Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature

• Publication date

  2001-12-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/414756aPMID 11742401
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

  2001cited by this paper
• Drosophila immunity: two paths to NF-kappaB.

  2001cited by this paper
• Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses.

  2001cited by this paper
• Toll-like receptors: critical proteins linking innate and acquired immunity

  2001cited by this paper
• The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.

  2001cited by this paper
• Drosophila immunity: two paths to NF-κB

  2001cited by this paper
• Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.

  2000cited by this paper
• Role of Drosophila IKK gamma in a toll-independent antibacterial immune response.

  2000cited by this paper
• Toll-related receptors and the control of antimicrobial peptide expression in Drosophila.

  2000cited by this paper
• The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.

  2000cited by this paper
• Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth*

  2000cited by this paper
• Mannose-binding lectin: structure, function, genetics and disease associations.

  2000cited by this paper
• The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila.

  2000cited by this paper
• Innate recognition systems in insect immunity and development: new approaches in Drosophila.

  2000cited by this paper
• Role of Drosophila IKKγ in a Toll-independent antibacterial immune response

  2000cited by this paper
• A Toll-like receptor recognizes bacterial DNA

  2000cited by this paper
• The Drosophila caspase Dredd is required to resist Gram‐negative bacterial infection

  2000cited by this paper
• A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster.

  2000cited by this paper
• Toll receptor-mediated Drosophila immune response requires Dif, an NF-κB factor

  1999cited by this paper
• Relish, a central factor in the control of humoral but not cellular immunity in Drosophila.

  1999cited by this paper
• Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

  1999cited by this paper
• Phylogenetic perspectives in innate immunity.

  1999influential reference
• Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor.

  1999cited by this paper
• Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila.

  1999cited by this paper
• A peptidoglycan recognition protein in innate immunity conserved from insects to humans.

  1998cited by this paper
• Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

  1998cited by this paper
• Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.

  1997cited by this paper
• A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

  1997cited by this paper
• A conserved signaling pathway: the Drosophila toll-dorsal pathway.

  1996cited by this paper
• The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.

  1996cited by this paper
• A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.

  1995cited by this paper
• Approaching the asymptote? Evolution and revolution in immunology.

  1989cited by this paper

• Application of Proteins Binding Components of Bacterial Cell Wall for Extraction, Concentration, and Analysis of Biological Samples

  2026cites this paper
• Toll signalling controls intestinal regeneration in Drosophila

  2026cites this paper
• UuPGRP, a peptidoglycan recognition protein of Urechis unicinctus, promotes immune defense against bacterial infection.

  2026cites this paper
• Diversity and Evolutionary Adaptations of the IMD Signaling Pathway in Hemipteran Innate Immunity against Bacterial Infections

  2026cites this paper
• Peptidoglycan recognition protein L1 regulates intestinal immunity and microbial homeostasis  via the IMD pathway in the silkworm, Bombyx mori.

  2025cites this paper
• Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood–brain barrier

  2025cites this paper
• Midgut immune profiling and functional characterization of Aedes aegypti ABC transporter gene(s) using systemic and local bacterial challenges

  2025cites this paper
• The serine protease homolog Skanda modulates Toll-Phenoloxidase-mediated immunity in Drosophila

  2025cites this paper
• Genome-Wide Identification of PGRP Gene Family and Its Role in Dendrolimus kikuchii Immune Response Against Bacillus thuringiensis Infection

  2025cites this paper
• 2Innate immune signaling mediates differential acute and long-term outcomes of repeated vs. single TBI in Drosophila.

  2025cites this paper
• Functional Analysis of BmHemolin in the Immune Defense of Silkworms

  2025cites this paper
• The functional Mi-2/Foxo complex targets PGRP-SC2 for the Drosophila immune defense against bacterial infection

  2025cites this paper
• Nanomaterial ZIF8@ZIF67 may regulate ROS/BmRelish axis to enhance the silkworm resistance against Bacillus cereus.

  2025cites this paper
• Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling.

  2025cites this paper
• Antimicrobial Peptides Against Arboviruses: Mechanisms, Challenges, and Future Directions

  2025cites this paper
• Regulation of AMPs expression by six Tolls in stomach during WSSV infection in Macrobrachium nipponense.

  2025cites this paper
• Recent advances in antimicrobial peptide-based therapy.

  2024cites this paper
• Insights into ecology, pathogenesis, and biofilm formation of Enterococcus faecalis from functional genomics

  2024cites this paper
• Larval microbiota primes the Drosophila adult gustatory response

  2024cites this paper
• Bacterial peptidoglycan serves as a critical modulator of the gut-immune-brain axis in Drosophila.

  2024influential citation
• Identification of immunity-related genes distinctly regulated by Manduca sexta Spӓtzle-1/2 and Escherichia coli peptidoglycan.

