Gene therapy for arthritis: what next?

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Arthritis & Rheumatism

• Publication date

  2006-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ART.21886PMID 16729280
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Will arthritis gene therapy become a clinical reality?

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• Immune modulation of collagen-induced arthritis by intranasal cytokine gene delivery: a model for the therapy of rheumatoid arthritis.

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• Human immunodeficiency virus vector-mediated intra-articular expression of angiostatin inhibits progression of collagen-induced arthritis in mice

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• Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro.

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• Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis.

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• Retroviral gene therapy: safety issues and possible solutions.

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• A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab

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• Gene therapies for osteoarthritis

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• An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint

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• Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?

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• Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis.

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• Gene Therapy of Collagen-Induced Arthritis by Electrotransfer of Human Tumor Necrosis Factor-α Soluble Receptor I Variants

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• Immune Response Against Gene Therapy Vectors: Influence of Synovial Fluid on Adeno-Associated Virus Mediated Gene Transfer to Chondrocytes

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• On the TRAIL of an arthritis cure

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• Gene therapy progress and prospects: transcription regulatory systems

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• Specific antigen vaccination to treat autoimmune disease

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• Osteoarthritis gene therapy

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• Interleukin-4 Cellular Gene Therapy and Osteoprotegerin Decrease Inflammation-Associated Bone Resorption in Collagen-Induced Arthritis

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• Plasmid encoding interleukin-4 in the amelioration of murine collagen-induced arthritis.

  2004cited by this paper
• DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response.

  2004cited by this paper
• Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collagen-induced arthritis.

  2004cited by this paper
• AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

  2003cited by this paper
• Protection against collagen-induced arthritis by intramuscular gene therapy with an expression plasmid for the interleukin-1 receptor antagonist

  2003cited by this paper
• Gene transfer as a future therapy for rheumatoid arthritis

  2003cited by this paper
• Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis

  2003cited by this paper
• Mature But Not Immature Fas Ligand (CD95L)-Transduced Human Monocyte-Derived Dendritic Cells Are Protected from Fas-Mediated Apoptosis and Can Be Used as Killer APC1

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• Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein

  2003cited by this paper
• A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer

  2003cited by this paper
• Gene therapy for arthritis.

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• CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.

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• Occurrence of leukaemia following gene therapy of X-linked SCID

  2003cited by this paper
• Adenoviral delivery of IL-18 binding protein C ameliorates Collagen-Induced Arthritis in mice

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• Occurrence of leukaemia following gene therapy of X-linked SCID

  2003cited by this paper
• Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts.

  2003cited by this paper
• Efficacy of interleukin‐10 gene electrotransfer into skeletal muscle in mice with collagen‐induced arthritis

  2003cited by this paper
• Gene therapy for arthritis.

  2003cited by this paper
• Amelioration of antigen-induced arthritis in rats by transfer of extracellular superoxide dismutase and catalase genes

  2003cited by this paper
• CHAPTER 28 – Interleukin-1 receptor antagonist [IL-1F3]

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• The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen

  2003cited by this paper
• Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium

  2003cited by this paper
• Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation.

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• Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid

  2003cited by this paper
• Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis

  2003cited by this paper
• Effectiveness of the soluble form of the interleukin-1 receptor accessory protein as an inhibitor of interleukin-1 in collagen-induced arthritis.

  2003cited by this paper
• Development of gene-based therapies for cartilage repair.

  2002cited by this paper
• Gene transfer of a fibronectin peptide inhibits leukocyte recruitment and suppresses inflammation in mouse collagen-induced arthritis.

  2002cited by this paper
• Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4.

  2002cited by this paper
• Non-viral gene delivery systems.

  2002cited by this paper
• In vivo gene delivery to synovium by lentiviral vectors.

  2002cited by this paper
• Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

  2002cited by this paper
• Adenovirus-mediated gene transfer of urokinase plasminogen inhibitor inhibits angiogenesis in experimental arthritis

  2002cited by this paper
• Tetracycline-Inducible Interleukin-10 Gene Transfer Mediated by an Adeno-Associated Virus: Application to Experimental Arthritis

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• Endogenous regulation of a therapeutic transgene restores homeostasis in arthritic joints.

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• Inhibition of Adjuvant Arthritis by a DNA Vaccine Encoding Human Heat Shock Protein 601

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• Tetracycline Transcriptional Silencer Tightly Controls Transgene Expression After In Vivo Intramuscular Electrotransfer: Application to Interleukin 10 Therapy in Experimental Arthritis

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• C3-Tat/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgene.

  2002cited by this paper
• Gene therapy for rheumatoid arthritis

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• Adoptive cellular gene therapy of autoimmune disease.

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• Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis.

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• Angiostatin gene transfer as an effective treatment strategy in murine collagen-induced arthritis.

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• Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis.

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• Inhibition of adjuvant-induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery.

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• Gene therapy for rheumatoid arthritis

  2001cited by this paper
• IL-4 Adenoviral Gene Therapy Reduces Inflammation, Proinflammatory Cytokines, Vascularization, and Bony Destruction in Rat Adjuvant-Induced Arthritis1

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• Therapeutic Efficacy in Experimental Polyarthritis of Viral-Driven Enkephalin Overproduction in Sensory Neurons

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• Effective Treatment of Established Murine Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express IL-41

  2001cited by this paper
• Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

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  2001cited by this paper
• Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.

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• Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages.

  2001cited by this paper
• Future of adenoviruses in the gene therapy of arthritis

  2001cited by this paper
• Treatment of murine collagen-induced arthritis by ex vivo extracellular superoxide dismutase gene transfer.

  2001cited by this paper
• Gene therapy for rheumatoid arthritis.

  2001cited by this paper
• Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21(Cip1) gene into the joints.

  2001cited by this paper
• Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis.

