Migratory response of granulomatous alveolar cells from BCG-sensitized rabbits.

Rabbits sensitized subcutaneously with bacillus Calmette Guérin (BCG) in oil routinely developed dermal tuberculin sensitivity but failed to develop pulmonary granulomas. Alveolar cells procured from such animals were not always inhibited by purified protein derivative (PPD) in the migration-inhibition test. In contrast, the majority of rabbits sensitized with the same dose of BCG by the intravenous route developed a pulmonary granulomatous response reflected by increased lung weight/body weight ratios and increased numbers of alveolar cells. The majority of such animals did not develop dermal tuberculin sensitivity. However, the granulomatous alveolar cells obtained from rabbits sensitized by the i.v. route were consistently inhibited by PPD in the migration-inhibition test. Alveolar cells procured from rabbits with extensive pulmonary granulomas exhibited inhibition of migration (auto-inhibition) in the absence of PPD. Granulomatous cells exhibiting auto-inhibition showed a tendency to escape both auto-inhibition and PPD-induced inhibition. Some BCG-immune sera potentiated PPD-induced inhibition, whereas other BCG-immune sera exhibited a tendency to relieve the auto-inhibitory response of granulomatous cells. Supernatant fluids obtained from granulomatous cells incubated with PPD inhibited the migration of normal alveolar cells. The possible role of the migration-inhibition response in granuloma formation is discussed.

• Publication year

  1970

• Venue

  Journal of Immunology

• Publication date

  1970-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4049/jimmunol.105.1.227PMID 5425345
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Macrophage migration.

  1968cited by this paper
• In vitro studies on the mechanism of macrophage migration inhibition in tuberculin sensitivity.

  1968cited by this paper
• The cell-migration-inhibition correlate of delayed hypersensitivity. Conversion of human nonsensitive lymph node cells to sensitive cells with an RNA extract.

  1968cited by this paper
• Migration inhibitory factor associated with delayed-type hypersensitivity.

  1968cited by this paper
• Formation of cytotoxic factor by macrophages from normal guinea pigs.

  1967cited by this paper
• Transfer of delayed-type hypersensitivity. A critical review and experimental study in the guinea pig.

  1967cited by this paper
• Cell-free cytotoxic fluids from tuberculin-treated guinea pigs.

  1967cited by this paper
• SUPPRESSION OF DELAYED HYPERSENSITIVITY IN VITRO BY INHIBITION OF PROTEIN SYNTHESIS

  1965cited by this paper
• DELAYED HYPERSENSITIVITY IN VITRO. II. EFFECT OF SENSITIVE CELLS ON NORMAL CELLS IN THE PRESENCE OF ANTIGEN.

  1964cited by this paper
• IN VITRO STUDIES OF CELLULAR HYPERSENSITIVITY

  1963cited by this paper
• IN VITRO STUDIES OF CELLULAR HYPERSENSITIVITY. I. SPECIFIC INHIBITION OF MIGRATION OF CELLS FROM ADJUVANT-IMMUNIZED ANIMALS BY PURIFIED PROTEIN DERIVATIVE AND OTHER PROTEIN ANTIGENS.

  1963cited by this paper
• In vitro Cell Migration as a Model for Delayed Hypersensitivity.∗

  1962cited by this paper
• Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity.

  1961cited by this paper
• Demonstration of delayed (tuberculin) type hypersensitivity in vitro. I. Selection of methods.

  1961cited by this paper
• The submerged culture of mammalian cells; the spinner culture.

  1957cited by this paper

• Rabbit Nocardiosis as a Tuberculosis Mimic: Immunopathology and Translational Gaps : A Narrative Review

  2025cites this paper
• Dermal Tuberculin Sensitivity and Allergic Pulmonary Granuloma Formation

  2003cites this paper
• The experimental granuloma. A hypothesis to explain the persistence of the lesion.

  1995cites this paper
• Determinants of drug and polypeptide bioavailability from aerosols delivered to the lung

  1990cites this paper
• Lymphocyte recruitment to the lung.

  1990cites this paper
• Regulation and Pharmacology of Granulomatous Inflammation

  1988cites this paper
• Induction of a macrophage migration enhancement factor after desensitization of tuberculin-positive rabbits with purified protein derivative

  1986cites this paper
• Granulomatous pneumonitis induced by bacille Calmette-Guérin in the mouse and its treatment with cyclosporin A.

  1986cites this paper
• [A histopathologic study of bronchus-associated lymphoid tissue (BALT) in delayed-type hypersensitive reaction of the lung].

  1985cites this paper
• [A study of bronchus-associated lymphoid tissue (BALT) in pulmonary delayed type hypersensitivity. Immunological significance of the bronchoalveolar lavage (BAL) fluid in rabbits].

  1985cites this paper
• In defense of the lung: paradoxical role of the pulmonary alveolar macrophage.

  1985cites this paper
• Food hypersensitivity.

  1984cites this paper
• Glucocorticoid modulation of lymphokine-induced giant cell formation

  1984cites this paper
• The diagnosis and treatment of food allergy.

