Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2017-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0016-5085(17)33402-9PMID 27849619PMCID PMC5137749
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Peptidoglycan architecture of Gram-positive bacteria by solid-state NMR.

  2015cited by this paper
• Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin

  2014cited by this paper
• Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

  2013influential reference
• Immunological goings-on in visceral adipose tissue.

  2013cited by this paper
• Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches.

  2013cited by this paper
• Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.

  2013cited by this paper
• Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

  2012cited by this paper
• Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system.

  2012cited by this paper
• ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules.

  2012cited by this paper
• An ex vivo method for studying mucus formation , properties , and thickness in human colonic biopsies and mouse small and large intestinal explants

  2012cited by this paper
• An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants.

  2012cited by this paper
• Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

  2012cited by this paper
• How glycan metabolism shapes the human gut microbiota

  2012cited by this paper
• Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold.

  2011cited by this paper
• Improvement of phylum- and class-specific primers for real-time PCR quantification of bacterial taxa.

  2011cited by this paper
• Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

  2011cited by this paper
• The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

  2010influential reference
• The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

  2008influential reference
• Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

  2006cited by this paper
• Isolation of DNA from bacterial samples of the human gastrointestinal tract

  2006cited by this paper
• Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

  2006cited by this paper
• Three-dimensional structure of the bacterial cell wall peptidoglycan.

  2006cited by this paper
• Inflammation and metabolic disorders

  2006cited by this paper
• Host-Bacterial Mutualism in the Human Intestine

  2005cited by this paper
• LightCycler qPCR optimisation for low copy number target DNA.

  2002cited by this paper
• Purification and characterization of sialyl-Le(a)-carrying mucins of human bile; evidence for the presence of MUC1 and MUC3 apoproteins.

  1994cited by this paper
• lnterleukin-10-Deficient Mice Develop Chronic Enterocolitis

  year unknowncited by this paper

• Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes.

  2026cites this paper
• Decreased salivary ZG16B expression is associated with exocrine dysfunction in Sjögren disease

  2025cites this paper
• Next Decade Research in Asthma: Broad Omics-Based Exploration Versus Targeted Airway Epithelium Studies

  2025cites this paper
• Single-cell RNA sequencing uncovers intestinal immune alterations and cellular diversity from chronic fluoride exposure in mice

  2025cites this paper
• Calreticulin in the nasal mucus promotes neutrophil migration and pathogen clearance

  2025cites this paper
• Translational control of innate barrier defense by the gut microbiota

  2025cites this paper
• Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection

  2025cites this paper
• Using MUC2 mucin producing tumorigenic human goblet-like cells to uncover functional properties of the mucus barrier

  2025cites this paper
• Disentangling the impact of obesity, diet, host factors, and microbiota on small intestinal antimicrobial peptide expression

  2025cites this paper
• Tools for investigating host-microbe crosstalk using glycan analysis probes inspired by human lectins.

  2025cites this paper
• Targeting symbionts by apolipoprotein L proteins modulates gut immunity

  2025cites this paper
• Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon

  2025influential citation
• Comprehensive bioinformatics analysis was used to identify and verify differentially expressed genes in targeted therapy of colon cancer

  2025cites this paper
• In Vitro Analysis of Probiotic Properties Related to the Adaptation of Levilactobacillus brevis to Intestinal Microenvironment and Involvement of S-Layer Proteins

  2025cites this paper
• Spatial transcriptomics reveals recasting of signalling networks in the small intestine following tissue invasion by the helminth parasite Heligmosomoides polygyrus

  2025cites this paper
• Intestinal mucus: the unsung hero in the battle against viral gastroenteritis

  2025cites this paper
• The proteomic landscape of stool-derived extracellular vesicles in patients with pre-cancerous lesions and colorectal cancer

  2025cites this paper
• Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease.