  2024cites this paper
• Characterization of a novel short-type peptidoglycan recognition protein from the sea cucumber Apostichopus japonicus.

  2024cites this paper
• The humoral immune response of the lepidopteran model insect, silkworm Bombyx mori L., to microbial pathogens

  2024cites this paper
• Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila

  2024cites this paper
• NF‐κB/Relish readjusts miR‐100 expression and recovers immune homeostasis in Drosophila melanogaster

  2024cites this paper
• The role of a novel secretory peptidoglycan recognition protein with antibacterial ability from the Chinese Oak Silkworm Antheraea pernyi in humoral immunity.

  2024cites this paper
• Pathogen-specific social immunity is associated with erosion of individual immune function in an ant

  2024cites this paper
• Maintenance of persistent transmission of a plant arbovirus in its insect vector mediated by the Toll-Dorsal immune pathway

  2024cites this paper
• Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila

  2024cites this paper
• Comparative genomic analysis of copepod humoral immunity genes with sex-biased expression in Labidocera rotunda.

  2024cites this paper
• Pattern recognition receptors in Crustacea: immunological roles under environmental stress

  2024cites this paper
• Immune Reactions of Vector Insects to Parasites and Pathogens

  2024cites this paper
• Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis

  2024cites this paper
• A metalloprotease secreted by an environmentally acquired gut bacterium hinders Borrelia afzelii colonization in Ixodes ricinus

  2024cites this paper
• Transcriptional induction of the IMD signaling pathway and associated antibacterial activity in the digestive tract of cat fleas (Ctenocephalides felis)

  2024cites this paper
• Comparative Analysis of PGRP Family in Polymorphic Worker Castes of Solenopsis invicta

  2024cites this paper
• An evolutionarily conserved serine protease network mediates melanization and Toll activation in Drosophila

  2023cites this paper
• Immune functions of pattern recognition receptors in Lepidoptera

  2023cites this paper
• Ubiquitin signalling in Drosophila innate immune responses

  2023cites this paper
• A novel short-type peptidoglycan recognition protein with unique polysaccharide recognition specificity in sea cucumber, Apostichopus japonicus.

  2023cites this paper
• The effects of NOD-like receptors on adaptive immune responses

  2023cites this paper
• Changes in histamine, HSF1, Cysteinyl leukotriene, TLR1 and TLR2 in Galleria mellonella hemolymph after Conidiobolus coronatus infection

  2023cites this paper
• Real-time, label-free detection and identification of bacteria through non-invasive optical imaging.

  2023cites this paper
• Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration

  2023cites this paper
• Effects of TmTak1 silencing on AMP production as an Imd pathway component in Tenebrio molitor

  2023cites this paper
• The genetic basis of variation in immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster

  2023cites this paper
• Infection with a non-lethal fungal parasite is associated with increased immune investment in the ant Myrmica scabrinodis.

  2023cites this paper
• Drosophila melanogaster Imd signaling interacts with insulin signaling and alters feeding rate upon parasitic nematode infection

  2023cites this paper
• Induced expression modes of genes related to Toll, Imd, and JAK/STAT signaling pathway-mediated immune response in Spodoptera frugiperda infected with Beauveria bassiana

  2023cites this paper
• A novel virus-induced cyclic dinucleotide, 2′3′-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

  2023cites this paper
• Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies

  2023cites this paper
• Larval microbiota primes the Drosophila adult gustatory response

  2023cites this paper
• Rift Valley Fever Virus Primes Immune Responses in Aedes aegypti Cells

  2023cites this paper
• Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks

  2023cites this paper
• Peptidoglycan Recognition Protein S5 of Bombyx mori Facilitates the Proliferation of Bombyx mori Cypovirus 1.

  2023cites this paper
• Identification and characterization of two long-type peptidoglycan recognition proteins, PGRP-L1 and PGRP-L2, in the orange-spotted grouper, Epinephelus coioides.

  2023cites this paper
• The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila.

  2023cites this paper
• Peptidoglycan recognition protein MsPGRP in largemouth bass (Micropterus salmoides) mediates immune functions with broad nonself recognition ability.

  2023cites this paper
• MicroRNAs reshape the immunity of insects in response to bacterial infection

  2023cites this paper
• Rickettsia parkeri hijacks tick hemocytes to manipulate cellular and humoral transcriptional responses

  2022cites this paper
• CLIPA7 Exhibits Pleiotropic Roles in the Anopheles gambiae Immune Response

  2022cites this paper
• Antiviral function of peptidoglycan recognition protein in Spodoptera exigua (Lepidoptera: Noctuidae)

  2022cites this paper
• Novel studies on Drosophila melanogaster model reveal the roles of JNK-Jak/STAT axis and intestinal microbiota in insulin resistance

  2022cites this paper
• Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature

  2022cites this paper
• Short Peptides of Innate Immunity Protein Tag7 Inhibit the Production of Cytokines in CFA-Induced Arthritis

  2022cites this paper
• A short-type peptidoglycan recognition protein from Asian corn borer, Ostrinia furnacalis (Guenée) exhibits antibacterial activity, and regulates the expression of antimicrobial peptides

  2022cites this paper
• Preferential binding of DAP-PGs by major peptidoglycan recognition proteins found in cell-free hemolymph of Manduca sexta.

