The receptors and coding logic for bitter taste

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature

• Publication date

  2007-03-01

• Fields of study

  Medicine, Philosophy, Business

• Identifiers
  DOI 10.1038/nature05641PMID 15759003
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The receptors and coding logic for bitter taste

  2005cited by this paper
• Bitter Taste Receptors for Saccharin and Acesulfame K

  2004cited by this paper
• Single Spine Ca2+ Signals Evoked by Coincident EPSPs and Backpropagating Action Potentials in Spiny Stellate Cells of Layer 4 in the Juvenile Rat Somatosensory Barrel Cortex

  2004cited by this paper
• The human taste receptor hTAS2R14 responds to a variety of different bitter compounds.

  2004cited by this paper
• Identification of ligands for two human bitter T2R receptors.

  2004cited by this paper
• Dendrites: bug or feature?

  2003cited by this paper
• Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice

  2003cited by this paper
• Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study.

  2003cited by this paper
• Reduced sodium appetite and increased oxytocin gene expression in mutant mice lacking β-endorphin

  2003cited by this paper
• Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide

  2003cited by this paper
• Reduced sodium appetite and increased oxytocin gene expression in mutant mice lacking beta-endorphin.

  2003cited by this paper
• Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors.

  2003cited by this paper
• Molecular Supralinear Ca 2 Influx into Dendritic Tufts of Layer 2 / 3 Neocortical Pyramidal Neurons In Vitro and In Vivo

  2003cited by this paper
• The receptors for mammalian sweet and umami taste.

  2003cited by this paper
• Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

  2003cited by this paper
• Cell Type- and Subcellular Position-Dependent Summation of Unitary Postsynaptic Potentials in Neocortical Neurons

  2002cited by this paper
• The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides

  2002cited by this paper
• Spike-timing-dependent synaptic modification induced by natural spike trains

  2002cited by this paper
• An amino-acid taste receptor

  2002cited by this paper
• Dendritic spikes as a mechanism for cooperative long-term potentiation

  2002cited by this paper
• Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons

  2002cited by this paper
• A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function.

  2002cited by this paper
• Mammalian sweet taste receptors.

  2001cited by this paper
• Differential shunting of EPSPs by action potentials.

  2001cited by this paper
• Synaptic modification by correlated activity: Hebb's postulate revisited.

  2001cited by this paper
• Dendritic coincidence detection of EPSPs and action potentials

  2001cited by this paper
• Taste Receptor Cells That Discriminate Between Bitter Stimuli

  2001cited by this paper
• T2Rs function as bitter taste receptors.

  2000cited by this paper
• Competitive Hebbian learning through spike-timing-dependent synaptic plasticity

  2000cited by this paper
• Untangling dendrites with quantitative models.

  2000cited by this paper
• A family of candidate taste receptors in human and mouse

  2000cited by this paper
• A novel family of mammalian taste receptors.

  2000cited by this paper
• Timing-based LTP and LTD at vertical inputs to layer II/III pyramidal cells in rat barrel cortex.

  2000cited by this paper
• A model for intradendritic computation of binocular disparity

  2000cited by this paper
• Dendritic integration of excitatory synaptic input

  2000cited by this paper
• Dendritic GABA release depresses excitatory transmission between layer 2/3 pyramidal and bitufted neurons in rat neocortex.

  1999cited by this paper
• The role of dendritic filtering in associative long-term synaptic plasticity.

  1999cited by this paper
• Transduction for Sweet Taste of Saccharin May Involve Both Inositol 1,4,5-Trisphosphate and cAMP Pathways in the Fungiform Taste Buds in C57BL Mice

  1999cited by this paper
• A new cellular mechanism for coupling inputs arriving at different cortical layers

  1999cited by this paper
• Calcium- and activity-dependent synaptic plasticity.

  1999cited by this paper
• Linear summation of excitatory inputs by CA1 pyramidal neurons.

  1999cited by this paper
• Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo

  1999cited by this paper
• Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites

  1998cited by this paper
• Controlling signaling with a specifically designed Gi-coupled receptor.

  1998cited by this paper
• A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons

  1997cited by this paper
• Neural responses to bitter compounds in rats.

  1997cited by this paper
• Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

  1997cited by this paper
• Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons.

  1995cited by this paper
• Synaptic desensitization of NMDA receptors by calcineurin

  1995cited by this paper
• ELECTRON MICROSCOPE STUDY OF THE DEVELOPING TASTE BUD IN RAT FUNGIFORM PAPILLA.

