The neurobiology of drug addiction.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  The Journal of Neuropsychiatry and Clinical Neurosciences

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1176/JNP.9.3.482PMID 9276849
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal

  2006cited by this paper
• The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

  2005cited by this paper
• Animal models of drug craving

  2005cited by this paper
• Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

  2004cited by this paper
• Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

  2004cited by this paper
• Self-administration of psychoactive substances by the monkey

  2004cited by this paper
• Molecular neurobiology of drug addiction.

  2004cited by this paper
• Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes

  2004cited by this paper
• Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat

  2004cited by this paper
• Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system

  2004cited by this paper
• Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

  2004cited by this paper
• Reinstatement of cocaine-reinforced responding in the rat

  2004cited by this paper
• Amphetamine and the reward system: Evidence for tolerance and post-drug depression

  2004cited by this paper
• Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats.

  1996cited by this paper
• Drug addiction: the yin and yang of hedonic homeostasis.

  1996cited by this paper
• Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons.

  1996cited by this paper
• Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence.

  1996cited by this paper
• Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats

  1996cited by this paper
• Under siege: The brain on opiates.

  1996cited by this paper
• [Pharmacotherapy of alcoholism].

  1996cited by this paper
• Addiction to cocaine and amphetamine.

  1996cited by this paper
• Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.

  1996cited by this paper
• Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB

  1996cited by this paper
• Opposite Modulation of Cocaine-Seeking Behavior by D1- and D2-Like Dopamine Receptor Agonists

  1996cited by this paper
• Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat.

  1995cited by this paper
• Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis

  1995cited by this paper
• The glutamatergic basis of human alcoholism.

  1995cited by this paper
• Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.

  1995cited by this paper
• Pretreatment with the dopamine agonist 7‐OH‐DPAT shifts the cocaine self‐administration dose‐effect function to the left under different schedules in the rat

  1995cited by this paper
• GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats.

  1995cited by this paper
• Molecular mechanisms of drug reinforcement and addiction.

  1995cited by this paper
• Molecular and cellular adaptations in signal transduction pathways following ethanol exposure.

  1995cited by this paper
• Agonist-induced Desensitization of the Mu Opioid Receptor-coupled Potassium Channel (GIRK1) (*)

  1995cited by this paper
• Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.

  1995cited by this paper
• The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis.

  1995cited by this paper
• Decreased brain reward produced by ethanol withdrawal.

  1995cited by this paper
• Corticotropin releasing factor, stress and behavior

  1994cited by this paper
• The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat

  1994cited by this paper
• Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.

  1994cited by this paper
• Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse.

  1994cited by this paper
• Molecular Neurobiology of Drug Addiction

  1994cited by this paper
• Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments.

  1994cited by this paper
• Tolerance to the reinforcing effects of cocaine in a progressive ratio paradigm

  1994cited by this paper
• Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food.

  1994cited by this paper
• Potentiation of lateral hypothalamic and midline mesencephalic brain stimulation reinforcement by nicotine: examination of repeated treatment.

  1994cited by this paper
• Naloxone precipitates nicotine abstinence syndrome in the rat

  1993cited by this paper
• Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.

  1993cited by this paper
• Opponent process and drug dependence: Neurobiological mechanisms

  1993cited by this paper
• Tolerance and sensitization to the behavioral effects of drugs.

  1993cited by this paper
• Drug addiction: a model for the molecular basis of neural plasticity.

  1993cited by this paper
• Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats

  1993cited by this paper
• The neural basis of drug craving: an incentive-sensitization theory of addiction.

  1993cited by this paper
• Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons

  1993cited by this paper
• From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters.

  1993cited by this paper
• GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol.

  1993cited by this paper
• Effect of antagonists selective for mu, delta and kappa opioid receptors on the reinforcing effects of heroin in rats.

  1993cited by this paper
• Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.

  1993cited by this paper
• Destruction of the locus coeruleus decreases physical signs of opiate withdrawal.

  1993cited by this paper
• The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat.

  1993cited by this paper
• 5-HT and alcohol abuse.

  1992cited by this paper
• Serotonergic and dopaminergic involvement in ethanol intake.

  1992cited by this paper
• Molecular mechanisms of drug addiction [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

  1992cited by this paper
• Naltrexone in the treatment of alcohol dependence.

