Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of NutriLife

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/JN/138.1.42PMID 18156402
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women.

  2006cited by this paper
• Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells.

  2006influential reference
• Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans.

  2006cited by this paper
• Olive oil consumption and risk of breast cancer in the Canary Islands: a population-based case–control study

  2006cited by this paper
• Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation.

  2006cited by this paper
• DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide

  2005cited by this paper
• Pocket proteins and cell cycle control

  2005cited by this paper
• Implication of CDK inhibitors p21 and p27 in the differentiation of HL-60 cells.

  2004cited by this paper
• Dietary patterns and risk of breast cancer in the ORDET cohort.

  2004cited by this paper
• Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils.

  2004cited by this paper
• Foods, nutrients and prostate cancer

  2004cited by this paper
• Green Tea Polyphenols Induce Differentiation and Proliferation in Epidermal Keratinocytes

  2003cited by this paper
• Mechanisms involved in the induced differentiation of leukemia cells.

  2003cited by this paper
• Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis

  2002cited by this paper
• Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells

  2002cited by this paper
• Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand)

  2000cited by this paper
• p21(WAF1/Cip1): more than a break to the cell cycle?

  2000cited by this paper
• Diet, metabolic polymorphisms and dna adducts: the EPIC-Italy cross-sectional study.

  2000cited by this paper
• Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.

  2000cited by this paper
• Food groups, oils and butter, and cancer of the oral cavity and pharynx

  1999cited by this paper
• Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol.

  1999cited by this paper
• Nutrients and food groups and large bowel cancer in Europe.

  1999cited by this paper
• Diet and cancer of the prostate: a case‐control study in Greece

  1999cited by this paper
• CDK inhibitors: positive and negative regulators of G1-phase progression.

  1999influential reference
• Overexpression of p21Cip1 or p27Kip1 in the promyelocytic leukemia cell line HL60 accelerates its lineage-specific differentiation.

  1999cited by this paper
• Resveratrol arrests the cell division cycle at S/G2 phase transition.

  1998cited by this paper
• Olive oil, other seasoning fats, and the risk of colorectal carcinoma

  1998cited by this paper
• Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer.

  1998cited by this paper
• Some Perspectives on Dietary Inhibition of Carcinogenesis: Studies with Curcumin and Tea

  1997cited by this paper
• Cancer Cell Cycles

  1996cited by this paper
• Regulation of p21WAF1/CIP1 expression by p53-independent pathways.

  1996cited by this paper
• Tobacco and diet as determinants of survival in male laryngeal cancer patients

  1996cited by this paper
• Olive oil, other dietary fats, and the risk of breast cancer (Italy)

  1995cited by this paper
• Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece.

  1995cited by this paper
• Properties of three proteinases functioning at G1, S and G2 phases in HeLa cells and their inhibition by guanidino- and amidino-acid esters.

  1994cited by this paper
• Dietary fat, olive oil intake and breast cancer risk

  1994cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• Simple and hydrolyzable phenolic compounds in virgin olive oil. 1. Their extraction, separation, and quantitative and semiquantitative evaluation by HPLC

  1992cited by this paper
• Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

  1985cited by this paper

• Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil

  2024cites this paper
• Beneficial Effect of Olive Oil and Its Derivates: Focus on Hematological Neoplasm

  2024cites this paper
• Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

  2024cites this paper
• Olive Leaves as a Source of Anticancer Compounds: In Vitro Evidence and Mechanisms

  2024cites this paper
• A Novel Synthesized Cyclohexane-Hydroxytyrosol Derivative Suppresses Ovarian Cancer Cell Growth Through Inducing Reactive Oxidative Species and Blocking Autophagic Flux

  2024cites this paper
• Hydroxytyrosol and Its Potential Uses on Intestinal and Gastrointestinal Disease

  2023cites this paper
• Oleuropein exhibits anticarcinogen effects against gastric cancer cell lines

  2023cites this paper
• Nutraceutical Role of Polyphenols and Triterpenes Present in the Extracts of Fruits and Leaves of Olea europaea as Antioxidants, Anti-Infectives and Anticancer Agents on Healthy Growth

  2022cites this paper
• Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity

  2022cites this paper
• In Vitro Anti-Proliferative and Apoptotic Effects of Hydroxytyrosyl Oleate on SH-SY5Y Human Neuroblastoma Cells

  2022cites this paper
• Hydroxytyrosol magnetic molecularly imprinted polymers as the sorbent for solid-phase extraction for selective recognition of hydroxytyrosol from Chinese olive leaves

  2021cites this paper
• The Anti-cancer Effect of Olea europaea L. Products: a Review

  2021cites this paper
• A Comparison of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the HT-29 Colorectal Cancer Cell Line.

