Autologous protein solution inhibits MMP‐13 production by IL‐1β and TNFα‐stimulated human articular chondrocytes

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Orthopaedic Research

• Publication date

  2011-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jor.21384PMID 21437966
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Autologous Conditioned Serum in the Treatment of Orthopedic Diseases

  2012cited by this paper
• Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

  2011influential reference
• Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial

  2010cited by this paper
• Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults.

  2010cited by this paper
• Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions

  2010cited by this paper
• Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis.

  2009cited by this paper
• Systemic effects of intra-articular corticosteroids

  2009cited by this paper
• Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial.

  2008cited by this paper
• IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro.

  2008cited by this paper
• Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism

  2008cited by this paper
• Update on the biology of the chondrocyte and new approaches to treating cartilage diseases.

  2006cited by this paper
• Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.

  2005influential reference
• Hyaluronic acid injections for knee osteoarthritis. Systematic review of the literature.

  2004cited by this paper
• Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing.

  2004influential reference
• Competition between IL-1, IL-1ra and TGF-β1 modulates the response of the ELA4.NOB-1/CTLL bioassay: Implications for clinical investigations

  2004cited by this paper
• Functional interactions between mucosal IL-1, IL-ra and TGF-beta 1 in ulcerative colitis.

  2004cited by this paper
• Anticytokine therapy for osteoarthritis

  2001influential reference
• Corticosteroids alter the differentiated phenotype of articular chondrocytes

  2001cited by this paper
• Basic science of articular cartilage repair.

  2001cited by this paper
• Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis.

  2000influential reference
• The role of the chondrocyte in osteoarthritis.

  2000cited by this paper
• Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways.

  1999cited by this paper
• Interleukin-1 receptor antagonist: a "novel" acute phase protein with antiinflammatory activities.

  1997cited by this paper
• Formation of cartilage-like spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with transforming growth factor-beta 1.

  1995cited by this paper
• Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity.

  1995cited by this paper
• Biochemical characterization of the extracellular domain of the 75-kilodalton tumor necrosis factor receptor.

  1993influential reference
• Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

  1992influential reference
• Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro.

  1991cited by this paper
• Intra-articular steroid injection. A risk-benefit assessment.

  1990cited by this paper
• Intra-Articular Steroid Injection

  1990cited by this paper

• Hand Osteoarthritis: Molecular Mechanisms, Randomized Controlled Trials, and the Future of Targeted Treatment

  2025cites this paper
• Regenerative Medicine: The Next Generation of Autologous Blood Formulations

  2025cites this paper
• Clinical Outcomes and Magnetic Resonance Imaging Evaluation of Autologous Protein Solution Treatment for Knee Osteoarthritis

  2025cites this paper
• Mechanistic Insights and Real-World Evidence of Autologous Protein Solution (APS) in Clinical Use

  2025cites this paper
• 3D-MRI analysis of cartilage thickness changes after PRP injection in medial knee osteoarthritis: A preliminary report

  2025cites this paper
• Personalized Alginate Encapsulation: The Role of Autologous Blood Additives in Parathyroid Cell Transplantation

  2025cites this paper
• Effect of Hyaluronic Acid Compared to Platelet-Rich Plasma as Adjuvants to Bone Marrow Mesenchymal Stem Cell Treatment of Knee Osteoarthritis: Analysis from Two Clinical Trials

  2025cites this paper
• Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies

  2024cites this paper
• Single injection of intra‐articular autologous protein solution in horses with acute interleukin‐1B‐induced synovitis decreases joint pathology scores

  2024cites this paper
• The Implications of Brain-Derived Neurotrophic Factor in the Biological Activities of Platelet-Rich Plasma

  2024cites this paper
• Pathological Site Pain During Injections as a Predictive Sign for Clinical Response in Autologous Protein Solution and Hyaluronic Acid Injections for Knee Osteoarthritis

  2024cites this paper
• Research Progress of Mesenchymal Stem Cell Intra-Articular Injection in the Treatment of Keen Osteoarthritis

  2024cites this paper
• Cigarette smoke extract exacerbates progression of osteoarthritic‐like changes in cartilage explant cultures

  2024cites this paper
• Autologous Protein Solution (APS) and Osteoarthritis of the Knee: A Scoping Review of Current Clinical Evidence

  2024cites this paper
• TNFα-Related Chondrocyte Inflammation Models: A Systematic Review

  2024cites this paper
• Effect of Freeze–Thawing Treatment on Platelet-Rich Plasma Purified with Different Kits

  2024cites this paper
• The effect of intra-articular autologous protein solution on knee osteoarthritis symptoms.

  2024cites this paper
• Clinical results of autologous protein solution injection for knee osteoarthritis with severe disease grade is inferior to mild or moderate grade

  2023cites this paper
• Individual immune cell and cytokine profiles determine platelet-rich plasma composition

  2023cites this paper
• Platelet-Rich Plasma Injection for Thumb Carpometacarpal Joint Osteoarthritis

  2023cites this paper
• A one-health perspective: use of hemoderivative regenerative therapies in canine and equine patients.

