Arginase modulates nitric oxide production in activated macrophages.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpheart.1998.274.1.H342PMID 9458885
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Coinduction of Nitric-oxide Synthase and Arginase I in Cultured Rat Peritoneal Macrophages and Rat Tissues in Vivo by Lipopolysaccharide*

  1997cited by this paper
• Comparative properties of arginases.

  1996cited by this paper
• Computer-aided comparison of the inhibition of arginase and nitric oxide synthase in macrophages by amino acids not related to arginine.

  1996influential reference
• Alteration in IL-1 and arginase activity of tumor-associated macrophages: a role in the promotion of tumor growth.

  1996cited by this paper
• Regulation of the expression of the inducible isoform of nitric oxide synthase.

  1995cited by this paper
• Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation.

  1995cited by this paper
• Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

  1995cited by this paper
• l‐Arginine depletion by arginase reduces nitric oxide production in endotoxic shock: an electron paramagnetic resonance study

  1995cited by this paper
• Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity.

  1995cited by this paper
• An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality

  1995cited by this paper
• Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide.

  1995influential reference
• Determination of arginase activity in macrophages: a micromethod.

  1994cited by this paper
• Nitric oxide synthases: roles, tolls, and controls.

  1994cited by this paper
• New insights into the regulation of inducible nitric oxide synthesis.

  1994cited by this paper
• Glycogenesis from glucose and ureagenesis in isolated perfused rat livers. Influence of ammonium ion, norvaline, and ethoxyzolamide.

  1994cited by this paper
• An enzymatic route to L-ornithine from arginine--activation, selectivity and stabilization of L-arginase.

  1994cited by this paper
• Arginine metabolism in experimental glomerulonephritis: interaction between nitric oxide synthase and arginase.

  1994cited by this paper
• Beneficial circulatory effect of L-arginine.

  1994cited by this paper
• Arginine supply for nitric oxide synthesis and arginase is mainly exogenous in elicited murine and rat macrophages.

  1994influential reference
• Rat liver arginase: kinetic mechanism, alternate substrates, and inhibitors.

  1994cited by this paper
• Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

  1993cited by this paper
• The effects of endotoxin administration on blood amino acid concentrations: similarities with sepsis.

  1993cited by this paper
• Macrophages can convert citrulline into arginine.

  1992cited by this paper
• Macrophage arginine metabolism and the inhibition or stimulation of cancer.

  1992cited by this paper
• Nitric oxide: physiology, pathophysiology, and pharmacology.

  1991cited by this paper
• The macrophage response to bacteria: flow of L-arginine through the nitric oxide and urea pathways and induction of tumoricidal activity.

  1991cited by this paper
• Temporal expression of different pathways of 1-arginine metabolism in healing wounds.

  1990cited by this paper
• Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

  1990cited by this paper
• Nitric oxide: a cytotoxic activated macrophage effector molecule.

  1988cited by this paper
• The role of arginase in the immune response.

  1985cited by this paper
• Arginase inhibition.

  1981cited by this paper
• Stimulation of peritoneal cell arginase by bacterial lipopolysaccharides.

  1980cited by this paper
• Regulation of urea synthesis in rat liver. Inhibition of urea synthesis by L-norvaline.

  1979cited by this paper
• Studies on rat liver argininosuccinate synthetase. Inhibition by various amino acids.

  1979cited by this paper
• Activated macrophages kill tumour cells by releasing arginase

  1978cited by this paper
• Sources of ammonia for urea synthesis in isolated rat liver cells.

  1977cited by this paper
• THE INHIBITION OF ARGINASE BY AMINO ACIDS

  1945cited by this paper

• Protective effects of licofelone on experimental skin flap survival rat model via cyclooxygenase and lipoxygenase inhibition: involvement of inflammatory cytokines and nitric oxide

  2025cites this paper
• Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo

  2025cites this paper
• Crosstalk between Nitric Oxide and Bioinorganic Centers: Implications for Cellular Signaling.

  2025cites this paper
• Systemic Administration of Allogeneic Mesenchymal Stem Cells Attenuates Post-Resuscitation Left Ventricular Dysfunction in a Porcine Model of Cardiac Arrest.

  2025cites this paper
• Synergistic alleviation of obesity and associated cardiovascular complications by combined modulation of FASN/Arginase/eNOS uncoupling.

  2025cites this paper
• Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

  2025cites this paper
• Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

  2025cites this paper
• Honokiol, a Neolignan from Magnolia officinalis, Attenuated Fructose-Induced Hepatic Fat Accumulation by Improving Intestinal Barrier Function in Mice

  2025cites this paper
• Immunosurveillance encounters cancer metabolism

  2024cites this paper
• How does Nogo-A signalling influence mitochondrial function during multiple sclerosis pathogenesis?