  2025cites this paper
• Organosilicone double-long-chain diquaternary ammonium salt acts as a biofilm scavenger to ameliorate colitis induced by dextran sulfate sodium salt

  2025cites this paper
• Single-cell transcriptome analysis reveals the association between ketone body synthesis and morphogenic profile of intestinal epithelia in neonatal mice.

  2025cites this paper
• Low microbial abundance and community diversity within the egg capsule of the oviparous cloudy catshark (Scyliorhinus torazame) during oviposition

  2024cites this paper
• MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease

  2024cites this paper
• Soluble Human Lectins at the Host-Microbe Interface.

  2024cites this paper
• Glycan analysis probes inspired by human lectins for investigating host-microbe crosstalk

  2024cites this paper
• MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease

  2024cites this paper
• Bacterial clustering biomaterials as anti-infective therapies.

  2024cites this paper
• Intestinal mucus barrier: A potential therapeutic target for IBD.

  2024cites this paper
• Low microbial abundance and community diversity in the egg capsule of the oviparous cloudy catshark (Scyliorhinus torazame) during oviposition

  2024cites this paper
• Interferon lambda 4 is a gut antimicrobial protein

  2024cites this paper
• Intestinal distribution of anionic, cationic, and neutral polymer-stabilized nanocarriers measured with a lanthanide (europium) tracer assay.

  2024cites this paper
• LncRNA HAND2-AS1 Inhibited Colon Cancer Progression By Regulating miR-3118/ZG16 Axis

  2024cites this paper
• ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer

  2024cites this paper
• Goblet cells: guardians of gut immunity and their role in gastrointestinal diseases

  2024cites this paper
• Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation

  2024cites this paper
• ZG16 impacts gut microbiota-associated intestinal inflammation and pulmonary mucosal function through bacterial metabolites.

  2024cites this paper
• The past, present and future of polymicrobial infection research: Modelling, eavesdropping, terraforming and other stories.

  2024cites this paper
• Nutritional Interventions, Probiotics, Synbiotics and Fecal Microbiota Transplantation in Steatotic Liver Disease : Pediatric Fatty Liver and Probiotics.

  2024cites this paper
• Identification and validation of metastasis-related gene ZG16 in the prognosis and progression in colorectal cancer

  2024cites this paper
• The immune interactions of gut glycans and microbiota in health and disease

  2024cites this paper
• Gut–Liver Axis Dysregulation in Portal Hypertension: Emerging Frontiers

  2024cites this paper
• scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis

  2024cites this paper
• A history of repeated antibiotic usage leads to microbiota-dependent mucus defects

  2024cites this paper
• SLE serum induces altered goblet cell differentiation and leakiness in human intestinal organoids

  2024cites this paper
• Viral Liver Disease and Intestinal Gut–Liver Axis

  2024cites this paper
• Microbiota of the gastrointestinal tract: Friend or foe?

  2023cites this paper
• The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine

  2023cites this paper
• Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons

  2023cites this paper
• Lectin-Seq: a method to profile lectin-microbe interactions in native communities

  2023cites this paper
• The gut mucus network: A dynamic liaison between microbes and the immune system.

  2023cites this paper
• Procyanidin C1 inhibits tumor growth and metastasis in colon cancer via modulating miR-501-3p/HIGD1A axis

  2023cites this paper
• Porcine Deltacoronavirus Infection Disrupts the Intestinal Mucosal Barrier and Inhibits Intestinal Stem Cell Differentiation to Goblet Cells via the Notch Signaling Pathway

  2023cites this paper
• Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host–microbe interactions with oral commensals

  2023cites this paper
• Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease

  2023cites this paper
• Goblet cell‐associated antigen passage: A gatekeeper of the intestinal immune system

  2023cites this paper
• Intestinal mucus components and secretion mechanisms: what we do and do not know

  2023cites this paper
• Flagella-driven motility is a target of human Paneth cell defensin activity

  2023cites this paper
• Lectin-Seq: A method to profile lectin-microbe interactions in native communities

  2023cites this paper
• Mucin networks: Dynamic structural assemblies controlling mucus function.