  1984cites this paper
• T‐ AND B‐CELL MEMORY ON MUCOSAL SURFACES

  1983cites this paper
• Infectious bovine keratoconjunctivitis: bacteriologic, immunologic, and clinical responses of cattle to experimental exposure with Moraxella bovis.

  1983cites this paper
• The structural basis for immunity in the respiratory tract.

  1982cites this paper
• Immunoadjuvant therapy for lung cancer. A critical review.

  1982cites this paper
• Immunology of Respiratory Viruses

  1982cites this paper
• [An animal model of hypersensitivity pneumonitis--histological and immunological studies of pigeon breeder's lung in rabbits].

  1982cites this paper
• The clinical spectrum of aspergillosis--part 1: epidemiology, pathogenicity, infection in animals and immunology of Aspergillus.

  1981cites this paper
• Strain variation in BCG-induced chronic pulmonary inflammation in mice: control by a cyclophosphamide-sensitive thymus-derived suppressor cell.

  1981cites this paper
• Inhibition of pulmonary granuloma formation in mice by treatment with Mycobacterial protoplasm and immuno-suppressants and its relation to protection against aerosol infection with virulent Mycobacterium tuberculosis.

  1981cites this paper
• BCG-induced granulomatous pulmonary inflammation and splenomegaly in mice: A T-cell-dependent response

  1981cites this paper
• Genetic basis of BCG-induced suppression of delayed hypersensitivity

  1981cites this paper
• Immunology of Enterobacterial Infections

  1981cites this paper
• Immune Mechanisms in Infectious Diarrhea

  1980cites this paper
• Selective suppression of granuloma formation and delayed hypersensitivity in rabbits

  1980cites this paper
• Lymphokine-mediated fusion and migration inhibition of alveolar macrophages.

  1980cites this paper
• A study of lung lavage materials in patients with hypersensitivity pneumonitis: in vitro response to mitogen and antigen in pigeon breeders' disease.

  1980cites this paper
• Production and partial characterization of dog macrophage migration inhibitory factor.

  1980cites this paper
• Cytolytic activity of pulmonary and systemic lymphoid cells from C57BL/6 mice following intrapulmonary or intraperitoneal immunization with allogeneic tumor cells.

  1980cites this paper
• Genetic control of BCG-induced chronic granulomatous inflammation and anergy.

  1980cites this paper
• Guinea Pig Lung Lavage Cells After Intranasal BCG Sensitization

  1979cites this paper
• Suppression of phytohemagglutinin and lipopolysaccharide responses in mouse spleen cells by Bacillus Calmette-Guerin.

  1979cites this paper
• Immunopathology of the lung: a review.

  1979cites this paper
• Cell-mediated immunity in the lungs of rabbits using conjugated proteins.

  1978cites this paper
• Immunization of mice after airborne infection with various strains of BCG.

  1978cites this paper
• Acquired cellular resistance, delayed hypersensitivity, and altered macrophage migration in Listeria monocytogenes-infected guinea pigs

  1978cites this paper
• Cell-mediated immunity on secretory surfaces.

  1978cites this paper
• Studies on Pasteurella multocida. VII. Dynamics and temporal development of local humoral immunity induced by a live avirulent fowl cholera vaccine.

  1978cites this paper
• [The role of immunocompetent cells in the murine pulmonary granulomatous response induced by BCG (author's transl)].

  1978cites this paper
• Studies on Pasteurella multocida. VII. Dynamics and temporal development of local humoral immunity induced by a live avirulent fowl cholera vaccine.

  1978cites this paper
• Effects of NO2 on the response of baboon alveolar macrophages to migration inhibitory factor.

  1978cites this paper
• The defense of the lung: studies of the role of cell-mediated immunity.

  1977cites this paper
• [Kinetics of pulmonary defense in deep lung (author's transl)].

  1977cites this paper
• Immunopathogenesis of hypersensitivity pneumonitis.

  1977cites this paper
• Macrophage-Agglutinating Factor Produced In Vitro by BCG-Sensitized Lymphocytes

  1977cites this paper
• Mycobacterium

  1977cites this paper
• Nonspecific protection of mice against influenza virus infection by local or systemic immunization with Bacille Calmette-Guérin.

  1977cites this paper
• The role of normal alveolar macrophages in cell-mediated immunity.

  1977cites this paper
• Respiratory tract cell-mediated immunity.

  1977cites this paper
• Development of local immunity1

  1977cites this paper
• Experimental studies of sensitization to beryllium, zirconium, and aluminum compounds in the rabbit.

  1977cites this paper
• Induction and expression of immunity after BCG immunization

  1977cites this paper
• Strain variation in BCG-induced chronic pulmonary inflammation in mice. I. Basic model and possible genetic control by non-H-2 genes.

  1977cites this paper
• Development of local immunity.

  1977cites this paper
• Immune responses to influenza virus in rabbits after local immunization. II. Local and systemic cell mediated response.

  1977cites this paper
• Rabbit alveolar macrophages as indicator cells in migration inhibitory factor assays.

  1977cites this paper
• The effect of respiratory immunization on cell-mediated immune effector cells of the lung.

