The Hedgehog and Wnt signalling pathways in cancer

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Nature

• Publication date

  2001-05-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/35077219PMID 11357142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

  2001cited by this paper
• The Metabolic and Molecular Bases of Inherited Disease

  2001cited by this paper
• The developmental biology of brain tumors.

  2001cited by this paper
• Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

  2001cited by this paper
• Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

  2000cited by this paper
• Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.

  2000cited by this paper
• TGFbeta signaling in growth control, cancer, and heritable disorders.

  2000cited by this paper
• Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.

  2000cited by this paper
• WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

  2000cited by this paper
• An LDL-receptor-related protein mediates Wnt signalling in mice

  2000cited by this paper
• Feedback control of intercellular signalling in development

  2000cited by this paper
• More surprises in the Hedgehog signaling pathway.

  2000cited by this paper
• Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.

  2000cited by this paper
• Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila.

  2000cited by this paper
• The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.

  2000cited by this paper
• Stem Cells A New Lease on Life

  2000cited by this paper
• Mechanism-based target identification and drug discovery in cancer research.

  2000cited by this paper
• Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas.

  2000cited by this paper
• Transducing the hedgehog signal.

  2000cited by this paper
• Wnt signaling and cancer.

  2000cited by this paper
• A Role for p27/Kip1 in the Control of Cerebellar Granule Cell Precursor Proliferation

  2000cited by this paper
• Linking colorectal cancer to Wnt signaling.

  2000cited by this paper
• Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors

  2000cited by this paper
• The Hallmarks of Cancer Review

  2000cited by this paper
• Gut instincts: thoughts on intestinal epithelial stem cells.

  2000cited by this paper
• Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.

  2000cited by this paper
• Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.

  2000cited by this paper
• A niche maintaining germ line stem cells in the Drosophila ovary.

  2000cited by this paper
• Activation of β-catenin in epithelial and mesenchymal hepatoblastomas

  2000cited by this paper
• Transmembrane molecular pump activity of Niemann-Pick C1 protein.

  2000cited by this paper
• Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.

  1999cited by this paper
• Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor)

  1999cited by this paper
• Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog.

  1999cited by this paper
• Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle

  1999cited by this paper
• Cell-cycle inhibitor p27/Kip-1 expression in non-astrocytic and non-oligodendrocytic human nervous system tumors.

  1999cited by this paper
• A frequent activated smoothened mutation in sporadic basal cell carcinomas

  1999cited by this paper
• Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression.

  1999cited by this paper
• Creation of human tumour cells with defined genetic elements

  1999cited by this paper
• Size Control in Animal Development Review and Enlarge) and Duplicate Their Contents before They

  1999cited by this paper
• Transducing Hedgehog: the story so far

  1998cited by this paper
• Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

  1998cited by this paper
• Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.

  1998cited by this paper
• Mechanisms of Wnt signaling in development.

  1998cited by this paper
• Sonic hedgehog signaling is essential for hair development.

  1998cited by this paper
• Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog*

  1998cited by this paper
• Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

  1998cited by this paper
• Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

  1998cited by this paper
• Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.

  1998cited by this paper
• Hedgehog and patched in neural development and disease.

  1998cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• Skin precancer.

  1998cited by this paper
• Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer

  1998cited by this paper
• Activating Smoothened mutations in sporadic basal-cell carcinoma

  1998cited by this paper
• Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

  1997cited by this paper
• Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor.

  1997cited by this paper
• Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

  1997cited by this paper
• Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

  1997cited by this paper
• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  1997cited by this paper
• Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

  1996cited by this paper
• Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

  1996cited by this paper
• Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome

  1996cited by this paper
• Post-irradiation somatic mutation and clonal stabilisation time in the human colon.

  1996cited by this paper
• Frequent clones of p53-mutated keratinocytes in normal human skin.

  1996cited by this paper
• Lessons from Hereditary Review Colorectal Cancer

  1996cited by this paper
• Functional interaction of beta-catenin with the transcription factor LEF-1.

