Mechanotransduction through growth-factor shedding into the extracellular space

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature

• Publication date

  2004-05-06

• Fields of study

  Biology, Medicine, Physics

• Identifiers
  DOI 10.1038/nature02543PMID 15103386PMCID PMC5539413
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium.

  2003cited by this paper
• Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

  2003cited by this paper
• Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium.

  2003cited by this paper
• Endogenously released ATP mediates shear stress-induced Ca2+ influx into pulmonary artery endothelial cells.

  2003cited by this paper
• Molecular mechanisms of mechanosensation: big lessons from small cells.

  2003cited by this paper
• Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins

  2002cited by this paper
• Mechanotransduction determines the structure and function of lung and bone

  2002cited by this paper
• Autocrine loops with positive feedback enable context-dependent cell signaling.

  2002cited by this paper
• Endothelial responses to mechanical stress: Where is the mechanosensor?

  2002cited by this paper
• Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression.

  2002cited by this paper
• Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells.

  2002cited by this paper
• Spatial range of autocrine signaling: modeling and computational analysis.

  2001cited by this paper
• Molecular basis of mechanotransduction in living cells.

  2001cited by this paper
• Mechanical stress is communicated between different cell types to elicit matrix remodeling

  2001cited by this paper
• Cell to Cell Communication in Response to Mechanical Stress via Bilateral Release of Atp and Utp in Polarized Epithelia

  2000cited by this paper
• Molecular responses of rat tracheal epithelial cells to transmembrane pressure.

  2000cited by this paper
• Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor.

  1999cited by this paper
• Expression of c-erbB receptors and ligands in human bronchial mucosa.

  1999cited by this paper
• EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

  1999cited by this paper
• Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals.

  1998cited by this paper
• Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.

  1998cited by this paper
• Signal transduction of mechanical stresses in the vascular wall.

  1998cited by this paper
• Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals.

  1998cited by this paper
• On the mechanism of mucosal folding in normal and asthmatic airways.

  1997cited by this paper
• Fluid flow rapidly activates G proteins in human endothelial cells. Involvement of G proteins in mechanochemical signal transduction.

  1996cited by this paper
• Mechanisms of flow-mediated signal transduction in endothelial cells: kinetics of ATP surface concentrations.

  1992cited by this paper
• Changes in permeability of dog tracheal epithelium in response to hydrostatic pressure.

  1992cited by this paper
• Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma.

  1992cited by this paper
• Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs.

  1990cited by this paper
• Size and shape of the lateral intercellular spaces in a living epithelium.

  1978cited by this paper
• following articles: Role of Integrins in Endothelial Mechanosensing of Shear Stress Dance Band on the Titanic: Biomechanical Signaling in Cardiac Hypertrophy Spatial Microstimuli in Endothelial Mechanosignaling Dynamic Regulation of Connexins in Connectio

  year unknowncited by this paper
• Correspondence and requests for materials should be addressed to M.L.L. (email:

  year unknowncited by this paper

• Just a little prick: careful cell contacts enabled by ceramic nanostraws

  2026cites this paper
• Mechanoresponsive Biomaterials: Principles, Mechanisms, and Applications.

  2026cites this paper
• Beyond the membrane: rethinking EGFR signaling in physiology and cancer

  2026cites this paper
• Hic-5 transduces mechanical force that drives a vicious cycle of bronchoconstriction

  2025cites this paper
• MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation

  2025cites this paper
• De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

  2025cites this paper
• Oligodendroglial changes in AGINGageing human white matter

  2025cites this paper
• ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells.

  2025cites this paper
• Risk factors and management of lung cancer in idiopathic pulmonary fibrosis: A comprehensive review

  2025cites this paper
• Visualizing pulmonary pathologies using smart molecular fluorescent probes

  2025cites this paper
• Microdevice for confinement of T-cells on functionalized bio-interfaces

  2025cites this paper
• Piezo1 Agonist Yoda1 Induces Rapid Relaxation in Cultured Airway Smooth Muscle Cells and Bronchodilation in Mouse Models.