  1992cited by this paper
• Heroin, 6-acetylmorphine and morphine effects on threshold for rewarding and aversive brain stimulation.

  1992cited by this paper
• Effects of nicotine on the threshold for rewarding brain stimulation in rats.

  1992cited by this paper
• Neurobiology of opiate abuse.

  1992cited by this paper
• Dopamine, addiction and reward

  1992cited by this paper
• Role of Neuronal Calcium Channels in Ethanol Dependence: From Cell Cultures to the Intact Animal a

  1992cited by this paper
• Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations.

  1992cited by this paper
• Drugs of abuse: anatomy, pharmacology and function of reward pathways.

  1992cited by this paper
• Neural substrates of opiate withdrawal.

  1992cited by this paper
• Conditioning of Opioid Reinforcement: Neuroanatomical and Neurochemical Substrates

  1992cited by this paper
• Role of different brain structures in the expression of the physical morphine withdrawal syndrome.

  1992cited by this paper
• Naltrexone and coping skills therapy for alcohol dependence. A controlled study.

  1992cited by this paper
• Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration.

  1992cited by this paper
• Interaction between Endogenous Opioids and Dopamine within the Nucleus Accumbens a

  1992cited by this paper
• Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.

  1991cited by this paper
• Cloning and functional characterization of a cocaine‐sensitive dopamine transporter

  1991cited by this paper
• Cloning and expression of a functional serotonin transporter from rat brain

  1991cited by this paper
• Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input

  1991cited by this paper
• Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens.

  1991cited by this paper
• Specificity in the projection patterns of accumbal core and shell in the rat.

  1991cited by this paper
• Cloning and expression of a cocaine-sensitive rat dopamine transporter.

  1991cited by this paper
• Postcocaine anhedonia. An animal model of cocaine withdrawal.

  1991cited by this paper
• Opioidergic, serotonergic, and dopaminergic manipulations and rats' intake of a sweetened alcoholic beverage.

  1991cited by this paper
• Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection.

  1991cited by this paper
• Homeostatic theory of drug tolerance: a general model of physiological adaptation.

  1991cited by this paper
• Piecing together the puzzle of basal forebrain anatomy.

  1991cited by this paper
• Benzodiazepine receptors: new vistas

  1991cited by this paper
• Ethanol and Rewarding Brain Stimulation

  1991cited by this paper
• Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers

  1990cited by this paper
• Changes in mood, craving, and sleep during short-term abstinence reported by male cocaine addicts. A controlled, residential study.

  1990cited by this paper
• Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists.

  1990cited by this paper
• Antagonism of cocaine self‐administration by selective dopamine D1 and D2 antagonists

  1990cited by this paper
• Ethanol withdrawal seizures and the NMDA receptor complex.

  1990cited by this paper
• Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal.

  1990cited by this paper
• Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates

  1990cited by this paper
• Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis.

  1989cited by this paper
• N‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production

  1989cited by this paper
• The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food.

  1989cited by this paper

• The effects of sub-chronic calcium treatment on ethanol-induced dopamine elevation and the alcohol deprivation effect in the rat

  2026cites this paper
• Electroconvulsive therapy is associated with a decrease in anhedonia and axial diffusivity in the medial forebrain bundle in major depressive disorder.

  2025cites this paper
• The neurobiology of love and addiction: Central nervous system signaling and energy metabolism

  2025cites this paper
• The art of social media influencers: exploring women’s healthcare marketing journey to prescription drug abuse and treatment engagement

  2025cites this paper
• Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

  2025cites this paper
• Effect of Celastrus paniculatus on Alcohol-Elicited Conditioned Place Preference and Alcohol Withdrawal-Induced Anxiety in Mice

  2025cites this paper
• From Stress to Substance Use Disorders: The Expanding Role of Microglia–Astrocyte Crosstalk in Neuroimmune and Glutamate Alterations in the Nucleus Accumbens

  2025cites this paper
• Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder

  2025cites this paper
• Isradipine, an L-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release.

  2024cites this paper
• Hypothalamic Pituitary Adrenal and Autonomic Nervous System Biomarkers of Stress and Tobacco Relapse: Review of the Research.

