Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2012-10-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1209357109PMID 23071314PMCID PMC3511727
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization.

  2012cited by this paper
• of a-Tubulin Constrains Protofilament Number in Native Microtubules

  2012cited by this paper
• MYST-family histone acetyltransferases: beyond chromatin

  2011cited by this paper
• Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation*

  2011cited by this paper
• MYST protein acetyltransferase activity requires active site lysine autoacetylation

  2011cited by this paper
• The major α-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensation

  2010cited by this paper
• Faculty Opinions recommendation of The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.

  2010influential reference
• MEC-17 is an α-tubulin acetyltransferase

  2010cited by this paper
• Faculty Opinions recommendation of MEC-17 is an alpha-tubulin acetyltransferase.

  2010cited by this paper
• Acetylation of non-histone proteins modulates cellular signalling at multiple levels.

  2009cited by this paper
• Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

  2009cited by this paper
• Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP

  2008cited by this paper
• A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

  2008cited by this paper
• Single-molecule studies of fork dynamics in Escherichia coli DNA replication

  2008cited by this paper
• The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

  2008cited by this paper
• Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP

  2008cited by this paper
• Anti-tumor activity of capecitabine and vinorelbine in patients with anthracycline- and taxane-pretreated metastatic breast cancer: findings from the EORTC 10001 randomized phase II trial.

  2008cited by this paper
• Histone deacetylases and cancer

  2007cited by this paper
• Yeast Rtt109 Promotes Genome Stability by Acetylating Histone H3 on Lysine 56

  2007cited by this paper
• Microtubule acetylation promotes kinesin-1 binding and transport.

  2006cited by this paper
• Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.

  2005cited by this paper
• Acetylation and deacetylation of non-histone proteins.

  2005cited by this paper
• Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

  2003cited by this paper
• The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate

  2002influential reference
• Histone acetylation and disease

  2001cited by this paper
• Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism.

  2000cited by this paper
• The 4 A X-ray structure of a tubulin:stathmin-like domain complex.

  2000cited by this paper
• Acetylation: a regulatory modification to rival phosphorylation?

  2000cited by this paper
• High-resolution model of the microtubule.

  1999cited by this paper
• Expanded Lysine Acetylation Specificity of Gcn5 in Native Complexes*

  1999cited by this paper
• Additivity of dilantin and vinblastine inhibitory effects on microtubule assembly.

  1999cited by this paper
• Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide

  1999cited by this paper
• High-Resolution Model of the Microtubule We recently obtained the structure of the tubulin dimer

  1998cited by this paper
• The transcriptional coactivators p300 and CBP are histone acetyltransferases.

  1996cited by this paper
• Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

  1987cited by this paper
• The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules

  1986cited by this paper
• Chlamydomonas alpha-tubulin is posttranslationally modified by acetylation on the epsilon-amino group of a lysine.

  1985cited by this paper
• Enzyme kinetics: Behavior and analysis of rapid equilibrium and steady‐state enzyme systems. Author: Irwin H. Segal (University of California, Davis). Published by Wiley‐Interscience, New York, 1975. Price: $24.50. No. of pages: 957

  1976cited by this paper
• Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.

  1971cited by this paper
• ROLE OF CHANCE OBSERVATIONS IN CHEMOTHERAPY: VINCA ROSEA *

  1958cited by this paper

• Tubulin Acetylation: A Critical Regulator of Microtubule Function.

  2025cites this paper
• Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress

  2025cites this paper
• Tubulin isotypes of C. elegans harness the mechanosensitivity of the lattice for microtubule luminal accessibility

  2025cites this paper
• Computational and experimental identification of putative αTAT1 modulators: implications for nervous system function

  2025cites this paper
• Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence

  2025cites this paper
• Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration

  2025cites this paper
• Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity

  2024cites this paper
• Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets

  2024cites this paper
• The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases

  2024cites this paper
• Microtubule acetylation dyshomeostasis in Parkinson’s disease

  2023cites this paper
• Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation

  2023cites this paper
• Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation

  2022cites this paper
• GCN5/KAT2A contributes to axon growth and neurogenesis.

  2022cites this paper
• Lumenal components of cytoplasmic microtubules

  2022cites this paper
• Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol

  2021cites this paper
• Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization

  2021cites this paper
• Pharmacophore anchor models of ATAT1 to discover potential inhibitors and lead optimization

  2021cites this paper
• Primary cilium and its role in tumorigenesis.

  2021cites this paper
• Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules

  2021cites this paper
• Journal of Reproduction and Development

  2021cites this paper
• Protein lysine acetylation and its role in different human pathologies: a proteomic approach

  2021cites this paper
• Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle

  2020cites this paper
• Non-enzymatic Activity of the α-Tubulin Acetyltransferase αTAT Limits Synaptic Bouton Growth in Neurons.

