A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature

• Publication date

  2001-12-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/414759aPMID 11742402
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The VSG expression sites of Trypanosoma brucei: multipurpose tools for the adaptation of the parasite to mammalian hosts.

  2001cited by this paper
• The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

  2001cited by this paper
• Toll-like receptors: critical proteins linking innate and acquired immunity

  2001cited by this paper
• The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.

  2001cited by this paper
• Control of VSG gene expression sites.

  2001cited by this paper
• Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei

  2000cited by this paper
• Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth*

  2000cited by this paper
• Innate recognition systems in insect immunity and development: new approaches in Drosophila.

  2000cited by this paper
• A Toll-like receptor recognizes bacterial DNA

  2000cited by this paper
• The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.

  2000cited by this paper
• Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.

  2000cited by this paper
• A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster.

  2000cited by this paper
• Toll-related receptors and the control of antimicrobial peptide expression in Drosophila.

  2000cited by this paper
• In Vitro Analysis of α-Amanitin-Resistant Transcription from the rRNA, Procyclic Acidic Repetitive Protein, and Variant Surface Glycoprotein Gene Promoters inTrypanosoma brucei

  1999cited by this paper
• Predominance of Duplicative VSG Gene Conversion in Antigenic Variation in African Trypanosomes

  1999cited by this paper
• Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila.

  1999cited by this paper
• The organization of replication and transcription.

  1999cited by this paper
• Structure and function of the nucleolus.

  1999cited by this paper
• Mono-allelic expression of genes in simple eukaryotes.

  1999cited by this paper
• Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/inactivation and chromatin remodeling of expression sites

  1999cited by this paper
• Control of variant surface glycoprotein gene‐expression sites in Trypanosoma brucei

  1999cited by this paper
• Phylogenetic perspectives in innate immunity.

  1999cited by this paper
• Toll receptor-mediated Drosophila immune response requires Dif, an NF-κB factor

  1999cited by this paper
• Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III

  1999cited by this paper
• Activation by locus control regions?

  1999cited by this paper
• Relish, a central factor in the control of humoral but not cellular immunity in Drosophila.

  1999cited by this paper
• Trypanosoma brucei

  1998cited by this paper
• The role of transferrin-receptor variation in the host range of Trypanosoma brucei

  1998cited by this paper
• In situ analysis of a variant surface glycoprotein expression-site promoter region in Trypanosoma brucei.

  1998cited by this paper
• A peptidoglycan recognition protein in innate immunity conserved from insects to humans.

  1998cited by this paper
• Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei.

  1998cited by this paper
• Monoallelic expression: 'there can only be one'.

  1998cited by this paper
• Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.

  1997cited by this paper
• Partitioning of large and minichromosomes in Trypanosoma brucei.

  1997cited by this paper
• A conserved signaling pathway: the Drosophila toll-dorsal pathway.

  1996cited by this paper
• In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition

  1996cited by this paper
• DNA rearrangements associated with multiple consecutive directed antigenic switches in Trypanosoma brucei

  1996cited by this paper
• Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes

  1994cited by this paper
• RNA B is the major nucleolar trimethylguanosine-capped small nuclear RNA associated with fibrillarin and pre-rRNAs in Trypanosoma brucei

  1993cited by this paper
• The PARP and VSG genes of Trypanosoma brucei do not resemble RNA polymerase II transcription units in sensitivity to Sarkosyl in nuclear run-on assays.

  1992cited by this paper
• Efficient production of functional mRNA mediated by RNA polymerase I in Trypanosoma brucei

  1991cited by this paper
• The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei.

  1990cited by this paper
• Alpha‐amanitin resistant transcription of protein coding genes in insect and bloodstream form Trypanosoma brucei.

  1989cited by this paper
• Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei

  1989cited by this paper
• The genes and transcripts of an antigen gene expression site from T. brucei.

  1989cited by this paper
• Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes.

  1984cited by this paper
• Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei

  1975cited by this paper

• A factor integrating transcription and repression of surface antigen genes in African trypanosomes

  2026cites this paper
• An octadecameric O-glucosyltransferase generates diversity in antibody epitopes on variant surface antigens in African trypanosomes

  2026cites this paper
• The Strange Case of the Noncanonical Lamina: Deep Divisions in Nuclear Organisation?

