stimulation improves falls in Parkinson's disease.

  2010cited by this paper
• Spinal plasticity following intermittent hypoxia: implications for spinal injury

  2010cited by this paper
• Decomposing Muscle Activity in Motor TasksMethods and Interpretation

  2010influential reference
• Leg extension is an important predictor of paretic leg propulsion in hemiparetic walking.

  2010cited by this paper
• Rehabilitation of locomotion after spinal cord injury

  2010cited by this paper
• Effect of Balance Training on Postural Instability in Patients With Idiopathic Parkinson’s Disease

  2010cited by this paper
• Evaluation of Abnormal Synergy Patterns Poststroke: Relationship of the Fugl-Meyer Assessment to Hemiparetic Locomotion

  2010cited by this paper
• Subject-specific muscle synergies in human balance control are consistent across different biomechanical contexts.

  2010cited by this paper
• Effects of Dance on Gait and Balance in Parkinson’s Disease: A Comparison of Partnered and Nonpartnered Dance Movement

  2010cited by this paper
• Motor memory and local minimization of error and effort, not global optimization, determine motor behavior.

  2010cited by this paper
• Merging of healthy motor modules predicts reduced locomotor performance and muscle coordination complexity post-stroke.

  2010influential reference
• A Neural Basis for Motor Primitives in the Spinal Cord

  2010cited by this paper
• Enhancing neuroplasticity in the basal ganglia: The role of exercise in Parkinson's disease

  2010influential reference
• Simplified and effective motor control based on muscle synergies to exploit musculoskeletal dynamics

  2009influential reference
• Stability of muscle synergies for voluntary actions after cortical stroke in humans

  2009cited by this paper
• Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

  2009cited by this paper
• Structured variability of muscle activations supports the minimal intervention principle of motor control.

  2009influential reference
• Health-related quality of life and alternative forms of exercise in Parkinson disease.

  2009cited by this paper
• Direct and Indirect Connections with Upper Limb Motoneurons from the Primate Reticulospinal Tract

  2009cited by this paper

• Quantitative Assessment of Upper Limb Multi-Modal Feature Fusion Under Task-Oriented Movement

  2026cites this paper
• From Modules to Movement: Deconstructing the Modular Architecture of the Motor System

  2026cites this paper
• Neuromechanical gait signatures reveal holistic biomechanical responses to walking speed modulation in stroke survivors

  2026cites this paper
• Locomotion engages context-dependent motor strategies for head stabilization in primates

  2026cites this paper
• Comparative Analysis of Muscle Coordination Patterns During Squatting in Trained and Untrained Individuals.

  2026cites this paper
• Ground gradient affects stride-to-stride fluctuations and gait variability in overground walking

  2025cites this paper
• Neuromechanics of nonuse and compensation: implications for rehabilitation after stroke

  2025cites this paper
• Clinical usability and functional outcomes of a lightweight robotic orthosis (HKAFO) in chronic stroke patients with hemiplegic gait: a pilot study

  2025cites this paper
• Neuro-Modulation Analysis Based on Muscle Synergy Graph Neural Network in Human Locomotion

  2025cites this paper
• Inter-subject variability in muscle synergies during squatting movements.

  2025cites this paper
• Neuromechanical basis of region-specific differences and their implications for sport performance and injury prevention: a narrative review

  2025cites this paper
• Comparing muscle coordination patterns in yoga-focused exercises with those in standard stabilization exercises.

  2025cites this paper
• Foot placement control underlies stable locomotion across species

  2025cites this paper
• The effects of shoe structural features on agility and stability tasks during walking

  2025cites this paper
• Ground Compliance Improves Retention of Visual Feedback-Based Propulsion Training for Gait Rehabilitation

  2025cites this paper
• Post-stroke Stiff-Knee gait: are there different types or different severity levels?

  2025cites this paper
• Evaluation of the trunk modules in the symmetrical and three-dimensional asymmetrical trunk positions

  2025influential citation
• Gait transition mechanism from quadrupedal to bipedal locomotion in the Japanese macaque based on inverted pendulum

  2025cites this paper
• Functional Organization of the Spinal Locomotor Network Based on Analysis of Interneuronal Activity

  2025cites this paper
• Differences in Ankle Neuromuscular Control Between the Preferred Speed and Fixed Speeds During Walking

  2025cites this paper
• Muscle synergy analysis during badminton forehand overhead smash: integrating electromyography and musculoskeletal modeling

  2025cites this paper
• MIMIC-MJX: Neuromechanical Emulation of Animal Behavior

  2025cites this paper
• Next-Generation Neurotechnologies Inspired by Motor Primitive Model for Restoring Human Natural Movement

  2025cites this paper
• Does body weight support improve neural and biomechanical measures during treadmill gait in children with unilateral cerebral palsy?

