The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature

• Publication date

  2014-06-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature13418PMID 24896179
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

  2013cited by this paper
• The Parkinson’s disease genes Fbxo7 and Parkin interact to mediate mitophagy

  2013cited by this paper
• Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism.

  2013cited by this paper
• Characterizing Ubiquitination Sites by Peptide-based Immunoaffinity Enrichment*

  2012cited by this paper
• Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease.

  2012cited by this paper
• PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

  2012cited by this paper
• Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

  2011cited by this paper
• Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

  2011cited by this paper
• Rotenone, Paraquat, and Parkinson’s Disease

  2011cited by this paper
• A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery.

  2011cited by this paper
• Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane*♦

  2011cited by this paper
• Systematic and quantitative assessment of the ubiquitin-modified proteome.

  2011cited by this paper
• PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

  2010cited by this paper
• PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

  2010cited by this paper
• Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

  2010cited by this paper
• PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

  2010cited by this paper
• Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

  2010cited by this paper
• Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

  2010cited by this paper
• p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

  2010cited by this paper
• PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

  2009cited by this paper
• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

  2008cited by this paper
• Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane.

  2008cited by this paper
• Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat*

  2008cited by this paper
• Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity

  2008cited by this paper
• Systematic approach for validating the ubiquitinated proteome.

  2008cited by this paper
• Drosophila Overexpressing Parkin R275W Mutant Exhibits Dopaminergic Neuron Degeneration and Mitochondrial Abnormalities

  2007cited by this paper
• A Drosophila Model of Mutant Human Parkin-Induced Toxicity Demonstrates Selective Loss of Dopaminergic Neurons and Dependence on Cellular Dopamine

  2007cited by this paper
• A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining

  2006cited by this paper
• Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

  2006cited by this paper
• Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

  2006cited by this paper
• A probability-based approach for high-throughput protein phosphorylation analysis and site localization

  2006cited by this paper
• Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.

  2006cited by this paper
• Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

  2005cited by this paper
• Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.

  2005cited by this paper
• Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators*

  2004cited by this paper
• Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

  2004cited by this paper
• Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

  2003cited by this paper
• Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics.

  2003cited by this paper
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  1998cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993cited by this paper
• The Parkinson ’ s disease – linked proteins Fbxo 7 and Parkin interact to mediate mitophagy

  year unknowncited by this paper

• USP30 alleviates intestinal ischemia-reperfusion injury by deubiquitinating MFN2 mediating the mitochondrial endoplasmic reticulum pathway.

  2026cites this paper
• Deubiquitinase USP15 restricts LC3-dependent targeting of Mycobacterium tuberculosis.

  2026cites this paper
• Targeting mitochondrial deubiquitinase USP30 to induce mitophagy in heteroplasmic mitochondrial diseases.

  2026cites this paper
• USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression

  2026cites this paper
• Molecular and Cellular Mechanisms of Myocardial Ischemia and Reperfusion Injury: A Narrative Review

  2026cites this paper
• Measuring lysosome damage and lysophagy in vivo.

  2026cites this paper
• USP30 senses serine/glycine levels to regulate serine biosynthesis and colorectal tumorigenesis by deubiquitinating FTO.

  2026cites this paper
• USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms

  2026cites this paper
• USP25 inhibition ameliorates Parkinson's disease by restoring mitophagy.

  2026cites this paper
• Mitophagy in the pathogenesis and management of disease

  2026cites this paper
• Function and regulation of the mitochondrial stress response.

  2026cites this paper
• Mitophagy and Ubiquitination Coordinate Context-Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion.

  2026cites this paper
• The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers

  2025cites this paper
• Effects and mechanisms of aflatoxin B1 on oocytes and embryo development.

  2025cites this paper
• Protein mechanism and therapeutic design in Parkinson's disease: A structural biology perspective.

  2025cites this paper
• Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

  2025influential citation
• Acetylation in Cardiac Aging: Molecular Mechanism and Therapeutic Approaches.

  2025cites this paper
• Integrative proximal-ubiquitomics profiling for deubiquitinase substrate discovery applied to USP30.