  1965cited by this paper

• BIPE: Artificial Intelligence-Driven Peptide Bitterness Intensity Prediction Engine.

  2026cites this paper
• Nitrate supplementation affects taste by changing the oral metabolome and microbiome

  2025cites this paper
• Ginkgo biloba leaf alleviates bronchial asthma via the TAS2Rs/Gβγ/SERCA signaling pathway.

  2025cites this paper
• Food-Induced Adverse Reactions: A Review of Physiological Food Quality Control, Mucosal Defense Mechanisms, and Gastrointestinal Physiology

  2025cites this paper
• Structural basis of β-glucopyranoside salicin recognition by a human bitter taste GPCR.

  2025cites this paper
• TRP Channels from Sensory Coding to Physiology

  2025cites this paper
• Bitter Taste Receptors in Bacterial Infections and Innate Immunity

  2025cites this paper
• A brain center that controls consummatory responses.

  2025cites this paper
• Artificial Nervous Systems

  2025cites this paper
• Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

  2025cites this paper
• Nutrient Sensing by Lingual G-Protein-Coupled Taste Receptors.

  2025cites this paper
• Identification of Compounds That Impact Consumer Flavor Liking of American-European Hazelnut Hybrids Using Nontargeted LC/MS Analysis.

  2024cites this paper
• Neural circuits for taste sensation

  2024cites this paper
• Bitter taste receptor activation by cholesterol and an intracellular tastant

  2024cites this paper
• Bitter taste receptors in the reproductive system: Function and therapeutic implications

  2024cites this paper
• Neural basis for pheromone signal transduction in mice

  2024cites this paper
• International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors: Structures, functions, activators and blockers.

  2024cites this paper
• Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes

  2024cites this paper
• Recent advances in the characterization of genetically defined neurons that regulate internal‐state‐dependent taste modification in mice

  2024cites this paper
• Adverse Food Reactions: Physiological and Ecological Perspectives.

  2024cites this paper
• Tastant-receptor interactions: insights from the fruit fly

  2024cites this paper
• Extragustatory bitter taste receptors in head and neck health and disease

  2024cites this paper
• What are Olfaction and Gustation, And Do All Animals Have Them?

  2024cites this paper
• Recent advancements in the taste transduction mechanism, identification, and characterization of taste components.

  2023cites this paper
• Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine

  2023cites this paper
• Neurobiology of eating behavior, nutrition, and health

  2023cites this paper
• Zebrafish and medaka T1R (taste receptor type 1) proteins mediate highly sensitive recognition of l‐proline

  2023cites this paper
• Human Gingival Fibroblasts as a Novel Cell Model Describing the Association between Bitter Taste Thresholds and Interleukin-6 Release

  2023cites this paper
• Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B

  2023cites this paper
• Ligand and G-protein selectivity in the κ-opioid receptor

  2023cites this paper
• GPCR‐G protein selectivity revealed by structural pharmacology

  2023cites this paper
• A neural substrate for short-term taste memories.

  2023cites this paper
• Cortical field maps across human sensory cortex

  2023cites this paper
• A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells

  2023cites this paper
• Taste.

  2023cites this paper
• A functional division of Drosophila sweet taste neurons that is value-based and task-specific

  2022cites this paper
• Molecular Mechanism of L-Pyroglutamic Acid Interaction with the Human Sour Receptor

  2022cites this paper
• Synergism, Bifunctionality, and the Evolution of a Gradual Sensory Trade-off in Hummingbird Taste Receptors

  2022cites this paper
• Taste Receptors beyond Taste Buds

  2022cites this paper
• The effect of adulteration with a bitter tastant, denatonium benzoate, on the reinforcing value of sucrose.

  2022cites this paper
• Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway

  2022cites this paper
• Regional specialization of the tongue revealed by gustatory ganglion imaging

  2022cites this paper
• Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors.

  2022cites this paper
• From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion

  2022cites this paper
• The effective taste masking of alkaloids by a water-soluble terphen[3]arene.

  2022cites this paper
• Extraoral expression and characterization of bitter taste receptors in Astyanax mexicanus (Mexican tetra fish)

  2022cites this paper
• Molecular insights into human taste perception and umami tastants: A review

  2022cites this paper
• Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems

  2022cites this paper
• Remodeling of the ryanodine receptor isoform 1 channel regulates the sweet and umami taste perception of Rattus norvegicus

  2022cites this paper
• Neuromorphic Gustatory System with Salt-Taste Perception, Information Processing, and Excessive-Intake Warning Capabilities.