  2025cites this paper
• Examining muscle synergy composition and segmental coordination during overground walking in individuals with a rotationplasty about the knee

  2025cites this paper
• The Effects of Adapted Tango on Dynamic Balance and Dual-Task Performance in Parkinson’s Disease

  2025cites this paper
• Shared muscle synergies between running and physical performance tests

  2025cites this paper
• Human–machine collaborative rehabilitation toward Industry 5.0: principles, technologies and challenges

  2025cites this paper
• Study on the motor development and biomechanical characteristics of children aged 3–5 years

  2025cites this paper
• Effective Oil and Dye Adsorption Using Green Synthesized Copper Oxide Nanoparticles Obtained from Combretum indicum Leaf Extract

  2025cites this paper
• A single low-dimensional neural component of spinal motor neuron activity explains force generation across repetitive isometric tasks

  2025cites this paper
• Analysis of Conjoint Response in Post-stroke Patients Using the Attention-coupled Weighting Method

  2025cites this paper
• New neural-inspired controller generalises modularity over lower limb tasks through internal models

  2025cites this paper
• Postural control of sway dynamics on an unstable surface reduces similarity in activation patterns of synergistic lower leg muscles

  2025cites this paper
• The Differential Effects of Fast Walking Speed on Muscle Coactivation in the Paretic and Non-Paretic Extremities Post-Stroke

  2025cites this paper
• Kinematic synergies in upper-limb drawing tasks: Effects of geometric complexity on fine motor control.

  2025cites this paper
• Identified neurons B4/B5 function as sensory neurons, motor neurons and interneurons in Aplysia.

  2025cites this paper
• EMG-guided human–machine interaction training develops new intermuscular coordination patterns in stroke: a pilot study

  2025cites this paper
• Mechanisms of Post-Stroke Stiff Knee Gait: A Narrative Review.

  2025cites this paper
• Mapping the complexity of motor variability: From individual space of variability to motor fingerprints

  2025cites this paper
• Enhancing Jump Performance Through Blood Flow Restriction Squat Exercise: A Muscle Synergy Analysis Using Wavelet Packet Transformation.

  2025cites this paper
• Age-related differences in the modulation of muscle coordination complexity for goal-directed lateral stepping.

  2025cites this paper
• Networks of intermuscular coordination distinguish male and female responses to exercise

  2025cites this paper
• A muscle synergy-based method to improve robot-assisted movements

  2025cites this paper
• Functional organization of the spinal locomotor network based on analysis of interneuronal activity

  2025cites this paper
• A comprehensive review on lower limb exoskeleton: from origin to future expectations

  2024cites this paper
• Lower-limb muscle synergies in musician’s dystonia: a case study of a drummer

  2024cites this paper
• The Volitional Control of Individual Motor Units Is Constrained within Low-Dimensional Neural Manifolds by Common Inputs

  2024cites this paper
• Global dynamical structures from infinitesimal data

  2024cites this paper
• The impact of ankle-foot orthotics on selective motor control during gait in children and adolescents with cerebral palsy.

  2024cites this paper
• Quantification of Upper-Limb Motor Function for Stroke Rehabilitation Through Manifold Similarity of Muscle Synergy

  2024cites this paper
• Prediction of Back Disability Using Clinical, Functional, and Biomechanical Variables in Adults with Chronic Nonspecific Low Back Pain

  2024cites this paper
• Robust fatigue markers obtained from muscle synergy analysis

  2024cites this paper
• Spatiotemporal modulation of a common set of muscle synergies during unpredictable and predictable gait perturbations in older adults

  2024cites this paper
• Ethnokinesiology: towards a neuromechanical understanding of cultural differences in movement

  2024influential citation
• "Data Is One Thing, But I Want To Know The Story Behind": Designing For Self-Tracking and Remote Patient Monitoring In The Context Of Multiple Sclerosis Care

  2024cites this paper
• Analysis of muscle synergies and muscle network in sling exercise rehabilitation technique

  2024cites this paper
• Muscle synergies for multidirectional isometric force generation during maintenance of upright standing posture

  2024cites this paper
• Changes in muscle coordination patterns during 400‐m sprint: Impact of fatigue and performance decline

  2024cites this paper
• Cerebellar control of targeted tongue movements

  2024cites this paper
• Learning to stand with sensorimotor delays generalizes across directions and from hand to leg effectors

  2024cites this paper
• Noninvasive spinal stimulation improves walking in chronic stroke survivors: a proof-of-concept case series

  2024cites this paper
• Kinematic and neuromuscular characterization of cognitive involvement in gait control in healthy young adults

  2024cites this paper
• Direction-Specific Changes in Trunk Muscle Synergies in Individuals With Extension-Related Low Back Pain

  2024cites this paper
• Motor modules are largely unaffected by pathological walking biomechanics: a simulation study

  2024cites this paper
• Diverse plantarflexor module characteristics influence immediate effects of plastic ankle-foot orthosis on gait performance in patients with stroke: A cross-sectional study.

