The active sites of the influenza cap‐dependent endonuclease are on different polymerase subunits

No abstract is available for this paper.

• Publication year

  2001

• Venue

  EMBO Journal

• Publication date

  2001-04-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/20.8.2078PMID 11296240PMCID PMC125234
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

  1999cited by this paper
• Metal ion catalysis of RNA cleavage by the influenza virus endonuclease.

  1999cited by this paper
• Two separate sequences of PB2 subunit constitute the RNA cap‐binding site of influenza virus RNA polymerase

  1999cited by this paper
• RNA-protein interactions in the Tat-trans-activation response element complex determined by site-specific photo-cross-linking.

  1998cited by this paper
• Activation/Attenuation Model for RNase H

  1998cited by this paper
• Sequence specificity of viral end DNA binding by HIV‐1 integrase reveals critical regions for protein–DNA interaction

  1998cited by this paper
• RNA‐dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA‐binding sites

  1998cited by this paper
• Thionucleobases as intrinsic photoaffinity probes of nucleic acid structure and nucleic acid-protein interactions.

  1998cited by this paper
• Effects of mutations in the polymerase domain on the polymerase, RNase H and strand transfer activities of human immunodeficiency virus type 1 reverse transcriptase.

  1998cited by this paper
• Insertion Sequences

  1998cited by this paper
• Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium.

  1998cited by this paper
• Effect of RNA secondary structure on RNA cleavage catalyzed by HIV-1 reverse transcriptase.

  1997cited by this paper
• Structure of translation factor elF4E bound to m7GDP and interaction with 4E-binding protein

  1997cited by this paper
• Structure of the RNA-dependent RNA polymerase of poliovirus.

  1997cited by this paper
• Specific protein recognition of an mRNA cap through its alkylated base

  1997cited by this paper
• EFFECT OF RNA SECONDARY STRUCTURE ON RNA CLEAVAGE CATALYZED BY HIV-1 REVERSE TRANSCRIPTASE

  1997cited by this paper
• Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.

  1997cited by this paper
• Functional identification of nucleotides conferring substrate specificity to retroviral integrase reactions

  1997cited by this paper
• Retroviral integrases and their cousins.

  1996cited by this paper
• A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export

  1996cited by this paper
• Analysis of the mRNA cap-binding ability of human eukaryotic initiation factor-4E by use of recombinant wild-type and mutant forms.

  1996cited by this paper
• Surprising function of the three influenza viral polymerase proteins: selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins.

  1996cited by this paper
• Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme.

  1995cited by this paper
• Differential activation of the influenza virus polymerase via template RNA binding

  1995cited by this paper
• Polymerase structures and function: variations on a theme?

  1995cited by this paper
• Recombining the structures of HIV integrase, RuvC and RNase H.

  1995cited by this paper
• Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1

  1994cited by this paper
• Recombinant influenza virus polymerase: requirement of both 5' and 3' viral ends for endonuclease activity

  1994cited by this paper
• The use of DNA and RNA oligonucleotides in hybrid structures with longer polynucleotide chains to probe the structural requirements for moloney murine leukemia virus plus strand priming.

  1994cited by this paper
• Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases.

  1994cited by this paper
• Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

  1993cited by this paper
• Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.

  1992cited by this paper
• Transpositional recombination: mechanistic insights from studies of mu and other elements.

  1992cited by this paper
• Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase.

  1991cited by this paper
• Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage

  1991cited by this paper
• Specificities involved in the initiation of retroviral plus-strand DNA

  1990cited by this paper
• Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

  1990cited by this paper
• Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybrids.

  1990cited by this paper
• Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.

  1990cited by this paper
• Identification of four conserved motifs among the RNA‐dependent polymerase encoding elements.

  1989cited by this paper
• Expression and Replication of the Influenza Virus Genome

  1989cited by this paper
• A sequence motif in many polymerases.

  1988cited by this paper
• Synthesis and cellular location of the ten influenza polypeptides individually expressed by recombinant vaccinia viruses.

  1987cited by this paper
• Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates.

  1987cited by this paper
• A specific sub-set of host-cell mRNAs prime influenza virus mRNA synthesis.

  1984cited by this paper
• Identification of the cap binding protein of influenza virus.

  1982cited by this paper
• Selected host cell capped RNA fragments prime influenza viral RNA transcription in vivo.

  1981cited by this paper
• Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription.

  1981cited by this paper
• A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription.

