Guidance for engineering of synthetic methylotrophy based on methanol metabolism in methylotrophy

Methanol is increasingly becoming an attractive substrate for production of different metabolites, such as commodity chemicals, and biofuels via biological conversion, due to the increment of annual production capacity and decrement of prices. In recent years, genetic engineering towards native menthol utilizing organisms – methylotrophy has developed rapidly and attracted widespread attention. Therefore, it is vital to elucidate the distinct pathways that involve methanol oxidation, formaldehyde assimilation and disassimilation in the different methylotrophies for future synthetic work. In addition, this will also help to genetically construct some new and non-native methylotrophies. This review summarizes the current knowledge about the methanol metabolism pathways in methylotrophy, discusses and compares different pathways on methanol utilization, and finally presents the strategies to integrate the methanol metabolism with other chemicals, biofuels or other high value-added product formation pathways.

• Publication year

  2017

• Venue

  RSC Advances

• Publication date

  2017-01-09

• Fields of study

  Chemistry, Engineering, Environmental Science

• Identifiers
  DOI 10.1039/C6RA27038G
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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