  2021cites this paper
• Tyrosol, at the Concentration Found in Maltese Extra Virgin Olive Oil, Induces HL-60 Differentiation towards the Monocyte lineage

  2021influential citation
• Investigation of the anti-cancer effects of free and PLGA-PAA encapsulated Hydroxytyrosol on the MCF-7 breast cancer cell line.

  2020cites this paper
• Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy.

  2020cites this paper
• Secoiridoids of olive and derivatives as potential coadjuvant drugs in cancer: A critical analysis of experimental studies

  2019cites this paper
• Hydroxytyrosol: Bioavailability, toxicity, and clinical applications.

  2018cites this paper
• Olive leaf extract counteracts cell proliferation and cyst growth in an in vitro model of autosomal dominant polycystic kidney disease.

  2018cites this paper
• Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates.

  2018cites this paper
• Antioxidant activity of hydroxytyrosyl esters studied in liposome models.

  2018cites this paper
• MINOR FRUITS OF JAMMU SUBTROPICS POSSESS IN VITRO CYTOTOXICITY AGAINST HUMAN CANCER CELLS

  2018cites this paper
• Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor.

  2018cites this paper
• CLOSURE EMPLOYING OLIVAMINE AND HUMAN UMIBILICAL VEN ENDOTHELIAL CELLS

  2017cites this paper
• Inhibition of cell cycle progression by the hydroxytyrosol–cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells

  2017cites this paper
• Nutrigenomics of extra‐virgin olive oil: A review

  2017cites this paper
• Hydroxytyrosol and the Colonic Metabolites Derived from Virgin Olive Oil Intake Induce Cell Cycle Arrest and Apoptosis in Colon Cancer Cells.

  2017cites this paper
• COMPOSITIONS FOR INDUCTION OF DNA

  2017cites this paper
• Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells

  2017cites this paper
• High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells

  2016cites this paper
• Olive Oil Phenolic Compounds: May Prevent Cancer in Human?

  2016cites this paper
• In vitro chemo-preventive activities of hydroxytyrosol: the main phenolic compound present in extra-virgin olive oil.

  2016cites this paper
• Cytotoxic and apoptotic effects of hydroxytyrosol on ovarian cancer cell lines: relationship of cytotoxic effect with ERK 1/2 pathway Yumurtalik kanseri hücre hatlari üzerinde hidroksitirozolün sitotoksik ve apoptotik etkileri: sitotoksik etkinin ERK 1/2 yolaği ile ilişkisi

  2016cites this paper
• Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation.

  2016cites this paper
• Cytotoxic and Apoptotic Effects of Hydroxytyrosol on Ovarian Cancer Cell Lines: Relationship of Cytotoxic Effect with ERK 1/2 Pathway

  2016cites this paper
• Importance of Olives and Olive Oil in the Mediterranean Diet

  2015cites this paper
• DOTTORATO DI RICERCA IN MEDICINA SPERIMENTALE

  2015cites this paper
• Plant derived and dietary phenolic antioxidants: anticancer properties.

  2015influential citation
• Cellular and Molecular Effects of Bioactive Phenolic Compounds in Olives and Olive Oil

  2015cites this paper
• The role of hydroxytyrosol in health and disease

  2014cites this paper
• Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS

  2014cites this paper
• Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

  2014cites this paper
• Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways.

  2014cites this paper
• Most Relevant Polyphenols Present in the Mediterranean Diet and Their Incidence in Cancer Diseases

  2014cites this paper
• Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation.

  2014cites this paper
• Role of natural phenolic compounds in cancer chemoprevention via regulation of the cell cycle.

  2014cites this paper
• Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.

  2013cites this paper
• Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration‐dependent modulation of multiple nuclear receptor‐mediated pathways in androgen‐responsive prostate cancer cell LNCaP

  2013cites this paper
• Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: a review of in vitro studies.

  2013influential citation
• Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells.

  2013cites this paper
• A 001 1-Chloromethyl-6 , 7-dimethoxy-3 , 4-dihydro-1 H-isoqui noline-2-sulfonic acid amide , a derivative of tetrahydroisoquinoline , induces granulocytic differentiation of the human leukemic HL-60 cells via G 0 / G 1 phase arrest

  2013cites this paper
• Naturally occurring hydroxytyrosol: synthesis and anticancer potential.