  2023cites this paper
• Prebióticos y microbiota: Factores clave en el síndrome metabólico

  2022cites this paper
• Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues

  2022cites this paper
• Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota—A Mutual Relationship

  2022cites this paper
• Current Perspectives on Gastrointestinal Models to Assess Probiotic-Pathogen Interactions

  2022cites this paper
• Shiga Toxin-Producing Escherichia coli and Milk Fat Globules

  2022cites this paper
• BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states.

  2022cites this paper
• Flagella at the Host-Microbe Interface: Key Functions Intersect With Redundant Responses

  2022cites this paper
• The barrier and beyond: Roles of intestinal mucus and mucin-type O-glycosylation in resistance and tolerance defense strategies guiding host-microbe symbiosis

  2022cites this paper
• Evaluation and simultaneous determination of rectal mucosa markers by multiplex reverse transcription-PCR for biological evidence of sexual assault with anal penetration.

  2022cites this paper
• Leaky Gut in IBD: Intestinal Barrier–Gut Microbiota Interaction

  2022cites this paper
• Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report

  2022cites this paper
• Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer

  2022cites this paper
• An integrative transcriptome analysis reveals potential predictive, prognostic biomarkers and therapeutic targets in colorectal cancer

  2022cites this paper
• Colon mucus in colorectal neoplasia and beyond

  2022cites this paper
• Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure

  2022cites this paper
• The role of goblet cells and mucus in intestinal homeostasis

  2022cites this paper
• Diet, microbiota, and the mucus layer: The guardians of our health

  2022cites this paper
• Modeling mucus physiology and pathophysiology in human organs-on-chips.

  2022cites this paper
• Substituting fish meal with castor meal in diets of hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂): Effects on growth performance, immune response, antioxidant and digestive enzymes activities, gut morphology, and inflammatory-related gene expression.

  2022cites this paper
• Disulfide bond formation and redox regulation in the Golgi apparatus

  2022cites this paper
• Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease

  2022cites this paper
• The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation

  2022cites this paper
• Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice

  2021cites this paper
• Physiological properties, composition and structural profiling of porcine gastrointestinal mucus.

  2021cites this paper
• Conformational switches and redox properties of the colon cancer‐associated human lectin ZG16

  2021cites this paper
• 3D Structural View of Pathogen Recognition by Mammalian Lectin Receptors

  2021cites this paper
• Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis

  2021cites this paper
• Gut–Liver Axis in Nonalcoholic Fatty Liver Disease: the Impact of the Metagenome, End Products, and the Epithelial and Vascular Barriers

  2021cites this paper
• Investigation of the Initial Host Response of Naïve Atlantic Salmon (Salmo salar) Inoculated with Paramoeba perurans

  2021cites this paper
• Intestinal Barrier and Permeability in Health, Obesity and NAFLD

  2021cites this paper
• The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability

  2021cites this paper
• An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

  2021cites this paper
• Cellular and functional heterogeneity of the airway epithelium

  2021cites this paper
• Heme Peroxidases at Unperturbed and Inflamed Mucous Surfaces

  2021cites this paper
• JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice

  2021cites this paper
• MHC II-PI3K/Akt/mTOR Signaling Pathway Regulates Intestinal Immune Response Induced by Soy Glycinin in Hybrid Grouper: Protective Effects of Sodium Butyrate

  2021cites this paper
• Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations

  2020cites this paper
• In Vitro Evaluation of the Effects of Commercial Prebiotic GOS and FOS Products on Human Colonic Caco–2 Cells

  2020cites this paper
• Does an Apple a Day Also Keep the Microbes Away? The Interplay Between Diet, Microbiota, and Host Defense Peptides at the Intestinal Mucosal Barrier

  2020cites this paper
• Mucins and the Microbiome.

  2020cites this paper
• Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations

  2020cites this paper
• The role of goblet cells in viral pathogenesis

  2020cites this paper