Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Nature

• Publication date

  2016-09-29

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1038/nature20105PMID 27749818
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• INNATE LYMPHOID CELLS Innate lymphoid cells : A new paradigm in immunology

  2018cited by this paper
• The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2

  2016cited by this paper
• Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling.

  2016cited by this paper
• NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors.

  2015cited by this paper
• Transcriptional regulation of innate lymphoid cell fate

  2015cited by this paper
• The biology of innate lymphoid cells

  2015cited by this paper
• Innate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor

  2015cited by this paper
• Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.

  2015cited by this paper
• TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow

  2015cited by this paper
• Single cell analysis defines the divergence between the innate lymphoid cell and lymphoid tissue inducer lineages

  2015cited by this paper
• Transcriptional Programs Define Molecular Characteristics of Innate Lymphoid Cell Classes and Subsets

  2015cited by this paper
• Innate lymphoid cells: A new paradigm in immunology

  2015cited by this paper
• The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

  2015cited by this paper
• Bcl11b is essential for group 2 innate lymphoid cell development

  2015cited by this paper
• Full-length RNA-seq from single cells using Smart-seq2

  2014cited by this paper
• A committed hemopoietic precursor to innate lymphoid cells

  2014cited by this paper
• IL-25-responsive, lineage-negative KLRG1hi cells are multipotential “inflammatory” type 2 innate lymphoid cells

  2014cited by this paper
• HTSeq—a Python framework to work with high-throughput sequencing data

  2014cited by this paper
• The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.

  2014cited by this paper
• Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

  2014cited by this paper
• The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

  2014cited by this paper
• Gata3 drives development of RORγt+ group 3 innate lymphoid cells

  2014cited by this paper
• Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.

  2014cited by this paper
• Nfil3 is required for the development of all innate lymphoid cell subsets

  2014cited by this paper
• Accounting for technical noise in single-cell RNA-seq experiments

  2013cited by this paper
• STAR: ultrafast universal RNA-seq aligner

  2013cited by this paper
• Innate lymphoid cells — a proposal for uniform nomenclature

  2013cited by this paper
• The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.

  2012cited by this paper
• Bcl11a is essential for lymphoid development and negatively regulates p53

  2012cited by this paper
• The blockade of immune checkpoints in cancer immunotherapy

  2012cited by this paper
• Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity.

  2012cited by this paper
• Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation.

  2012cited by this paper
• Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages

  2011cited by this paper
• A critical role for TCF-1 in T-lineage specification and differentiation

  2011cited by this paper
• Anti-Programmed Cell Death 1 Antibody Reduces CD4+PD-1+ T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice

  2010cited by this paper
• Visualizing Data using t-SNE

  2008cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Growth Suppression by Acute PromyelocyticLeukemia-Associated Protein PLZF Is Mediated by Repression ofc-mycExpression

  2003cited by this paper
• On Nearest-Neighbor Error-Correcting Output Codes with Application to All-Pairs Multiclass Support Vector Machines

  2003cited by this paper
• Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.

  1996cited by this paper
• Papain-induced asthma--physiological and immunological features.

  1979cited by this paper

• GATA-3 localization shapes lymphocyte function.

  2026cites this paper
• Innate lymphoid cells as emerging players in cancer immunotherapy

  2026cites this paper
• Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming.

  2026cites this paper
• The development of innate lymphoid cells

  2026cites this paper
• Optimized detection and inference of immune cell type names in single-cell RNA sequencing data.

  2025cites this paper
• Modulating the PD-1-FABP5 Axis in ILC2s to Regulate Adipose Tissue Metabolism in Obesity.

  2025cites this paper
• Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironment

  2025cites this paper
• PD-1IR2 promotes tumor evasion via deregulating CD8+ T cell function

  2025cites this paper
• Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

  2025cites this paper
• Cardiac Innate Lymphoid Cells: The Role of Innate Immune Regulation in Cardiovascular Diseases.

  2025cites this paper
• The role of ILC2s in asthma combined with atopic dermatitis: bridging the gap from research to clinical practice

  2025cites this paper
• PD1+ innate lymphoid cells 3 predict JAK-dependent inflammation in rheumatoid arthritis.

