Genetically Modified Human Keratinocytes Overexpressing PDGF-A Enhance the Performance of a Composite Skin Graft

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Human Gene Therapy

• Publication date

  1998-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1089/hum.1998.9.4-529PMID 9525314
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sustainability of Keratinocyte Gene Transfer and Cell Survival In Vivo

  1997cited by this paper
• Loss of expression of a retrovirus-transduced gene in human keratinocytes.

  1996cited by this paper
• Permanent skin replacement using chimeric epithelial cultured sheets comprising xenogeneic and syngeneic keratinocytes.

  1996cited by this paper
• Evaluation of human skin reconstituted from composite grafts of cultured keratinocytes and human acellular dermis transplanted to athymic mice.

  1996cited by this paper
• Comparative Assessment of Cultured Skin Substitutes and Native Skin Autograft for Treatment of Full‐Thickness Burns

  1995cited by this paper
• Human keratinocytes express the three major splice forms of vascular endothelial growth factor.

  1995cited by this paper
• ALLOGENEIC‐SYNGENEIC CULTURED EPITHELIA: A SUCCESSFUL THERAPEUTIC OPTION FOR SKIN REGENERATION

  1995cited by this paper
• Genetically modified human epidermis overexpressing PDGF-A directs the development of a cellular and vascular connective tissue stroma when transplanted to athymic mice--implications for the use of genetically modified keratinocytes to modulate dermal regeneration.

  1995cited by this paper
• MIXED CULTURES COMPRISING SYNGENEIC AND ALLOGENEIC MOUSE KERATINOCYTES AS A GRAFTABLE SKIN SUBSTITUTE

  1995cited by this paper
• Angiogenic factors stimulate mast-cell migration.

  1995cited by this paper
• Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.

  1994cited by this paper
• Development of a bilayered living skin construct for clinical applications

  1994cited by this paper
• Wound Coverage With Biologic Dressings and Cultured Skin Substitutes

  1992cited by this paper
• PDGF AA homodimers are potent chemoattractants for fibroblasts and neutrophils, and for monocytes activated by lymphocytes or cytokines.

  1992cited by this paper
• The surgical applications and implications of cultured human epidermis: a comprehensive review.

  1992cited by this paper
• Treatment of leg ulcers with cryopreserved allogeneic cultured epithelium. A multicenter study.

  1992cited by this paper
• Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing

  1992cited by this paper
• In vitro reconstitution of skin: fibroblasts facilitate keratinocyte growth and differentiation on acellular reticular dermis.

  1991cited by this paper
• Repeated cultured epidermal allografts in the treatment of chronic leg ulcers of various origins.

  1991cited by this paper
• Epidermis generated in vitro: practical considerations and applications

  1991cited by this paper
• Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.

  1990cited by this paper
• Vascular endothelial growth factor is a secreted angiogenic mitogen.

  1989cited by this paper
• Survival of cultured allografts in patients with burns assessed with probe specific for Y chromosome.

  1989cited by this paper
• Cultured allogenic keratinocyte grafts in the management of wound healing: prognostic factors.

  1989cited by this paper
• Cultured composite skin grafts: biological skin equivalents permitting massive expansion.

  1989cited by this paper
• Treatment of skin ulcers with cultured epidermal allografts.

  1989cited by this paper
• Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate.

  1989cited by this paper
• Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA.

  1989cited by this paper
• REJECTION, AFTER A SLIGHTLY PROLONGED SURVIVAL TIME, OF LANGERHANS CELL‐FREE ALLOGENEIC CULTURED EPIDERMIS USED FOR WOUND COVERAGE IN HUMANS

  1988cited by this paper
• Artificial Dermis for Major Burns: A Multi‐Center Randomized Clinical Trial

  1988cited by this paper
• Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

  1988cited by this paper
• Angiogenic factors.

  1987cited by this paper
• Multiple hormones stimulate the production of somatomedin by cultured human fibroblasts.

  1984cited by this paper
• Grafting of burn patients with allografts of cultured epidermal cells.

  1983cited by this paper
• Molecular cloning of gene sequences regulated by platelet-derived growth factor.

  1983cited by this paper
• Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness.

  1981cited by this paper
• Successful Use of a Physiologically Acceptable Artificial Skin in the Treatment of Extensive Burn Injury

  1981cited by this paper
• Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.

  1975cited by this paper
• Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

  1975cited by this paper
• [Free skin grafts].

  1959cited by this paper
• Angiogenic Factors Stimulate Mast-Cell Migration

  year unknowncited by this paper

• Spatial and Functional Roles of Syndecans in Skin Wound Healing

  2025cites this paper
• Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects.