  2025cites this paper
• Multifaceted impacts of UVB radiation on morphology, cellular dynamics, and behavior in Macrobrachium olfersii larvae.

  2025cites this paper
• Targeting mitophagy in neurodegenerative diseases

  2025cites this paper
• Comprehensive analysis of autophagy status and its relationship with immunity and inflammation in ischemic stroke through integrated transcriptomic and single-cell sequencing

  2025cites this paper
• Visualizing bulk autophagy in vivo by tagging endogenous LC3B

  2025cites this paper
• Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease

  2025cites this paper
• Definition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein.

  2025cites this paper
• Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion.

  2025cites this paper
• Structure-based discovery of novel non-covalent small molecule inhibitors of USP30

  2025cites this paper
• Nuclear and cytoplasmic USP30-AS1 coordinately regulate breast cancer progression through HnRNPF/p21 and EZH2/c-Myc/p21 axes

  2025cites this paper
• Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

  2025cites this paper
• USP30 Knockdown Drives Mitophagy and Suppresses Pyroptosis in Heart Failure by Activating the PINK1/Parkin Pathway.

  2025cites this paper
• mTORC1‐USP30‐LEF1 Cascade Regulates Cancer Stemness and Malignant Progression Through Mitonuclear Crosstalk

  2025cites this paper
• The interconnective role of the UPS and autophagy in the quality control of cancer mitochondria

  2025cites this paper
• Molecular Symphony of Mitophagy: Ubiquitin‐Specific Protease‐30 as a Maestro for Precision Management of Neurodegenerative Diseases

  2025influential citation
• Insights into PINK1/Parkin function and dysfunction from Drosophila models

  2025cites this paper
• Galectin-3 directs mitophagy in response to Parkin-/proteasome-dependent rupture of mitochondrial outer membrane

  2025cites this paper
• Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

  2025cites this paper
• Deubiquitinating enzymes in parkinson’s disease: molecular mechanisms and therapeutic potential

  2025cites this paper
• Mapping the global research landscape of mitophagy in Parkinson's disease: a bibliometric and visualization analysis

  2025cites this paper
• Ubiquitin signaling in PINK1/Parkin-dependent mitophagy.

  2025cites this paper
• Pathological roles of ubiquitination and deubiquitination systems in sepsis-induced myocardial dysfunction

  2025influential citation
• Immune evasion through mitochondrial transfer in the tumour microenvironment

  2025cites this paper
• Mitophagy in breast cancer: Regulatory mechanisms and therapeutic potential

  2025cites this paper
• Mitochondrial Quality Control in Neurodegeneration and Cancer: A Common Denominator, Distinct Therapeutic Challenges

  2025cites this paper
• Predicting Which Mitophagy Proteins Are Dysregulated in Spinocerebellar Ataxia Type 3 (SCA3) Using the Auto-p2docking Pipeline

  2025cites this paper
• Chemical Synthesis of Activity‐Based Ubiquitin Probes for Profiling Arabidopsis thaliana Deubiquitinases

  2025cites this paper
• USP30 inhibition augments mitophagy to prevent T cell exhaustion

  2025cites this paper
• Aloe‐Emodin Improves Mitophagy in Alzheimer's Disease via Activating the AMPK/PGC‐1α/SIRT3 Signaling Pathway

  2025cites this paper
• Spautin-1 alleviates depression-like behaviors in mice after traumatic brain injury by inhibiting MMP3 expression in microglia in the Hippocampal CA1 region.

  2025cites this paper
• A structural switch reveals how to disarm USP30 and unlock mitophagy

  2025cites this paper
• Xin-Fu-Kang oral liquid mitigates chronic heart failure through NR4A1-Dependent regulation of endoplasmic reticulum-mitochondrial crosstalk in Cardiomyocytes.

  2025cites this paper
• Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes

  2025cites this paper
• Recent advances in small molecule inhibitors of deubiquitinating enzymes.

  2025cites this paper
• Unclogging of the TOM complex under import stress

  2025cites this paper
• Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer.

  2025cites this paper
• Mitophagy in Neurons: Mechanisms Regulating Mitochondrial Turnover and Neuronal Homeostasis.

