Corticostriatal neurones in auditory cortex drive decisions during auditory discrimination

The neural pathways by which information about the acoustic world reaches the auditory cortex are well characterized, but how auditory representations are transformed into motor commands is not known. Here we use a perceptual decision-making task in rats to study this transformation. We demonstrate the role of corticostriatal projection neurons in auditory decisions by manipulating the activity of these neurons in rats performing an auditory frequency-discrimination task. Targeted channelrhodopsin-2 (ChR2)-mediated stimulation of corticostriatal neurons during the task biased decisions in the direction predicted by the frequency tuning of the stimulated neurons, whereas archaerhodopsin-3 (Arch)-mediated inactivation biased decisions in the opposite direction. Striatal projections are widespread in cortex and may provide a general mechanism for the control of motor decisions by sensory cortex.

• Publication year

  2013

• Venue

  Nature

• Publication date

  2013-04-17

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1038/nature12077PMID 23636333PMCID 3670751
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1992cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1988cited by this paper
• Auditory cortical field projections to the basal ganglia of the cat.

  1983cited by this paper
• Efferent connections of the substantia nigra and ventral tegmental area in the rat.

  1979cited by this paper
• Auditory sensitivity of the albino rat.

  1976cited by this paper
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