  2024cites this paper
• The Effect of Antinociceptive Dose of Morphine on Cell Therapy in Rats with Spinal Cord Injury

  2024cites this paper
• The effects of amphetamine exposure on stress susceptibility in mice

  2024cites this paper
• C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and heightened ethanol-induced anxiolysis

  2024influential citation
• Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala

  2023cites this paper
• The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

  2023cites this paper
• Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats.

  2023cites this paper
• Risk for Cannabis Use Disorder in People Who Use Cannabis to Cope with Internalizing Disorders: Implications for Policy and Practice

  2023cites this paper
• Acute toxicity (LD50 values) and neuropharmacological profile of n-hexane fraction of Petiveria alliacea L. (Phytolaccaceae) in mice

  2023cites this paper
• Neural oscillations in the ventral striatum reveal differences between the encoding of palatable food and ethanol consumption.

  2023cites this paper
• Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice

  2022cites this paper
• The potent α2-adrenoceptor antagonist RS 79948 also inhibits dopamine D2 -receptors: Comparison with atipamezole and raclopride.

  2022cites this paper
• The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement

  2022cites this paper
• Sodium acamprosate and calcium exert additive effects on nucleus accumbens dopamine in the rat

  2022cites this paper
• Anomalies in global network connectivity associated with early recovery from alcohol dependence: A network transcranial magnetic stimulation and electroencephalography study

  2022cites this paper
• Symptoms of Protracted Alcohol Withdrawal in Patients with Alcohol Use Disorder: A Comprehensive Systematic Review

  2022cites this paper
• HU-910, a CB2 receptor agonist, reverses behavioral changes in pharmacological rodent models for schizophrenia.

  2022cites this paper
• Mental health correlates of quitting cigarette smoking in youth experiencing homelessness.

  2022cites this paper
• Activation of α7 nicotinic receptors suppresses sucrose addiction in mice.

  2021cites this paper
• CRHCeA→VTA inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal

  2021cites this paper
• Interactions of neuroimmune signaling and glutamate plasticity in addiction

  2021cites this paper
• Substance Use: Prevalence, Pattern and Risk Factors among Undergraduate Students in a Tertiary Institution in Southwest Nigeria

  2021cites this paper
• Wake-promoting medications

  2021cites this paper
• Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight

  2021cites this paper
• Altered neural activities during response inhibition in adults with addiction: a voxel-wise meta-analysis

  2021cites this paper
• Pharmacological management of psychoactive substance withdrawal syndrome

  2021cites this paper
• TNF signaling pathway upregulation as a potential pharmaceutical target for cocaine-addicted individuals

  2021cites this paper
• Animal Models of Eating Disorders

  2021cites this paper
• Sedative‐Hypnotic Agents That Impact Gamma‐Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma‐Hydroxybutyric Acid, Phenibut, and Selank

  2021cites this paper
• Anabolic androgenic steroid abuse in the United Kingdom: An update

  2020cites this paper
• Serotonin in eating behavior

  2020cites this paper
• Does the use of illicit drugs specifically class a drugs influence the crime rate?

  2020cites this paper
• Regulation of μ-opioid receptor function by pH

  2020cites this paper
• Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones

  2020cites this paper
• Exploring the Neural Underpinnings of an Antidepressant and Rewarding Action of Early Anorexia

  2020cites this paper
• Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit

  2020cites this paper
• Management of patients with alcohol withdrawal syndrome

  2020cites this paper
• Effect of Withania somnifera (L.) Dunal aqueous root extract on reinstatement using conditioned place preference and brain GABA and dopamine levels in alcohol dependent animals.

  2020cites this paper
• Association of Dopamine Transporter Gene with Heroin Dependence in an Indian Subpopulation from Manipur

  2020cites this paper
• Noradrenergic Source of Dopamine Assessed by Microdialysis in the Medial Prefrontal Cortex

  2020cites this paper
• Drug Self-Administration as a Model to Study the

  2020cites this paper
• The multifaceted nature of risk-taking in drug addiction

  2020cites this paper
• The role of perceived discrimination in substance use trajectories in Hispanic young adults: A longitudinal cohort study from high school through emerging adulthood.

  2019cites this paper
• Virtual Reality Therapy and Machine Learning Techniques in Drug Addiction Treatment

  2019cites this paper
• A positive shift in resting-state functional connectivity between the insula and default mode network regions reflects the duration of illness in gambling disorder patients without lifetime substance abuse.