  2024cites this paper
• New Technology and Tissue Repair and Regeneration (3): Application of Other New Technologies in Tissue Repair and Regeneration

  2021cites this paper
• Regenerative Engineering Approaches to Scar-Free Skin Regeneration

  2021cites this paper
• Gene therapy in wound healing using nanotechnology

  2020cites this paper
• Influence of fibrin matrices and their released factors on epidermal substitute phenotype and engraftment

  2019cites this paper
• Treatment of Burns: Established and Novel Technologies

  2019cites this paper
• Biomaterials and controlled release strategy for epithelial wound healing.

  2019cites this paper
• Experimental models for cutaneous hypertrophic scar research

  2019cites this paper
• Strategies to promote the vascularization of skin substitutes after transplantation

  2018cites this paper
• Fibrin‐based delivery strategies for acute and chronic wound healing

  2017cites this paper
• Innovative Therapien der Wundheilung

  2017cites this paper
• Fibrin biomatrix‐conjugated platelet‐derived growth factor AB accelerates wound healing in severe thermal injury

  2016cites this paper
• Macrophage polarization: the link between inflammation and related diseases

  2015cites this paper
• Bioengineering a Human Plasma‐Based Epidermal Substitute With Efficient Grafting Capacity and High Content in Clonogenic Cells

  2015cites this paper
• Innovations in wound medicine

  2014cites this paper
• Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing

  2014cites this paper
• Cutaneous Cell- and Gene-Based Therapies for Inherited and Acquired Skin Disorders

  2014cites this paper
• Models of Abnormal Scarring

  2013cites this paper
• Innovative Solutions for Wound Therapy

  2013cites this paper
• Wound Coverage Technologies in Burn Care-Established and Novel Approaches

  2013cites this paper
• A comparative study of cell therapy and fibrin glue applied to chronic venous ulcers

  2013cites this paper
• Wound Coverage Technologies in Burn Care: Novel Techniques

  2013cites this paper
• New Strategies in Clinical Care of Skin Wound Healing

  2012cites this paper
• Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 2: role of growth factors in normal and pathological wound healing: therapeutic potential and methods of delivery.

  2012cites this paper
• Treatment of burns — established and novel technology

  2012cites this paper
• Topical application of hPDGF-A-modified porcine BMSC and keratinocytes loaded on acellular HAM promotes the healing of combined radiation-wound skin injury in minipigs

  2011cites this paper
• A new technique of ex vivo gene delivery of VEGF to wounds using genetically modified skin particles promotes wound angiogenesis.

  2011cites this paper
• Patientenvorbereitung und -nachbehandlung, inkl. interdisziplinäres postoperatives Schmerztherapiekonzept

  2011cites this paper
• Gene Transfer Techniques for Therapeutic Angiogenesis

  2010cites this paper
• Microvascularisation d'un substitut cutané reconstruit par génie tissulaire : mise au point et application à la recherche clinique et fondamentale

  2010cites this paper
• A review of gene and stem cell therapy in cutaneous wound healing.

  2009cites this paper
• On the way to total integration of prosthetic pylon with residuum.

  2009cites this paper
• Phase I/II clinical evaluation of StrataGraft: a consistent, pathogen-free human skin substitute.

  2009cites this paper
• Efficient retroviral gene transfer to epidermal stem cells.

  2008cites this paper
• Capítulo 15 – Cicatrización de las heridas en el pie diabético

  2008cites this paper
• CHAPTER 15 – WOUND HEALING IN THE DIABETIC FOOT

  2008cites this paper
• Cutaneous antimicrobial gene therapy: engineering human skin replacements to combat wound infection

  2008cites this paper
• Assessment of optimal virus-mediated growth factor gene delivery for human cutaneous wound healing enhancement.

  2008cites this paper
• Molecular mechanism and evolutional significance of epithelial-mesenchymal interactions in the body- and tail-dependent metamorphic transformation of anuran larval skin.

  2007cites this paper
• Gene therapy and wound healing.

  2007cites this paper
• Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-beta receptor II.

  2007cites this paper
• Gene-modified tissue-engineered skin: the next generation of skin substitutes.

  2007cites this paper
• Review Skin gene therapy for acquired and inherited disorders

  2006cites this paper
• Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair.

  2006cites this paper
• Skin gene therapy for acquired and inherited disorders.

  2006cites this paper
• Bioengineering of Human Skin Substitutes

  2006cites this paper
• Stellenwert der Gentherapie in Unfallchirurgie und Orthopädie

  2006cites this paper
• Pressure Ulcers and Wound Bed Preparation

  2006cites this paper
• Efficient gene transfer to human epidermal keratinocytes on fibronectin: in vitro evidence for transduction of epidermal stem cells.

  2005cites this paper
• Gene delivery of PDGF for wound healing therapy.