  2013cites this paper
• Antiproliferative effect of alkaloids via cell cycle arrest from Pseuduvaria rugosa

  2013cites this paper
• 1-Chloromethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid amide, a derivative of tetrahydroisoquinoline, induces granulocytic differentiation of the human leukemic HL-60 cells via G0/G1 phase arrest

  2013cites this paper
• Biological Activity of Oleuropein and its Derivatives

  2013cites this paper
• Apoptotic and antiproliferative activity of olive oil hydroxytyrosol on breast cancer cells

  2013cites this paper
• Efecto del hidroxitirosol sobre la cardiotoxicidad producida por doxorubicina

  2013cites this paper
• CYCLE_XXIV SYNTHESIS AND STRUCTURE/ANTIOXIDANT ACTIVITY RELATIONSHIP OF LIPOPHILIC HYDROXYTYROSYL ESTERS AND THEIR ANALOGUES

  2013cites this paper
• In Vitro Antitumor Activity of Olive Oil Tyrosol and Hydroxytyrosol and their Methyl Carbonate Derivatives

  2013cites this paper
• Synthesis and structure/antioxidant activity relationship of lipophilic hydroxytyrosyl esters and their analogues

  2013cites this paper
• Mechanisms of Action of Phenolic Compounds in Olive

  2012cites this paper
• Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide

  2012cites this paper
• N-Benzoyl-12-nitrodehydroabietylamine-7-one, a novel dehydroabietylamine derivative, induces apoptosis and inhibits proliferation in HepG2 cells.

  2012cites this paper
• Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters.

  2012cites this paper
• Novel, biocatalytically produced hydroxytyrosol dimer protects against ultraviolet-induced cell death in human immortalized keratinocytes.

  2012cites this paper
• Olive Oil Polyphenols Differentially Inhibit Smooth Muscle Cell Proliferation through a G1/S Cell Cycle Block Regulated by ERK1/2

  2012cites this paper
• Antiproliferative and antioxidant effects on breast cancer cells of oleuropein and its semisynthetic peracetylated derivatives

  2011cites this paper
• Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells.

  2011cites this paper
• Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells.

  2011cites this paper
• Olive oil polyphenol oleuropein inhibits smooth muscle cell proliferation.

  2011cites this paper
• Cancer Chemopreventive Activity of Hydroxytyrosol

  2010cites this paper
• Huile d’olive, Olea europaea L.

  2010cites this paper
• Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells.

  2010cites this paper
• Hydroxytyrosol: from laboratory investigations to future clinical trials.

  2010cites this paper
• Effect of the long-term regular intake of virgin olive oil on the phenolic metabolites in human fasting plasma.

  2010cites this paper
• Natural polyphenols that display anticancer properties through inhibition of kinase activity.

  2010cites this paper
• Fatty acid hydroxytyrosyl esters: structure/antioxidant activity relationship by ABTS and in cell-culture DCF assays.

  2010cites this paper
• Effects of Hydroxytyrosol on Cyclosporine Nephrotoxicity

  2010cites this paper
• Modulation of Hepatic Apoptotic Pathways by Dietary Olive and Sunflower Oil

  2010cites this paper
• Anticarcinogenic Properties of Olive Oil Phenols: Effects on Proliferation, Apoptosis and Differentiation

  2010cites this paper
• Health Benefits of Traditional Culinary and Medicinal Mediterranean Plants

  2009cites this paper
• A novel use of the recyclable polymer-supported IBX: an efficient chemoselective and regioselective oxidation of phenolic compounds. The case of hydroxytyrosol derivatives.

  2009cites this paper
• Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells.

  2009cites this paper
• Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.

  2009cites this paper
• Olive oil phenolic compounds inhibit homocysteine-induced endothelial cell adhesion regardless of their different antioxidant activity.

  2009cites this paper
• Natural Polyphenols that Display Anticancer Activity through Inhibition of Kinase Activity

  2009cites this paper
• Isolation of a powerful antioxidant from Olea europaea fruit-mill waste : 3,4-Dihydroxyphenylglycol

  2009cites this paper
• Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP

  2009cites this paper
• Estudio de la capacidad antioxidante y la biodisponibilidad de los compuestos fenólicos del aceite de oliva. Primeras etapas en el desarrollo de un aceite de oliva funcional

  2009cites this paper
• Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol.

  2008cites this paper
• Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest.

  2008cites this paper
• 2-Arylhydroxytyrosol derivatives via Suzuki-Miyaura cross-coupling.

  2008cites this paper