  1976cites this paper
• Expression of immune mechanisms in the lung.

  1976cites this paper
• Host defense mechanisms in the gastrointestinal tract.

  1976cites this paper
• Immune responses in experimental tuberculosis after bacillus Calmette-Guerin vaccination and challenge with H37RV.

  1976cites this paper
• Cellular and humoral bronchopulmonary immune response of rabbits immunized with thermophilic actinomyces antigen.

  1976cites this paper
• Lung defense mechanisms (second of two parts).

  1976cites this paper
• Local and systemic cell-mediated immunity against transmissible gastroenteritis, an intestinal viral infection of swine.

  1976cites this paper
• Chemoimmunotherapy of human solid tumors.

  1976cites this paper
• Inhibition of Macrophage Migration by Normal Guinea Pig Intestinal Secretions 1

  1976cites this paper
• Skin reaction and macrophage migration inhibition tests for polysaccharides from Aspergillus fumigatus and Candida albicans.

  1975cites this paper
• The induction of delayed hypersensitivity in guinea pigs to poly U and poly A:U.

  1975cites this paper
• Studies on the respiratory and systemic cell-mediated immunity. Development of local and systemic cell-mediated immunity in guinea pigs given killed BCG intratracheally or parenterally.

  1975cites this paper
• The adjuvant activity of mycobacterial RNA preparations and synthetic polynucleotides for induction of delayed hypersensitivity to purified protein derivative in guinea pigs.

  1975cites this paper
• The role of phagocytosis and natural lymphokines in the fusion of alveolar macrophages to form Langhans giant cells.

  1975cites this paper
• Experimental production of granulomatous pneumonitis. Comparison of immunological and morphological sequelae with particulate and soluble antigens administered via the respiratory route.

  1975cites this paper
• A macrophage agglutinating factor produced during a pulmonary delayed hypersensitivity reaction.

  1975cites this paper
• Elevated 7S Immunoglobulin and Acute Phase Proteins in Adjuvant-Injected Chickens 1

  1975cites this paper
• Mycobacterial Components Responsible for the Induction of a Chronic Immunological Inflammatory Response in Rabbit Lungs

  1974cites this paper
• Inhibition of normal rabbit alveolar macrophages by factor(s) resembling migration inhibition factor.

  1974cites this paper
• Respiratory Tract Cell-Mediated Immunity: Comparison of Primary and Secondary Response

  1974cites this paper
• Development of cellular and humoral immunity in the respiratory tract of rabbits to Pseudomonas lipopolysaccharide.

  1974cites this paper
• THE IMMUNOLOGIC ROLE OF TONSILLAR TISSUES IN LOCAL CELL-MEDIATED IMMUNE RESPONSES

  1974cites this paper
• Cell-mediated immunity after bacterial infection of the lower respiratory tract.

  1974influential citation
• Local and systemic cell-mediated immunity after immunization of guinea pigs with live or killed m. tuberculosis by various routes.

  1974cites this paper
• Perspectives in immunotherapy of lung cancer.

  1974cites this paper
• Immunochemotherapy of human cancer.

  1974cites this paper
• Pulmonary host defenses in rabbits after immunization with Pseudomonas antigens: the interaction of bacteria, antibodies, macrophages, and lymphocytes.

  1974cites this paper
• The role of the secretory immune system in protection against agents which infect the respiratory tract.

  1974cites this paper
• Immunologic events in pigeon breeders' disease.

  1974cites this paper
• Immunity to infections on secretory surfaces.

  1974cites this paper
• EXPERIMENTAL STUDIES ON THE FORMATION OF EPITHELIOID CELLS INDUCED BY FRACTIONATED SUBSTANCES OF TUBERCLE BACILLI

  1974cites this paper
• ADJUVANTS

  1974cites this paper
• Immune response of the human respiratory tract. II. Cell-mediated immunity in the lower respiratory tract to tuberculin and mumps and influenza viruses.

  1973cites this paper
• Alveolar macrophage migration inhibition in animals immunized with thermophilic actinomycete antigen.

  1973cites this paper
• Specificity of a BCG-Induced Pulmonary Granulomatous Response in Rabbits

  1973cites this paper
• Local and systemic cellular immune responses in guinea-pigs given antigen parenterally or directly into the lower respiratory tract.

  1973cites this paper
• Immune enhancement of pulmonary bactericidal activity in murine virus pneumonia.

  1973cites this paper
• Inhibition of Migration of Mouse Macrophages by Tuberculin-Sensitive Mouse Lymphocytes and by Mouse Migration Inhibitory Factor

  1973cites this paper
• Relationship of BCG-Induced Pulmonary Delayed Hypersensitivity to Accelerated Granuloma Formation in Rabbit Lungs: Effect of Cortisone Acetate

  1973influential citation
• Respiratory and systemic cellular and humoral immune responses to influenza virus vaccine administered parenterally or by nose drops.

  1972cites this paper
• Cellular hypersensitivity and immunity. Inhibition of macrophage migration and the lymphocyte mediators.

  1972cites this paper