  2001cited by this paper
• Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis.

  2001cited by this paper
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• Collagen II-pulsed antigen-presenting cells genetically modified to secrete IL-4 down-regulate collagen-induced arthritis

  2001cited by this paper
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  2001cited by this paper
• Adeno-associated virus production of soluble tumor necrosis factor receptor neutralizes tumor necrosis factor alpha and reduces arthritis.

  2000cited by this paper

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  2025cites this paper
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  2020cites this paper
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  2018cites this paper
• Prospects of Gene Therapy for Skeletal Diseases

  2018cites this paper
• The potential of genetically guided treatment in Behçet's disease.

  2016cites this paper
• Gene therapy of arthritis

  2016cites this paper
• Vector-delivered artificial miRNA effectively inhibited replication of Chikungunya virus

  2016cites this paper
• Arthritis Gene Therapy: A Brief History and Perspective

  2015cites this paper
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  2013cites this paper
• Prospects of Gene Therapy

  2013cites this paper
• Advances and challenges in gene‐based approaches for osteoarthritis

  2013cites this paper
• Therapies intended for joint regeneration in the horse

  2013cites this paper
• Gene Therapy in the Treatment of Knee Disorders

  2012cites this paper
• Gene Therapy for Human Osteoarthritis

  2012influential citation
• Immunosuppressive Exosomes: A New Approach for Treating Arthritis

  2012cites this paper
• Gene Therapy for Cartilage Repair

  2011cites this paper
• Clinical potential and challenges of using genetically modified cells for articular cartilage repair

  2011cites this paper
• Interleukin-1 and tumor necrosis factor- α inhibit chondrogenesis by human mesenchymal stem cells through NF- κ B dependent pathways

  2011cites this paper
• Gene Therapy for Rheumatoid Arthritis

  2011cites this paper
• In vivo evaluation of gene transfer into mesenchymal cells (in view of cartilage repair).

  2011cites this paper
• Safety, Tolerability, and Clinical Outcomes after Intraarticular Injection of a Recombinant Adeno-associated Vector Containing a Tumor Necrosis Factor Antagonist Gene: Results of a Phase 1/2 Study

  2010cites this paper
• Arthritis Gene Therapy Trials Reach Phase II

  2010cites this paper
• Prospects for gene therapy in inflammatory arthritis.

  2010cites this paper
• Novel fusion protein-expressing lentiviral vectors ameliorate collagen induced arthritis

  2010cites this paper
• Gene therapy for arthritis

  2010cites this paper
• In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes.

  2010cites this paper
• Molekulare Werkzeuge zur Wiederherstellung von arthrotischem Knorpel

  2009cites this paper
• Tolerance induction using lentiviral gene delivery delays onset and severity of collagen II arthritis.

  2009cites this paper
• Mesenchymal stem cell-based therapy for cartilage repair: a review

  2009cites this paper
• Inflammatory cell‐specific transgene expression system responding to Iκ‐B kinase beta activation

  2009cites this paper
• Perfusion and cyclic compression of mesenchymal cell-loaded and clinically applicable osteochondral grafts

  2009cites this paper
• Intra‐articular gene delivery and expression of interleukin‐1Ra mediated by self‐complementary adeno‐associated virus

  2009cites this paper
• Gene therapy of the rheumatic diseases: 1998 to 2008

  2009cites this paper
• Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways.

  2009cites this paper
• TREATMENT OF ARTHRITIS WITH TK-GANCICLOVIR 2737

  2009cites this paper
• Optimizing adeno-associated virus as a gene therapy vector for treating arthritis

  2009cites this paper
• Arthrocentesis and Injection of Joints and Soft Tissue

  2009cites this paper
• [Molecular tools to remodel osteoarthritic articular cartilage : growth, transcription, and signaling factors].

  2009cites this paper
• Medical Advances in Treating the Masters Athlete

  2009cites this paper
• Orthopedic gene therapy in 2008.

  2009cites this paper
• Metalloproteases as potential therapeutic targets in arthritis treatment

  2008cites this paper
• Arthritis gene therapy's first death

  2008cites this paper
• Transforming growth factor-beta1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis.

  2008cites this paper
• Cell-based resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis.

  2008cites this paper
• A system for engineering an osteochondral construct in the shape of an articular surface: preliminary results.

  2008cites this paper
• Current status of gene therapy for rheumatoid arthritis

  2008cites this paper
• In vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis.

  2008cites this paper
• Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders.

  2008cites this paper
• Clinical Responses to Gene Therapy in Joints of Two Subjects with Rheumatoid Arthritis

  2008cites this paper
• Polymer therapeutics: reservoir drugs.

  2008cites this paper
• Genetic Architecture of Knee Radiographic Joint Space in Healthy Young Adults

  2008cites this paper
• Arthritis gene therapy at an inflection point

  2008cites this paper
• Tissue engineering of osteochondral constructs in vitro using bioreactors.

  2008cites this paper
• Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity

  2008cites this paper
• Gene therapy for rheumatoid arthritis: recent advances.

  2008cites this paper
• Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor α antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study

  2008cites this paper
• Application techniques de thérapie aux maladies ostéo-articulaires

  2007cites this paper
• siRNA targeting PLK-1 induces apoptosis of synoviocytes in rheumatoid arthritis.

  2007cites this paper
• [Gene therapy for osteoarticular disorders].

  2007cites this paper
• Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases.

  2007cites this paper
• Primer: pitfalls of aspiration and injection

  2007cites this paper
• Peptide-based therapies for arthritis

  2007cites this paper
• Application des techniques de thérapie génique aux maladies ostéo-articulaires

  2007cites this paper
• Gene therapy with the interleukin-1 receptor antagonist for the treatment of arthritis

  2006cites this paper