  2024influential citation
• Harnessing the Power of Our Immune System: The Antimicrobial and Antibiofilm Properties of Nitric Oxide

  2024cites this paper
• Fish Arginase constrains Excessive Production of Nitric Oxide and Limits Mitochondrial Damage during Aeromonas hydrophila infection.

  2024cites this paper
• Decline in nitrosative stress drives antibiotic persister regrowth during infection.

  2023cites this paper
• Tryptophanase Expressed by Salmonella Halts Breast Cancer Cell Growth In Vitro and Inhibits Production of Immunosuppressive Kynurenine

  2023cites this paper
• Melatonin modulates L-arginine metabolism in tumor-associated macrophages by targeting arginase 1 in lymphoma

  2023cites this paper
• Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival

  2023cites this paper
• Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications

  2022cites this paper
• Mogroside V exerts anti-inflammatory effects on fine particulate matter-induced inflammation in porcine alveolar macrophages.

  2022cites this paper
• Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation

  2022cites this paper
• Fermented seeds of Pentaclethra macrophylla mitigate against memory deficit and restored altered enzymatic activity in the brain of streptozotocin-diabetic rats

  2022cites this paper
• Quercetin boosts nitric oxide levels and modulates the activities of arginase, acetylcholinesterase and adenosine deaminase in the corpus cavernosum of cyclosporine‐treated rats

  2022cites this paper
• Preventive role of spirulina on the some biomarkers in heart aging induced by D- galactose on the male rabbits

  2022cites this paper
• Candida albicans Activation of Human Monocytes Toward M2 Profile is Reversed by Amphotericin B and Fluconazole

  2021cites this paper
• Transcriptomic Analysis of Polyhexamethyleneguanidine-Induced Lung Injury in Mice after a Long-Term Recovery

  2021cites this paper
• Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage

  2021cites this paper
• Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

  2021cites this paper
• Mycobacterium Lrp/AsnC family transcriptional factor modulates the arginase pathway as both a sensor and a transcriptional repressor.

  2021cites this paper
• Distinct Responsiveness of Tumor-Associated Macrophages to Immunotherapy of Tumors with Different Mechanisms of Major Histocompatibility Complex Class I Downregulation

  2021cites this paper
• Arginase Activity in Eisenia andrei Coelomocytes: Function in the Earthworm Innate Response

  2021influential citation
• Evaluation of nitric oxide metabolism and malondialdehyde levels as an indicator of oxidant stress in malign and parapneumonic pleural effusion

  2021cites this paper
• In vitro immunomodulatory activity of water-soluble glucans from fresh and dried Longan (Dimocarpus longan Lour.).

  2021cites this paper
• Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

  2021cites this paper
• CDC-Derived Extracellular Vesicles Reprogram Inflammatory Macrophages to an Arginase 1-Dependent Pro-Angiogenic Phenotype.

  2020cites this paper
• Experimental and clinical evidence of endothelial dysfunction in inflammatory bowel disease.

  2020cites this paper
• Effects of different level of arginine on antioxidant status, serum carotenoid levels and carcass traits in broilers challenged with Eimeria spp

  2020cites this paper
• Microglia in the hypothalamus respond to tumor‐derived factors and are protective against cachexia during pancreatic cancer

  2020cites this paper
• What Is an M2 Macrophage? Historical Overview of the Macrophage Polarization Model. The Th1/Th2 and M1/M2 Paradigm, the Arginine Fork

  2020cites this paper
• Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters

  2020cites this paper
• Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease

  2020cites this paper
• Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective

  2020cites this paper
• Dietary arginine and citrulline supplementation modulates the immune condition and inflammatory response of European seabass.

  2020cites this paper
• Cellular and physiological upregulation of inducible nitric oxide synthase, arginase, and inducible cyclooxygenase in wound healing

  2019cites this paper
• Hyperglycemia‐impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways

  2019cites this paper
• Nitric oxide-enhancing or -releasing agents as antithrombotic drugs.

  2019cites this paper
• Target identification and intervention strategies against amebiasis.

  2019cites this paper
• Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer's disease.

  2019cites this paper
• Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling cascades.

  2019cites this paper
• Determination of l-norvaline and l-tryptophan in dietary supplements by nano-LC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-silica hybrid monolithic column

  2019cites this paper
• A New Perspective on Alzheimer’s Disease as a Brain Expression of a Complex Metabolic Disorder

  2019cites this paper
• Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension

  2019cites this paper
• Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of Lipopolysaccharide-Induced Inflammation

  2019influential citation
• African star apple fruit pulp-supplemented diet modulates fertility-related biomolecules in the testis and epididymis of high-fat diet/streptozotocin-induced diabetic rats.

