Critical Role of Conserved Hydrophobic Residues within the Major Homology Region in Mature Retroviral Capsid Assembly

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Virology

• Publication date

  2008-04-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JVI.00214-08PMID 18400856PMCID PMC2395126
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Solution structure of a double mutant of the carboxy-terminal dimerization domain of the HIV-1 capsid protein.

  2008cited by this paper
• Cooperative role of the MHR and the CA dimerization helix in the maturation of the functional retrovirus capsid.

  2008influential reference
• RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis.

  2008cited by this paper
• Envelope lipids regulate the in vitro assembly of the HIV-1 capsid.

  2008cited by this paper
• Structure of full-length HIV-1 CA: a model for the mature capsid lattice.

  2007cited by this paper
• Genetic Studies of the beta-hairpin loop of Rous sarcoma virus capsid protein.

  2007cited by this paper
• Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein.

  2007cited by this paper
• Flexibility in HIV-1 assembly subunits: solution structure of the monomeric C-terminal domain of the capsid protein.

  2007cited by this paper
• Electron cryotomography of immature HIV‐1 virions reveals the structure of the CA and SP1 Gag shells

  2007cited by this paper
• Ty3 Capsid Mutations Reveal Early and Late Functions of the Amino-Terminal Domain

  2007cited by this paper
• Domain-swapped dimerization of the HIV-1 capsid C-terminal domain

  2007influential reference
• Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3′,3′-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection

  2007cited by this paper
• The mechanism of HIV-1 core assembly: insights from three-dimensional reconstructions of authentic virions.

  2006cited by this paper
• 3-O-(3′,3′-Dimethysuccinyl) Betulinic Acid Inhibits Maturation of the Human Immunodeficiency Virus Type 1 Gag Precursor Assembled In Vitro

  2006cited by this paper
• Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag.

  2006cited by this paper
• Genetic Studies of the β-Hairpin Loop of Rous Sarcoma Virus Capsid Protein

  2006cited by this paper
• Cryo-electron microscopy reveals conserved and divergent features of gag packing in immature particles of Rous sarcoma virus and human immunodeficiency virus.

  2006cited by this paper
• Continuum theory of retroviral capsids.

  2006cited by this paper
• Binding of the C-terminal domain of the HIV-1 capsid protein to lipid membranes: a biophysical characterization.

  2006cited by this paper
• Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain.

  2005cited by this paper
• Electrostatic interactions govern both nucleation and elongation during phage P22 procapsid assembly.

  2005cited by this paper
• Three-dimensional structure of HIV-1 virus-like particles by electron cryotomography.

  2005cited by this paper
• The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor

  2005cited by this paper
• Domain swapping and retroviral assembly.

  2005cited by this paper
• A peptide inhibitor of HIV-1 assembly in vitro

  2005cited by this paper
• Effect of Macromolecular Crowding Agents on Human Immunodeficiency Virus Type 1 Capsid Protein Assembly In Vitro

  2005cited by this paper
• The Retroviral Capsid Domain Dictates Virion Size, Morphology, and Coassembly of Gag into Virus-Like Particles

  2005cited by this paper
• Analysis of Human Immunodeficiency Virus Type 1 Gag Dimerization-Induced Assembly

  2005cited by this paper
• Protein production by auto-induction in high density shaking cultures.

  2005cited by this paper
• Structural and Dynamics Studies of the D54A Mutant of Human T Cell Leukemia Virus-1 Capsid Protein*

  2005cited by this paper
• Key interactions in HIV-1 maturation identified by hydrogen-deuterium exchange

  2004influential reference
• High-resolution structure of a retroviral capsid hexameric amino-terminal domain

  2004cited by this paper
• Dimeric rous sarcoma virus capsid protein structure relevant to immature Gag assembly.

  2004cited by this paper
• The stoichiometry of Gag protein in HIV-1

  2004cited by this paper
• Computation and Analysis of Protein Circular Dichroism Spectra

  2004cited by this paper
• Assembly Properties of the Human Immunodeficiency Virus Type 1 CA Protein

  2004cited by this paper
• Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein

  2003cited by this paper
• Antiviral inhibition of the HIV-1 capsid protein.

  2003cited by this paper
• Retrovirus capsid protein assembly arrangements.

  2003cited by this paper
• PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing

  2003cited by this paper
• Structural organization of authentic, mature HIV‐1 virions and cores

  2003cited by this paper
• Three‐dimensional structure of the M‐MuLV CA protein on a lipid monolayer: a general model for retroviral capsid assembly

  2003cited by this paper
• Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometry.

  2003influential reference
• Formation of a Human Immunodeficiency Virus Type 1 Core of Optimal Stability Is Crucial for Viral Replication

  2002cited by this paper
• Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein

  2002cited by this paper
• Kinetic Analysis of the Role of Intersubunit Interactions in Human Immunodeficiency Virus Type 1 Capsid Protein Assembly In Vitro

  2002cited by this paper
• Analysis of Rous sarcoma virus capsid protein variants assembled on lipid monolayers.