  1996cited by this paper
• Embryonic precursor cells from the rhombic lip are specified to a cerebellar granule neuron identity.

  1996cited by this paper
• Functional interaction of β-catenin with the transcription factor LEF-1

  1996cited by this paper
• The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

  1996cited by this paper
• A new member of the frizzled family from Drosophila functions as a Wingless receptor

  1996cited by this paper
• Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.

  1992cited by this paper
• The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

  1992cited by this paper
• Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

  1982cited by this paper
• China: the legacy of the Cultural Revolution

  1979cited by this paper

• Broadening horizons: new links between cilia and heart development and disease.

  2026cites this paper
• Languages of Hereditary Information Unfolding in Development: Linguistic Analogies and Semiotic Aspects.

  2025cites this paper
• The role of Sonic Hedgehog (SHH) in the formation of motor neurons and neurodegenerative diseases

  2025cites this paper
• Evaluation of Sonidegib Cytoreductive Activity in Locally Advanced Basal Cell Carcinoma Treatment: A Delphi Consensus

  2025cites this paper
• Regulatory Mechanism of Intestinal Stem Cells Based on Hippo Pathway and Signaling Crosstalk in Chicken

  2025cites this paper
• Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression

  2025cites this paper
• Cancer stem cells in hepatocellular carcinoma: therapy resistance and emerging treatments

  2025cites this paper
• Unveiling role of oncogenic signalling pathways in complicating breast cancer

  2025cites this paper
• Echinochrome A inhibits epithelial–mesenchymal transition and induces cell death mediated by DNA damage in human triple-negative breast cancer cells

  2025cites this paper
• Role of Aberrant GLI as a Biomarker and Signaling Pathway in Cancers

  2025cites this paper
• DNA-guided transcription factor interactions extend human gene regulatory code

  2025cites this paper
• Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer.

  2025cites this paper
• Demethylase, ALKBH1, regulates osteosarcoma chemosensitivity through FZD8/Wnt/β-catenin signaling pathway in the m7G manner.

  2025cites this paper
• Mechanical force-driven cell competition ensures robust morphogen gradient formation.

  2025cites this paper
• Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies

  2025influential citation
• G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa

  2025cites this paper
• The β-1,4 GalT-V Interactome—Potential Therapeutic Targets and a Network of Pathways Driving Cancer and Cardiovascular and Inflammatory Diseases

  2025cites this paper
• Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila

  2025cites this paper
• ETEC heat-labile toxin promotes β-catenin stabilization and transcriptional reprogramming to disrupt intestinal epithelial differentiation

  2025cites this paper
• Low-grade endometrial stroma-like sarcoma with smooth-muscle-like differentiation, DOG1 expression and JAZF1::SUZ12 fusion in a male patient

  2025cites this paper
• THE PATTERNING AND PROLIFERATION ROLES OF SHH ARE PARTITIONED ON DISTINCT EXOSOMES.

  2025cites this paper
• Bacterial Lipopolysaccharide Induces PD-L1 Expression and an Invasive Phenotype of Oral Squamous Cell Carcinoma Cells

  2024cites this paper
• Safety and Effectiveness of Perioperative Hyperthermic Intraperitoneal Chemotherapy with Gemcitabine in Patients with Resected Pancreatic Ductal Adenocarcinoma: Clinical Trial EudraCT 2016-004298-41

  2024cites this paper
• Inflammation-Associated Stem Cells in Gastrointestinal Cancers: Their Utility as Prognostic Biomarkers and Therapeutic Targets

  2024cites this paper
• Epidermal stem cells: skin surveillance and clinical perspective

  2024cites this paper
• Structural Simplification of Osimertinib to elaborate new indolyle-pyrimidine-5-carbonitrile derivatives with Anti-proliferative and Anti-SARS-CoV-2 activities assisted by molecular dynamic simulation

  2024cites this paper
• Exploring the role of the Rab network in epithelial-to-mesenchymal transition

  2024cites this paper
• Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation

  2024cites this paper
• RGD Density on Tadpole Nanostructures Regulates Cancer Stem Cell Proliferation and Stemness.