  2025cites this paper
• Parasite genome organization: come together, right now!

  2025cites this paper
• TblncRNA-23, a long non-coding RNA transcribed by RNA polymerase I, regulates developmental changes in Trypanosoma brucei

  2025cites this paper
• Chromosome compartment assembly is essential for subtelomeric gene silencing in trypanosomes

  2025cites this paper
• Next generation genetic screens in kinetoplastids

  2025cites this paper
• A non-coding role for trypanosome VSG transcripts in allelic exclusion

  2025cites this paper
• Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei

  2024cites this paper
• TelAP2 links TelAP1 to the telomere complex in Trypanosoma brucei

  2024cites this paper
• Mono-allelic epigenetic regulation of bi-directional silencing of RNA Polymerase II polycistronic transcription initiation in Trypanosoma brucei

  2024cites this paper
• Physiology and pharmacological targeting of phase separation

  2024cites this paper
• Protein phosphatase PP1 regulation of RNA polymerase II transcription termination and allelic exclusion of VSG genes in trypanosomes

  2024cites this paper
• Unwrap RAP1’s Mystery at Kinetoplastid Telomeres

  2024cites this paper
• The Dual Role of the 16mer Motif Within the 3′ Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei

  2024cites this paper
• The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression

  2023cites this paper
• An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome

  2023cites this paper
• PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic

  2023influential citation
• Genome-wide chromatin interaction map for Trypanosoma cruzi

  2023cites this paper
• PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

  2023cites this paper
• A PI(3,4,5)P3-dependent allosteric switch controls antigenic variation in trypanosomes 1

  2023influential citation
• Protein Phosphatase PP1 Regulation of Pol II Phosphorylation is Linked to Transcription Termination and Allelic Exclusion of VSG Genes and TERRA in Trypanosomes

  2023cites this paper
• Behind Base J: The Roles of JBP1 and JBP2 on Trypanosomatids

  2023cites this paper
• 3D genome organization drives gene expression in trypanosomes

  2023cites this paper
• Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires

  2023cites this paper
• Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes

  2023cites this paper
• Imaging of genomic loci in Trypanosoma brucei using an optimised LacO-LacI system

  2023cites this paper
• Decoding the impact of nuclear organization on antigenic variation in parasites

  2023cites this paper
• Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma brucei

  2022cites this paper
• Synthetic biology tools for engineering Goodwin oscillation in Trypanosoma brucei brucei

  2022cites this paper
• An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes

  2022cites this paper
• Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome.

  2022cites this paper
• May the Odds Be Ever in Your Favor: Non-deterministic Mechanisms Diversifying Cell Surface Molecule Expression

  2022influential citation
• Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

  2022influential citation
• Identification of sequence-specific promoters driving polycistronic transcription initiation by RNA polymerase II in trypanosomes.

  2022cites this paper
• Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes

  2022cites this paper
• Nuclear Condensates: New Targets to Combat Parasite Immune Evasion?

  2022cites this paper
• Antigenic diversity of MASP gene family of Trypanosoma cruzi.

  2022cites this paper
• VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei

  2022influential citation
• Nucleolar targeting in an early-branching eukaryote suggests a general mechanism for ribosome protein sorting

  2022influential citation
• Construction and Application of Orthogonal T7 Expression System in Eukaryote: An Overview

  2022cites this paper
• Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites

  2022cites this paper
• An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes

  2022cites this paper
• The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands

  2021influential citation
• Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities

  2021cites this paper
• Nucleolar targeting in an early-branching eukaryote suggests a general physicochemical mechanism for ribosome protein sorting

  2021influential citation
• DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids

  2021cites this paper
• Quantification of RNA Polymerase I transcriptional attenuation at the active VSG expression site in Trypanosoma brucei

  2021cites this paper
• Monoallelic antigen expression in trypanosomes requires a stage-specific transcription activator

  2021cites this paper
• Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites

  2021cites this paper
• TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei

  2021cites this paper
• A nuclear enterprise: zooming in on nuclear organization and gene expression control in the African trypanosome