  2025cites this paper
• Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system.

  2025cites this paper
• The roles of natural killer cells in bone and arthritic disease: a narrative review

  2025cites this paper
• NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity

  2025cites this paper
• The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow.

  2025cites this paper
• Single-Cell RNA-Seq Identifies Immune Remodeling in Lungs of β-Carotene Oxygenase 2 Knockout Mice with Improved Antiviral Response

  2025cites this paper
• Epigenetic imprinting in innate lymphoid cell precursors directs the lineage segregation of innate lymphoid cells

  2025cites this paper
• TOX-induced lnc-SUMF2-8 compromises antitumor function and anti-PD-1 response of CD8+ T cells via lysosome-dependent degradation of TCF-1.

  2025cites this paper
• Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage impeding type 2 immune programs

  2025cites this paper
• BMP Signaling Alleviates Allergic Airway Inflammation by Controlling Group 2 Innate Lymphoid Cells Homeostasis

  2025cites this paper
• The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes or peripheral players?

  2025cites this paper
• IL-25-induced memory ILC2s mediate long-term small intestinal adaptation

  2025cites this paper
• Innate lymphoid cells originate from fetal liver-derived tissue-resident progenitors.

  2025cites this paper
• Combination of IL-33 with PD-1 blockade augment mILC2s-mediated anti-tumor immunity

  2024cites this paper
• Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny.

  2024cites this paper
• Single-cell Technology in Stem Cell Research.

  2024cites this paper
• Eomes expression identifies the early bone marrow precursor to classical NK cells

  2024cites this paper
• PD-1 regulates ILC3-driven intestinal immunity and homeostasis.

  2024cites this paper
• Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment.

  2024cites this paper
• Single-Cell Analysis: A Method for In-Depth Phenotyping of Cells Involved in Asthma

  2024cites this paper
• Using Ribonucleic Acid Sequencing to Gain Single-cell Understanding

  2024cites this paper
• Cancer immunity by tissue‐resident type 1 innate lymphoid cells and killer innate‐like T cells

  2024cites this paper
• Microbiota regulates the TET1-mediated DNA hydroxymethylation program in innate lymphoid cell differentiation

  2024cites this paper
• Regulatory factors of ILC2 are therapeutic targets for lung inflammation

  2024cites this paper
• Distinctive CD39+CD9+ lung interstitial macrophages suppress IL-23/Th17-mediated neutrophilic asthma by inhibiting NETosis

  2024cites this paper
• Prenatal inflammation remodels lung immunity and function by programming ILC2 hyperactivation.

  2024cites this paper
• Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

  2024cites this paper
• Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule.

  2024cites this paper
• A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation

  2024cites this paper
• Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling.

  2024cites this paper
• Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors

  2024influential citation
• Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors

  2024cites this paper
• SCInter: A comprehensive single-cell transcriptome integration database for human and mouse

  2023cites this paper
• ILC3: a case of conflicted identity

  2023cites this paper
• Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

  2023cites this paper
• Exploring the global immune landscape of peripheral blood mononuclear cells in H5N6-infected patient with single-cell transcriptomics

  2023cites this paper
• Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration

  2023cites this paper
• Versatile roles of innate lymphoid cells at the mucosal barrier: from homeostasis to pathological inflammation

  2023cites this paper
• Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung

  2023cites this paper
• Bcl6 is a subset defining transcription factor of Lymphoid Tissue inducer-like ILC3

  2023cites this paper
• Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

  2023cites this paper
• Natural killer cells and type 1 innate lymphoid cells in cancer.

  2023cites this paper
• PD-1 receptor outside the main paradigm: tumour-intrinsic role and clinical implications for checkpoint blockade

  2023cites this paper
• Assessing lineage and cytolytic functional potential of murine tissue-resident innate lymphocytes

  2023cites this paper
• Purification of Bone Marrow Precursors to T Cells and ILCs.