  2024cites this paper
• Aberrant stem cell and developmental programs in pediatric leukemia

  2024cites this paper
• Reconstruction of single-cell lineage trajectories and identification of diversity in fates during the epithelial-to-mesenchymal transition

  2024cites this paper
• Dual role of pregnancy in breast cancer risk.

  2024cites this paper
• Inhibition of PCSK9: A Promising Enhancer for Anti-PD-1/PD-L1 Immunotherapy

  2024cites this paper
• Unravelling the Mysteries of the Sonic Hedgehog Pathway in Cancer Stem Cells: Activity, Crosstalk and Regulation

  2024cites this paper
• Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis

  2023cites this paper
• The potential relevance of long non-coding RNAs in colorectal cancer pathogenesis and treatment: A review focus on signaling pathways.

  2023cites this paper
• Dual role of CASP8AP2/FLASH in regulating epithelial-to-mesenchymal transition plasticity (EMP)

  2023cites this paper
• Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development

  2023influential citation
• Transition-metal catalyzed C-H activation as a means of synthesizing complex natural products.

  2023cites this paper
• Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases

  2023cites this paper
• Transcriptome analysis reveals molecular mechanisms of lymphocystis formation caused by lymphocystis disease virus infection in flounder (Paralichthys olivaceus)

  2023cites this paper
• Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.

  2023cites this paper
• DESIGN, PREPARATION, AND IN SILICO STUDY OF NOVEL CURCUMIN-BIPHENYL CARBONITRILE CONJUGATE AS NOVEL ANTICANCER DRUG MOLECULES

  2023cites this paper
• HIB/SPOP inhibits Ci/Gli-mediated tumorigenesis by modulating the RNA Polymerase II components stabilities

  2023cites this paper
• Developmental competence of IVF and SCNT goat embryos is improved by inhibition of canonical WNT signaling

  2023cites this paper
• Dietary phytochemicals and cancer chemoprevention

  2023cites this paper
• Modulatory effect of rupatadine on mesenchymal stem cell-derived exosomes in hepatic fibrosis in rats: A potential role for miR-200a.

  2023cites this paper
• B13, a well-tolerated inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against colorectal carcinoma in vitro and in vivo.

  2023cites this paper
• The healing effects of thymoquinone on experimentally induced traumatic tendinopathy in rabbits

  2023cites this paper
• Molecular mechanisms of endothelial remodeling under doxorubicin treatment.

  2023cites this paper
• Cellular and molecular mechanisms of Hedgehog signalling

  2023cites this paper
• PF-04449913 Inhibits Proliferation and Metastasis of Colorectal Cancer Cells by Down-regulating MMP9 Expression through the ERK/p65 Pathway.

  2023cites this paper
• Understanding the Roles of the Hedgehog Signaling Pathway during T-Cell Lymphopoiesis and in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

  2023cites this paper
• Neuroendocrine Neoplasms: Genetics and Epigenetics.

  2023cites this paper
• Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action

  2023cites this paper
• Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells

  2023cites this paper
• Dual role of CASP8AP2/FLASH in regulating epithelial-to-mesenchymal (EMT) plasticity

  2023cites this paper
• Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability

  2023cites this paper
• Regulation of Cell Plasticity by Bromodomain and Extraterminal Domain (BET) Proteins: A New Perspective in Glioblastoma Therapy

  2023cites this paper
• Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity

  2022cites this paper
• Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer

  2022cites this paper
• Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma: A Retrospective Study

  2022cites this paper
• Expression of the hedgehog signaling pathway and the effect of inhibition at the level of Smoothened in canine osteosarcoma cell lines.

