Rational Biosynthetic Engineering for Optimization of Geldanamycin Analogues

No abstract is available for this paper.

• Publication year

  2009

• Venue

  ChemBioChem

• Publication date

  2009-05-04

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/cbic.200800763PMID 19308924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.

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• Mutasynthesis of Geldanamycin by the Disruption of a Gene Producing Starter Unit: Generation of Structural Diversity at the Benzoquinone Ring

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• Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications.

  2006cited by this paper
• Combinatorial biosynthesis--potential and problems.

  2006cited by this paper
• Biosynthesis of the Heat‐Shock Protein 90 Inhibitor Geldanamycin: New Insight into the Formation of the Benzoquinone Moiety

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• The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H:Quinone Oxidoreductase 1 to More Potent Heat Shock Protein 90 Inhibitors, the Hydroquinone Ansamycins

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• Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.

  2005cited by this paper
• The Lego-ization of polyketide biosynthesis

  2005cited by this paper
• Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition.

  2005cited by this paper
• Combinatorial biosynthesis of reduced polyketides

  2005cited by this paper
• High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity.

  2004cited by this paper
• Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.

  2004cited by this paper
• Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.

  2004cited by this paper
• Isolation and characterization of novel geldanamycin analogues.

  2004cited by this paper
• Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

  2004cited by this paper
• Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

  2003cited by this paper
• Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.

  2003cited by this paper
• Clinical development of 17-allylamino, 17-demethoxygeldanamycin.

  2003cited by this paper
• Combinatorial Biosynthesis of Antibiotics: Challenges and Opportunities

  2002cited by this paper
• Heat-shock protein 90 inhibitors as novel cancer chemotherapeutic agents

  2002cited by this paper
• Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae.

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Structure and in vivo function of Hsp90.

  2000cited by this paper
• Dissecting and exploiting intermodular communication in polyketide synthases.

  1999cited by this paper
• DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.

  1999cited by this paper
• Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

  1999cited by this paper
• The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

  1998cited by this paper
• ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

  1998cited by this paper
• Combinatorial biosynthesis: lesson learned from nature.

  1998cited by this paper
• Combinatorial biosynthesis of erythromycin and complex polyketides.

  1998cited by this paper
• Combinatorial biosynthesis for new drug discovery.

  1998cited by this paper
• Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.

  1997cited by this paper
• Manipulation of Modular Polyketide Synthases.

  1997cited by this paper
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  1997cited by this paper
• Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site.

  1996cited by this paper
• A hybrid modular polyketide synthase obtained by domain swapping.

  1996cited by this paper
• A functional chimeric modular polyketide synthase generated via domain replacement.

  1996cited by this paper
• Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

  1994cited by this paper
• Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase.

  1993cited by this paper
• Construction, expression, and characterization of a mutated animal fatty acid synthase deficient in the dehydrase function.

  1993cited by this paper
• Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea.

  1992cited by this paper
• Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

  1992cited by this paper
• An improved aminoglycoside resistance gene cassette for use in gram-negative bacteria and Streptomyces.

  1991cited by this paper
• Modular organization of genes required for complex polyketide biosynthesis.

  1991cited by this paper
• The structure and cytocidal activity of herbimycin C.

  1986cited by this paper
• Macbecins I and II, new antitumor antibiotics. II. Isolation and characterization.

  1980cited by this paper
• Geldanamycin, a new antibiotic.

  1970cited by this paper

• Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy

  2024cites this paper
• Nagimycins A and B, Antibacterial Ansamycin-Related Macrolactams from Streptomyces sp. NA07423.

  2023cites this paper
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  2023cites this paper
• Bioprospecting potential of microbes for the therapeutic application

  2022cites this paper
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  2022cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Diversification of polyketide structures via synthase engineering.

  2019cites this paper
• New geldanamycin derivatives with anti Hsp properties by mutasynthesis.

  2019cites this paper
• Total synthesis based modification of benzoquinone ansamycin antibiotics: C8 diversification of C5-C15 fragments

  2019cites this paper
• A Review of the Microbial Production of Bioactive Natural Products and Biologics

  2019cites this paper
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  2018cites this paper
• Acyltransferases as Tools for Polyketide Synthase Engineering

  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2010cites this paper
• ATPase inhibitors of heat-shock protein 90, second season.

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