Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature

• Publication date

  2014-07-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature13473PMID 25043018PMCID PMC6879323
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of MIZ-1 in MYC-dependent tumorigenesis.

  2013cited by this paper
• Miz1 is required to maintain autophagic flux

  2013cited by this paper
• Transcriptional amplification in tumor cells with elevated c-Myc.

  2012cited by this paper
• The RNA polymerase II CTD coordinates transcription and RNA processing.

  2012cited by this paper
• c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.

  2012cited by this paper
• MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

  2012cited by this paper
• Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

  2012cited by this paper
• MEME-ChIP: motif analysis of large DNA datasets

  2011cited by this paper
• A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.

  2011cited by this paper
• seqMINER: an integrated ChIP-seq data interpretation platform

  2010cited by this paper
• Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model

  2010cited by this paper
• c-Myc regulates transcriptional pause release.

  2010cited by this paper
• Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation.

  2010cited by this paper
• The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance.

  2010cited by this paper
• Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes

  2010cited by this paper
• Aligning Short Sequencing Reads with Bowtie

  2010cited by this paper
• edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

  2009cited by this paper
• The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets

  2009cited by this paper
• Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

  2008cited by this paper
• Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.

  2008cited by this paper
• Model-based Analysis of ChIP-Seq (MACS)

  2008cited by this paper
• Global mapping of c-Myc binding sites and target gene networks in human B cells

  2006cited by this paper
• Myc-binding-site recognition in the human genome is determined by chromatin context

  2006cited by this paper
• Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

  2005cited by this paper
• Myc‐induced proliferation and transformation require Akt‐mediated phosphorylation of FoxO proteins

  2004cited by this paper
• Negative regulation of the mammalian UV response by Myc through association with Miz-1.

  2002cited by this paper
• Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter*

  2002cited by this paper
• BIOINFORMATICS APPLICATIONS NOTE

  2001cited by this paper
• Repression of p15INK4b expression by Myc through association with Miz-1

  2001cited by this paper
• Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3

  2001cited by this paper
• c-Myc Mediates Activation of the cad Promoter via a Post-RNA Polymerase II Recruitment Mechanism*

  2001cited by this paper
• Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.

  2001cited by this paper
• Myc versus USF: discrimination at the cad gene is determined by core promoter elements

  1997cited by this paper
• Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

  1996cited by this paper
• Binding of myc proteins to canonical and noncanonical DNA sequences

  1993cited by this paper
• Induction of apoptosis in fibroblasts by c-myc protein.

  1992cited by this paper

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• Integrative pan-cancer genomic analysis highlights mitochondrial protein p32 as a potential therapeutic target in Myc-driven tumorigenesis

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• The multi-faceted roles of MYC in the prognosis of chronic lymphocytic leukemia

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• HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

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• Reprogramming the tumor microenvironment with c-MYC-based gene circuit platform to enhance specific cancer immunotherapy

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• PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis

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• Inhibition of both SWI/SNF ATPases by BRM014 impairs homologous recombination, sensitizes cells to DNA damage and PARP inhibitors, and activates the cGAS/STING response.

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• MYC: The Guardian of Its Own Chaos

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• Aberrantly High Expression of Steroid Receptor Coactivator-1 Drives Lung Cancer Growth and Metastasis by Enhancing Cancer Stemness

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• ZBTB12 promotes breast cancer progression through transcriptional activation of the DNMT3B/ALDH1A2 axis.

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• Targeting the undruggable MYC in cancer: the rationale of using XPO1 inhibitors

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• MFC-GCN: Identifying Disease Driver Genes via Graph Neural Networks and Multi-Network Fusion Contrastive Learning

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• Cyclin-dependent kinases as mediators of aberrant transcription in prostate cancer

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• Integrative characterization of MYC RNA-binding function

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• Early-onset colorectal cancer patients exhibit a distinct molecular fingerprint: insights from a large-scale NGS study of 1209 patients

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• MYC as a Target for Cancer Treatment: from Undruggable to Druggable?

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• Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes.

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• The evolutionary foundations of transcriptional regulation in animals

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• MYC and AP-1 oncogenes synergistically bind enhancers to rewire transcription

  2025influential citation
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• Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation

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• Engineered Peptide Coacervates Enable Efficient Intracellular Delivery of the MYC Inhibitor omoMYC

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• MYC drives left-handed Z-DNA formation to shape gene expression

  2025cites this paper
• Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer.

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