  2022cites this paper
• Arachidonate 15-lipoxygenase is required for chronic myeloid Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival leukemia stem cell survival Let us know how access to this document benefits you.

  2022cites this paper
• Mechanisms and inhibition of Porcupine-mediated Wnt acylation

  2022cites this paper
• Cellular crosstalk during liver regeneration: unity in diversity

  2022cites this paper
• Quantum dots bind nanosheet to promote nanomaterial stability and resist endotoxin-induced fibrosis and PM2.5-induced pneumonia.

  2022cites this paper
• Impaired Wnt/beta‐catenin and protein patched homolog 1 signaling in extraocular sebaceous carcinoma: A clinical and histopathological study

  2022cites this paper
• The antitumour activity of C21 steroidal glycosides and their derivatives of Baishouwu: A review.

  2022cites this paper
• Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling

  2022cites this paper
• Mechanism of cancer stemness maintenance in human liver cancer

  2022cites this paper
• Dose-dependent phosphorylation and activation of Hh pathway transcription factors

  2022cites this paper
• PKD-1 Signaling Is Required for the Maintenance of CSCs with Epithelial-mesenchymal Plasticity in Pancreatic Neuroendocrine Tumors

  2022cites this paper
• N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-catenin pathway in nasopharyngeal carcinoma

  2022cites this paper
• The Potential for Natural Products to Overcome Cancer Drug Resistance by Modulation of Epithelial-Mesenchymal Transition

  2022cites this paper
• Role of sonic hedgehog ligand in gastric cancer therapeutics

  2022cites this paper
• Emerging mechanisms progress of colorectal cancer liver metastasis

  2022cites this paper
• Pyrvinium Pamoate: Past, Present, and Future as an Anti-Cancer Drug

  2022cites this paper
• Protein Kinase D1 Signaling in Cancer Stem Cells with Epithelial-Mesenchymal Plasticity

  2022cites this paper
• DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy

  2022cites this paper
• Developing therapeutic approaches for chronic myeloid leukemia: a review

  2022cites this paper
• The Cross-Talk between Epigenetic Gene Regulation and Signaling Pathways Regulates Cancer Pathogenesis.

  2022cites this paper
• Role of Hedgehog and Hippo signaling pathways in cancer: A special focus on non-coding RNAs.

  2022cites this paper
• Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.

  2022cites this paper
• Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney Disease–Induced Myocardial Fibrosis by Activating the Sonic Hedgehog Signaling Pathway

  2022cites this paper
• Lineage-specific oncogenes drive growth of major forms of human cancer using common downstream mechanisms

  2022cites this paper
• Repurposing antifungal drugs for cancer therapy

  2022cites this paper
• Homeostases of epidermis and hair follicle, and development of basal cell carcinoma.

  2022cites this paper
• Emerging Prospects for the Study of Colorectal Cancer Stem Cells using Patient-Derived Organoids.

  2022cites this paper
• Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways

  2022cites this paper
• Hedgehog signaling mechanism and role in cancer.

  2021cites this paper
• Aniridia-related keratopathy relevant cell signaling pathways in human fetal corneas

  2021cites this paper
• Pancreatic cancer.

  2021cites this paper
• Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway

  2021cites this paper
• Wnt/β-catenin Pathway, PTEN/PI3K/AKT Pathway, RAS/Raf/Epidermal Growth Factor Receptor/Mitogen-activated Protein Kinases Pathway, and Nuclear Factor Kappa B in Colorectal Cancer Treatment and Management

  2021cites this paper
• RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

  2021cites this paper
• Glasdegib in newly diagnosed acute myeloid leukemia

  2021cites this paper
• Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

  2021cites this paper
• Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model

  2021cites this paper
• Measurement of activity of developmental signal transduction pathways to quantify stem cell pluripotency and phenotypically characterize differentiated cells

  2021cites this paper