In vitro chemo-preventive activities of hydroxytyrosol: the main phenolic compound present in extra-virgin olive oil.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Food & Function

• Publication date

  2016-01-20

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1039/c5fo00932dPMID 26469183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hydroxytyrosol Prevents Increase of Osteoarthritis Markers in Human Chondrocytes Treated with Hydrogen Peroxide or Growth-Related Oncogene α

  2014cited by this paper
• Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case–control, cohort and intervention studies

  2014cited by this paper
• Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol.

  2013cited by this paper
• Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: a review of in vitro studies.

  2013cited by this paper
• Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide

  2012cited by this paper
• Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells

  2011cited by this paper
• Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells.

  2011cited by this paper
• Olive oil and cancer risk: an update of epidemiological findings through 2010.

  2011cited by this paper
• Olive oil intake is inversely related to cancer prevalence: a systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies

  2011cited by this paper
• Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells.

  2009cited by this paper
• Chemistry and bioactivity of olive biophenols in some antioxidant and antiproliferative in vitro bioassays.

  2009cited by this paper
• Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells.

  2009cited by this paper
• Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure

  2009cited by this paper
• Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.

  2009cited by this paper
• Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells

  2009cited by this paper
• Cytoprotective effects of phenolic antioxidants and essential fatty acids in human blood monocyte and neuroblastoma cell lines: surrogates for neurological damage in vivo.

  2008cited by this paper
• Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells.

  2008cited by this paper
• Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells.

  2008cited by this paper
• Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cells

  2007cited by this paper
• Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

  2006cited by this paper
• Evaluation of phenolic compounds in virgin olive oil by direct injection in high-performance liquid chromatography with fluorometric detection.

  2006cited by this paper
• Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.

  2005cited by this paper
• DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide

  2005cited by this paper
• The comet assay for DNA damage and repair

  2004cited by this paper
• Oxidative DNA damage: mechanisms, mutation, and disease

  2003cited by this paper
• Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis

  2002cited by this paper
• Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells

  2002cited by this paper
• Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.

  2000cited by this paper
• The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells.

  1995cited by this paper
• Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine.

  1994cited by this paper
• A new approach for measurement of cytotoxicity using colorimetric assay.

  1993cited by this paper
• A simple technique for quantitation of low levels of DNA damage in individual cells.

  1988cited by this paper
• The glomerular permeability determined by dextran clearance using Sephadex gel filtration.

  1968cited by this paper
• Isolation of mononuclear cells and granulocytes from human blood.

  1968cited by this paper

• Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells

  2025cites this paper
• A Comprehensive Review of the Antitumor Activity of Olive Compounds: The Case of Olive Oil, Pomace, and Leaf Extracts, Phenolic Alcohols, Secoiridoids, and Triterpenes

  2025cites this paper
• The multifaceted properties of manna in skin wound healing include the enhancement of cell motility and differentiation, and antioxidant and anti-inflammatory actions.

  2025cites this paper
• Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil

  2024cites this paper
• Effects of Phenols from Olive Vegetation Water on Mutagenicity and Genotoxicity of Stored-Cooked Beef Patties

  2024influential citation
• Phenolic extract from olive mill wastewater sustains mitochondrial bioenergetics upon oxidative insult

  2024cites this paper
• Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

  2024influential citation
• Health Outcomes Related to the Consumption of Olive Products: A Brief Review

  2023cites this paper
• Metabolomics Insights into the Differential Response of Breast Cancer Cells to the Phenolic Compounds Hydroxytyrosol and Luteolin

  2023cites this paper
• Olive Mill Wastewater Fermented with Microbial Pools as a New Potential Functional Beverage

  2023cites this paper
• Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

  2022cites this paper
• Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms

  2022cites this paper
• Implication of the Mediterranean diet on the human epigenome

  2022cites this paper
• Type does matter. Use VIRGIN olive oil as your preferred fat to reduce your risk of breast cancer: case-control EpiGEICAM study

  2022cites this paper
• Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity

  2022cites this paper
• Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation

  2021cites this paper
• The Anti-cancer Effect of Olea europaea L. Products: a Review

  2021cites this paper
• Benefits of Phenolic Compounds Isolated from Olive Oil on Prevention of Cancer

  2021influential citation
• Inhibition of the pesticide rotenone-induced Ca2+ signaling, cytotoxicity and oxidative stress in HCN-2 neuronal cells by the phenolic compound hydroxytyrosol.

