The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Journal of Virology

• Publication date

  1989-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.63.10.4317-4324.1989PMID 2476572PMCID PMC251048
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: transactivation is mediated by the conserved amino-terminal domain.

  1989cited by this paper
• Characterization of primary human keratinocytes transformed by human papillomavirus type 18

  1988cited by this paper
• Interaction of the bovine papillomavirus type 1 E2 transcriptional control protein with the viral enhancer: purification of the DNA-binding domain and analysis of its contact points with DNA

  1988cited by this paper
• Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation.

  1988cited by this paper
• Evidence for cooperativity between E2 binding sites in E2 trans-regulation of bovine papillomavirus type 1

  1988cited by this paper
• The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.

  1988cited by this paper
• The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2‐dependent enhancer.

  1988cited by this paper
• The carboxy‐terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activity.

  1988cited by this paper
• Interplay of viral and cellular proteins along the long control region of human papillomavirus type 18

  1988cited by this paper
• Study of the E2 gene product of the cottontail rabbit papillomavirus reveals a common mechanism of transactivation among papillomaviruses

  1988cited by this paper
• Functional mapping of the human papillomavirus type 11 transcriptional enhancer and its interaction with the trans-acting E2 proteins.

  1988cited by this paper
• Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells

  1988cited by this paper
• Regulation of human papillomavirus type 11 enhancer and E6 promoter by activating and repressing proteins from the E2 open reading frame: functional and biochemical studies

  1988cited by this paper
• A dimer of BPV‐1 E2 containing a protease resistant core interacts with its DNA target.

  1988cited by this paper
• Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18

  1988cited by this paper
• Structural and mutational analysis of E2 trans‐activating proteins of papillomaviruses reveals three distinct functional domains.

  1988cited by this paper
• Induction of anchorage-independent growth of human embryonic fibroblasts with a deletion in the short arm of chromosome 11 by human papillomavirus type 16 DNA

  1988cited by this paper
• Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.

  1987cited by this paper
• A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator.

  1987influential reference
• Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

  1987cited by this paper
• Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA

  1987cited by this paper
• Transcriptional regulation of the human papillomavirus‐16 E6‐E7 promoter by a keratinocyte‐dependent enhancer, and by viral E2 trans‐activator and repressor gene products: implications for cervical carcinogenesis.

  1987cited by this paper
• Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames.

  1987cited by this paper
• Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

  1987cited by this paper
• Trans‐activation of an upstream early gene promoter of bovine papilloma virus‐1 by a product of the viral E2 gene.

  1987cited by this paper
• Identification of the HPV‐16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

  1987cited by this paper
• Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridization

  1987cited by this paper
• Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens

  1987cited by this paper
• Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product

  1987cited by this paper
• The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells

  1987cited by this paper
• Enhancers and trans-acting E2 transcriptional factors of papillomaviruses

  1987cited by this paper
• Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control region

  1987influential reference
• The E2 "gene" of bovine papillomavirus encodes an enhancer-binding protein.

  1987cited by this paper
• Characterization of a cell type‐specific enhancer found in the human papilloma virus type 18 genome.

  1987cited by this paper
• The BPV1‐E2 trans‐acting protein can be either an activator or a repressor of the HPV18 regulatory region.

  1987cited by this paper
• Differential promoter utilization by the bovine papillomavirus in transformed cells and productively infected wart tissues.

  1987cited by this paper
• Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system

  1987cited by this paper
• The Role of Papillomaviruses in Human Anogenital Cancer

  1987cited by this paper
• Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

  1986cited by this paper
• Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

  1986cited by this paper
• Transforming activity of human papillomavirus type 16 DNA sequence in a cervical cancer.

  1986cited by this paper
• Nonsense mutation in open reading frame E2 of bovine papillomavirus DNA

  1986cited by this paper
• The nucleotide sequence and genome organization of human papilloma virus type 11.

  1986cited by this paper
• Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix.

  1985cited by this paper
• Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product.

  1985cited by this paper
• Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

  1985cited by this paper
• Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

  1985influential reference
• Bovine papillomavirus contains multiple transforming genes.

  1985cited by this paper
• Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma.

  1984cited by this paper
• Characterization of the bovine papilloma virus plasmid maintenance sequences.

  1984cited by this paper
• Origin of replication in episomal bovine papilloma virus type 1 DNA isolated from transformed cells.

  1984cited by this paper
• A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

  1984cited by this paper
• The search for a culture system for papillomavirus.

  1984cited by this paper
• Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

  1982cited by this paper
• Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences.

  1981cited by this paper
• Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.

  1975cited by this paper
• Transcriptional transActivation by the Human Papillomavirus Type 16 E 2 Gene Product

  year unknowncited by this paper

• Anisomelic acid promotes proteasomal degradation of HPV16 E6 via E3 ligase recruitment: A mass spectrometry-based interactome study.