  2019cites this paper
• Immunometabolic phenotype of BV-2 microglia cells upon murine cytomegalovirus infection

  2019cites this paper
• Criteria for Safe Use of Plant Ingredients in Diets for Aquacultured Fish

  2018cites this paper
• Immunohistochemical Characterization of the Inflammatory Responses in Wound Healing and the Use of the Subcutaneous Polyvinyl Alcohol (PVA) Sponge Implantation for Evaluation of the Healing Process

  2018cites this paper
• Arginase as a Potential Target in the Treatment of Alzheimer’s Disease

  2018cites this paper
• Proteomic Analysis of Mouse Brain Subjected to Spaceflight

  2018cites this paper
• Dietary Flavone Tectochrysin Exerts Anti‐Inflammatory Action by Directly Inhibiting MEK1/2 in LPS‐Primed Macrophages

  2018cites this paper
• Diversity and environmental adaptation of phagocytic cell metabolism

  2018cites this paper
• Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner

  2018cites this paper
• Protective effects of hydro-ethanolic extract of Terminalia chebula on primary microglia cells and their polarization (M1/M2 balance).

  2018cites this paper
• Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

  2018cites this paper
• Identification of agmatinase from Vibrio splendidus and its roles in modulating arginine metabolism of Apostichopus japonicus

  2018cites this paper
• Dietary supplementation of tiger nut alters biochemical parameters relevant to erectile function in l-NAME treated rats.

  2018cites this paper
• Experimental Combined Immunotherapy of Tumours with Major Histocompatibility Complex Class I Downregulation

  2018cites this paper
• Effectiveness of arginase inhibitors against experimentally induced stroke

  2018cites this paper
• Modulation of inflammation in the reduction of intra hepatic resistance

  2018cites this paper
• Edinburgh Explorer In-depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus

  2018cites this paper
• Moringa oleifera supplemented diet modulates nootropic-related biomolecules in the brain of STZ-induced diabetic rats treated with acarbose

  2018cites this paper
• L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer’s Disease

  2018influential citation
• CNS inflammation and neurodegeneration.

  2017cites this paper
• Neuregulin‐1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury

  2017cites this paper
• Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors

  2017cites this paper
• Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair.

  2017cites this paper
• Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.

  2017cites this paper
• Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels

  2017cites this paper
• Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPARγ dependent mechanisms.

  2017cites this paper
• Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

  2017cites this paper
• Bone marrow transplantation in mice as a tool to study M2 macrophage activation in atherogenesis

  2017cites this paper
• A novel TNFAIP8 gene mediates l-arginine metabolism in Apostichopus japonicus.

  2017cites this paper
• The use of adjuvant L-arginine in schizophrenia: A behavioural and neurochemical analysis

  2016cites this paper
• Effects of Eimeria acervulina infection severity on growth performance, apparent ileal amino acid digestibility, and plasma concentrations of amino acids, carotenoids, and α1-acid glycoprotein in broilers.

  2016cites this paper
• infection and stress Candida albicans Immunocompetence of macrophages in rats exposed to

  2016cites this paper
• Enantiomeric separation of non-protein amino acids by electrokinetic chromatography.

  2016cites this paper
• Interactive effects of dietary arginine and Eimeria acervulina infection on broiler growth performance and metabolism

  2016cites this paper
• Severe Paracoccidioidomycosis in a 14-Year-Old Boy

  2016cites this paper
• uptake in bovine pulmonary arterial endothelial cells Cytokine treatment increases arginine metabolism and

  2016cites this paper
• The first description of complete invertebrate arginine metabolism pathways implies dose-dependent pathogen regulation in Apostichopus japonicus

  2016cites this paper
• Copper oxide nanoparticles recruit macrophages and modulate nitric oxide, proinflammatory cytokines and PGE2 production through arginase activation.

  2016cites this paper
• The Effect of Leishmania Donovani Cathepsin B on Transforming Growth Factor Beta-1 Activation and Regulation of Inducible Nitric Oxide Synthase and Arginase Activity Inside the Macrophages

  2016cites this paper
• Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 “Nanoplex” a Possible Neurotherapeutic?

  2016cites this paper
• Aging affects the responsiveness of rat peritoneal macrophages to GM-CSF and IL-4

  2016cites this paper
• Lipopolysaccharide-stimulated Inducible Nitric-oxide Synthase in NotMediates Expression of Arginase II but Extracellular Signal-regulated Kinase Signal Transduction :

  2015cites this paper
• Neuroprotective Effect of L-Norvaline against Ischemic Brain Damage in Rats

  2015cites this paper
• Studies of the effect of grasshopper abdominal secretion on wound healing with the use of murine model.

  2015cites this paper
• Opioid Analgesic Agents and Cancer Cell Biology

  2015cites this paper
• Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages

  2015cites this paper
• Solubilized extracellular matrix from brain and urinary bladder elicits distinct functional and phenotypic responses in macrophages.

  2015cites this paper
• Eimeria acervulina infection and amino acid nutrition in broiler chickens

  2015cites this paper
• Electrostatically self-assembled biodegradable microparticles from pseudoproteins and polysaccharide: fabrication, characterization, and biological properties.

  2015cites this paper