  2023cites this paper
• Inotodiol ameliorates the progression of osteoarthritis: An in vitro and in vivo study

  2023cites this paper
• Role of Nigella sativa L. in the Management of Osteoarthritis: A Systematic Review

  2023cites this paper
• Comparative effectiveness of hyaluronic acid, platelet-rich plasma, and platelet-rich fibrin in treating temporomandibular disorders: a systematic review and network meta-analysis

  2023cites this paper
• Equine Autologous Conditioned Serum and Autologous Protein Solution.

  2023cites this paper
• The Effects of the Combination of Rhein and Platelet-Rich Plasma on Human Articular Chondrocytes

  2023cites this paper
• Platelet-rich plasma treatment for talar cartilage repair: a systematic review and meta-analysis

  2023cites this paper
• Patients With Knee Osteoarthritis Who Receive Platelet-Rich Plasma or Bone-Marrow Aspirate Concentrate Injections Have Better Outcomes Than Patients Who Receive Hyaluronic Acid: Systematic Review and Meta-analysis.

  2023cites this paper
• Autologous Protein Solution processing alters lymphoid and myeloid cell populations and modulates gene expression dependent on cell type

  2022cites this paper
• Modalitas Terapi Vitiligo Pada Anak

  2022cites this paper
• Intra-Articular Mesenchymal Stem Cell Injection for Knee Osteoarthritis: Mechanisms and Clinical Evidence

  2022cites this paper
• Combination of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) in the treatment of knee osteoarthritis: a meta-analysis of randomised controlled trials

  2022cites this paper
• In Vitro Anti-Inflammatory and Regenerative Effects of Autologous Conditioned Serum from Dogs with Osteoarthritis

  2022cites this paper
• The mechanism of action of platelet-rich plasma for knee osteoarthritis: a systematic review

  2022cites this paper
• Repair of experimentally induced femoral chondral defect in a rabbit model using Lyophilized growth promoting factor extracted from horse blood platelets (L-GFequina).

  2022cites this paper
• Low-fluence laser-facilitated platelet-rich plasma permeation for treating MRSA-infected wound and photoaging of the skin.

  2021cites this paper
• Potential Mechanism of Action of Current Point-of-Care Autologous Therapy Treatments for Osteoarthritis of the Knee—A Narrative Review

  2021cites this paper
• VMRR_A_286913 53..65

  2021cites this paper
• Autologous Protein Solution Effect on Chondrogenic Differentiation of Mesenchymal Stem Cells from Adipose Tissue and Bone Marrow in an Osteoarthritic Environment

  2021cites this paper
• The Use of Autologous Protein Solution (Pro-Stride®) and Leukocyte-Rich Platelet-Rich Plasma (Restigen®) in Canine Medicine

  2021cites this paper
• High Dose IL-17A Enhances the Antiosteoarthritic Effect of Dental Pulp Mesenchymal Stem Cells by Reducing In ammatory Response and Promoting Chondrocyte Proliferation

  2021cites this paper
• Autologous protein solution: a promising solution for osteoarthritis?

  2021cites this paper
• Evaluation of Autologous Protein Solution Injection for Treatment of Superficial Digital Flexor Tendonitis in an Equine Model

  2021cites this paper
• Comparación de la inyección intraarticular de plasma rico en plaquetas (PRGF®) y ácido hialurónico (Hyalone®) en el tratamiento de las lesiones condrales: estudio clínico prospectivo aleatorizado

  2021cites this paper
• Monograph : Treatment of chondral ulcers Comparison of the intraarticular injection of platelet rich plasma ( PRGF ® ) and hyaluronic acid ( Hyalone ® ) in the treatment of chondral lesions : a randomized , prospective clinical study

  2021cites this paper
• A Critical Overview of the Use of Platelet-Rich Plasma in Equine Medicine Over the Last Decade

  2021cites this paper
• Effect of Platelet-Rich Plasma on M1/M2 Macrophage Polarization

  2021cites this paper
• Quality comparison between two different types of platelet-rich plasma for knee osteoarthritis

  2020cites this paper
• Characteristics of autologous protein solution and leucocyte-poor platelet-rich plasma for the treatment of osteoarthritis of the knee

  2020cites this paper
• Therapeutic effects of combination of platelet lysate and sulfasalazine administration in TNBS-induced colitis in rat.

  2020cites this paper
• Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?

  2020cites this paper
• Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  2020influential citation
• The Usefulness of Platelet-Rich Plasma (PRP) for the Treatment of Vitiligo: State of the Art and Review

  2020cites this paper
• Effects of Autologous Conditioned Serum, Autologous Protein Solution, and Triamcinolone on Inflammatory and Catabolic Gene Expression in Equine Cartilage and Synovial Explants Treated With IL-1β in Co-culture

  2020cites this paper
• Phase II Multicenter Randomized Controlled Clinical Trial on the E cacy of Intra-articular Injection of Autologous Bone Marrow Mesenchymal Stem Cells with Platelet Rich Plasma for the Treatment of Knee Osteoarthritis

  2020cites this paper
• Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis

  2020cites this paper
• The Usefulness of Platelet-Rich Plasma (PRP) for the Treatment of Vitiligo: State of the Art and Review