  2025cites this paper
• Higher Expression of HPV16 Derived E7_LI Transcript Observed in Men With HIV and Recurrent Anal Cancer

  2025cites this paper
• The functions of papillomavirus E2 proteins.

  2024cites this paper
• The Natural History of Cervical Cancer and the Case for MicroRNAs: Is Human Papillomavirus Infection the Whole Story?

  2024cites this paper
• Sequence-Dependent Interaction of the Human Papillomavirus E2 Protein with the DNA Elements on Its DNA Replication Origin

  2023cites this paper
• Utilization of a cell‐penetrating peptide‐adaptor for delivery of human papillomavirus protein E2 into cervical cancer cells to arrest cell growth and promote cell death

  2023cites this paper
• Clinical applications and utility of ctDNA in cervical cancer and its precursor lesions: from screening to predictive biomarker

  2023cites this paper
• Protein–DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis

  2023cites this paper
• Circulating Virus–Host Chimera DNAs in the Clinical Monitoring of Virus-Related Cancers

  2022cites this paper
• CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells.

  2021cites this paper
• Cervical Cancer

  2021cites this paper
• Multiple Roles of Brd4 in the Infectious Cycle of Human Papillomaviruses

  2021cites this paper
• The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications

  2021cites this paper
• Human-Derived Model Systems in Gynecological Cancer Research.

  2020cites this paper
• Recent developments in immunotherapy of cancers caused by human papillomaviruses

  2020cites this paper
• CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 and E7 induces senescence in cervical cancer cells

  2020cites this paper
• Molecular basis of gynecologic diseases

  2020cites this paper
• Epigenetic regulation of human papillomavirus transcription in the productive virus life cycle

  2020cites this paper
• Is viral E6 oncoprotein a viable target? A critical analysis in the context of cervical cancer.

  2020cites this paper
• Utilization of a cell-penetrating peptide-adaptor for delivery of HPV protein E2 into cervical cancer cells to arrest cell growth and promote cell death

  2020cites this paper
• Prueba de concepto de una PCR multiplex de primera generación (cualitativa) para detección del oncogén E7 de VPHS de alto riesgo

  2019cites this paper
• A head and neck squamous cell carcinoma model to 2 study and target HPV replication and transcription 3

  2019cites this paper
• Regulation of HPV transcription

  2018cites this paper
• Fundamental Biology of Human Papillomaviruses

  2018cites this paper
• Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication.

  2018cites this paper
• The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA

  2018cites this paper
• HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes

  2018cites this paper
• HPV replication regulation by acetylation of a conserved lysine in the E2 protein

  2017cites this paper
• Human papillomavirus molecular biology.

  2017cites this paper
• Dysregulation of Host Cellular microRNA Expression by the Human Papillomavirus E6 and E7 Oncoproteins

  2017cites this paper
• The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets.

  2017cites this paper
• Human Papillomavirus Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein

  2017cites this paper
• From Gene to Therapy: Understanding Human Disease through Genetics

  2017cites this paper
• Genetic variations in the DNA replication origins of human papillomavirus family correlate with their oncogenic potential.

  2017cites this paper
• The cellular DNA helicase ChlR 1 regulates chromatin and nuclear matrix attachment of the human papillomavirus type 16 E 2 protein and high copy viral genome establishment

  2016cites this paper
• The Diagnostic of Cervical Carcinoma: From Theory to Practice

  2016cites this paper
• Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement.

  2016cites this paper
• University of Birmingham The cellular DNA helicase ChlR1 regulates chromatin and nuclear matrix attachment of the human papillomavirus type 16 E2 protein and high copy viral genome establishment

  2016cites this paper
• Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle

  2016cites this paper
• In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral Cancer

  2016cites this paper
• Genetic variation of high-risk HPV-16 from a cervical cancer biopsy collected in Pakistan

  2016cites this paper
• The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment

  2016cites this paper
• Human papillomavirus in recurrent respiratory papillomatosis, tonsillar and mobile tongue cancer

  2016cites this paper
• CCCTC-Binding Factor Recruitment to the Early Region of the Human Papillomavirus 18 Genome Regulates Viral Oncogene Expression

  2015cites this paper
• Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation

  2015cites this paper
• HPV Virology: Cellular Targets of HPV Oncogenes and Transformation

  2015cites this paper
• The human papillomavirus type 16 L1 protein directly interacts with E2 and enhances E2-dependent replication and transcription activation

  2015cites this paper
• Targeting the DEK oncogene in head and neck squamous cell carcinoma: functional and transcriptional consequences

  2015cites this paper
• University of Birmingham The human papillomavirus type 16 L1 protein interacts directly with E2 and enhances E2-dependent replication and transcription activation

  2015cites this paper
• A study of PDZ protein expression during the human papillomavirus life cycle

  2015cites this paper
• Immune Escape and Immunotherapy of HPV-Related Oropharyngeal Cancer: Has the Future Arrived?

