The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature

• Publication date

  2014-05-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature13264PMID 24828042PMCID PMC4263271
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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  2011cited by this paper
• Assessing mitochondrial dysfunction in cells

  2011cited by this paper
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  2011cited by this paper
• Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

  2011cited by this paper
• The genetics of ageing

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

  2009cited by this paper
• Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

  2009cited by this paper
• Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO‐dependent pathway

  2009cited by this paper
• Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

  2009cited by this paper
• Target identification using drug affinity responsive target stability (DARTS)

  2009cited by this paper
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  2009cited by this paper
• Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

  2009cited by this paper
• Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

  2009cited by this paper
• The TOR pathway comes of age.

  2009cited by this paper
• Measuring Caenorhabditis elegans Life Span on Solid Media

  2009cited by this paper
• C. elegans behavior of preference choice on bacterial food

  2009cited by this paper
• A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

  2008cited by this paper
• Expanding chemical biology of 2-oxoglutarate oxygenases.

  2008cited by this paper
• The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.

  2008cited by this paper
• Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells.

  2007cited by this paper
• PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

  2007cited by this paper
• Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation.

  2007cited by this paper
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  2007cited by this paper
• Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

  2007cited by this paper
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  2007cited by this paper
• Conservation of the metabolomic response to starvation across two divergent microbes

  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Hierarchical phosphorylation of the translation inhibitor 4E-BP1.

  2001cited by this paper
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  2001cited by this paper
• Mitochondrial Respiratory Chain Deficiency inCaenorhabditis elegans Results in Developmental Arrest and Increased Life Span*

  2001cited by this paper
• Regulation of translation initiation by FRAP/mTOR.

  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Specific interference by ingested dsRNA

  1998cited by this paper
• RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

  1998cited by this paper
• The genetics of caloric restriction in Caenorhabditis elegans.

  1998cited by this paper
• The modular phosphorylation and activation of p70s6k

  1997cited by this paper
• The ATP synthase--a splendid molecular machine.

  1997cited by this paper
• Molecular biology of the cell (3rd edn)

  1995cited by this paper
• Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria

  1994cited by this paper
• [Genetics of Caenorhabditis elegans].

  1989cited by this paper
• Metabolites of citric acid cycle, carbohydrate and phosphorus metabolism, and related reactions, redox and phosphorylating states of hepatic tissue, liver mitochondria and cytosol of the pigeon, under normal feeding and natural nocturnal fasting conditions.

  1982cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper

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