  2023cites this paper
• Helper Innate Lymphoid Cells—Unappreciated Players in Melanoma Therapy

  2023cites this paper
• Speed and navigation control of thymocyte development by the fetal T‐cell gene regulatory network

  2023cites this paper
• Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s

  2023cites this paper
• Recent advancements in the B7/CD28 immune checkpoint families: new biology and clinical therapeutic strategies

  2023cites this paper
• Targeting Potential of Innate Lymphoid Cells in Melanoma and Other Cancers

  2023influential citation
• Function of Innate Lymphoid Cells in Periodontal Tissue Homeostasis: A Narrative Review

  2023cites this paper
• ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses

  2023cites this paper
• Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

  2023cites this paper
• Identification of a novel cord blood NK cell subpopulation expressing functional programmed death receptor-1

  2023cites this paper
• Early Development of Innate Lymphoid Cells.

  2023cites this paper
• m^6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner

  2023cites this paper
• Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues

  2023cites this paper
• Single-cell landscape dissecting the transcription and heterogeneity of innate lymphoid cells in ischemic heart

  2023cites this paper
• Organoids capture tissue-specific innate lymphoid cell development in mice and humans

  2022cites this paper
• Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum

  2022cites this paper
• Enhanced Programmed Cell Death Protein 1/Programmed Cell Death Ligand 1 Expression Induced by Severe Influenza A Virus Infection Impairs Host's Antiviral Response

  2022cites this paper
• Impact of single‐cell RNA sequencing on understanding immune regulation

  2022cites this paper
• PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation

  2022cites this paper
• Keeping ILCs in shape: PD-1 as a metabolic checkpoint

  2022cites this paper
• Heterogeneity of ILC2s in the Lungs

  2022cites this paper
• Title: Spatial anchor of adaptive immune cell around biomaterials mediated large-scale wound regeneration

  2022cites this paper
• IL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs

  2022cites this paper
• Tracing immune cells around biomaterials with spatial anchors during wound regeneration

  2022cites this paper
• Deciphering Innate Immune Cell-Tumor Microenvironment Crosstalk at a Single-Cell Level

  2022cites this paper
• Overview: Themes in Innate Lymphoid Cell Biology.

  2022cites this paper
• Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity

  2022influential citation
• Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells.

  2022cites this paper
• Human induced-T-to-natural killer cells have potent anti-tumour activities

  2022influential citation
• ILC Differentiation in the Thymus.

  2022cites this paper
• Multimodal analysis of immune cell heterogeneity around implanted biosynthetic scaffold in large-area wound healing immune-regulatory effect on adaptive immune system indicating the significant role of local immune environment in HF regeneration. in sections using Immunofluorescence and immunofluore

  2022cites this paper
• Innate Lymphoid Cells: Emerging Players in Pancreatic Disease

  2022cites this paper
• Transcription factors TCF-1 and GATA3 are key factors for the epigenetic priming of early innate lymphoid progenitors toward distinct cell fates.

  2022cites this paper
• Innate lymphoid cells: potential targets for cancer therapeutics.

  2022cites this paper
• ILC Differentiation from Progenitors in the Bone Marrow.

  2022cites this paper
• Single-cell RNA sequencing to track novel perspectives in HSC heterogeneity

  2022cites this paper
• Immunotherapy targeting inhibitory checkpoints: The role of NK and other innate lymphoid cells.

  2022cites this paper
• Altered Frequencies and Functions of Innate Lymphoid Cells in Melanoma Patients Are Modulated by Immune Checkpoints Inhibitors

  2022cites this paper
• The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection

  2022cites this paper
• Programmed Cell Death Protein 1 Axis Inhibition in Viral Infections: Clinical Data and Therapeutic Opportunities

  2022cites this paper
• Identification and characterization of innate lymphoid cells generated from pluripotent stem cells.

  2022cites this paper
• Identification of two novel variants of the BCL11B gene in two Chinese pedigrees associated with neurodevelopmental disorders

  2022cites this paper
• PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype

  2022cites this paper
• Effects of PD-1 Signaling on Immunometabolic Reprogramming

  2022cites this paper
• Dampening of cytotoxic innate lymphoid cells: A new tumour immune escape mechanism in B cell non-Hodgkin's lymphoma.

  2022cites this paper