  2022cites this paper
• Innate Immunity Mechanisms in Marine Multicellular Organisms

  2022cites this paper
• Peptidoglycan recognition protein 6 (PGRP6) from Asian corn borer, Ostrinia furnacalis (Guenée) serve as a pattern recognition receptor in innate immune response.

  2022cites this paper
• Redclaw crayfish (Cherax quadricarinatus) responds to Vibrio parahaemolyticus infection by activating toll and immune deficiency signaling pathways and transcription of associated immune response genes.

  2022cites this paper
• Drosophila as a Model Organism to Study Basic Mechanisms of Longevity

  2022cites this paper
• Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues

  2022cites this paper
• Identification, Phylogeny and Expressional Profiles of Peptidoglycan Recognition Protein (PGRP) Gene Family in Sinonovacula constricta

  2022cites this paper
• Effects of exposure to trace pyriproxyfen on the intestinal bacterial diversity and immune signal pathways of silkworm (Bombyx mori) larvae

  2022cites this paper
• Regulating metabolism to shape immune function: Lessons from Drosophila.

  2022cites this paper
• Beneficial commensal bacteria promote Drosophila growth by downregulating the expression of peptidoglycan recognition proteins

  2022cites this paper
• The Intriguing Role of TLR Accessory Molecules in Cardiovascular Health and Disease

  2022influential citation
• Antimicrobial peptide expression in the cockroach gut during enterobacterial infection is specific and influenced by type III secretion

  2022cites this paper
• Advances in the Immune Regulatory Role of Non-Coding RNAs (miRNAs and lncRNAs) in Insect-Pathogen Interactions

  2022cites this paper
• Sensing microbial infections in the Drosophila melanogaster genetic model organism

  2022cites this paper
• Infection-induced molecular pattern recognition proteins in larvae of Protaetia brevitarsis seulensis (Coleoptera: Cetoniidae)

  2022cites this paper
• Transgenic Silkworms Overexpressing Relish and Expressing Drosomycin Confer Enhanced Immunity to Multiple Pathogens

  2022cites this paper
• Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila

  2022cites this paper
• Toll-Like Receptors (TLRs) in Health and Disease: An Overview.

  2022cites this paper
• Mutations of γCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa

  2022influential citation
• Impact of Microorganisms and Parasites on Neuronally Controlled Drosophila Behaviours

  2021cites this paper
• LncRNA-CR11538 Decoys Dif/Dorsal to Reduce Antimicrobial Peptide Products for Restoring Drosophila Toll Immunity Homeostasis

  2021cites this paper
• The transposable element-rich genome of the cereal pest Sitophilus oryzae

  2021cites this paper
• Verloren negatively regulates the expression of IMD pathway dependent antimicrobial peptides in Drosophila

  2021cites this paper
• An apocrine mechanism delivers a fully immunocompetent exocrine secretion

  2021cites this paper
• Bacterial Engulfment Mechanism Is Strongly Conserved in Evolution Between Earthworm and Human Immune Cells

  2021cites this paper
• Identification and functional characterization of a short-type peptidoglycan recognition protein, PGRP-S in the orange-spotted grouper, Epinephelus coioides

  2021cites this paper
• Characterization of PGRP-LB and immune deficiency in the white-backed planthopper Sogatella furcifera (Hemiptera: Delphacidae)

  2021cites this paper
• Peptidoglycan recognition protein-S1 (PGRP-S1) from Diaphania pyloalis (Walker) is involved in the agglutination and prophenoloxidase activation pathway.

  2021cites this paper
• Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias

  2021cites this paper
• Peptidoglycan Recognition Peptide 2 Aggravates Weight Loss in a Murine Model of Chemotherapy-Induced Gastrointestinal Toxicity

  2021cites this paper
• Regulators and signalling in insect antimicrobial innate immunity: Functional molecules and cellular pathways.

  2021cites this paper
• Comparative Analysis of Adelphocoris suturalis Jakovlev (Hemiptera: Miridae) Immune Responses to Fungal and Bacterial Pathogens

  2021cites this paper
• Reactive oxygen species: the root cause of nanoparticle-induced toxicity in Drosophila melanogaster

  2021cites this paper
• Structural and functional understanding of the toll‐like receptors

  2021cites this paper