  2002cited by this paper
• Organization of Immature Human Immunodeficiency Virus Type 1

  2001cited by this paper
• Second-Site Suppressors of Rous Sarcoma Virus CA Mutations: Evidence for Interdomain Interactions

  2001influential reference
• Structural analysis of the N-terminal domain of the human T-cell leukemia virus capsid protein.

  2001cited by this paper
• The organization of mature Rous sarcoma virus as studied by cryoelectron microscopy.

  2001cited by this paper
• Viral DNA Synthesis Defects in Assembly-Competent Rous Sarcoma Virus CA Mutants

  2001cited by this paper
• Human Immunodeficiency Virus Type 1 N-Terminal Capsid Mutants That Exhibit Aberrant Core Morphology and Are Blocked in Initiation of Reverse Transcription in Infected Cells

  2001cited by this paper
• Solution structure and dynamics of the Rous sarcoma virus capsid protein and comparison with capsid proteins of other retroviruses.

  2000influential reference
• A conformational switch controlling HIV‐1 morphogenesis

  2000cited by this paper
• Image reconstructions of helical assemblies of the HIV-1 CA protein

  2000influential reference
• Structure and self-association of the Rous sarcoma virus capsid protein.

  2000influential reference
• Biochemical and Structural Analysis of Isolated Mature Cores of Human Immunodeficiency Virus Type 1

  2000cited by this paper
• Properties and crystal structure of a beta-barrel folding mutant.

  2000cited by this paper
• Properties and Crystal Structure of a -Barrel Folding Mutant

  2000cited by this paper
• Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26.

  1999cited by this paper
• Head‐to‐tail dimers and interdomain flexibility revealed by the crystal structure of HIV‐1 capsid protein (p24) complexed with a monoclonal antibody Fab

  1999cited by this paper
• Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.

  1999cited by this paper
• Solution structure of the capsid protein from the human T-cell leukemia virus type-I.

  1999influential reference
• Assembly and analysis of conical models for the HIV-1 core.

  1999cited by this paper
• Genetic Determinants of Rous Sarcoma Virus Particle Size

  1998cited by this paper
• Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: implications for retroviral assembly mechanisms.

  1998cited by this paper
• Proteolytic refolding of the HIV‐1 capsid protein amino‐terminus facilitates viral core assembly

  1998influential reference
• In vitro assembly of virus-like particles with Rous sarcoma virus Gag deletion mutants: identification of the p10 domain as a morphological determinant in the formation of spherical particles

  1997cited by this paper
• Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.

  1997influential reference
• In vitro assembly properties of purified bacterially expressed capsid proteins of human immunodeficiency virus.

  1997cited by this paper
• Crystals of Rous sarcoma virus capsid protein show a helical arrangement of protein subunits.

  1997cited by this paper
• Mutations in the Ty3 major homology region affect multiple steps in Ty3 retrotransposition

  1996cited by this paper
• Structure of the Amino-Terminal Core Domain of the HIV-1 Capsid Protein

  1996cited by this paper
• Genetic analysis of the major homology region of the Rous sarcoma virus Gag protein

  1995influential reference
• Differential proteolytic processing leads to multiple forms of the CA protein in avian sarcoma and leukemia viruses

  1995cited by this paper
• Role of the major homology region of human immunodeficiency virus type 1 in virion morphogenesis

  1994cited by this paper
• Nucleation and growth phases in the polymerization of coat and scaffolding subunits into icosahedral procapsid shells.

  1993cited by this paper
• Mutational analysis of the major homology region of Mason-Pfizer monkey virus by use of saturation mutagenesis

  1992cited by this paper
• Modeling of the Bacterial Growth Curve

  1990cited by this paper
• Mechanism of microtubule assembly. Changes in polymer structure and organization during assembly of sea urchin egg tubulin.

  1985cited by this paper
• Kinetics and mechanism of tobacco mosaic virus assembly: direct measurement of relative rates of incorporation of 4S and 20S protein.

  1979cited by this paper
• Interpretation of the light scattering from long rods.

  1974cited by this paper
• Studies on the morphopoiesis of the head of phage T-even

  1968cited by this paper
• Studies on the morphopoiesis of the head of phage T-even. I. Morphological, immunological, and genetic characterization of polyheads.

  1965cited by this paper
• Biological Crystallography Structures of the Hiv-1 Capsid Protein Dimerization Domain at 2.6 a Ê Resolution

  year unknowncited by this paper

• Determinants in the HTLV-1 capsid major homology region that are critical for virus particle assembly

  2024cites this paper
• Endogenous capsid-forming protein ARC for self-assembling nanoparticle vaccines

  2024cites this paper
• The Rous sarcoma virus Gag polyprotein forms biomolecular condensates driven by intrinsically-disordered regions.

  2023cites this paper
• Inositol Phosphates and Retroviral Assembly: A Cellular Perspective

  2021influential citation
• Bottleneck Size-Dependent Changes in the Genetic Diversity and Specific Growth Rate of a Rotavirus A Strain

  2019cites this paper
• The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.