  2021cites this paper
• Potential of olive oil and its phenolic compounds as therapeutic intervention against colorectal cancer: a comprehensive review

  2021cites this paper
• Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA‐PAA nano‐encapsulation on PANC‐1 pancreatic cancer cell line

  2020cites this paper
• Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence.

  2020cites this paper
• Anti-Proliferative Activity of A Hydrophilic Extract of Manna from Fraxinus angustifolia Vahl through Mitochondrial Pathway-Mediated Apoptosis and Cell Cycle Arrest in Human Colon Cancer Cells

  2020cites this paper
• The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells

  2020cites this paper
• A review on management of cardiovascular diseases by olive polyphenols

  2020cites this paper
• The protective role of olive oil against gibberellic acid-induced embryotoxicity at prenatal stages of mice

  2020cites this paper
• Influence of Pomace Matrix and Cyclodextrin Encapsulation on Olive Pomace Polyphenols’ Bioaccessibility and Intestinal Permeability

  2020cites this paper
• The Effects of Oleuropein on Epirubicin and Cyclophosphamide Induced Toxicity in Rats Oleuropeinin Ratlarda Epirubisin ve Siklofosfamid ile Indüklenen Toksisitede Etkileri

  2020cites this paper
• Effects of Oleuropein on Epirubicin and Cyclophosphamide Combination Treatment in Rats

  2020cites this paper
• Efficacy of Hydroxytyrosol as Chemopreventive Agent on Induced Hamster Buccal Pouch Carcinogenesis

  2019cites this paper
• Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer

  2019cites this paper
• Downregulation of Pro-Inflammatory and Pro-Angiogenic Pathways in Prostate Cancer Cells by a Polyphenol-Rich Extract from Olive Mill Wastewater

  2019cites this paper
• Secoiridoids of olive and derivatives as potential coadjuvant drugs in cancer: A critical analysis of experimental studies

  2019cites this paper
• Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

  2019cites this paper
• Nitrogen Headspace Improves the Extra Virgin Olive Oil Shelf-Life, Preserving Its Functional Properties

  2019cites this paper
• Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018

  2019cites this paper
• Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer

  2019influential citation
• Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs

  2019cites this paper
• Transformation of Psoralen and Isopsoralen by Human Intestinal Microbial In Vitro, and the Biological Activities of Its Metabolites

  2019cites this paper
• Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System

  2018cites this paper
• ROLE OF PTEN IN MODULATING PREVENTIVE EFFECT OF 3,4-DHPEA AGAINST OXIDATIVE STRES

  2018cites this paper
• Hydroxytyrosol Exerts Anti-Inflammatory and Anti-Oxidant Activities in a Mouse Model of Systemic Inflammation

  2018cites this paper
• Genotoxicity of heterocyclic amines (HCAs) on freshly isolated human peripheral blood mononuclear cells (PBMC) and prevention by phenolic extracts derived from olive, olive oil and olive leaves.

  2018cites this paper
• Postmenopausal osteoporosis and breast cancer: The biochemical links and beneficial effects of functional foods.

  2018cites this paper
• Phenolic Compounds Isolated from Olive Oil as Nutraceutical Tools for the Prevention and Management of Cancer and Cardiovascular Diseases

  2018influential citation
• Pharma-Nutritional Properties of Olive Oil Phenols. Transfer of New Findings to Human Nutrition

  2018cites this paper
• Hydroxytyrosol: Bioavailability, toxicity, and clinical applications.

  2018cites this paper
• A Therapeutic Connection between Dietary Phytochemicals and ATP Synthase

  2017cites this paper
• Semen quality as affected by olive oil

  2017cites this paper
• High quality, good health: The case for olive oil

  2017cites this paper
• Lipophilization of Hydroxytyrosol-Enriched Fractions from Olea europaea L. Byproducts and Evaluation of the in Vitro Effects on a Model of Colorectal Cancer Cells.

  2017cites this paper
• Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells

  2017cites this paper
• Understanding the link between antimicrobial properties of dietary olive phenolics and bacterial ATP synthase.

  2017cites this paper
• Dietary Chapter 1 Olive Oil : An Angel of Protection Against Cancer

  2017cites this paper
• Anti-cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies.

  2016cites this paper
• High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells

  2016cites this paper
• Comet assay: an essential tool in toxicological research

  2016cites this paper
• Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells

  2016cites this paper