Force interacts with macromolecular structure in activation of TGF-β

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature

• Publication date

  2017-01-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature21035PMID 28117447PMCID PMC5586147
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural Biology and Evolution of the TGF-β Family.

  2016cited by this paper
• Coordinated integrin activation by actin-dependent force during T-cell migration

  2016cited by this paper
• Structure and activation of pro-activin A

  2016cited by this paper
• Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.

  2016cited by this paper
• Structure of bone morphogenetic protein 9 procomplex

  2015cited by this paper
• β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece*

  2015cited by this paper
• Force-induced remodelling of proteins and their complexes

  2015cited by this paper
• Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin

  2014cited by this paper
• Structural determinants of integrin β-subunit specificity for latent TGF-β

  2014cited by this paper
• An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2

  2013cited by this paper
• Complete integrin headpiece opening in eight steps

  2013cited by this paper
• Protein structure alignment beyond spatial proximity

  2013cited by this paper
• Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation.

  2013cited by this paper
• Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements.

  2013cited by this paper
• Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

  2012cited by this paper
• Integrin inside-out signaling and the immunological synapse.

  2012cited by this paper
• A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13.

  2011cited by this paper
• Fibronectins, their fibrillogenesis, and in vivo functions.

  2011cited by this paper
• Latent TGF-β structure and activation

  2011cited by this paper
• Intact αIIbβ3 Integrin Is Extended after Activation as Measured by Solution X-ray Scattering and Electron Microscopy*

  2011cited by this paper
• Tgf-beta superfamily signaling in embryonic development and homeostasis.

  2009cited by this paper
• Hydrogen exchange mass spectrometry for the analysis of protein dynamics.

  2006cited by this paper
• Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment

  2005cited by this paper
• PRIMUS: a Windows PC-based system for small-angle scattering data analysis

  2003cited by this paper
• Molecular recognition in antibody-antigen complexes.

  2002cited by this paper
• Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

  2002cited by this paper
• Strength of a weak bond connecting flexible polymer chains.

  1999cited by this paper
• An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.

  1994cited by this paper

• Targeting focal adhesion kinase: From molecular mechanisms to next-generation cancer therapeutics

  2026cites this paper
• Selective blockade of latent TGF-β1 activation suppresses tissue fibrosis with good safety

  2026cites this paper
• Wound healing under the regulation of mechanically active biomaterials: From mechanism exploration to scar prevention.

  2026cites this paper
• Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation

  2025cites this paper
• The role of NK cells in regulating tumorimmunity: current state, challenges and future strategies

  2025cites this paper
• Synthesis and Preclinical Development of a Novel 68Ga/89Zr-Labelled ανβ6-Integrin Targeting Trimer

  2025cites this paper
• Importance of integrin transmembrane helical interactions for antagonistic versus agonistic ligand behavior: Consequences for medical applications.

  2025cites this paper
• Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

  2025cites this paper
• Overcoming Immune Checkpoint Inhibitor Resistance via Potent and Selective Dual αvβ6/8 Inhibitors Based on Engineered Lasso Peptides

  2025influential citation
• Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity.

  2025cites this paper
• The pivotal role of TGF-β/Smad pathway in fibrosis pathogenesis and treatment

  2025cites this paper
• Stiffness regulates extracellular matrix synthesis in fibroblasts by DDR1-TGF-β/STAT3 mechanotransduction axis.

  2025cites this paper
• PET/CT imaging of esophageal cancer targeting tumor cell specific αvβ6-integrin expression

  2025cites this paper
• Persistent tissue regeneration and transforming growth factor-β induced fibrosis in the masseter muscle of mdx5Cv mice

  2025cites this paper
• Potential of Bombyx mori fibroin peptide as an inhibitor of BMP2 and TGFB1 in the treatment of pulp tissue damage

  2025cites this paper
• Microenvironmental and structural regulation of BMP signaling: insights into the prodomain-growth factor interface.

  2025cites this paper
• Effect of TGFβ-ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer.

  2025cites this paper
• Immunoprofile of some surface and cytoplasmic peripheral cell adhesion molecules in oral squamous cell carcinoma

  2025cites this paper
• Cell Niche Properties as Tuned by Physical Factors: ECM Proteins as Mechanochemical Switches

  2025cites this paper
• Latent-TGF-β has a domain swapped architecture

  2025influential citation
• Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells.