  2022cites this paper
• Why Taste Is Pharmacology.

  2022cites this paper
• Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation

  2021cites this paper
• Taste receptors in chronic rhinosinusitus, what is the evidence? A systematic review

  2021cites this paper
• Evolvement of taste sensitivity and taste buds in chickens during selective breeding

  2021cites this paper
• Molecular Tools for Targeted Control of Nerve Cell Electrical Activity. Part II

  2021cites this paper
• Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020

  2021cites this paper
• Nutrition and Functions of Amino Acids in Fish.

  2021cites this paper
• Bitter Taste Receptors in the Airway Cells Functions.

  2021cites this paper
• Deciphering molecular mechanics in the taste masking ability of Maltodextrin: Developing pediatric formulation of Oseltamivir for viral pandemia.

  2021cites this paper
• Dietary supplementation with monosodium glutamate with dietary balance such as protein, salt and sugar intake with increasing T1R3 taste receptor gene expression in healthy females.

  2021cites this paper
• Functional molecular switches of mammalian G protein-coupled bitter-taste receptors

  2021cites this paper
• An update on extra-oral bitter taste receptors

  2021cites this paper
• Mouse mandibular retromolar taste buds associated with a mucus salivary gland.

  2021cites this paper
• Taste Receptor Signaling.

  2021cites this paper
• Top-Down Control of Sweet and Bitter Taste in the Mammalian Brain.

  2021cites this paper
• Recent Advances in Neural Circuits for Taste Perception in Hunger

  2021cites this paper
• Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant‐induced bronchodilation

  2021cites this paper
• Is it still still water? Relationships between sparkling sensitivity and consumption frequency of carbonated waters.

  2021cites this paper
• Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients

  2021cites this paper
• Whole-Brain Mapping of the Expression Pattern of T1R2, a Subunit Specific to the Sweet Taste Receptor

  2021cites this paper
• Encoding Taste: From Receptors to Perception.

  2021cites this paper
• Identification of non-volatile compounds that negatively impact whole wheat bread flavor liking.

  2021cites this paper
• Pharmacology of the Umami Taste Receptor.

  2021cites this paper
• Gene expression profiling of α-gustducin-expressing taste cells in mouse fungiform and circumvallate papillae.

  2021cites this paper
• Effects of bitter receptor antagonists on behavioral lick responses of mice.

  2020cites this paper
• “TRUPATH, an Open-Source Biosensor Platform for Interrogating the GPCR Transducerome”

  2020cites this paper
• A Bitter Taste in Your Heart

  2020cites this paper
• Functions of Opsins in Drosophila Taste.

  2020cites this paper
• Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists.

  2020cites this paper
• Electrophysiological Responses from the Human Tongue to the Six Taste Qualities and Their Relationships with PROP Taster Status

  2020cites this paper
• Sensing Senses: Optical Biosensors to Study Gustation

  2020cites this paper
• Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans

  2020cites this paper
• The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity

  2020cites this paper
• G Protein-Coupled Receptors in Taste Physiology and Pharmacology

  2020cites this paper
• An alternative pathway for sweet sensation: possible mechanisms and physiological relevance

  2020cites this paper
• [Taste science~The relationship between aging and taste sensitivity~].

  2020cites this paper
• Expression of Eya1 in mouse taste buds

  2020cites this paper
• A cross-talk between fat and bitter taste modalities.

  2019cites this paper
• Sour Sensing from the Tongue to the Brain.

  2019cites this paper
• Acid Tongues Cause Sour Thoughts.

  2019cites this paper
• Dual binding mode of “bitter sugars” to their human bitter taste receptor target

  2019cites this paper
• Physiological Responses to Basic Tastes for Sensory Evaluation of Chocolate Using Biometric Techniques

  2019cites this paper
• Taste receptor function.

  2019cites this paper
• Bitter taste receptor T2R7 and umami taste receptor subunit T1R1 are expressed highly in Vimentin-negative taste bud cells in chickens.

  2019cites this paper
• Distinct representations of basic taste qualities in human gustatory cortex

  2019cites this paper
• Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rat circumvallate papillae.

  2019cites this paper
• How structure informs and transforms chemogenetics.

  2019cites this paper
• Recognizing Taste: Coding Patterns Along the Neural Axis in Mammals.

  2019cites this paper
• Tolerance of bitter stimuli and attenuation/accumulation of their bitterness in humans

  2018cites this paper
• Peripheral and Central Nutrient Sensing Underlying Appetite Regulation.

  2018cites this paper