  2025cites this paper
• Hic-5 drives epithelial mechanotransduction promoting a feed-forward cycle of bronchoconstriction

  2025cites this paper
• An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility

  2024cites this paper
• Forcing the code: tension modulates signaling to drive morphogenesis and malignancy

  2024cites this paper
• Epithelial cells crowded out in asthma

  2024cites this paper
• Pulling the strings on solid-to-liquid phase transitions in cell collectives.

  2024cites this paper
• Modelling and targeting mechanical forces in organ fibrosis

  2024cites this paper
• Mechanotransduction and the extracellular matrix: Key drivers of lung pathologies and drug responsiveness.

  2024cites this paper
• Identifying Super-Responders: a Review of the Road to Asthma Remission.

  2024cites this paper
• A map of signaling responses in the human airway epithelium.

  2024cites this paper
• Collagen Tubular Airway-on-Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics

  2023cites this paper
• Mechanical forces suppress antiviral innate immune responses from asthmatic airway epithelial cells following rhinovirus infection

  2023cites this paper
• Amphiregulin in infectious diseases: Role, mechanism, and potential therapeutic targets.

  2023cites this paper
• A gel-coated air-liquid-interface culture system with tunable substrate stiffness matching healthy and diseased lung tissues

  2023cites this paper
• A life off the beaten track in biomechanics: Imperfect elasticity, cytoskeletal glassiness, and epithelial unjamming.

  2023cites this paper
• Long-Term Radiological Pulmonary Changes in Mechanically Ventilated Patients with Respiratory Failure due to SARS-CoV-2 Infection

  2023cites this paper
• Piezo1 activates noncanonical EGFR endocytosis and signaling

  2023influential citation
• Chemical Activation of Piezo1 Alters Biomechanical Behaviors toward Relaxation of Cultured Airway Smooth Muscle Cells.

  2023cites this paper
• ERS International Congress 2022: highlights from the Basic and Translational Science Assembly

  2023cites this paper
• Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease

  2023cites this paper
• Emerging roles and mechanisms of ERK pathway mechanosensing

  2023influential citation
• Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research

  2023cites this paper
• Quantification of basal stem cell elongation and stress fiber accumulation in the pseudostratified airway epithelium during the unjamming transition

  2023cites this paper
• Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma

  2022cites this paper
• In airway epithelium, basal stem cells and their stress fibers remodel during the unjamming transition

  2022cites this paper
• A map of signaling responses in the human airway epithelium

  2022cites this paper
• Airway smooth muscle function in asthma

  2022cites this paper
• Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3

  2022cites this paper
• Mechanical Compression of Human Airway Epithelial Cells Induces Release of Extracellular Vesicles Containing Tenascin C

  2022cites this paper
• Mechanical forces: The missing link between idiopathic pulmonary fibrosis and lung cancer.

  2022cites this paper
• Localization of multiple hydrogels with MultiCUBE platform spatially guides 3D tissue morphogenesis in vitro

  2022cites this paper
• Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum

  2021influential citation
• A dynamical model of TGF-β activation in asthmatic airways

  2021cites this paper
• Soft robotic constrictor for in vitro modeling of dynamic tissue compression

  2021cites this paper
• Signaling and Control

  2021cites this paper
• Stretch-activated calcium mobilization in airway smooth muscle and pathophysiology of asthma

  2021cites this paper
• Modulating Cellular Responses to Mechanical Forces to Promote Wound Regeneration

  2021cites this paper
• Mechanical compression enhances ciliary beating through cytoskeleton remodeling in human nasal epithelial cells.

  2021cites this paper
• Tissue mechanics in stem cell fate, development, and cancer.

  2021cites this paper
• A Mouse Model to Investigate the Role of Cancer-associated Fibroblasts in Tumor Growth.