  2021influential citation
• Illuminating the mechanism of monogenic antigen expression in trypanosomes

  2021cites this paper
• DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice

  2021cites this paper
• Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids

  2021cites this paper
• Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes

  2021cites this paper
• Characterizing a novel endonuclease in Trypanosoma brucei

  2021cites this paper
• Endoplasmic reticulum-targeting but not translation is required for mRNA balancing in trypanosomes

  2021cites this paper
• Multiparametric Atomic Force Microscopy Identifies Multiple Structural and Physical Heterogeneities on the Surface of Trypanosoma brucei

  2020cites this paper
• Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

  2020influential citation
• VSG mRNA levels are regulated by the production of functional VSG protein

  2020cites this paper
• A DOT1B/Ribonuclease H2 Protein Complex Is Involved in R-Loop Processing, Genomic Integrity, and Antigenic Variation in Trypanosoma brucei

  2020cites this paper
• A photocaged, water-oxidizing, and nucleolus-targeted Pt(IV) complex with a distinct anticancer mechanism.

  2020cites this paper
• Antigenic variation by switching inter-chromosomal interactions with an RNA splicing locus in trypanosomes

  2020cites this paper
• Links DNA Damage Signaling during Antigenic Variation with Regulation of I-Transcribed Antigen

  2020cites this paper
• Therapeutics—how to treat phase separation-associated diseases

  2020cites this paper
• Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens

  2020cites this paper
• Characterization of unconventional kinetochore kinases KKT10 and KKT19 in Trypanosoma brucei

  2020cites this paper
• Rapid activation of distinct members of multigene families in Plasmodium spp

  2020cites this paper
• Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei

  2019cites this paper
• Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei

  2019cites this paper
• Mechanistic Similarities between Antigenic Variation and Antibody Diversification during Trypanosoma brucei Infection.

  2019cites this paper
• Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

  2019influential citation
• Regulation of gene expression in trypanosomatids: living with polycistronic transcription

  2019cites this paper
• PRIMER African trypanosomes

  2019cites this paper
• African trypanosomes

  2019cites this paper
• Unconventional kinetochore kinases KKT10/19 promote the metaphase to anaphase transition in Trypanosoma brucei

  2019cites this paper
• Escaping the immune system by DNA repair and recombination in African trypanosomes

  2019cites this paper
• SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes

  2019influential citation
• Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

  2019cites this paper
• Nucleolar Structure and Function in Trypanosomatid Protozoa

  2019cites this paper
• Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

  2018cites this paper
• TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes

  2018cites this paper
• Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei

  2018cites this paper
• Chromatin clues to the trypanosome parasite’s uniform coat

  2018cites this paper
• Independent regulation of Plasmodium falciparum rif gene promoters

  2018cites this paper
• Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes

  2018influential citation
• Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes

  2018cites this paper
• Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes

  2018cites this paper
• Chromatin architecture and virulence-related gene expression in eukaryotic microbial pathogens

  2018cites this paper
• Characterization of Trypanosomes and Determination of Trypanosome Immunogenic Proteins in Cattle in Ghana

  2018cites this paper
• The ATR kinase of Trypanosoma brucei links DNA damage signalling and monoallelic control of surface antigen gene expression during antigenic variation

  2018cites this paper
• Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections

  2018cites this paper
• Genome organization and DNA accessibility control antigenic variation in trypanosomes

  2018cites this paper
• Comparative structural genomics and phylogenomics of African Trypanosomes

  2018cites this paper
• Fluorescence‐based assay for accurate measurement of transcriptional activity in trypanosomatid parasites

  2018cites this paper
• Evolution of Antigenic Variation in African Trypanosomes: Variant Surface Glycoprotein Expression, Structure, and Function

  2018cites this paper
• Temperature shift activates bloodstream VSG expression site promoters in Trypanosoma brucei.

  2018cites this paper
• A single-point mutation in the RNA-binding protein 6 generates Trypanosoma brucei metacyclics that are able to progress to bloodstream forms in vitro.

  2018cites this paper
• How to create coats for all seasons: elucidating antigenic variation in African trypanosomes

  2017cites this paper