CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

This study addresses the mechanisms by which CHOP directs gene regulatory networks and determines cell fate. Transcriptional expression of ATF5 is activated by both CHOP and ATF4 in the integrated stress response. CHOP and ATF5 control a switch to activate apoptotic genes and decrease cell survival in response to loss of proteostatic control.

• Publication year

  2013

• Venue

  Molecular Biology of the Cell

• Publication date

  2013-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E13-01-0067PMID 23761072PMCID 3727939
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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