  2019cites this paper
• The epigenetic legacy of illicit drugs: developmental exposures and late-life phenotypes

  2019cites this paper
• Transgender and Gender Nonconforming Health and Aging

  2019influential citation
• The Stimulating Nature of Gambling Behaviors: Relationships Between Stimulant Use and Gambling Among Adolescents

  2019cites this paper
• The association between frequency of opioid misuse and opioid use disorder among youth and adults in the United States.

  2019cites this paper
• Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin seeking behavior in rats

  2019cites this paper
• Differences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence.

  2019cites this paper
• Acamprosate's ethanol intake‐reducing effect is associated with its ability to increase dopamine

  2018cites this paper
• TRPV1 modulates morphine self‐administration via activation of the CaMKII‐CREB pathway in the nucleus accumbens

  2018cites this paper
• Neonatal abstinence syndrome and neurodevelopmental health outcomes: A state of the science

  2018cites this paper
• “I am More Than my Addiction”: Perceptions of Stigma and Access to Care in Acute Opioid Crisis

  2018cites this paper
• Predictors of Tobacco and Alcohol Co-Use From Ages 15 to 32: The Amsterdam Growth and Health Longitudinal Study

  2018cites this paper
• Ghrelin receptor antagonism of hyperlocomotion in cocaine‐sensitized mice requires βarrestin‐2

  2018cites this paper
• CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety.

  2018cites this paper
• An open prospective pilot study of a herbal combination "Relief" as a supportive dietetic measure during alcohol withdrawal.

  2018cites this paper
• PPARγ agonism attenuates cocaine cue reactivity

  2018cites this paper
• Ethnic variations in the relationship between multiple stress domains and use of several types of tobacco/nicotine products among a diverse sample of adults

  2018cites this paper
• Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains

  2018cites this paper
• Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population

  2018cites this paper
• Regulatory Roles of MicroRNAs in Addictions and Other Psychiatric Diseases

  2018cites this paper
• Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment

  2018cites this paper
• Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide.

  2018cites this paper
• A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults

  2018cites this paper
• Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study

  2018cites this paper
• Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex

  2017cites this paper
• Influence of Maternal High Fat Diet, Stress and Cocaine on Neural Mechanisms of Reward and Anxiety in Rat Offspring

  2017cites this paper
• Serotonin 4 Receptors: A Cornerstone in Anorexia Nervosa?

  2017cites this paper
• Psychotic Symptoms Associated with the use of Dopaminergic Drugs, in Patients with Cocaine Dependence or Abuse

  2017cites this paper
• Presence of ethanol‐sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens

  2017influential citation
• The link between inflammation, bugs, the intestine and the brain in alcohol dependence

  2017cites this paper
• Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior

  2017cites this paper
• Demographic differences in drug dependency: implications for policy, practice, and research

  2017cites this paper
• Methamphetamine Induces TET1- and TET3-Dependent DNA Hydroxymethylation of Crh and Avp Genes in the Rat Nucleus Accumbens

  2017cites this paper
• Omega-3 Polyunsaturated Fatty Acids: Impact on Oxidative Stress, Antioxidant Responses and Vascular Function

  2017cites this paper
• The Thinking Process

  2017cites this paper
• EVALUATION OF KYNURENIC ACID ATTENUATES ETHANOL WITHDRAWAL INDUCED HYPEREXCITABILITY IN MICE

  2017cites this paper
• MicroRNAs and Cocaine

  2017cites this paper
• Anxiety-Like Behaviors and c-Fos Expression in Adult Zebrafish: Effects of Housing Conditions, Alcohol and Caffeine

  2017cites this paper
• Clinical Syndromes of Substance Use Disorder

  2016cites this paper
• Amphetamine Usage, Misuse, and Addiction Processes

  2016cites this paper
• The Neurobiology and Genetics of Affiliation and Social Bonding in Animal Models

  2016cites this paper
• Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement.

  2016cites this paper
• Novel Approaches in Assessing Abuse Potential of Psychotropic Medications - Pregabalin as a Test Case

  2016cites this paper
• Neurochemical Aspects in Dual Pathology

  2016cites this paper
• Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons

  2016cites this paper
• The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction.

  2016cites this paper
• Consumption of Substances of Abuse during Pregnancy Increases Consumption in Offspring: Possible Underlying Mechanisms

  2016cites this paper