  2005cites this paper
• Cellular and molecular facets of keratinocyte reepithelization during wound healing.

  2005cites this paper
• New tissue repair strategies

  2005cites this paper
• What's new in burns and metabolism.

  2004cites this paper
• Gene transfer into human epidermis as an experimental model for somatic gene therapy.

  2004cites this paper
• FGF-7 expression enhances the performance of bioengineered skin.

  2004cites this paper
• Current approaches and perspectives in human keratinocyte-based gene therapies

  2004cites this paper
• Gene transfer in tissue repair: status, challenges and future directions

  2004cites this paper
• An in vivo model of wound healing in genetically modified skin-humanized mice.

  2004cites this paper
• In Vivo Model of Wound Healing Based on Transplanted Tissue-Engineered Skin

  2004cites this paper
• Tissue and cellular approaches to wound repair.

  2004cites this paper
• Gene transfer to epidermal stem cells: implications for tissue engineering

  2004cites this paper
• TGF-beta: a fibrotic factor in wound scarring and a potential target for anti-scarring gene therapy.

  2004cites this paper
• Gene Therapy in the Treatment of Lower Extremity Wounds

  2004cites this paper
• The chronic wound: impaired healing and solutions in the context of wound bed preparation.

  2004cites this paper
• WHAT ’ S NEW IN SURGERY What ’ s New in Burns and Metabolism

  2004cites this paper
• Platelet Derived Growth Factor (PDGF) Responsive Epidermis Formed from Human Keratinocytes Transduced with the PDGFβ Receptor Gene

  2003cites this paper
• Quantitative assessment of cell viability and apoptosis in cultured epidermal autografts: application to burn therapy.

  2003cites this paper
• Cutaneous Gene Therapy with Cultured Skin Substitutes

  2003cites this paper
• [Molecular mechanisms of healing].

  2003cites this paper
• Culture of rat keratinocytes with acellular pig dermis.

  2003cites this paper
• Platelet derived growth factor (PDGF) responsive epidermis formed from human keratinocytes transduced with the PDGF beta receptor gene.

  2003cites this paper
• Gene therapy in wound healing.

  2003cites this paper
• Sense oligonucleotide competition for gene promoter binding and activation.

  2003cites this paper
• Platelet‐derived growth factor signaling as a cue of the epithelial–mesenchymal interaction required for anuran skin metamorphosis

  2003cites this paper
• Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes.

  2002cites this paper
• Skin as a potential organ for ectopic monoclonal antibody production.

  2002cites this paper
• The effect of epidermal growth factor & platelet-derived growth factors on wound healing process.

  2002cites this paper
• [Gene therapy concepts for promoting wound healing].

  2002cites this paper
• Gene technology and tissue engineering

  2002cites this paper
• Treatment of Chronic Wounds: State of the Art and Future Concepts

  2002cites this paper
• Gentherapeutische Konzepte zur Förderung der Wundheilung

  2002cites this paper
• Genetically Modified Skin Substitutes

  2002cites this paper
• Cutaneous gene transfer for skin and systemic diseases

  2002cites this paper
• Cell Interaction and Epithelial Differentiation

  2002cites this paper
• Recent advances in gene therapy with skin cells

  2002cites this paper
• Transient Hyperproliferation of a Transgenic Human Epidermis Expressing Hepatocyte Growth Factor

  2002cites this paper
• Tissue-engineered skin substitutes

  2002cites this paper
• Treatment of Ischemic Wounds Using Cultured Dermal Fibroblasts Transduced Retrovirally With PDGF-B and VEGF121 Genes

  2001cites this paper
• Gene Transfer Strategies in Tissue Repair

  2001cites this paper
• Growth factor regulation and manipulation in wound repair: to scar or not to scar, that is the question

  2001cites this paper
• Development of a Three-Dimensional Transmigration Assay for Testing Cell–Polymer Interactions for Tissue Engineering Applications

  2001cites this paper
• Gene therapy of scarring: a lesson learned from fetal scarless wound healing.

  2001cites this paper
• Matrix Immobilization Enhances the Tissue Repair Activity of Growth Factor Gene Therapy Vectors

  2001cites this paper
• Plasmid Gene Delivery to Human Keratinocytes Through a Fibrin-Mediated Transfection System

  2001cites this paper
• Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet‐derived growth factor‐A

  2001cites this paper
• Craniofacial tissue engineering.

  2001cites this paper
• Advances in skin gene therapy

  2000cites this paper
• Virus-Mediated Gene Transfer for Cutaneous Gene Therapy

  2000cites this paper
• Transcriptional targeting of adenoviral gene delivery into migrating wound keratinocytes using FiRE, a growth factor-inducible regulatory element

  2000cites this paper