Glutamine-Induced Secretion of Intestinal Secretory Immunoglobulin A: A Mechanistic Perspective

Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA production; however, the underlying mechanism by which glutamine stimulates secretion of intestinal SIgA is unknown. Here, we review current knowledge regarding glutamine in intestinal immunity and show that glutamine-enhanced secretion of SIgA in the intestine may involve intestinal microbiota, intestinal antigen sampling and presentation, induction pathways for SIgA production by plasma cells (both T-dependent and T-independent pathway), and even transport of SIgA. Altogether, the glutamine-intestinal SIgA axis has broad therapeutic implications for intestinal SIgA-associated diseases, such as celiac disease, allergies, and inflammatory bowel disease.

• Publication year

  2016

• Venue

  Frontiers in Immunology

• Publication date

  2016-11-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fimmu.2016.00503PMID 27933057PMCID 5121228
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• The glutamine-intestinal secretory immunoglobulin A axis is positioned as a potential therapeutic target for celiac disease, allergies, and inflammatory bowel disease.

  Confidence 0.92

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• Glutamine-enhanced intestinal secretory immunoglobulin A secretion may involve intestinal microbiota, intestinal antigen sampling and presentation, plasma cells, and secretory IgA transport.

  Confidence 0.97

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review

• allergies

  disease

  Hypersensitivity conditions involving inappropriate immune responses to otherwise harmless antigens.

  Aliases: allergy

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• celiac disease

  disease

  An immune-mediated intestinal disorder triggered by dietary gluten.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• glutamine

  amino acid

  A conditionally essential amino acid discussed here as a nutritional factor influencing intestinal immunity.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• inflammatory bowel disease

  disease

  A group of chronic inflammatory disorders affecting the gastrointestinal tract.

  Aliases: IBD

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• intestinal antigen sampling and presentation

  immune process

  The mucosal process by which intestinal antigens are captured and presented to immune cells.

  Aliases: antigen sampling, antigen presentation

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• intestinal microbiota

  microbiota

  The community of microorganisms living in the intestinal tract and interacting with mucosal immunity.

  Aliases: gut microbiota

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• intestinal secretory immunoglobulin a

  immune molecule

  The polymeric antibody present in the intestinal mucosal surface that contributes to mucosal immune defense.

  Aliases: SIgA, secretory immunoglobulin A

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• plasma cells

  cell type

  Antibody-secreting B cells in mucosal tissues that produce immunoglobulins.

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review
• secretory iga transport

  transport process

  The transcellular movement of secretory IgA across the intestinal epithelium into the lumen.

  Aliases: SIgA transport

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAnonymous (12632b8b5f) review

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