A dermal HOX transcriptional program regulates site-specific epidermal fate.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Genes & Development

• Publication date

  2008-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.1610508PMID 18245445PMCID PMC2216690
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.

  2007cited by this paper
• Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

  2006cited by this paper
• Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs

  2006influential reference
• Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay

  2005cited by this paper
• Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.

  2005influential reference
• Genomic maps and comparative analysis of histone modifications in human and mouse.

  2005cited by this paper
• Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

  2005cited by this paper
• HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis

  2004cited by this paper
• Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway.

  2004cited by this paper
• Mesenchymal–epithelial interactions in the skin

  2004cited by this paper
• Genomewide view of gene silencing by small interfering RNAs

  2003cited by this paper
• Diversity, topographic differentiation, and positional memory in human fibroblasts

  2002cited by this paper
• Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs.

  2001cited by this paper
• Coordinated expression of Hoxb genes and signaling molecules during development of the chick respiratory tract.

  2000cited by this paper
• Regulation of keratin 9 in nonpalmoplantar keratinocytes by palmoplantar fibroblasts through epithelial-mesenchymal interactions.

  1999cited by this paper
• Hox genes: from master genes to micromanagers.

  1998cited by this paper
• Visualization of gene expression patterns by in situ hybridization.

  1997cited by this paper
• Mutation of HOXA13 in hand-foot-genital syndrome

  1997cited by this paper
• Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK)

  1994cited by this paper
• The making of a feather: Homeoproteins, retinoids and adhesion molecules

  1993cited by this paper
• Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified.

  1992cited by this paper

• Perspectives on the future of skin-prosthetic interactions.

  2026cites this paper
• Fibroblasts of disparate developmental origins harbor anatomically variant scarring potential.

  2026cites this paper
• The cellular logic of limb regeneration

  2026cites this paper
• Signal control during tissue regeneration in adult animals.

  2025cites this paper
• Research progress on scar-free healing

  2025cites this paper
• Site-specific expression of HOXA genes in skin and its effect on skin elasticity.

  2025cites this paper
• Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans

  2025cites this paper
• Fibroblasts in immune responses, inflammatory diseases and therapeutic implications

  2025cites this paper
• Clinical Features and Mechanisms of Differential Wound Healing and Scarring Across Anatomical Sites.

  2025cites this paper
• The fundamentals of WNT10A

  2025cites this paper
• Molecular basis of positional memory in limb regeneration

  2025cites this paper
• Unravelling the Regulatory Roles of lncRNAs in Melanoma: From Mechanistic Insights to Target Selection

  2025cites this paper
• Engineering a skin-mimicking asymmetric poly(L-lactic acid/gelatin bioscaffold for skin repair

  2025cites this paper
• Complex Wounds in Ectodermal Dysplasias: Translating Discovery to Therapy

  2025cites this paper
• The expression pattern of Wnt6 and HOXA13 during regenerating tails of Gekko Japonicus.

  2024cites this paper
• Hallmarks of regeneration.

  2024cites this paper
• Cell Therapy and the Skin: Great Potential but in Need of Optimization.

  2024cites this paper
• A chromatin code for limb segment identity in axolotl limb regeneration.

  2024cites this paper
• The use of ectopic volar fibroblasts to modify skin identity

  2024cites this paper
• ProT-Patch: A Smart Coated Polymeric Microneedle Enables Noninvasive Protein Delivery and Reprogramming of Epidermal Skin Identity

  2024cites this paper
• Volar Fibroblasts and their Potential Therapeutic Use.

  2024cites this paper
• Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity

  2024cites this paper
• Joint-specific regulation of homeobox D10 expression in rheumatoid arthritis fibroblast-like synoviocytes

  2024cites this paper
• Fibroblast mechanoperception instructs pulmonary developmental and pattern specification gene expression programs

  2024cites this paper
• Convergent deployment of ancestral functions during the evolution of mammalian flight membranes

  2023cites this paper
• Making a new limb out of old cells: Exploring endogenous cell reprogramming and its role during limb regeneration.

  2023cites this paper
• Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing.

  2023cites this paper
• Multi-omics analyses identify transcription factor interplay in corneal epithelial fate determination and disease

  2023cites this paper
• A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization.

  2023cites this paper
• Identification of the regulatory circuit governing corneal epithelial fate determination and disease

  2023cites this paper
• Fibroblasts – the cellular choreographers of wound healing

  2023cites this paper
• Long non-coding RNAs: definitions, functions, challenges and recommendations

  2023cites this paper
• Perilesional Epigenomes Distinguish Melanocytic Nevus Subtypes.

  2023cites this paper
• Comparative computational analysis to distinguish mesenchymal stem cells from fibroblasts

  2023cites this paper
• The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis

  2023cites this paper
• TGF-β Isoforms Affect the Planar and Subepithelial Fibrogenesis of Human Conjunctival Fibroblasts in Different Manners

  2023cites this paper
• Unravelling morphoea aetiopathogenesis by next-generation sequencing of paired skin biopsies

  2023cites this paper
• Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi.

  2023cites this paper
• En1 and Lmx1b do not recapitulate embryonic dorsal-ventral limb patterning functions during mouse digit tip regeneration

  2022cites this paper
• Myofibroblasts Are Not Characteristic Features of Keloid Lesions

  2022cites this paper
• Adult mouse fibroblasts retain organ-specific transcriptomic identity

  2022cites this paper
• Fibroblast Heterogeneity in Healthy and Wounded Skin.