  2018cites this paper
• Genetic Characterization and Phylogenetic Analysis of Small Ruminant Lentiviruses Detected in Spanish Assaf Sheep with Different Mammary Lesions

  2018cites this paper
• Molecular characteristics and prevalence of small ruminant lentiviruses in goats in Japan

  2017cites this paper
• In vitro methods for testing antiviral drugs

  2017cites this paper
• Recent Advances in Electron Crystallography

  2017cites this paper
• Synergic Investigation Of The Self-Assembly Structure And Mechanism Of Retroviral Capsid Proteins By Solid State NMR, Transmission Electron Microscopy And Multiscale simulation

  2017cites this paper
• Biochemical and Genetic Investigation of Immature Murine Leukemia Virus Assembly

  2017cites this paper
• Self-assembly of Rous Sarcoma Virus capsid protein, probed by Solid-state NMR and TEM

  2016cites this paper
• HIV Capsid Assembly, Mechanism, and Structure.

  2016cites this paper
• Contributions of Charged Residues in Structurally Dynamic Capsid Surface Loops to Rous Sarcoma Virus Assembly

  2016cites this paper
• HIV-1 Capsid as a Target for Antiviral Therapy

  2016cites this paper
• Episodic Diversifying Selection Shaped the Genomes of Gibbon Ape Leukemia Virus and Related Gammaretroviruses

  2015cites this paper
• Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins

  2015cites this paper
• Biophysical analysis of the MHR motif in folding and domain swapping of the HIV capsid protein C-terminal domain.

  2015cites this paper
• Potential Role for CA-SP in Nucleating Retroviral Capsid Maturation

  2014influential citation
• In Vitro Assembly of Retroviruses.

  2014cites this paper
• Higher-Order Structure of the Rous Sarcoma Virus SP Assembly Domain

  2014cites this paper
• Lethal mutations in the major homology region and their suppressors act by modulating the dimerization of the rous sarcoma virus capsid protein C‐terminal domain

  2013cites this paper
• One number does not fit all: mapping local variations in resolution in cryo-EM reconstructions.

  2013cites this paper
• Biophysical Characterization of the Feline Immunodeficiency Virus p24 Capsid Protein Conformation and In Vitro Capsid Assembly

  2013cites this paper
• HIV Gag polyprotein: processing and early viral particle assembly.

  2013cites this paper
• A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition

  2013cites this paper
• Equine infectious anemia and equine infectious anemia virus in 2013: a review.

  2013cites this paper
• Assembly and architecture of HIV.

  2012cites this paper
• A structural model for the generation of continuous curvature on the surface of a retroviral capsid.

  2012cites this paper
• The Maturational Refolding of the β-Hairpin Motif of Equine Infectious Anemia Virus Capsid Protein Extends Its Helix α1 at Capsid Assembly Locus

  2012cites this paper
• Structural and Functional Insights into the HIV-1 Maturation Inhibitor Binding Pocket

  2012cites this paper
• The isolated major homology region of the HIV capsid protein is mainly unfolded in solution and binds to the intact protein.

  2011cites this paper
• Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

  2011cites this paper
• Design of in vitro symmetric complexes and analysis by hybrid methods reveal mechanisms of HIV capsid assembly.

  2011cites this paper
• Molekulare Untersuchungen zum Gag-Protein der Foamyviren

  2011cites this paper
• Statistical Mechanical Models Of Virus Capsid Assembly

  2010cites this paper
• STATISTICAL MECHANICAL MODELS OF VIRUS CAPSID

  2010cites this paper
• Directionality of nucleocytoplasmic transport of the retroviral gag protein depends on sequential binding of karyopherins and viral RNA

  2010cites this paper
• Proton-driven Assembly of the Rous Sarcoma Virus Capsid Protein Results in the Formation of Icosahedral Particles*

  2010cites this paper
• Suppression of a Morphogenic Mutant in Rous Sarcoma Virus Capsid Protein by a Second-Site Mutation: a Cryoelectron Tomography Study

  2010influential citation
• Visualization of a Missing Link in Retrovirus Capsid Assembly

  2009cites this paper
• The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly

  2009cites this paper
• Proton-linked dimerization of a retroviral capsid protein initiates capsid assembly.

  2009cites this paper
• Retroviral capsid assembly: a role for the CA dimer in initiation.

  2009cites this paper
• ANALYSIS OF THE ROLES OF THE P10 DOMAIN OF GAG AND OF DIMERIZATION IN ROUS SARCOMA VIRUS ASSEMBLY

  2008influential citation
• A Single Amino Acid Substitution in a Segment of the CA Protein within Gag That Has Similarity to Human Immunodeficiency Virus Type 1 Blocks Infectivity of a Human Endogenous Retrovirus K Provirus in the Human Genome

  2008cites this paper
• Cooperative role of the MHR and the CA dimerization helix in the maturation of the functional retrovirus capsid.

  2008cites this paper