  2025cites this paper
• Are Mitochondria the True Origin of Cancer? A Hypothesis-Driven Perspective

  2025cites this paper
• Research progress of deubiquitinating enzymes in cerebral ischemia-reperfusion injury

  2025cites this paper
• Mitophagy’s impacts on cancer and neurodegenerative diseases: implications for future therapies

  2025cites this paper
• Deubiquitinating enzymes at the crossroads of blood–brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions

  2025cites this paper
• Driving Therapeutic Innovation in Neurodegenerative Disease With Hydrogen Deuterium eXchange Mass Spectrometry

  2025cites this paper
• The ubiquitin-binding protein ANKRD13A mediates VCP-dependent mitochondrial outer membrane rupture during PINK1/Parkin-mediated mitophagy

  2025cites this paper
• Assessing the Suitability of Deubiquitylases As Substrates For Targeted Protein Degradation

  2025cites this paper
• NIPSNAP1 and NIPSNAP2 facilitate healthy aging independent of mitophagy.

  2025cites this paper
• Mitophagy in Age-Dependent Neurodegeneration

  2025cites this paper
• Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy

  2025cites this paper
• Circadian rhythm genes and immune cell infiltration in myasthenia gravis: A comprehensive analysis

  2025cites this paper
• Ubiquitination in the Nervous System: From Molecular Mechanisms to Disease Implications

  2025cites this paper
• Mitochondrial Metabolism in T-Cell Exhaustion

  2025cites this paper
• FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

  2025cites this paper
• Spotlight on USP30: structure, function, disease and target inhibition

  2025cites this paper
• Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress

  2025cites this paper
• PINK1 functions in mitophagy and mitochondrial homeostasis during mice oocyte maturation

  2025cites this paper
• Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

  2025cites this paper
• Pathogenesis of Parkinson's Disease.

  2025cites this paper
• Mitochondrial proteases modulate mitochondrial stress signalling and cellular homeostasis in health and disease.

  2024cites this paper
• Exploring the Role of Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease

  2024cites this paper
• Quantitative control of subcellular protein localization with a photochromic dimerizer

  2024cites this paper
• Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models

  2024cites this paper
• The neuroprotective effect of Chinese herbal medicine for cerebral ischemia reperfusion injury through regulating mitophagy

  2024cites this paper
• A novel marine‐derived mitophagy inducer ameliorates mitochondrial dysfunction and thermal hypersensitivity in paclitaxel‐induced peripheral neuropathy

  2024cites this paper
• The interplay between mitophagy and mitochondrial ROS in acute lung injury.

  2024cites this paper
• Therapeutic approaches in proteinopathies.

  2024cites this paper
• Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network.

  2024cites this paper
• Conserved quality control mechanisms of mitochondrial protein import

  2024cites this paper
• Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling

  2024cites this paper
• Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases

  2024cites this paper
• Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease models

  2024cites this paper
• The Role of Autophagy in Vascular Endothelial Cell Health and Physiology

  2024cites this paper
• Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies

  2024cites this paper
• Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)

  2024cites this paper
• USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy

  2024cites this paper
• Erasing marks: Functions of plant deubiquitylating enzymes in modulating the ubiquitin code.

  2024cites this paper
• Spatial transcriptomics reveals molecular dysfunction associated with cortical Lewy pathology

  2024cites this paper
• Mammalian pexophagy at a glance

  2024cites this paper
• Chinese botanical drugs targeting mitophagy to alleviate diabetic kidney disease, a comprehensive review

  2024cites this paper
• LncRNA NR_030777 promotes mitophagy by targeting CDK1-related mitochondrial fission and ATG12 to attenuate paraquat-induced Parkinson's disease.

  2024cites this paper
• Epigenetic Modifications in Parkinson's Disease: A Critical Review.

  2024cites this paper
• PRKN-linked familial Parkinson’s disease: cellular and molecular mechanisms of disease-linked variants

  2024cites this paper
• Substrate and Functional Diversity of Protein Lysine Post-translational Modifications

  2024cites this paper
• Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase

  2024influential citation
• Advances in the study of mitophagy in osteoarthritis

  2024cites this paper