The role of SHIP in cytokine-induced signaling.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Reviews of Physiology, Biochemistry and Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/S10254-003-0016-YPMID 12692707
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.

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• Co-clustering of Fcgamma and B cell receptors induces dephosphorylation of the Grb2-associated binder 1 docking protein.

  2001influential reference
• Effects of overexpression of the SH2-containing inositol phosphatase SHIP on proliferation and apoptosis of erythroid AS-E2 cells

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• The lipid phosphatase SHIP2 controls insulin sensitivity

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• The adaptor protein shc is involved in the negative regulation of NK cell‐mediated cytotoxicity

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• The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin

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  2001influential reference
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• The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro

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• Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export.

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• Scaffolding Protein Gab2 Mediates Differentiation Signaling Downstream of Fms Receptor Tyrosine Kinase

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• CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A1

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• Partially Distinct Molecular Mechanisms Mediate Inhibitory FcγRIIB Signaling in Resting and Activated B Cells1

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• SHIP1, an SH2 Domain Containing Polyinositol-5-phosphatase, Regulates Migration through Two Critical Tyrosine Residues and Forms a Novel Signaling Complex with DOK1 and CRKL*

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• SH2 Domain-Containing Inositol Polyphosphate 5′-Phosphatase Is the Main Mediator of the Inhibitory Action of the Mast Cell Function-Associated Antigen1

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• Lipid phosphatases in the immune system.

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• Bilevel control of B‐cell activation by the inositol 5‐phosphatase SHIP

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• The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.

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• Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation. Contribution of Shc PTB and SH2 domains.

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• The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.

  2000influential reference
• Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulation

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• Chapter 11 – Regulation of Mast Cell Degranulation by SHIP

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• Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling

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• Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.

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• Cloning of the genomic locus of mouse SH2 containing inositol 5-phosphatase (SHIP) and a novel 110-kDa splice isoform, SHIPdelta.

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• Enzymatic Activity of the Src Homology 2 Domain-containing Inositol Phosphatase Is Regulated by a Plasma Membrane Location*

  2000cited by this paper
• Stat3-Dependent Induction of p19INK4D by IL-10 Contributes to Inhibition of Macrophage Proliferation1

  2000cited by this paper
• The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells.

  2000influential reference
• Positive Regulation of Interleukin-4-mediated Proliferation by the SH2-containing Inositol-5′-phosphatase*

  2000cited by this paper
• Essential Role for the C-Terminal Noncatalytic Region of SHIP in FcγRIIB1-Mediated Inhibitory Signaling

  2000influential reference
• New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

  1999cited by this paper
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  1999cited by this paper
• A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.

  1999influential reference
• The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function*

  1999cited by this paper
• Altered responsiveness to chemokines due to targeted disruption of SHIP.

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• A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development.

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• The Src Homology Domain 2-Containing Inositol Phosphatase SHIP Forms a Ternary Complex with Shc and Grb2 in Antigen Receptor-stimulated B Lymphocytes*

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• The Two SH2-Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 Are Coexpressed in Human T Lymphocytes

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• The role of SHIP in growth factor induced signalling.

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• The Role of the SRC Homology 2-Containing Inositol 5′-Phosphatase in FcɛR1-Induced Signaling

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• Inhibitory signaling by B cell Fc gamma RIIb.

  1998cited by this paper
• The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis.

  1998influential reference
• The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

  1998cited by this paper
• The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate*

  1998influential reference
• The SH2 domain containing inositol 5‐phosphatase SHIP2 displays phosphatidylinositol 3,4,5‐trisphosphate and inositol 1,3,4,5‐tetrakisphosphate 5‐phosphatase activity

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• Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

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• Phosphatidylinositol 3'-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the granulocyte colony-stimulating factor receptor.

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• Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span.

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• Targeted disruption of SHIP leads to Steel factor‐induced degranulation of mast cells

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• Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation.

  1998cited by this paper
• The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.

  1998cited by this paper
• The Negative Signaling Molecule SH2 Domain-containing Inositol-Polyphosphate 5-Phosphatase (SHIP) Binds to the Tyrosine-phosphorylated β Subunit of the High Affinity IgE Receptor*

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• The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood.

  1997cited by this paper
• Differential association of phosphatases with hematopoietic co‐receptors bearing immunoreceptor tyrosine‐based inhibition motifs

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• Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2

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• Shc Interaction with Src Homology 2 Domain Containing Inositol Phosphatase (SHIP) in Vivo Requires the Shc-Phosphotyrosine Binding Domain and Two Specific Phosphotyrosines on SHIP*

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• Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.

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• The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors

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• Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling.

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• Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP.

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• The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis*

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• Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif

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• The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

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• Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

  1996cited by this paper
• The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation*

  1996influential reference

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