  1981cited by this paper

• Multiple antiviral mechanisms of Ephedrae Herba and Cinnamomi Cortex against influenza: inhibition of entry and replication

  2025cites this paper
• The Influenza A Virus Replication Cycle: A Comprehensive Review

  2024cites this paper
• Identification of potential antiviral compounds from Egyptian sea stars against seasonal influenza A/H1N1 virus

  2024cites this paper
• Natural History of Influenza B Virus—Current Knowledge on Treatment, Resistance and Therapeutic Options

  2023cites this paper
• Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins

  2023cites this paper
• A Characterization and an Evolutionary and a Pathogenicity Analysis of Reassortment H3N2 Avian Influenza Virus in South China in 2019–2020

  2022cites this paper
• Role of RNA Polymerase II Promoter-Proximal Pausing in Viral Transcription

  2022cites this paper
• Innate and adaptive immune responses against Influenza A Virus: Immune evasion and vaccination strategies.

  2022cites this paper
• Modeling an immune response to influenza A virus infection in alveolar epithelial cells

  2022cites this paper
• Identification of HNH endonuclease domain in the basic protein 2 subunit of the polymerase of human influenza viruses

  2022influential citation
• Lead Optimization of Influenza Virus RNA Polymerase Inhibitors Targeting PA-PB1 Interaction.

  2021cites this paper
• Being on the alert for continuously evolving influenza viruses: Early detection and rapid intervention of newly emerging viruses

  2021influential citation
• Evaluation of Self-Adjuvanting M2e Vaccine Efficacy in Response to Influenza A Virus Challenge

  2020cites this paper
• Investigation of Binding Affinity between Potential Antiviral Agents and PB2 Protein of Influenza A: Non-equilibrium Molecular Dynamics Simulation Approach

  2020cites this paper
• The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses

  2020cites this paper
• MAMMALIAN ADAPTATION MECHANISM OF INFLUENZA A VIRUS REPLICATION MECHINERY

  2019cites this paper
• Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

  2019cites this paper
• Molecular insights into viral respiratory infections

  2019cites this paper
• Ermittlung der Bindespezifitäten für das canine MHC-Klasse-I-Allel DLA-88*03201 sowie vergleichende Betrachtung viraler und zellulärer Liganden von DLA-88*50101 und HLA-A*02:01

  2018cites this paper
• Structure and Function of Influenza Virus Ribonucleoprotein.

  2018cites this paper
• CHARACTERIZING THE ROLE OF N TERMINUS OF INFLUENZA A NUCLEOPROTEIN FOR LOCATION AND VIRAL RNP ACTIVITY

  2018cites this paper
• Priming events and development of tolerance upon influenza A virus and Staphylococcus aureus infection

  2018cites this paper
• Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy

  2018cites this paper
• Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design

  2018cites this paper
• Biologie structurale de complexes protéine:ARN

  2017cites this paper
• Identification of influenza A nucleoprotein body domain residues essential for viral RNA expression expose antiviral target

  2017cites this paper
• Evaluation of a novel computationally designed prophylactic against pandemic influenza virus in the ferret model

  2017cites this paper
• Molecular characterization of emaraviruses associated with Pigeonpea sterility mosaic disease

  2017cites this paper
• Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

  2016cites this paper
• The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

  2016cites this paper
• CHARACTERIZATION OF INFLUENZA NUCLEOPROTEIN BODY DOMAIN AS ANTIVIRAL TARGET

  2016cites this paper
• Inhibition of endosomal fusion activity of influenza virus by Rheum tanguticum (da-huang)

  2016cites this paper
• Tracking the Evolution in Phylogeny, Structure and Function of H5N1 Influenza Virus PA Gene.

  2016cites this paper
• A molecular modelling approach to understand the effect of co-evolutionary mutations (V344M, I354L) identified in the PB2 subunit of influenza A 2009 pandemic H1N1 virus on m7GTP ligand binding.

  2016cites this paper
• Development of universal Influenza vaccine in chicken with insights on the extracellular domain of Matrix protein 2

  2016influential citation
• Influenza A virus-host interactions and their control by viral non-structural protein NS1

  2015influential citation
• Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality

  2015cites this paper
• Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation

  2015cites this paper
• Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation

  2014cites this paper
• Mutations associated with severity of the pandemic influenza A(H1N1)pdm09 in humans: a systematic review and meta-analysis of epidemiological evidence

  2014cites this paper
• Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process

  2014cites this paper
• Common and unique features of viral RNA-dependent polymerases

  2014cites this paper
• Introduction to molecular biology of influenza a viruses.

  2014cites this paper
• Emerging antiviral resistant strains of influenza A and the potential therapeutic targets within the viral ribonucleoprotein (vRNP) complex

  2014cites this paper
• Design of the influenza virus inhibitors targeting the PA endonuclease using 3D-QSAR modeling, side-chain hopping, and docking.

  2014cites this paper
• Upolu virus and Aransas Bay virus, Two Presumptive Bunyaviruses, Are Novel Members of the Family Orthomyxoviridae

  2014cites this paper
• Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition.

