Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Natural Products

• Publication date

  2012-07-31

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/np3001738PMID 22849774
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A pair of sulfur-containing geldanamycin analogs, 19-S-methylgeldanamycin and 4,5-dihydro- 19-S-methylgeldanamycin, from Streptomyces hygroscopicus 17997

  2011cited by this paper
• Thiazinogeldanamycin, a new geldanamycin derivative produced by Streptomyces hygroscopicus 17997.

  2011cited by this paper
• Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

  2011cited by this paper
• [Analysis of geldanamycin analogues in trace amounts by LC-MS/MS].

  2009cited by this paper
• Rational Biosynthetic Engineering for Optimization of Geldanamycin Analogues

  2009cited by this paper
• New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

  2009cited by this paper
• Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.

  2008cited by this paper
• [Roles of geldanamycin biosynthetic genes in Streptomyces hygroscopicus 17997].

  2008cited by this paper
• Production of 8-demethylgeldanamycin and 4,5-epoxy-8-demethylgeldanamycin from a recombinant strain of Streptomyces hygroscopicus.

  2005cited by this paper
• Isolation and characterization of novel geldanamycin analogues.

  2004cited by this paper
• Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

  2004cited by this paper
• Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.

  2004cited by this paper
• Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

  2003cited by this paper
• Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.

  2001cited by this paper
• Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.

  1997cited by this paper
• MTPA vs MPA in the Determination of the Absolute Configuration of Chiral Alcohols by 1H NMR

  1996cited by this paper
• erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships.

  1995cited by this paper
• Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.

  1988cited by this paper
• On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols

  1986cited by this paper
• Macbecins I and II, new antitumor antibiotics. II. Isolation and characterization.

  1980cited by this paper
• Growth inhibition of virus transformed cells in vitro and antitumor activity in vivo of geldanamycin and its derivatives.

  1979cited by this paper
• Direct room temperature esterification of carboxylic acids

  1978cited by this paper
• The description and antibiotic production of Streptomyces hygroscopicus var. Geldanus.

  1976cited by this paper
• Geldanamycin biosynthesis and carbon magnetic resonance.

  1974cited by this paper
• Chrysanthemic acid. V. Thermal and photo [3,3]sigmatropic rearrangements in the cis-2,2-dimethyl-3-isobutenylcyclopropyl isocyanate-3,6-dihydro-3,3,6,6-tetramethyl-2H-azepin-2-one system

  1970cited by this paper
• Geldanamycin. I. Structure assignment.

  1970cited by this paper

• BARC Biostimulant 1, a novel Streptomyces rochei C3-based formulation for disease biocontrol and plant growth promotion

  2024cites this paper
• Rapid Discovery of Substances with Anticancer Potential from Marine Fungi Based on a One Strain–Many Compounds Strategy and UPLC-QTOF-MS

  2023influential citation
• Discovery of Bioactive Metabolites by Acidic Stress to a Geldanamycin Producer, Streptomyces samsunensis.

  2023cites this paper
• Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners.

  2022cites this paper
• Engineering of Microbial Substrate Promiscuous CYP105A5 for Improving the Flavonoid Hydroxylation

  2022cites this paper
• More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and Mycobacterium

  2020cites this paper
• Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

  2017cites this paper
• Molecular association of 2-(n-alkylamino)-1,4-naphthoquinone derivatives: Electrochemical, DFT studies and antiproliferative activity against leukemia cell lines

  2016cites this paper
• Two herbimycin analogs, 4,5-dihydro-(4S)-4-hydroxyherbimycin B and (15S)-15-hydroxyherbimycin B, from Streptomyces sp. CPCC 200291

  2015cites this paper
• Literature search and data collection on RA for human health for microorganisms used as plant protection products

  2015cites this paper
• Studies towards the total synthesis of hygrocins A and B

  2014cites this paper
• Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp.

  2014cites this paper
• The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria.

  2014cites this paper
• CYP105—diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces

  2014cites this paper
• Identification of 6-demethoxy-6-methylgeldanamycin and its implication of geldanamycin biosynthesis

  2013cites this paper
• Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.

  2013cites this paper
• Inactivation of putative PKS genes can double geldanamycin yield in Streptomyces hygroscopicus 17997.

  2013cites this paper
• 19-[(1'S,4'R)-4'-Hydroxy-1'-methoxy-2'-oxopentyl]geldanamycin, a natural geldanamycin analogue from Streptomyces hygroscopicus 17997.

  2013cites this paper
• Synthesis of the naphthoquinone core of divergolides (C–D) and model studies for elaboration of the ansabridge

  2013cites this paper