  2020cites this paper
• A phospho-regulated signal motif determines subcellular localization of α-TAT1 for dynamic microtubule acetylation

  2020influential citation
• Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice

  2020cites this paper
• HAT inhibitors in cancer therapy

  2020cites this paper
• A phospho-regulated ensemble signal motif of α-TAT1 drives dynamic microtubule acetylation

  2020influential citation
• Improved early development potence of in vitro fertilization embryos by treatment with tubacin increasing acetylated tubulin of matured porcine oocytes.

  2020cites this paper
• Lysine Acetyltransferase Inhibitors From Natural Sources

  2020cites this paper
• The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

  2019cites this paper
• Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors

  2019cites this paper
• Regulation of Microtubule Disassembly by Spatially Heterogeneous Patterns of Acetylation

  2019cites this paper
• Ultrastructural characterization of microtubules at high resolution in the mammalian peripheral nervous system

  2019cites this paper
• Histone Acetyltransferases: Targets and Inhibitors

  2019cites this paper
• Functional role of increased acetylated tubulin in porcine oocyte microtubule structure, meiotic maturation and embryogenesis

  2019cites this paper
• Structural and functional features of lysine acetylation of plant and animal tubulins

  2019cites this paper
• Optogenetic control of Cofilin and αTAT in living cells using Z-lock

  2019cites this paper
• A computational protocol for regulating protein binding reactions with a light sensitive protein dimer.

  2019cites this paper
• Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases.

  2019cites this paper
• Coordination of microtubule acetylation and the actin cytoskeleton by formins

  2018cites this paper
• Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.

  2018cites this paper
• Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications.

  2018cites this paper
• &agr;-Tubulin Acetylation Restricts Axon Overbranching by Dampening Microtubule Plus-End Dynamics in Neurons

  2018cites this paper
• p27Kip1 Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.

  2018influential citation
• hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells.

  2018influential citation
• Candidates for reproductive biomarkers: Protein phosphorylation and acetylation positively related to selected parameters of boar spermatozoa quality.

  2018cites this paper
• p27 Modulates Axonal Transport by Regulating a-Tubulin Acetyltransferase 1 Stability

  2018influential citation
• Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

  2018cites this paper
• Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.

  2017cites this paper
• Tubulin acetylation: A novel functional avenue for CDYL in sperm

  2017cites this paper
• Posttranslational Modifications of Tubulin and Cilia.

  2017cites this paper
• Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules

  2017cites this paper
• Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)

  2016influential citation
• Functional analysis of Prdm14 during Xenopus embryogenesis

  2016influential citation
• Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1*

  2016influential citation
• Intracellular localization of α-tubulin acetyltransferase ATAT1 in rat ciliated cells

  2016cites this paper
• The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target

  2016cites this paper
• The growing landscape of tubulin acetylation: lysine 40 and many more.

  2016cites this paper
• KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases.

  2016cites this paper
• A conceptual view at microtubule plus end dynamics in neuronal axons

  2016cites this paper
• Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity.

  2015cites this paper
• The elongation of primary cilia via the acetylation of α-tubulin by the treatment with lithium chloride in human fibroblast KD cells

  2015cites this paper
• Rôles de la "Dual leucine zipper-bearing Kinase" dans la réorganisation des microtubules et la différenciation des kératinocytes humains

  2015cites this paper
• Cryo-electron microscopy studies of microtubules and microtubule associated proteins : tubulin acetylation , engineered kinesins , yeast microtubules , and PRC 1 By

  2015cites this paper
• Tubulin acetylation: responsible enzymes, biological functions and human diseases

  2015cites this paper
• Structural basis of cofactor-mediated stabilization and substrate recognition of the α-tubulin acetyltransferase αTAT1.

  2015cites this paper
• Microtubule Regulation in Cystic Fibrosis Pathophysiology

  2015cites this paper
• Broader implications: Biological and clinical significance of microtubule acetylation

  2015cites this paper
• Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.

  2014influential citation
• Structural and functional characterization of the α-tubulin acetyltransferase MEC-17.

  2014cites this paper
• α-Tubulin K40 acetylation is required for contact inhibition of proliferation and cell–substrate adhesion

  2014cites this paper
• Primary Cilia Dynamics, Morphology and Acetylation are Abnormal in Huntington’s Disease Cell Models

  2014influential citation
• Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress*

  2014cites this paper
• A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis

  2014cites this paper
• Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

  2014cites this paper
• Mice Lacking α-Tubulin Acetyltransferase 1 Are Viable but Display α-Tubulin Acetylation Deficiency and Dentate Gyrus Distortion*

  2013cites this paper
• Application of systems biology to dissect glucocorticoid receptor function

  2013cites this paper
• Structure and mechanism of non‐histone protein acetyltransferase enzymes

  2013cites this paper
• αTAT1 is the major α-tubulin acetyltransferase in mice

  2013cites this paper
• α-Tubulin acetylation from the inside out

  2012influential citation
• Tubulin Acetyltransferase αTAT1 Destabilizes Microtubules Independently of Its Acetylation Activity

  2012cites this paper