  2025cites this paper
• Overcoming Immune Checkpoint Inhibitor Resistance with Potent, Selective Dual αvβ6/8 Inhibitors Based on Engineered Lasso Peptides.

  2025cites this paper
• Wuweizisu B for cancer treatment from multitarget mechanisms to precision delivery strategies (Review)

  2025cites this paper
• Molecular Signaling in Biomaterial-induced Foreign Body Response: Current Perspectives.

  2025cites this paper
• Immune Checkpoints and the Immunology of Liver Fibrosis

  2025cites this paper
• Keloids as a Spectrum of Auto-Inflammatory Fibrotic Disorders: Beyond the Conventional Wound-Healing Paradigm

  2025cites this paper
• Discussion of the material basis for prevention and treatment of pulmonary fibrosis using naturally medicinal and edible homologous herbs based on the dynamic process of Nrf2, NF-κB and TGF-β in PF.

  2025cites this paper
• Matrix metalloproteinases and their tissue inhibitors as indicators of aortic aneurysm and dissection development in extracellular matrix remodeling

  2025cites this paper
• LAG3-MHCII interaction induces a tight cell-cell interface at the immunological synapse.

  2025cites this paper
• Identification of Acanthopanax trifoliatus (L.) Merr as a Novel Potential Therapeutic Agent Against COVID-19 and Pharyngitis

  2025cites this paper
• Activation of transforming growth factor beta 1 through integrin alpha V beta 6 and its molecular insights into cancer progression, and future directions.

  2025cites this paper
• Integrin αvβ6‐Targeted PET/CT Imaging of Non‐Small Cell Lung Cancer with [68Ga]Ga‐Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry

  2025cites this paper
• TGF-β inhibitors: the future for prevention and treatment of liver fibrosis?

  2025cites this paper
• Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging

  2025cites this paper
• The Combination of Oncolytic Virus and Antibody Blockade of TGF-β Enhances the Efficacy of αvβ6-Targeting CAR T Cells Against Pancreatic Cancer in an Immunocompetent Model

  2025cites this paper
• Collagen-disrupting attIL12 TIL therapy boosts deep T cell infiltration via dual signaling activation and CCKAR reduction in sarcomas.

  2025cites this paper
• 3D hydrogel platform with macromolecular actuators for precisely controlled mechanical forces on cancer cell migration

  2025cites this paper
• Mechanical Unfolding of Network Nodes Drives the Stress Response of Protein-Based Materials.

  2024cites this paper
• The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation

  2024cites this paper
• Monocyte‐derived extracellular vesicles, stimulated by Trypanosoma cruzi, enhance cellular invasion in vitro via activated TGF‐β1

  2024cites this paper
• Molecular force-induced liberation of transforming growth factor-beta remodels the spleen for ectopic liver regeneration.

  2024cites this paper
• ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation

  2024cites this paper
• A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens

  2024cites this paper
• Dynamic allostery drives autocrine and paracrine TGF-β signaling

  2024cites this paper
• Unveiling the therapeutic potential: KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro

  2024cites this paper
• The role and regulation of integrins in cell migration and invasion

  2024influential citation
• Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells

  2024cites this paper
• A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance

  2024cites this paper
• Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis

  2024cites this paper
• Collagen-disruptive cell therapy: adoptive transfer of membrane-anchored, tumor cell surface vimentin-targeted interleukin 12–armed TILs suppress collagen expression to boost deep T-cell infiltration via dual signaling activation and significant CCKAR reduction

  2024cites this paper
• An engineered AAV targeting integrin alpha V beta 6 presents improved myotropism across species

  2024cites this paper
• On the pathogenesis of COVID-19: the role of transforming growth factor beta

  2024cites this paper
• 68Ga-Trivehexin PET/CT: a promising novel tracer for primary hyperparathyroidism

  2024cites this paper
• An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

  2024cites this paper
• Suppression of OGN in lung myofibroblasts attenuates pulmonary fibrosis by inhibiting integrin αv-mediated TGF-β/Smad pathway activation.