  2020cites this paper
• Functional genomic analyses highlights a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells (OPC) and underlying myelin dysregulation in the aged forebrain

  2020influential citation
• Airway mechanical compression: its role in asthma pathogenesis and progression

  2020cites this paper
• Bronchoconstriction: a potential missing link in airway remodelling

  2020influential citation
• In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition

  2020cites this paper
• The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma

  2020cites this paper
• Frustration of endocytosis potentiates compression-induced receptor signaling

  2020cites this paper
• Asthma

  2020cites this paper
• Genomic signatures of the unjamming transition in compressed human bronchial epithelial cells

  2020influential citation
• Airway Remodeling in Asthma

  2020cites this paper
• Compressive stress induces collective migration through cytoskeletal remodelling in nasal polyp epithelium.

  2020cites this paper
• Mechanical Forces as Determinants of Disseminated Metastatic Cell Fate

  2020cites this paper
• Developmentally-Inspired Biomimetic Culture Models to Produce Functional Islet-Like Cells From Pluripotent Precursors

  2020cites this paper
• Mechanical forces induce an asthma gene signature in healthy airway epithelial cells

  2020cites this paper
• Endocytosis frustration potentiates compression-induced receptor signalling.

  2020cites this paper
• Elevated extracellular maspin after mechanical compression in vitro or allergen challenges in vivo

  2019cites this paper
• Development of an in vitro Experimental Model for Investigating the Effect of Matrix Stiffness on Epithelial Barrier Permeability

  2019cites this paper
• Integrated lung tissue mechanics one piece at a time: Computational modeling across the scales of biology.

  2019cites this paper
• Electrostatic switching of nuclear basket conformations provides a potential mechanism for nuclear mechanotransduction

  2019cites this paper
• A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm

  2019cites this paper
• Mentoring and Education: A Lifetime of Experience and Learning.

  2019cites this paper
• Dying under pressure: cellular characterisation and in vivo functions of cell death induced by compaction

  2019cites this paper
• Elevated extracellular maspin after mechanical compression in vitro or allergen challenges in vivo.

  2019cites this paper
• The unjamming transition is distinct from the epithelial-to-mesenchymal transition

  2019cites this paper
• The Aftermath of Bronchoconstriction

  2019cites this paper
• Lung-Seeking Metastases

  2019cites this paper
• Endocytosis frustration potentiates compression-induced receptor signaling

  2019influential citation
• A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling

  2018cites this paper
• Possible involvement of acetylcholine-mediated inflammation in airway diseases.

  2018cites this paper
• The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle

  2018cites this paper
• Giants in Chest Medicine: Jeffrey M. Drazen, MD, FCCP.

  2018cites this paper
• Extracellular matrix deposited by Wharton's jelly mesenchymal stem cells enhances cell expansion and tissue specific lineage potential.

  2018cites this paper
• Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation

  2018cites this paper
• Inflammatory insights into airway remodelling in asthma

  2018cites this paper
• Phenotypic Basis for Matrix Stiffness-Dependent Chemoresistance of Breast Cancer Cells to Doxorubicin

  2018cites this paper
• Transportation in the Brain Extracellular Space of the Rat Brain Can Be Regulated by Neuronal Activity

  2018cites this paper
• Theory of mechanochemical patterning in biphasic biological tissues

  2018cites this paper
• Mechanical Regulation of Microvascular Growth and Remodeling

  2018cites this paper
• Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling.

  2017cites this paper
• Geometric constraints during epithelial jamming

  2017cites this paper
• Rat Liver Enzyme Release Depends on Blood Flow-Bearing Physical Forces Acting in Endothelium Glycocalyx rather than on Liver Damage

  2017cites this paper
• Hyperresponsiveness: Relating the Intact Airway to the Whole Lung.

  2017cites this paper
• Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

  2017cites this paper
• Conceptual and Experimental Tools to Understand Spatial Effects and Transport Phenomena in Nonlinear Biochemical Networks Illustrated with Patchy Switching.

  2017influential citation
• Integrating the glioblastoma microenvironment into engineered experimental models

  2017cites this paper
• Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches

  2017cites this paper
• In vitro 3D bone tissue models, from cells to controlled and dynamic environment

  2017cites this paper
• Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

  2017cites this paper
• Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.

  2017cites this paper
• Structure and Function of Cartilage

  2017cites this paper