  2014cites this paper
• Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex

  2014cites this paper
• Structure-Based Virtual Screening for Potential Inhibitors of Influenza A Virus RNA Polymerase PA Subunit

  2014cites this paper
• Evolution of Influenza Viruses

  2014cites this paper
• Characterizing immunogenetic factors associated with influenza cross-reactive responses and disease severity

  2014cites this paper
• A Crucial Epitope in the Influenza A and B Viral Neuraminidase and its Broad Inhibition by a Universal Antibody

  2014cites this paper
• Mechanism of cap-snatching in hantaviruses

  2014cites this paper
• Recent advances in computer-aided drug design as applied to anti-influenza drug discovery.

  2014cites this paper
• Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain.

  2014cites this paper
• Molecular Epidemiology and Evolution of Influenza A(H1N1) pdm09 Virus in Kenya

  2014cites this paper
• Structural insight into cap-snatching and RNA synthesis by influenza polymerase

  2014cites this paper
• Replication Cycle of Influenza Viruses

  2014cites this paper
• ROLE OF VIRAL AND HOST FACTORS IN INFLUENZA VIRUS MEDIATED INHIBITION OF INTERLEUKIN-23

  2014cites this paper
• Crystallization and X-ray crystallographic analysis of the cap-binding domain of influenza A virus H1N1 polymerase subunit PB2.

  2013influential citation
• Conformational Polymorphism of m7GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus

  2013cites this paper
• Sumoylation exerts minimal effects on the splicing regulatory activity of the influenza A virus non-structural protein NS1

  2013cites this paper
• Two amino acid residues in ion channel protein M2 and polymerase protein PA contribute to replication difference of H5N1 influenza viruses in mice.

  2013cites this paper
• Transcription and replication complex of influenza virus, a new antiviral drugs target.

  2013cites this paper
• The molecular basis of host range restriction of avian influenza virus polymerases in mammalian hosts

  2013cites this paper
• Targeting the Highly Conserved Sequences in Influenza A Virus

  2013cites this paper
• Antiviral activity of Jinchai capsule against influenza virus

  2013cites this paper
• Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalisation and mortality

  2012cites this paper
• Computational Studies on the Substrate Interactions of Influenza A Virus PB2 Subunit

  2012cites this paper
• Attenuation of bunyavirus replication by modification of genomic untranslated regions

  2012cites this paper
• Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design

  2012cites this paper
• Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice.

  2012cites this paper
• Signatures of Host mRNA 5′ Terminus for Efficient Hantavirus Cap Snatching

  2012cites this paper
• Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase.

  2012cites this paper
• Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity.

  2012cites this paper
• Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation

  2012cites this paper
• The impact of codon optimization in H5N1 vaccine

  2012cites this paper
• Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

  2012cites this paper
• Fig mosaic virus mRNAs show generation by cap-snatching.

  2012cites this paper
• PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection

  2012cites this paper
• The Molecular and Cellular Biology of Emerging Bunyaviruses

  2011cites this paper
• Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus

  2011cites this paper
• Polymerase activity of hybrid ribonucleoprotein complexes generated from reassortment between 2009 pandemic H1N1 and seasonal H3N2 influenza A viruses

  2011cites this paper
• Étude des mécanismes moléculaires gouvernant le réassortiment génétique des virus Influenza de type A

  2011cites this paper
• Heat Shock Protein 70 Inhibits the Activity of Influenza A Virus Ribonucleoprotein and Blocks the Replication of Virus In Vitro and In Vivo

  2011cites this paper
• Base-pairing promotes leader selection to prime in vitro influenza genome transcription.

  2011cites this paper
• Vergleichende Analyse saisonaler, aviärer, porziner und pandemischer Influenzaviren in humanen Lungen- und Zellkulturen

  2011cites this paper
• Nuclear localization of influenza B polymerase proteins and their binary complexes.

  2011cites this paper
• Élaboration de nouvelles stratégies thérapeutiques à l'encontre du virus de la grippe

  2011cites this paper
• Viral RNase Involvement in Strategies of Infection

  2011cites this paper
• Preferential use of RNA leader sequences during influenza A transcription initiation in vivo.

  2011cites this paper
• Structural Disorder in Proteins from Influenza Virus

  2011cites this paper
• Molecular mechanisms of transcription and replication of the influenza A virus genome

  2011cites this paper
• Characterization of the chicken and duck response to H5N1 avian influenza infection

  2011cites this paper
• Diversidade genética da neuraminidase de vírus Influenza A, isolados de crianças internadas na cidade de São Paulo, de 1995 a 2006.

  2010cites this paper
• Towards an atomic resolution understanding of the influenza virus replication machinery.

  2010cites this paper
• Avancées dans l'étude structurale et la compréhension moléculaire du mécanisme de transcription du virus de la grippe

  2010cites this paper
• The molecular virology and reverse genetics of influenza C virus.

  2010cites this paper
• Influenza A Virus Polymerase: Structural Insights into Replication and Host Adaptation Mechanisms*

  2010cites this paper
• Enzymology of RNA cap synthesis

  2010cites this paper