  2024cites this paper
• Galectin 3‐binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor‐β1 (TGF‐β1) availability and inhibits hepatocarcinogenesis

  2024cites this paper
• Loss of tolerance to dietary proteins: From mouse models to human model diseases

  2024cites this paper
• Latent-TGF-β has a domain swapped architecture

  2024cites this paper
• Binding requirements for latent transforming growth factor Beta2 activation

  2024cites this paper
• Potential Efficacy of 68Ga-Trivehexin PET/CT and Immunohistochemical Validation of αvβ6 Integrin Expression in Patients With Head and Neck Squamous Cell Carcinoma and Pancreatic Ductal Adenocarcinoma

  2024cites this paper
• Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

  2024cites this paper
• Integrins in cancer stem cells

  2024cites this paper
• Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis

  2024cites this paper
• Hypoglycemic Activity of Rice Resistant-Starch Metabolites: A Mechanistic Network Pharmacology and In Vitro Approach

  2024cites this paper
• Research Progress of Traditional Chinese Medicine Based on TGF-β/Smad Signal Pathway in Preventing and Treating Myocardial Fibrosis in Heart Failure

  2024cites this paper
• Role of integrin β1 and tenascin C mediate TGF-SMAD2/3 signaling in chondrogenic differentiation of BMSCs induced by type I collagen hydrogel

  2024cites this paper
• TGF-β signaling in health, disease and therapeutics

  2024cites this paper
• Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer

  2024cites this paper
• Stepwise release of Activin-A from its inhibitory prodomain is modulated by cysteines and requires furin coexpression to promote melanoma growth

  2024cites this paper
• A Hierarchical Mechanotransduction System: From Macro to Micro

  2023cites this paper
• Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles

  2023cites this paper
• Cancer cell-intrinsic mechanisms driving acquired immune tolerance.

  2023cites this paper
• De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

  2023cites this paper
• Family-wide analysis of integrin structures predicted by AlphaFold2

  2023cites this paper
• Stepwise Targeting and Tandem Responsive Peptide Nanoparticles Enhance Immunotherapy through Prolonged Drug Retention

  2023cites this paper
• The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers

  2023cites this paper
• Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy

  2023cites this paper
• Structural analysis of peptide binding to integrins for cancer detection and treatment

  2023cites this paper
• A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8

  2023cites this paper
• Decrypting the Pathological Pathways in IgA Nephropathy.

  2023cites this paper
• Family-wide analysis of integrin structures predicted by AlphaFold2

  2023cites this paper
• Extracellular Vesicle–associated GARP/TGFβ:LAP Mediates “Infectious” Allo-tolerance

  2023cites this paper
• S373P Mutation Stabilizes the Receptor-Binding Domain of the Spike Protein in Omicron and Promotes Binding

  2023cites this paper
• A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice

  2023cites this paper
• Integrin β3 Mediates Sepsis and Mechanical Ventilation-Associated Pulmonary Fibrosis Through Glycometabolic Reprogramming.

  2023cites this paper
• De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

  2023cites this paper
• New tools to study the interaction between integrins and latent TGFβ1

  2023cites this paper
• Cellular and Molecular Control of Lipid Metabolism in Idiopathic Pulmonary Fibrosis: Clinical Application of the Lysophosphatidic Acid Pathway

  2023cites this paper
• Targeting integrin pathways: mechanisms and advances in therapy

  2023cites this paper
• Macrophages and fibroblasts in foreign body reactions: How mechanical cues drive cell functions?

  2023cites this paper
• LINC01798/miR-17-5p axis regulates ITGA8 and causes changes in tumor microenvironment and stemness in lung adenocarcinoma

  2023cites this paper
• Integrin α5β1 contributes to cell fusion and inflammation mediated by SARS-CoV-2 spike via RGD-independent interaction

  2023cites this paper
• Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy

  2023cites this paper
• Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment

  2022cites this paper
• CD82 attenuates TGF-β1-mediated epithelial-mesenchymal transition by blocking smad-dependent signaling in ARPE-19 cells

  2022cites this paper
• Integrin Conformational Dynamics and Mechanotransduction

  2022cites this paper
• Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis

  2022cites this paper
• Functionalizing Polyacrylamide Hydrogels for Renal Cell Culture Under Fluid Shear Stress

  2022cites this paper
• TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective

  2022cites this paper
• Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

  2022cites this paper