  2024cites this paper
• Recent progress on smart lower prosthetic limbs: a comprehensive review on using EEG and fNIRS devices in rehabilitation

  2024influential citation
• Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies

  2024cites this paper
• NSF DARE—transforming modeling in neurorehabilitation: perspectives and opportunities from US funding agencies

  2024cites this paper
• Age-related modifications of muscle synergies during daily-living tasks: A scoping review.

  2024cites this paper
• Kinematic synergies show good consistency when extracted with a low-cost markerless device and a marker-based motion tracking system

  2024cites this paper
• A Propulsion Neuroprosthesis Improves Overground Walking in Community-Dwelling Individuals After Stroke

  2024cites this paper
• Extracting Muscle Synergies Using Constrained Non-Negative Matrix Factorization for Motion Intention in Rehabilitation Robotics

  2024cites this paper
• The Immediate Effect of a Single Treatment of Neuromuscular Electrical Stimulation with the StimaWELL 120MTRS System on Multifidus Stiffness in Patients with Chronic Low Back Pain

  2024cites this paper
• Kinematic coding: Measuring information in naturalistic behaviour.

  2024cites this paper
• Comparison of muscle synergies in walking and pedaling: the influence of rotation direction and speed

  2024cites this paper
• Constrained Tensor Decomposition Reveals Lever Arms Synergies in the Musculoskeletal System

  2024cites this paper
• The cognitive neuroscience and neurocognitive rehabilitation of dance

  2024cites this paper
• Motor styles in action: Developing a computational framework for operationalization of motor distances

  2024cites this paper
• Synergy quality assessment of muscle modules for determining learning performance using a realistic musculoskeletal model

  2024cites this paper
• Neuromechanical Circuits of the Spinal Motor Apparatus

  2024cites this paper
• Are cervical curvature and axioscapular muscle activity associated with disability in patients with chronic nonspecific neck pain? – a cross sectional exploratory study

  2024cites this paper
• Exoskeleton-Assisted Sit-to-Stand Training Improves Lower-Limb Function Through Modifications of Muscle Synergies in Subacute Stroke Survivors

  2023cites this paper
• Neuromechanical Justification of Lower-Limb Functional Tests for a Return to Running: A Muscle Coordination Analysis

  2023cites this paper
• Spatiotemporal modulation of a fixed set of muscle synergies during unpredictable and predictable gait perturbations in older adults

  2023cites this paper
• Unbiased estimation of the population-level motor module

  2023cites this paper
• Generalizability of muscle synergies in isometric force generation versus point-to-point reaching in the human upper extremity workspace

  2023cites this paper
• A longitudinal analysis of selective motor control during gait in individuals with cerebral palsy and the relation to gait deviations

  2023cites this paper
• Heavier Load Alters Upper Limb Muscle Synergy with Correlated fNIRS Responses in BA4 and BA6

  2023cites this paper
• Adaptability of the load sharing between the longissimus and components of the multifidus muscle during isometric trunk extension in healthy individuals

  2023cites this paper
• Muscle synergies in Parkinson’s disease before and after the deep brain stimulation of the bilateral subthalamic nucleus

  2023cites this paper
• Muscle synergies for evaluating upper limb in clinical applications: A systematic review

  2023cites this paper
• Context expectation influences the gait pattern biomechanics

  2023cites this paper
• Perturbing the muscle work loop paradigm to unravel the neuromechanics of unsteady locomotion.

  2023cites this paper
• Classification of gait phases based on a machine learning approach using muscle synergy

  2023cites this paper
• Variability of trunk muscle synergies underlying the multidirectional movements and stability trunk motor tasks in healthy individuals

  2023cites this paper
• Discovering individual-specific gait signatures from data-driven models of neuromechanical dynamics

  2023cites this paper
• Gradient descent decomposition of force-field motor primitives optogenetically elicited for motor mapping of the murine lumbosacral spinal cord

  2023cites this paper
• A graph-based approach to identify motor neuron synergies

  2023cites this paper
• Effect of aerobic exercises on patients with chronic mechanical low back pain: A randomized controlled clinical trial.

  2023cites this paper