  2022cites this paper
• Convergent deployment of ancestral programs during the evolution of mammalian flight membranes

  2022cites this paper
• Development of Wattles in the Chicken Embryo

  2022cites this paper
• Wound healing, fibroblast heterogeneity, and fibrosis.

  2022cites this paper
• Isolation and feeder-free primary culture of four cell types from a single human skin sample

  2022cites this paper
• The origins of skin diversity: lessons from dermal fibroblasts.

  2022cites this paper
• Hoxb1 Regulates Distinct Signaling Pathways in Neuromesodermal and Hindbrain Progenitors to Promote Cell Survival and Specification.

  2022cites this paper
• Organ- and Site-Specific HOX Gene Expression in Stromal Cells

  2021cites this paper
• Fibroblast Memory in Development, Homeostasis and Disease

  2021cites this paper
• The Role of Fibroblasts in Atherosclerosis Progression

  2021cites this paper
• Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity.

  2021cites this paper
• ECM-mediated positional cues are able to induce pattern, but not new positional information, during axolotl limb regeneration

  2021cites this paper
• Epigenetic and metabolic regulation of epidermal homeostasis

  2021cites this paper
• Skin organoids: A new human model for developmental and translational research

  2021cites this paper
• Human Cytomegalovirus Replication and Infection-Induced Syncytia Formation in Labial, Foreskin, and Fetal Lung Fibroblasts

  2021cites this paper
• Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice.

  2021cites this paper
• Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis

  2021cites this paper
• Fibroblast pathology in inflammatory joint disease

  2021cites this paper
• Endogenous Mechanisms of Craniomaxillofacial Repair: Toward Novel Regenerative Therapies

  2021cites this paper
• Can plantar fibroblast implantation protect amputees from skin injury? A recipe for skin augmentation

  2021cites this paper
• Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin

  2021cites this paper
• Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing.

  2020cites this paper
• Fibroblast Heterogeneity in Wound Healing: Hurdles to Clinical Translation.

  2020cites this paper
• Understanding the impact of fibroblast heterogeneity on skin fibrosis

  2020cites this paper
• The phenotype of gingival fibroblasts and their potential use in advanced therapies.

  2020cites this paper
• Identification of Heparan-Sulfate Rich Cells in the Loose Connective Tissues of the Axolotl (Ambystoma mexicanum) with the Potential to Mediate Growth Factor Signaling during Regeneration

  2020cites this paper
• How a Bird Gets Its Feathers: Insights from Chromatin Looping.

  2020cites this paper
• Fibroblasts as the subject of proliferative activity research in vitro

  2020cites this paper
• Folding Keratin Gene Clusters during Skin Regional Specification.

  2020cites this paper
• Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load

  2019cites this paper
• Hox gene expression determines cell fate of adult periosteal stem/progenitor cells

  2019cites this paper
• Hierarchical pattern formation during amphibian limb regeneration

  2019influential citation
• Age-related evolutions of the dermis: Clinical signs, fibroblast and extracellular matrix dynamics.

  2019cites this paper
• A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels

  2019cites this paper
• Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

  2019cites this paper
• Chemo‐enzymatic treatment of RNA to facilitate analyses

  2019cites this paper
• FRT—Fondation Rene Touraine

  2018cites this paper
• Hox5 genes direct elastin network formation during alveologenesis by regulating myofibroblast adhesion

  2018cites this paper
• Fibroblast heterogeneity: implications for human disease

  2018cites this paper
• Use of homeobox gene expression patterns to determine anatomical regions of origin for body surface tissues derived from adult mice

  2018cites this paper
• Revitalizing Aging Skin through Diet.

  2018cites this paper
• Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues

  2018cites this paper
• Epigenetic Regulation of Skin Development and Regeneration

  2018cites this paper
• Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression.

  2018cites this paper
• Embryonic skin development and repair

  2018cites this paper
• Tube Formation Potential of BMSCs and USSCs in Response to HIF-1α Overexpression under Hypoxia

  2018cites this paper
• Transcription and microRNA Profiling of Cultured Human Tympanic Membrane Epidermal Keratinocytes

  2018cites this paper
• Loss of Hox5 function results in myofibroblast mislocalization and distal lung matrix defects during postnatal development

  2018cites this paper
• The interstitium in cardiac repair: role of the immune–stromal cell interplay

  2018cites this paper
• Long Noncoding RNA and Its Role in the Control of Gene Expression in the Skin

  2018cites this paper
• Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

  2017cites this paper
• Hox genes in the adult skeleton: Novel functions beyond embryonic development

  2017cites this paper
• The molecular pathogenesis of morphoea: from genetics to future treatment targets

  2017cites this paper
• WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

  2017cites this paper
• Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

  2017cites this paper
• Allogeneic cell-based therapies for individuals with recessive dystrophic epidermolysis bullosa

  2017cites this paper
• EC-tagging allows cell type-specific RNA analysis

  2017cites this paper
• Wnt-expressing cells in the intestines: guides for tissue remodeling

  2017cites this paper
• Why location matters — site-specific factors in rheumatic diseases

  2017cites this paper