  2020cites this paper
• Autologous Protein Solution Injections for the Treatment of Knee Osteoarthritis: 3-Year Results

  2020cites this paper
• DDDT_A_239912 1749..1755

  2020cites this paper
• A comparative assessment of Autologous conditioned serum and ozone for knee osteoarthritis treatment: mid-term follow up

  2020cites this paper
• Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology

  2020cites this paper
• Platelet‐Rich Plasma (PRP) From Older Males With Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation

  2019influential citation
• The Concentration of Plasma Provides Additional Bioactive Proteins in Platelet and Autologous Protein Solutions

  2019cites this paper
• Utilizing platelet-rich fibrin bioscaffold at the graft site improves the structure and function of mice ovarian grafts.

  2019cites this paper
• Anti-Inflammatory Effects of Novel Standardized Platelet Rich Plasma Releasates on Knee Osteoarthritic Chondrocytes and Cartilage in Vitro.

  2019cites this paper
• Autologous Interleukin 1 Receptor Antagonist Blood-Derived Products for Knee Osteoarthritis: A Systematic Review.

  2019cites this paper
• Autologous fibrin scaffolds: When platelet- and plasma-derived biomolecules meet fibrin.

  2019cites this paper
• Cell Therapy—a Basic Science Primer for the Sports Medicine Clinician

  2019cites this paper
• Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency

  2019cites this paper
• An exploratory comparison of single intra‐articular injection of platelet‐rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee

  2019cites this paper
• Innovative regenerative medicine in the management of knee OA: The role of Autologous Protein Solution.

  2019cites this paper
• The Effect of Autologous Protein Solution on the Inflammatory Cascade in Stimulated Equine Chondrocytes

  2019cites this paper
• Platelet-Rich Plasma Injection

  2018cites this paper
• Effects of C-myc gene silencing on interleukin-1β-induced rat chondrocyte cell proliferation, apoptosis and cytokine expression

  2018cites this paper
• Platelet-rich Plasma ( PRP ) in Orthopedics and

  2018cites this paper
• Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial

  2018cites this paper
• Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies

  2018cites this paper
• Platelet-Rich Plasma versus Corticosteroid Intra-Articular Injections for the Treatment of Trapeziometacarpal Arthritis: A Prospective Randomized Controlled Clinical Trial

  2018cites this paper
• Non-Operative Regenerative Therapy for Musculoskeletal Disorders

  2018cites this paper
• Macromolecular crowding as a means to assess the effectiveness of chondrogenic media

  2018cites this paper
• Biological Therapies in Canine Sports Medicine

  2018cites this paper
• Human blood‐based anti‐inflammatory solution inhibits osteoarthritis progression in a meniscal‐tear rat study

  2017cites this paper
• Platelets and Inflammatory Disorders of Connective Tissue

  2017cites this paper
• Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial

  2017cites this paper
• Uterine clinical findings, fertility rate, leucocyte migration, and COX-2 protein levels in the endometrial tissue of susceptible mares treated with platelet-rich plasma before and after AI.

  2017cites this paper
• An Autologous Anti-Inflammatory Protein Solution Yielded a Favorable Safety Profile and Significant Pain Relief in an Open-Label Pilot Study of Patients with Osteoarthritis

  2017cites this paper
• An Autologous Anti-Inflammatory Protein Solution Yielded a Favorable Safety Profile and Significant Pain Relief in an Open-Label Pilot Study of Patients with Osteoarthritis.

  2017cites this paper
• Carvacrol ameliorates inflammatory response in interleukin 1β-stimulated human chondrocytes.

  2017cites this paper
• Plasma rich in growth factors to treat Knee Osteoarthritis

  2017cites this paper
• Safety and Treatment Effectiveness of a Single Autologous Protein Solution Injection in Patients with Knee Osteoarthritis

  2016cites this paper
• PRP: Tips for Application in the Musculoskeletal System

  2016cites this paper
• Small Molecules Alone or in Combination to Treat Joint Disease and Progress Toward Gene Therapy

  2016cites this paper
• Safety and Treatment Effectiveness of a Single Autologous Protein Solution Injection in Patients with Knee Osteoarthritis

  2016cites this paper
• White blood cell concentration correlates with increased concentrations of IL-1ra and improvement in WOMAC pain scores in an open-label safety study of autologous protein solution

  2016cites this paper
• Evaluation of a Single Intra-Articular Injection of Autologous Protein Solution for Treatment of Osteoarthritis in a Canine Population.

  2016cites this paper
• Autologous Protein Solution Exhibits Potential to Mitigate Osteoarthritis (OA) Progression in a Human Explant Co-Culture Model

  2016cites this paper
• Clinical Aspects of Regenerative Medicine

  2015cites this paper
• Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes.

  2015cites this paper
• Intra-articular Injection of Autologous Protein Solution for Treatment of Canine Osteoarthritis

  2015cites this paper
• Second Place: Alendronate reverses increases in MMP13 due to IL-1&bgr; stimulation in human chondrocytes in vitro

  2015cites this paper