  2015cites this paper
• The human papillomavirus type 16 L 1 protein interacts directly with E 2 and enhances E 2-dependent replication and transcription activation

  2015cites this paper
• The Molecular Biology of HPV-Related Head and Neck Cancer

  2015cites this paper
• Human Papillomavirus Induced Transformation in Cervical and Head and Neck Cancers

  2014cites this paper
• Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

  2014cites this paper
• Identification of novel E 2 binding sites within the HPV genome and their function in the regulation of viral gene expression By

  2014cites this paper
• MAD2 and CDC20 are Upregulated in High-grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Uterine Cervix

  2014cites this paper
• Human Papillomavirus (HPV)-associated Oral Cancers and Treatment Strategies

  2014cites this paper
• Identification of novel E2 binding sites within the HPV genome and their function in the regulation of viral gene expression

  2014cites this paper
• Human papillomaviruses of skin and genital lesions

  2014cites this paper
• Disordered interactome of human papillomavirus.

  2014cites this paper
• SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter.

  2014cites this paper
• Establishmentand Episomal Genome Required for Optimum Viral DNA Papillomavirus 16 E2 and TopBP1 Is An Interaction between Human

  2014cites this paper
• Recurrent Respiratory Papillomatosis - Causes and Consequences

  2013cites this paper
• Telomere-Related Factors and Human Papillomavirus Genome Maintenance

  2013cites this paper
• Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

  2013cites this paper
• Analysis of Pathways Affected by the Viral Oncogenes in Human Papillomavirus 16-Induced Neoplastic Progression

  2013cites this paper
• The papillomavirus E2 proteins.

  2013cites this paper
• An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome Establishment

  2012cites this paper
• The Life Cycle of Human Papillomavirus

  2012cites this paper
• Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation

  2012influential citation
• Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes

  2012cites this paper
• Human papillomavirus infections in laryngeal cancer

  2011cites this paper
• Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression.

  2011cites this paper
• Regulation of human papillomavirus type 16 early gene expression in trophoblastic and cervical cells.

  2011cites this paper
• The HPV transcriptome in HPV16 positive cell lines.

  2011cites this paper
• Interactions of the human papillomavirus E6 protein and their role in the persistence of viral episomes

  2011cites this paper
• The HPV16 transcriptome in cervical lesions of different grades.

  2011cites this paper
• Small Molecule Inhibitors of Human Papillomavirus Protein - Protein Interactions

  2011cites this paper
• The use of a human papillomavirus 18 promoter for tissue-specific expression in cervical carcinoma cells

  2011cites this paper
• The E 2 F 5 repressor is an activator of E 6 / E 7 transcription and of the S-phase entry in HPV 18-associated cells

  2010cites this paper
• Interaction of the Papillomavirus E8∧E2C Protein with the Cellular CHD6 Protein Contributes to Transcriptional Repression

  2010cites this paper
• The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells

  2010cites this paper
• Papillomavirus interaction with cellular chromatin.

  2010cites this paper
• Human papillomaviruses in skin cancer and cervical cancer

  2010cites this paper
• Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression

  2010cites this paper
• HPV-Mediated Genome Instability: At the Roots of Cervical Carcinogenesis

  2010cites this paper
• HPV 16 E2 Protein Induces Apoptosis in Human and Murine HPV 16 Transformed Epithelial Cells and Has Antitumoral Effects in vivo

  2009cites this paper
• Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2.

  2009cites this paper
• Abrogation of the Brd4-Positive Transcription Elongation Factor b Complex by Papillomavirus E2 Protein Contributes to Viral Oncogene Repression

  2009cites this paper
• The role of retinoid deficiency and estrogens as cofactors in cervical cancer.

  2009cites this paper
• Transmission and transformation : Reviewing HPV ’ s lifecycle

  2009cites this paper
• Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs).

  2008cites this paper
• Guidelines of the Italian Society for Virology on HPV testing and vaccination for cervical cancer prevention

  2008influential citation
• The effects of leptomycin B on HPV-infected cells

  2008cites this paper
• Cellular and molecular biological aspects of cervical intraepithelial neoplasia.

  2008cites this paper
• Replication and partitioning of papillomavirus genomes.

  2008cites this paper
• Senescence Induced by Repression of Human Papillomavirus Oncogenes in Cervical Cancer Cells

  2008cites this paper
• Human papillomavirus testing and its application in cervical cancer prevention

  2008cites this paper
• Historia natural de la infección del cérvix uterino por el virus papiloma humano

  2007cites this paper