MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Molecular Cancer Research

• Publication date

  2016-11-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-16-0247PMID 27899423PMCID PMC5290160
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Myc and mRNA capping☆

  2015cited by this paper
• CDK7-dependent transcriptional addiction in triple-negative breast cancer.

  2015cited by this paper
• THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.

  2015cited by this paper
• CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

  2014cited by this paper
• Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

  2014cited by this paper
• Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

  2014cited by this paper
• Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites

  2013cited by this paper
• Wnt/β-catenin signaling and disease.

  2012cited by this paper
• MYC on the path to cancer.

  2012cited by this paper
• Structural basis for molecular interactions involving MRG domains: implications in chromatin biology.

  2012cited by this paper
• Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

  2012influential reference
• c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.

  2012cited by this paper
• Transcriptional amplification in tumor cells with elevated c-Myc.

  2012cited by this paper
• RAM/Fam103a1 Is Required for mRNA Cap Methylation

  2011cited by this paper
• MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms.

  2010cited by this paper
• Enhanced mRNA cap methylation increases Cyclin D1 expression and promotes cell transformation

  2010influential reference
• Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors

  2009cited by this paper
• Reflecting on 25 years with MYC

  2008influential reference
• c-Myc Transforms Human Mammary Epithelial Cells through Repression of the Wnt Inhibitors DKK1 and SFRP1

  2007cited by this paper
• The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain Independently of Direct DNA Binding

  2007cited by this paper
• The c-Myc target gene network.

  2006cited by this paper
• Wnt signaling in disease and in development

  2005cited by this paper
• Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors.

  2005cited by this paper
• The role of c-myc in regulation of translation initiation

  2004cited by this paper
• The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

  2004cited by this paper
• The crystal structure of human CDK7 and its protein recognition properties.

  2004cited by this paper
• Wnt Proteins in Mammary Development and Cancer

  2004cited by this paper
• Recent highlights of RNA-polymerase-II-mediated transcription.

  2004cited by this paper
• Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.

  2002cited by this paper
• The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

  2002cited by this paper
• N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

  2001cited by this paper
• c-Myc regulates mammalian body size by controlling cell number but not cell size

  2001cited by this paper
• The transcriptional program of a human B cell line in response to Myc.

  2001cited by this paper
• The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

  2000cited by this paper
• Identification of c-myc responsive genes using rat cDNA microarray.

  2000cited by this paper
• Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo.

  2000cited by this paper
• Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34p.

  2000cited by this paper
• Control of cell growth by c-Myc in the absence of cell division.

  1999cited by this paper
• eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

  1999cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.

  1998cited by this paper
• Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme.

  1998cited by this paper
• 5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II.

  1997cited by this paper
• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

  1997cited by this paper
• Sequence-specific DNA binding by the c-Myc protein.

  1990cited by this paper
• 5′-Terminal structure and mRNA stability

  1977cited by this paper
• Modification of the 5' terminus of mRNA by an RNA (guanine-7-)-methyltransferase from HeLa cells.

  1976cited by this paper
• Capping of eucaryotic mRNAs.

  1976cited by this paper

• Untargeted Metabolomics Reveals Metabolic Reprogramming Linked to HCC Risk in Late Diagnosed Tyrosinemia Type 1

  2025cites this paper
• Development, validation, and updating of prognostic models for m7G-associated genes from TAMs in lower-grade gliomas

  2025cites this paper
• Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer

  2025cites this paper
• The diverse landscape of RNA modifications in cancer development and progression

  2024cites this paper
• eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production

  2024cites this paper
• M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

  2024cites this paper
• Proteome Profiling of Brain Vessels in a Mouse Model of Cerebrovascular Pathology

  2023cites this paper
• RNA modification: mechanisms and therapeutic targets

  2023cites this paper
• Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers

  2023cites this paper
• RNA modifications in cancer

  2023influential citation
• The effects of MYC on tumor immunity and immunotherapy

  2023cites this paper
• MYC: a complex problem.

  2022cites this paper
• Prognostic value of 12 m7G methylation-related miRNA markers and their correlation with immune infiltration in breast cancer

  2022cites this paper
• The emergent role of mitochondrial RNA modifications in metabolic alterations

  2022cites this paper
• Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn’s Disease Patients

  2022cites this paper
• MYC protein interactors in gene transcription and cancer

  2021cites this paper
• MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation

  2021cites this paper
• Single-cell analysis of colonic epithelium reveals unexpected shifts in cellular composition and molecular phenotype in treatment-naïve adult Crohn’s disease

  2021influential citation
• The Role of RNA Modifications and RNA-modifying Proteins in Cancer Therapy and Drug Resistance.

  2021cites this paper
• Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation

  2021cites this paper
• To cap it all off, again: dynamic capping and recapping of coding and non-coding RNAs to control transcript fate and biological activity

  2021cites this paper
• MYC Hyperactivates Wnt Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a–Dependent Repression of DKK3

  2021cites this paper
• Role of RNA modifications in cancer

  2020cites this paper
• Integrated requirement of non-specific and sequence-specific DNA binding in MYC-driven transcription

  2020cites this paper
• The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts

  2020cites this paper
• GPAA1 promotes progression of childhood acute lymphoblastic leukemia through regulating c-myc.

  2020cites this paper
• Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis

  2020cites this paper
• Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

  2019cites this paper
• WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating

  2019cites this paper
• Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells

  2019cites this paper
• Targeting CDK7 increases the stability of Snail to promote the dissemination of colorectal cancer

  2018cites this paper
• CDK7 activated beta‐catenin/TCF signaling in hepatocellular carcinoma

  2018cites this paper
• Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling

  2017cites this paper
• UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell‐Exosome Promoted Gastric Cancer Progression via Wnt/β‐Catenin Pathway

  2017cites this paper
• Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A

  2017cites this paper